special topic the bio downside the mechanism of carcinogensis by polycyclic aromatic compounds
Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... well as of the alleviation of this inhibition by another substrate of the enzyme, ATP, are presented [8,9] Results Solution properties of the N-terminal domain of PS, the C-terminal domain of PS, ... regions of the Ramachandran map [32,33] Comparison of the monomer of the substrate-free form of E coli PS [13] with the monomers of nPS in the pantoate-bound form at full occupancy indicates that the ... back to the position of the Fig Superimposition of the A-chain of nPS (green), the B-chain of nPS (cyan), and the substrate-free protein (1IHO.pdb; magenta) The carbon and oxygen atoms of pantoate...
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Tài liệu Special RepoRt The Dynamics of Public Trust in Business— Emerging Opportunities for Leaders ppt
... erupted in the Fall of 2008—but the events of the past several months, if anything, reinforced the importance of the topic The resulting report is not a comprehensive study of the broad issue of trust ... trust—particularly in the arena of risk management and the stability of the housing market the headwinds that leaders are facing as they attempt to get ahead of the crisis may in part be a result of low public ... permission and exists by public approval.”21 In the minds of many—including the vast majority of executives the major business scandals of recent years were primarily the result of greed There were, however,...
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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc
... compensates for the initial decrease of the oxaloacetate concentration in the equilibrium due to the accumulation of NADH [25] Lineweaver–Burk diagrams were obtained by use of the worksheet of the program ... on the inhibition of protein biosynthesis by the action of cycloheximide Cycloheximide binds to the 80S-subunit of eukaryotic ribosomes and prevents the initiation and elongation reaction of ... branch of the pentose phosphate pathway This was determined by the use of glucose-6-phosphate as the substrate and NADP as the hydrogen acceptor Due to the use of cell-free extracts, not only the...
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Tài liệu Báo cáo khoa học: The mechanism of a-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase doc
... under the action of TPL gives evidence for the orthogonal orientation of the a-proton with respect to the cofactor plane [17], and shows that the pattern of binding is the same for a variety of ... (c) the degree of restriction of the free rotation of the considered group in the active site For the reaction with L-phenylalanine the value of kr for nondeuterated substrate is more than for the ... contributions of these processes are described by a partition coefficient a, which is determined by: (a) the rates of the isotopic exchange between the enzyme functional group having abstracted the a-proton,...
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Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx
... hypothesize that the cytotoxic activity of the latter monomers was due to the presence in these proteins of disulde bonds, with their potential chemical instability It is well known that in the ... tested as such for inhibition by CRI, because the strongly reducing conditions of the assay produce the cleavage of their mixed disuldes This in turn generates, from either MSSAE or MSSG, M(SH)2 ... monomer was obtained by reaction with methyl aminoethanethiosulfonate of the sulfhydryls exposed by selective reduction of the Table Monomeric derivatives of BS-RNase LC50 is the protein concentration...
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Báo cáo khoa học: Purification and characterization of zebrafish hatching enzyme – an evolutionary aspect of the mechanism of egg envelope digestion pot
... analyzed the mechanism of its egg envelope digestion and compared it with that of medaka hatching enzyme Finally, the evolution of the mechanism of egg envelope digestion is discussed on the basis of ... that the amount of ZHE1 transcript is quite different from that of ZHE2 The amount of ZHE2 transcript is considered to be much lower than that of ZHE1 Taken together with the results of the northern ... than that of the 50 incubation, suggesting further digestion of the 43 kDa product Furthermore, their 36.5 kDa bands became broader than that for the 50 incubation The sequence analyses of the 36.5...
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Báo cáo khoa học: On the mechanism of a-amylase Acarbose and cyclodextrin inhibition of barley amylase isozymes pdf
... enzyme of the substrate and of the inhibitor, the weak afnity of maltoheptaose to enzyme (E) facilitated the binding of acarbose (I) to allow the formation of the abortive EI complex, the ES ... for the active site of AMY (E) than found for acarbose When the substrates and the inhibitor compete for the active site, the high afnity of the substrates facilitates their binding whereas the ... compartment of the control and one compartment of the sample cell and the reference line was determined (A0) Then acarbose (1.76.5 mM) was added to the buffer compartment of the control and to the compartment...
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Báo cáo Y học: The mechanism of nitrogen monoxide (NO)-mediated iron mobilization from cells NO intercepts iron before incorporation into ferritin and indirectly mobilizes iron from ferritin in a glutathione-dependent manner pot
... to the efficacy of the well-characterized Fe chelators, DFO and 311 [34,41] Each of the NO-generators resulted in the release of 18–24% of total cellular 59Fe, whereas the relevant control compounds ... metabolism of D-glucose potentiates NO-mediated Fe efflux from a variety of cell types Further, we demonstrated that the metabolism of D-glucose by the hexose monophosphate shunt (HMPS) and the maintenance ... Hypothetical model of D-glucose-dependent NO-mediated Fe mobilization from cells D-Glucose is transported into cells and is used by the tricarboxylic acid cycle for the production of ATP and by the...
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Báo cáo khoa học: Biosynthesis of isoprenoids – studies on the mechanism of 2C-methyl-D-erythritol-4-phosphate synthase pdf
... abundance level for the signals of C-3 and C-4 of a hypothetical product 1c The hypothetical positions of the 13C13C coupling satellites expected in the spectrum of 1c are marked by arrows in Fig ... week; the final ratio of the two compounds, believed to represent a state of equilibrium, was about : The apparent rate constant for the formation of from was · 10)7 s)1, and, the Mechanism of IspC ... case, the integrals of the satellite signals are in the range of 1% as compared to the central signal Signals of that size would be expected in the complete absence of fragment exchange, where they...
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Báo cáo khoa học: Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site pot
... then participate in the reductase reaction The reverse of the isomerase reaction is thermodynamically favoured by the near irreversibility of the conversion of the 2-ketoacid to TS2 However the ... is supported by the observation that mutating H132 to glutamine has by far the greatest effect on the Km for NADPH, increasing it by 28-fold (Table 4) Several of the mutations leave the reductase ... with DTNB by Mg2+ (A) The reaction of KARI with DTNB, followed by the increase in absorbance at 412 nm There is a fast initial burst followed by a slower reaction that is affected by the concentration...
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Báo cáo khoa học: The interaction of the Escherichia coli protein SlyD with nickel ions illuminates the mechanism of regulation of its peptidyl-prolyl isomerase activity ppt
... cluster that is the core of the domain The IF domain of SlyD is aligned with the IF domain of the archaeal homologous MtFKBP17 [32] (Fig 3) The main difference between these two domains is the longer ... impeded by the loss of the perturbed resonances, which could be attributable to either an intermediate equilibrium of the complex and or the paramagnetic effect of the nickel ion (see below) Nonetheless, ... insertion of the IF domain of SlyD into HsFKBP12 considerably boosts the chaperone-like activity of the latter [17], and by the recent observation that the IF domain of SlyD is directly involved in the...
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Báo cáo khoa học: A family of killer toxins Exploring the mechanism of ADP-ribosylating toxins pptx
... illustrates the stacking of the nicotinamide ring between the conserved tyrosines, the binding of the conserved His to the O2 of the adenine ribose and the carbonyl oxygen of Y54 and the binding of the ... catalytic mechanism The current understanding of the mechanism of catalysis is that NAD is bound by the ADPRT in a Table Summary of the ADPRTs that have had their 3D structures determined, giving their ... glutamate to the O2 of the nicotinamide ribose (B) Schematic view of the NAD binding cleft of the cholera-like class of toxins showing the intramolecular interactions around the active site and the key...
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scientific american - 1997 10 - special issue - the future of transportation
... for their origin, where they have come from and by what means It appears that the theory of their transportation is the ‘age of Drifts’—that this continent was once the bed of the sea and that these ... poisoning in the occupants Extensive researches have been made for the first time by Prof Emmerling of the Berlin University The results seem to confirm the correctness of the theory that the dust ... species of fish set the stage for the entire biological composition of Arctic lakes, ponds and streams Because fish are top predators, they control the zooplankton and the rest of the biota, explains...
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Báo cáo hóa học: " Cytotoxic effects and the mechanism of three types of magnetic nanoparticles on human hepatoma BEL-7402 cells" ppt
... bioaccumulation and clearance procedures of MNPs [29-31] Furthermore, the cytotoxicity studies of MNPs are limited by the fact that cytology mechanism remained unexplored In the present study, human hepatoma ... was selected as the model specimen for cytotoxicity assessment, and the aims were to evaluate the cytotoxicity of Fe3O4, OA-Fe3O4, and C-Fe and to elucidate the mechanisms of their cytotoxicities ... charged surfaces of MNPs due to the electrostatic effects, which could affect the amount of MNPs entering the cells and further affect cytotoxicity In our results, the surface charge of Fe O4 , OA-Fe3...
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Báo cáo sinh học: "Making the jump: new insights into the mechanism of trans-translation" pdf
... RNA at the start of translation How then is the resume triplet properly positioned? And what mechanism allows the ribosome to take off from the damaged mRNA template and land precisely on the tmRNA’s ... establish the contribution of the nucleotide residues that precede the resume codon to the correct positioning of the MLD Identifying determinants of template switching One problem in determining the ... permutations of the -1 triplet and determined their effect on survival in the kanamycin resistance assay They found that eight of the 18 codons that were prohibited according to the -1 hypothesis [12]...
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Báo cáo y học: "Outcome of crisis intervention for borderline personality disorder and post traumatic stress disorder: a model for modification of the mechanism of disorder in complex post traumatic syndromes" ppsx
... adjunct to psychotherapy that, in turn, may repair the mechanism of crises, thereby making medication unnecessary Some authors explain the limitations of pharmacotherapy by the nature of BPD and complex ... hypothesized mechanism that compounds the entrapment while adhering to the goal of safe intimacy By the same theory, treatment as usual should also shorten the duration of crises, however, by ... irrational activity In that lull, the therapist proposes that there is indeed a better method to become sure of the mother's intentions, one way or the other, and of others' in the future Engagement in...
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Báo cáo y học: "The mechanism of low-concentration sodium nitroprusside-mediated protection of chondrocyte deat" pps
... understanding of the mechanisms of chondrocyte apoptosis over the past several years, it is unclear whether chondrocyte apoptosis is the major mechanism of cartilage degradation or merely a byproduct of ... that produced by mM SNP, respectively, but the levels of cell death induced were not as profound as that produced by mM SNP These results demonstrate that the amount of NO produced by a NO donor ... is the sole mediator of SNP-induced chondrocyte death and peroxynitrite, a reaction product of NO and superoxide anions, or the primary byproducts of the R531 decomposition of SNP, such as the...
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The mechanism of prion strain propagation potx
... yeast: the expansion of the prion hypothesis Cell 1997, 89:495-498 Sparrer HE, Santoso A, Szoka FC Jr, Weissman JS: Evidence for the prion hypothesis: induction of the yeast [PSI+] factor by in ... range of phenotypic states - reminiscent of mammalian prion strains - which differ from each other in their levels of nonsense suppression, the involvement of chaperone proteins, and in the solubility ... [16], which is the prion isoform of the essential protein Sup35p, the yeast counterpart of the animal translational termination factor eRF3 As predicted for a prion-like mode of replication,...
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Human Physiology: The Mechanism of Body Function - part 1 pdf
... expose the binding site to one side of the membrane, then to the other, independent of the protein’s phosphorylation (3) Removal of the phosphate group from the transporter decreases the affinity of ... in the next section, the resolution of this paradox is found in the isolation of most of the cells of the body from the external environment and in the existence of an internal environment The ... with the polar regions at the surface and the nonpolar regions in the interior of the cluster IV The molecular weight of a molecule is the sum of the atomic weights of all its atoms One mole of...
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Human Physiology: The Mechanism of Body Function - part 2 pptx
... nucleus, followed by the translation of the RNA information into protein synthesis in the cytoplasm The proteins then perform the functions that determine the characteristics of the cell The genetic ... the region of the mRNA bound to the ribosome The amino acid on the tRNA is linked by a peptide bond to the end of the growing polypeptide chain (see Figure 5–6) The tRNA that has been freed of ... type of protein The development of an individual is determined by the controlled expression of the set of genes inherited at the time of conception Growth occurs through the successive division of...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose