speaking what is the most important anatomic layer in nasal reconstruction
Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... for the specific MAP2 binding resides within the 32 residues (amino acids 456–487) of the v-KIND KIND2 domain To examine whether the MAP2 binding core site of v-KIND binds to intact MAP2 protein, ... in the central domain of MAP2 contain the v-KIND binding core module MAP2 consists of three main structural domains: the cAMP-dependent protein kinase regulatory subunit RII binding domain, the ... dendrites via MAP2 binding, which is absent in the KINDs from other KIND-containing proteins To examine the dendrite localization signal domains in v-KIND, we first investigated the subcellular localization...
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Báo cáo khoa học: Proteolytic activation and function of the cytokine Spatzle in the innate immune response of a lepidopteran insect, Manduca sexta ppt
... suggesting that the recombinant protein is a disulfide-linked dimer ProSpatzle-1A is activated by proteinase HP8Xa ¨ In other insect species, proSpatzle is activated through ¨ proteolysis by a ... contained a 30 bp insertion in the ¨ ORF, beginning at nucleotide 516 This resulted in insertion of a 10 amino acid segment (TREIDYPETI) and one substitution (Ser fi Gly) at the C-terminal end of the ... cysteines are shaded and numbered The paired numbers (1–1, 2–2, 3–3) indicate the intrachain disulfide linkage in Dm_Spz [10] Cys4 forms an intermolecular disulfide bond with its counterpart in another...
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Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf
... of the C-domain, still retains its RF activity [15] The combination of the human M-domain and C-domain, in the absence of the N-domain, is able to bind to the mammalian ribosome and to induce the ... sequence in the N-domain and the strictly conserved GGQ triplet in the M-domain involved in peptidyl-tRNA hydrolysis are indicated by spheres around Ca atoms The minidomain is close to the N-domain ... ignoring the trivial case of the C-terminal tail of the protein, the most flexible region in the C-domain is loop 357–367 (Fig S5) It is important to mention that no noticeable differences in the...
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Báo cáo khoa học: Structure and function of the 3-carboxy-cis,cis-muconate lactonizing enzyme from the protocatechuate degradative pathway of Agrobacterium radiobacter S2 pdf
... substrate binding Furthermore, His228A is in the same loop as Arg224A, which is part of the ‘allosteric binding site’ 224–232 loop and adjacent to the Trp227 forming the basis of this binding site ... active site arginines (Arg155 and Arg312) are indicated by dashed lines The side chain of His278 is not visible in the ArCMLE1 structure The figure was created from the coordinates of the P212121 ... B-factor in one of the active sites of a tetramer and, as in our P212121 structure, they could see a few more residues of the loop, including the lysine pointing towards the active site The binding...
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structure and function of the arabic verb
... tome is for Arabists and Semitists as well as general linguists, who should always be interested in broadening their linguistic horizons and getting involved with non-Indo-European linguistic ... this century (Von Wright 1951, among others) and the special interest in the notion of Modality in linguistics during the second half of the century illustrates the independent directions of these ... immersed in and reminiscent of theory] In fact, the metaterm “enunciative operations” is specifically used to refer to the speaker’s activities upon the Lexis In other words, the utterance is the...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 1 pps
... roles in reducing the risk of noise induced hearing loss The basis for that is discussed in several chapters in the book The practical and legal aspects of hearing conservation are covered in an ... to the cochlea In humans, the labyrinthine artery is much longer than in the animals commonly used in experiments related to hearing This is because the distance between the brainstem and the ... process, of the incus forms one side of the incudo-stapedial joint The head of the malleus and the incus are fused together in a double saddle joint and the joint between these two bones is regarded...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 2 ppsx
... which increases with the increase in the sound pressure of the sound that elicits the CM Recording of the CM is often used to determine changes in sound transmission of the middle ear The generation ... malleus inward, increasing the stiffness of the middle ear and displacing the tympanic membrane inward The stapedius muscle pulls the stapes in a direction that is perpendicular to the piston-like ... as being the result of a traveling wave motion along the basilar membrane (Fig 3.2) The third epoch starting in the 1970s runs until the present That period is dominated by the finding that the...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 4 potx
... representations or both is the basis for discrimination of frequency 11 The frequency selectivity of the basilar membrane is the basis for the place principle of frequency discrimination Coding of the temporal ... computers is linear There is a limitation regarding the relationship between the width of the frequency bands within which the energy is obtained and the time over which the energy is integrated ... variability in the responses of nerve cells in the ascending auditory pathways, including frequency tuning The input to cells in the nuclei of the ascending auditory pathways, and the cerebral cortex, is...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 6 pot
... horizontal line is a line between the two ears and it is also the time axis The vertical axis is a line between the middle of that line and the vertex The origin of the vectors is the latency of the ... supports the hypothesis that the initial sharp positive deflection is generated by the terminations of the lateral lemniscus in the inferior colliculus on the side that is contralateral to the stimulation ... from the intracranial portion of the auditory nerve is the travel time in the auditory nerve from the ear to the recording site FIGURE 7.2 Comparison between recording from the round window of the...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 7 pot
... during paralysis of the stapedius muscle (from Bell’s Palsy) (thick continuous line), and after recovery of the paralysis (thin line) The thick interrupted line shows the discrimination scores in ... is now a routine test used in most clinics involved in diagnosis of the auditory system FIGURE 8.14 TTS in the affected ear during unilateral paralysis of the stapedius muscle compared with the ... can therefore only serve as a guide in estimating speech discrimination in an individual Only hearing loss of the high frequency type was included in the data shown in Fig 9.9 because that is the...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 8 docx
... “conditioning” is important for achieving this effect Several studies have suggested this toughening of the cochlea against noise-induced injury is related to induced changes in the hair cells by the ... carboplatin causes injury mainly to inner hair cells in one animal species, the chinchilla, leaving outer hair cells intact In the guinea pig, carboplatin injures outer hair cells, mainly in the basal ... environment after the noise exposure These studies also support the hypothesis that the nervous system is involved in noise induced hearing loss (see also tinnitus, p 254) 4.6 Hearing Loss Caused...
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ANATOMY, PHYSIOLOGY, AND DISORDERS OF THE AUDITORY SYSTEM - PART 9 pdf
... imaging in individuals who can voluntarily alter their tinnitus [248] have supported the hypothesis that the neural activity that causes tinnitus is not generated in the ear Other studies using the ... develop in the cochlear nucleus The changes in cochlear nucleus cells were most prominent when the destruction of the cochlea was done in the developing animal Protein synthesis in neurons of the ... Electronic Engineers) electrodes thereby distorting the spectrum information This problem was remedied by the introduction of continuous interleaved sampling (CIS) (Fig 11.3) [347] In the CIS configuration,...
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Báo cáo y học: "Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the protein" ppsx
... in in analysis Click proteins proteins proteinsthe inanalysis analysis tionalhere assignments of analysis in the analysis analysis FuncFunctional File usedof of thethe proteins analysis analysis ... analysis Additional data file contains the sequences of the proteins used in the analysis of the assignments The sequences assignments file in the used in Phyletic assignments the proteins used in ... of this paper Additional data file contains the functional assignments of the proteins used in the analysis Additional data file contains the phyletic assignments of the proteins used in the analysis...
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EXPRESSION AND FUNCTION OF THE PRL FAMILY OF PROTEIN TYROSINE PHOSPHATASE
... longitudinal axis of the digestive tract, increasing from esophagus and cardiac stomach to pyloric stomach and proximal small intestine, then decreasing again in the distal intestine and the colon ... metastasis, consistent with a previous report examining PRL-1 and PRL-2 protein in this tissue type [19] To determine whether changes seen at the RNA level are reflective of what is occurring in these ... tissue to tissue In most of the cases where an absence of PRL-1 staining was observed in the stroma, staining of all other structures within the tissue was also weak to absent However, in 2/4 normal...
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Regulation and function of the novel candidate tumor suppressor gene dlec1 in the HCT116 colorectal cancer cell line
... cells In the previous section we have identified the siRNA sequence that is most effective in knocking down DLEC1 in HCT116 cell line We then knocked down DLEC1 in the HCT116 cell line using this ... fall into several categories including the following: repression of genes that are essential for the continuing of the cell cycle; coupling the cell cycle to DNA damage to inhibit cell division ... from a ε-N-acetyl lysine amino acid on a histone Deacetylation restores the positive electric charge of the lysine amino acids, which increases the histone's affinity for the negatively charged...
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Tài liệu Body Size: The Structure and Function of Aquatic Ecosystems pptx
... However, this method of increasing energy gain will produce diminishing returns if the costs of producing and maintaining a larger feeding structure increase more rapidly than the gain provided ... fish eggs in the field give an exponent, À0.22, very close to the predicted À1/4, but there is considerable unexplained variation This is hardly surprising, giving the inherent difficulties in ... quadratic increase in pumping costs with filter size, in comparison to a linear increase in gain as the driving force for the development of gelatinous bodies As seen above, however, the same principle...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
... between the overall tumbling and the internal mobility, and is indicative of the degree of internal restraint of each 15N–1H vector motion In Fig 4, most of the points cluster in the same region The ... within helix III, but also over a large portion of the protein, from Phe8 to Met56, including the loop and the tight turn At the same time, in the vicinity of the Arg53 hinge point, precisely ... suggesting the occurrence of either a kinking or tightening of the local geometry A similar discontinuity had been noted in solution also in the Antp HD [8,9] and the Antp (C39S) HD [10], and indeed,...
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Tài liệu Báo cáo khoa học: Expression and function of Noxo1c, an alternative splicing form of the NADPH oxidase organizer 1 doc
... insertion in the PX domain (Fig 1) To determine the effect of the insertion, we examined the phosphoinositide-binding activity of the PX domain of Noxo1c by an overlay assay, in which each phosphoinositide ... contribute to phosphoinositide binding [31] The five-amino-acid insertion in the loop of Noxo1 might alter the configuration of the phosphoinositide-binding region, affecting the affinity for FEBS ... clarify the role of the lipid-binding activity in Nox3 activation, we examined the effect of substituting Gln for Arg40 in the PX domain, which completely abrogates the phosphoinositide-binding activity...
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Tài liệu Báo cáo khoa học: a-Conotoxins as tools for the elucidation of structure and function of neuronal nicotinic acetylcholine receptor subtypes doc
... different binding sites of the homomeric a7 nAChR or perhaps different microdomains within the same binding site [35] The proline residue in position 6, which is conserved in all other a-conotoxins, appears ... participate in the formation of EpI-resistant a7 receptors, or an ACh-binding protein reveals the ligand-binding domain of that the functional properties of the nAChR are modified in nicotinic receptors ... subtypes in native tissues and to investigate their physiological role In particular, the use of radiolabelled a-conotoxin MII has enabled the localization of distinct nAChR subtypes in the brain and...
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Tài liệu Báo cáo khoa học: Cold survival in freeze-intolerant insects The structure and function of b-helical antifreeze proteins pdf
... protein, rather than suggesting that this face of TmAFP interacts with the ice surface It is important to distinguish whether the mutations disrupt the ice–binding interaction by changing the surface ... protein–ligand interactions These include such issues as simulating the presence of the AFPs in a Ôsluggish-waterÕ layer [70] or the possibility that the protein modifies the ice surface after binding, ... solve the interaction at the atomic level and understand the role of the threonine side chains in ice binding The contradiction between the higher activity demonstrated by the longer insert AFP isoforms...
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