sorafenib a multikinase inhibitor results from clinical trials in melanoma patients

Báo cáo y học: " What have we learned from clinical trials in primary Sjögren’s syndrome about pathogenesis" ppsx

Ngày tải lên : 12/08/2014, 15:22

... of aquaporin-5, abnormally localized at the apical and basolateral membranes of the acinar epithelial cells, was restored to localization mainly at the apical membranes [14] Aquaporin-5 is involved ... in pSS with monoclonal antibodies to IFNα seems a rational approach Monoclonal Page of antibodies to IFNα are currently available and clinical trials in systemic lupus erythematosus and dermatomyositis/polymyositis ... months [30] A signiﬁcant increase in saliva production was observed Furthermore, serial labial salivary gland biopsies in nine patients showed a decrease in lymphocytic in ltration These data were...

8
222
0

Báo cáo y học: "Discontinuation rates in clinical trials in musculoskeletal pain: meta-analysis from etoricoxib clinical trial reports" ppt

Ngày tải lên : 09/08/2014, 10:23

... involved in planning the study, data extraction, analysis and preparing a manuscript SD and HJM were involved in planning, analysis and writing All authors read and approved the final manuscript Additional ... measure, perhaps as much or more so in clinical practice as in clinical trials, although discontinuations have been mentioned previously in clinical trials in rheumatology, as with meloxicam in ... than efficacy in clinical trials that is paramount There are few comparisons on which to draw, although it is generally assumed that discontinuation rates are higher in clinical practice than in...

11
262
0

Báo cáo khoa học: "Evidence-based medicine: Classifying the evidence from clinical trials – the need to consider other dimension" pot

Ngày tải lên : 13/08/2014, 03:20

... Delaney A, Bagshaw SM, Ferland A, Manns B, Laupland KB, Doig CJ: A systematic evaluation of the quality of meta-analyses in the critical care literature Crit Care 2005, 9:R575-582 GRADE Working ... J, Rasmussen K, Ryden L, Wedel H: Effects of the early administration of enalapril on mortality in patients with acute myocardial infarction Results of the Cooperative New Scandinavian Enalapril ... should be administered to a patient with condition A, assuming that no contraindications exist and that said patient fulfils the criteria used to enrol patients in the trial Yet, there are instances...

8
216
0

Báo cáo khoa học: " Hemodynamic goals in randomized clinical trials in patients with sepsis: a systematic review of the literature" pptx

Ngày tải lên : 13/08/2014, 03:21

... known about the variation in hemodynamic goals in clinical trials and whether this variation is associated with patient outcomes To better understand the hemodynamic goals in clinical trials in ... four largest clinical studies evaluating novel therapies in patients with sepsis – evaluating drotrecogin alpha, tissue factor pathway inhibitor, antithrombin III, and monoclonal antibodies to ... goals in sepsis trials trials (c) Pulmonary artery occlusion pressure (PAOP) goals in sepsis trials (d) Cardiac index in sepsis trials For studies that provided an interval goal range, the mean...

9
313
0

Báo cáo y học: "Protein C as a surrogate end-point for clinical trials of sepsis" docx

Ngày tải lên : 13/08/2014, 10:20

... Cardiac Arrhythmia Suppression Trial (CAST) Investigators: Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial ... what is the potential value of protein C as a surrogate end-point for treatment trials using DrotAA? The authors propose several potential but untested benefits, including identification of patients ... longer infusion times (up to days), and the efficacy of these infusions for normalization of protein C levels We agree that these are clinical scenarios in which protein C may have value as a surrogate...

2
222
0

Báo cáo y học: " Using Guasha to treat musculoskeletal pain: A systematic review of controlled clinical trials" pdf

Ngày tải lên : 13/08/2014, 15:21

... Korean and Chinese terms for Guasha AND pain were used when searching the Korean and Chinese databases We also searched in the journals Focus on Alternative and Complementary Therapies (FACT) and ... to assess the risk of bias [4] As it is difficult to blind Guasha therapists, we assessed the blinding of patient and assessor separately A point was given for assessor blinding if pain was assessed ... were searched Study selection We included all controlled clinical trials on using Guasha to treat patients (regardless gender or age) diagnosed with MS pain Trials published as journal articles,...

5
273
0

Báo cáo y học: "Measuring human rights violations in a conflictaffected country: results from a nationwide cluster survey in Central African Republic" pot

Ngày tải lên : 13/08/2014, 15:21

... by “other” actors (including a 23-year-old raped by people in a criminal gang, a 22-year-old raped by a man and later forced to marry him, and a 16-year-old raped by a 45-year old man in order ... Ruth M, Jappah-Samukai B, Mary S, Kamara R, Rosana DH, Schaack R, Rojatu S, Turay-Kanneh R: Violence Against Women During the Liberian Civil Conflict Journal of the American Medical Association ... two-thirds of all abducted children were male (n = 16) The largest perpetrator of incidents against children remained armed groups (12) and Zaraguinas (11), with Zaraguinas taking only boys and armed...

14
255
0

Báo cáo y học: "Diagnostic techniques for ventilator-associated pneumonia: Conflicting results from two trials" docx

Ngày tải lên : 13/08/2014, 16:20

... including “noninvasive” sampling via endotracheal aspirate (ETA) and “invasive” sampling via bronchoscopy using either a protected specimen brush or bronchoalveolar alveolar lavage (BAL) Debate ... Kalil AC, Cavalcanti M, Teixeira PJ: Quantitative versus qualitative cultures of respiratory secretions for clinical outcomes in patients with ventilator-associated pneumonia Cochrane Database ... evaluating the effects of different diagnostic strategies on clinical outcomes, such as use of antibiotics, length of stay, and mortality Randomized trials comparing invasive versus non-invasive...

3
233
0

Tài liệu Clinical trials in gynecological cancer ppt

Ngày tải lên : 13/02/2014, 07:20

... chemotherapy and surgical staging in early-stage ovarian carcinoma: European Organisation for Research and Treatment of Cancer-Adjuvant ChemoTherapy in Ovarian Neoplasm trial J Natl Cancer Inst 2003; ... randomized trial of docetaxel-carboplatin versus paclitaxel-carboplatin as ﬁrst-line chemotherapy for ovarian carcinoma [Clinical Trial Clinical Trial, Phase III Journal Article Multicenter Study Randomized ... 547–556 Clinical trials in gynecological cancer largest database is maintained by the United States National Cancer Institute (NCI-US)(47), called Physician Data Query (PDQ), it encompasses information...

10
578
0

Access to unapproved therapeutic goods Clinical trials in Australia pdf

Ngày tải lên : 07/03/2014, 08:20

... Guidelines, a pharmaceutical data sheet, a summary of the preclinical data and clinical data For medical device trials the TGA examines the design specifications and preclinical data The TGA Delegate ... way in Australia Access to unapproved therapeutic goods - clinical trials in Australia October 2004 Page 10 of 104 Therapeutic Goods Administration Classification of Clinical Trials Clinical Trials ... experience and training of the clinician using the device These are important points for consideration in assessing a clinical trial application Regulation of Medicine and Medical Device Clinical Trials...

104
1.7K
0

Báo cáo y học: "Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized, controlled clinical trial" docx

Ngày tải lên : 13/08/2014, 20:21

... ICU patients • Parenteral fish oil decreased length of hospital stay in septic ICU patients Abbreviations ALT: Alanine transaminase; AST: Aspartate transaminase; CRP: C-reactive protein; DHA: ... Bilirubin (mg/dL) Data are mean ± SEM CRP = C-reactive protein; AST = Aspartate transaminase; ALT = Alanine transaminase; GGT = γ-glutamyl transpeptidase *P = 0.024 vs MCT/LCT at the same timepoint ... Cite this article as: Barbosa et al., Effects of a fish oil containing lipid emulsion on plasma phospholipid fatty acids, inflammatory markers, and clinical outcomes in septic patients: a randomized,...

11
388
0

Báo cáo y học: "Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/ cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma"

Ngày tải lên : 26/10/2012, 09:53

... nedaplatin and 5-FU with radiation treatment for advanced esophageal carcinomas Anticancer Res 2003; 23: 3493-8 Yamada H, Maki H, Takeda Y, et al Evaluation of combined nedaplatin and docetaxel ... therapy for human head and neck cancer in vivo Anticancer Res 2006; 26: 989-94 Yamashita H, Nakagawa K, Tago M, et al Radiation therapy combined with cis-diammine-glycolatoplatinum (nedaplatin) and ... Yamamori M, Kuwahara A, et al Pharmacokinetics and pharmacogenomics in esophageal cancer chemoradiotherapy Adv Drug Deliv Rev 2009; 61: 388-01 Miki I, Tamura T, Nakamura T, et al Circadian variability...

7
531
0

báo cáo hóa học:" Validation of a HLA-A2 tetramer flow cytometric method, IFNgamma real time RT-PCR, and IFNgamma ELISPOT for detection of immunologic response to gp100 and MelanA/MART-1 in melanoma patients" doc

Ngày tải lên : 18/06/2014, 15:20

... cancer vaccine clinical trials These assays met key validation criteria necessary for generating reliable clinical data The assays were determined to be specific for each antigen, gp100 or MART-1 ... example, factors that contribute to inter assay variability for the tetramer assay include cell preparation, staining methods, machine setting, gating during acquisition and data analysis Percent ... value from the baseline value and subtraction of data from the negative control have also been used; analysis and interpretation of negative values remain challenging Interestingly, MART-1 tetramer...

25
639
0

Báo cáo sinh học: "Interferon signaling patterns in peripheral blood lymphocytes may predict clinical outcome after high-dose interferon therapy in melanoma patients" potx

Ngày tải lên : 18/06/2014, 19:20

... described variation of signaling responses in melanoma patients PBMCs using phosflow [15,40,41], suggesting that signaling abnormalities may not arise in all patients, but rather in a subset of patients ... alters IFN signaling patterns in patients with different clinical outcomes Assessing the IFN signaling patterns in peripheral blood T cells from melanoma patients from Day to Day 29 HDI therapy ... analyzed serial PBMC samples obtained from patients before and after the induction phase of HDI in a new independent cohort of minimally metastatic stage IIIb and IIIc melanoma patients to advance our...

9
369
0

báo cáo hóa học:" Interferon signaling patterns in peripheral blood lymphocytes may predict clinical outcome after high-dose interferon therapy in melanoma patients" pptx

Ngày tải lên : 20/06/2014, 03:20

... described variation of signaling responses in melanoma patients PBMCs using phosflow [15,40,41], suggesting that signaling abnormalities may not arise in all patients, but rather in a subset of patients ... alters IFN signaling patterns in patients with different clinical outcomes Assessing the IFN signaling patterns in peripheral blood T cells from melanoma patients from Day to Day 29 HDI therapy ... analyzed serial PBMC samples obtained from patients before and after the induction phase of HDI in a new independent cohort of minimally metastatic stage IIIb and IIIc melanoma patients to advance our...

9
233
0

báo cáo khoa học: "Effects of plasma concentrations of 5-fluorouracil on long-term survival after treatment with a definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma" doc

Ngày tải lên : 10/08/2014, 10:21

... Tamura T, Nakamura T, Makimoto H, Hamana N, Uchiyama H, Shirasaka D, Morita Y, Yamada H, Aoyama N, Sakaeda T, Okumura K, Kasuga M: Circadian variability of pharmacokinetics of 5-fluorouracil and ... polymorphism in patients with esophageal carcinoma Ther Drug Monit 2005, 27:369-374 Okuno T, Tamura T, Yamamori M, Chayahara N, Yamada T, Miki I, Okamura N, Kadowaki Y, Shirasaka D, Aoyama N, Nakamura T, ... Takemoto Y, Nakamura T, Kataoka K, Sakaeda T: Replacement of cisplatin with nedaplatin in a definitive 5-fluorouracil/ cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous...

7
259
0

báo cáo khoa học: " Implementing and evaluating a regional strategy to improve testing rates in VA patients at risk for HIV, utilizing the QUERI process as a guiding framework: QUERI Series" pptx

Ngày tải lên : 11/08/2014, 05:22

... testing a performance monitor, to support installation of the HIV Testing Clinical Reminder, and to participate as full partners in enhancing station accountability After obtaining national and ... training regarding streamlined counseling Nurse-based pre-test counseling Academic detailing, social marketing Telephonic notification of negative test results Academic detailing, social marketing ... an implementation strategy that uses: clinical reminders to provide decision support, audit/feedback as a clinical information system, and organizational change to achieve an appropriate delivery...

13
341
0

báo cáo khoa học: " Implementing and evaluating a regional strategy to improve testing rates in VA patients at risk for HIV, utilizing the QUERI process as a guiding framework: QUERI Series" docx

Ngày tải lên : 11/08/2014, 16:21

... testing a performance monitor, to support installation of the HIV Testing Clinical Reminder, and to participate as full partners in enhancing station accountability After obtaining national and ... training regarding streamlined counseling Nurse-based pre-test counseling Academic detailing, social marketing Telephonic notification of negative test results Academic detailing, social marketing ... an implementation strategy that uses: clinical reminders to provide decision support, audit/feedback as a clinical information system, and organizational change to achieve an appropriate delivery...

13
588
0

Báo cáo y học: " Changes in health-related quality of life and clinical implications in Chinese patients with chronic cough" pot

Ngày tải lên : 13/08/2014, 08:20

... was in charge of design and coordination of the program, review and correction of the manuscript All authors read and approved the final manuscript Additional material Additional file LCQ in Chinese ... questionnaire (LCQ) Thorax 2003, 58:339-343 Braido F, Baiardini I, Tarantini F, Fassio O, Balestracci S, Pasquali M, Tarchino F, Canonica GW: Chronic cough and QoL in allergic and respiratory diseases ... Birring, we translated it to standard Chinese The translation followed an established forward-backward translation procedure, with independent translations and counter-translation Independent translations...

7
394
0

báo cáo khoa học: "Still too little qualitative research to shed light on results from reviews of effectiveness trials: A case study of a Cochrane review on the use of lay health workers" potx

Ngày tải lên : 10/08/2014, 10:23

... C, van Royen P, Baker R: Qualitative methods in research on healthcare quality Qual Saf Health Care 2002, 11:148-152 35 Khan SH, Chowdury AM, Karim F, Barua MK: Training and retaining Shasthyo ... no information about data collection methods and/or data analysis In at least four of these six cases, the qualitative data were not the only focus of the paper In these 14 trials, lay health ... both in the same paper and in a separate paper [10,22] For the remaining ten trials [8,9,11,13-15, 17,18,20,21], qualitative data were presented separately, and in most cases published [23-32] and...

5
411
0