solidstate nmr spectroscopy of pharmaceutical materials
Tài liệu Báo cáo khóa học: Determination by electrospray mass spectrometry and 1H-NMR spectroscopy of primary structures of variously fucosylated neutral oligosaccharides based on the iso-lacto-N-octaose core doc
Ngày tải lên :
19/02/2014, 12:20
... and NMR has proved a powerful strategy for
complete assignment of the branched structures. NMR
Fig. 7. 1D and 2D
1
H-NMRspectra(600MHz)ofTFiLNOat27°C. Upper trace, the 5.5–0.5 p.p.m. region of ... this report, we demonstrate
our strategy of the combined use of ES-MS and NMR for
analysis of the core-branching pattern and full sequence
assignment of four oligosaccharides isolated from human
milk. ... different techniques, of
which MS and NMR are two of the most powerful.
Previously, we demonstrated the distinction of chain type
and blood-group type (such as Le
a/x
and Le
b/y
) of underi-
vatized...
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Tài liệu Báo cáo khoa học: Allosteric modulation of myristate and Mn(III)heme binding to human serum albumin Optical and NMR spectroscopy characterization pptx
Ngày tải lên :
20/02/2014, 02:22
... the spectroscopic analysis of the
myristate-dependent conformational changes of the N
and B states of Mn(III)heme–HSA, by optical absorb-
ance spectroscopy and NMR spectroscopy, that show
allosteric ... the affinity of Mn(III)heme for HSA and
the spectroscopic properties of the Mn(III)heme–HSA
adduct in the presence of myristate are similar to those
of the B conformational state of HSA, suggesting ... presence of
4.5 · 10
)5
M (dotted line) and 1.0 · 10
)4
M myristate (dashed line).
Fig. 5. Change of the relaxivity measured at 10 MHz of a
1.0 · 10
)3
M solution of Mn(III)heme–HSA as a function of...
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Chemistry of nanostructured materials
Ngày tải lên :
23/04/2013, 14:23
... mesoporous materials [11-13]. A number of reviews dealing with
different types of periodic mesoporous materials such as aluminophosphates [14],
non-silica materials [15-17], inclusion materials ... Robson R., Design and Construction of a New Class of
Scaffolding-like Materials Comprising Infinite Polymeric Frameworks of 3D-
Linked Molecular Rods. A Reappraisal of the Zn(CN)
2
and Cd(CN)
2
... use of germanium has also led
to the synthesis of the pure polymorph C of zeolite beta (BEC) even in the absence
of the fluoride medium that is generally believed to assist in the formation of...
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The chemistry of nanostructured materials
Ngày tải lên :
23/04/2013, 20:25
... frequently used term in the field of
microporous materials is “molecular sieves” [5] that refers to a class of porous
materials that can distinguish molecules on the basis of size and shape. This chapter ... Robson R., Design and Construction of a New Class of
Scaffolding-like Materials Comprising Infinite Polymeric Frameworks of 3D-
Linked Molecular Rods. A Reappraisal of the Zn(CN)
2
and Cd(CN)
2
... MOF-
5 [97,98,109]. A key structural feature of Cu-BTC is the dimeric Cu-Cu (2.628Å)
unit. A detailed investigation of sorption properties showed that Cu-BTC may be
useable for separation of...
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Machining of Hard Materials
Ngày tải lên :
18/10/2013, 03:15
... possible to obtain a surface finish of
Ra about 0.3 àm.
Typical applications of HB include finishing of a variety of internal profiles
such as prismatic internal profiles, internal gear flanks, ... Hastelloy, Stellite and other exotic materials are clas-
sified as hard-turned materials.
Machining of Hard Materials 117
In the contact zone, the austenite temperature of the workpiece material is ...
speeds of up to 42,000 rpm and finishing laser machining can be very profitable
for hard part machining. The elimination of EDM operations and the use of laser
shaping result in shortening of the...
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Static properties of granular materials Philippe Claudin
Ngày tải lên :
01/11/2013, 08:20
... probably one of the issues that has been at the origin of the interest
of many physicists for granular materials [359]. The last point of this subsection
will be dedicated to the study of the stress ... horizontal position of the apex of the
pile – also, changing the sign of x changes that of the shear σ
xz
. More generally,
the stress state of the jammed grain packing is assumed to be of the form
xx
= ... properties of granular materials
Fig. 14.6 Polar representation of the contact orientation distribution obtained in
a numerical simulation of a granular layer prepared by a uniform ‘rain’ of grains
[455]....
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The thermodynamics of granular materials Sir Sam Edwards and Raphael Blumenfeld
Ngày tải lên :
01/11/2013, 08:20
... thermodynamics of granular materials
Fig. 13.2 An example of two states of a granular system that differ only by the
positions of three particles confined to within a region, .
The first rigorous theory of ... heap of hot
sand will have many of the characteristics of a heap of cold sand) and we can write
S = S
th
+ S
conf
. (13.19)
It is interesting to note that confirmation of this ‘thermodynamics’ of ... sketch of the density of granular matter in a vessel after being shaken
at amplitude A. Adapted from [172, 173, 356].
Detailed studies of the density of shaken granular systems as a function of the
number...
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Tài liệu Mechanical Properties of Engineered Materials P2 pptx
Ngày tải lên :
23/12/2013, 00:15
... ặ
1
ẳ1=5boundaryisoneinwhich1in5ofthegrainboundaryatoms
match,asshowninFig.2.8(c).
Twinboundariesmayformwithincrystals.Suchboundarieslieacross
deformationtwinplanes,asshowninFig.2.8(d).Notethattheatomson
eithersideofthetwinplanesaremirrorimages.Stackingfaultsmayalsobe
formedwhentheperfectstackinginthecrystallinestackingsequenceis
disturbed,Figs2.8(e)and2.8(f).Thesemaybethoughtofastheabsence
ofaplaneofatoms(intrinsicstackingfaults)ortheinsertionofrowsof
atomsthatdisturbthearrangementofatoms(extrinsicstackingfaults).
IntrinsicandextrinsicstackingfaultsareillustratedschematicallyinFigs
2.8(e)and2.8(f),respectively.NotehowtheperfectABCABCstackingof
atomsisdisturbedbytheinsertionorabsenceofrowsofatoms.
2.3.4VolumeDefects
Volumedefectsareimperfectionssuchasvoids,bubble/gasentrapments,
porosity,inclusions,precipitates,andcracks.Theymaybeintroducedintoa
solidduringprocessingorfabricationprocesses.Anexampleofvolume
defectsispresentedinFig.2.9.ThisshowsMnSinclusionsinanA707
steel.AnotherexampleofavolumedefectispresentedinFig.1.16(d).
This ... approximately 0.3–0.5
of the melting temperature in degrees Kelvin.
Since the evolution of microstructure is often controlled by diffusion
processes, a brief introduction to elementary aspects of diffusion ... picture of nucleation and growth presented above is gen-
erally observed in most crystalline metallic materials. However, the rate of
nucleation is generally enhanced by the presence of pre-existing...
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Tài liệu Mechanical Properties of Engineered Materials P1 pptx
Ngày tải lên :
23/12/2013, 00:15
... macroscopic level of understanding of
structure [Figs 16(a)–(d)]. They are often unaware of the atomic and micro-
structural constituents that can affect the mechanical behavior of materials
and of the ... types/
classes of materials. Following a brief introduction to materials science and
basic strength of materials, the fundamentals of elasticity and plasticity are
presented, prior to a discussion of strengthening ... treatment of the fundamen-
tals of the mechanical behavior of materials. The text provides a rigorous
review of the fundamental mechanics aspects of the mechanical behavior of
materials.
Shackleford,...
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Tài liệu Supply and stock of raw materials pptx
Ngày tải lên :
25/01/2014, 00:20
... stock of raw materials
Issed by Date of release Version Page
Hr. Bauer 00
4/5
Check of delivery documents
The delivery note transferred by the driver is compared with the specification of ...
Supply and stock of raw materials
Issed by Date of release Version Page
Hr. Bauer 00
1/5
Process owner: Hr. Bauer
Process purpose and
target:
Transfer and storage of conformal material ... false storage
Environment: Disposal quantity because of false storage
PB-Nr: S05
Supply and stock of raw materials
Issed by Date of release Version Page
Hr. Bauer 00
2/5
flow/process...
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
Ngày tải lên :
16/02/2014, 09:20
... gradient probe. All NMR
spectra were acquired at 303 K. NMR data were processed
using nmrpipe ⁄ nmrdraw [53], and assigned using ansig
[54,55].
NMR titration studies
The stock solutions of substrates ... upon addition of ATP in
the absence of pantoate. An important feature of the
NMR study is the fact that a single set of resonances
were observed for nPS in the absence or presence of
substrates. ... effects of
one of the substrates, i.e. pantoate [8,9]. One of the
interesting features of the plant PSs is the presence of
a conserved 24 residue insertion in the sequence [9].
This sequence of amino...
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Tài liệu Báo cáo khoa học: Solution NMR structure of an immunodominant epitope of myelin basic protein Conformational dependence on environment of an intrinsically unstructured protein doc
Ngày tải lên :
19/02/2014, 07:20
... resonance assignments of the 18.5 kDa
isoform of murine myelin basic protein (MBP). J Biomol
NMR 29, 545–546.
31 Nygaard E, Mendz GL, Moore WJ & Martenson RE
(1984) NMR of a peptic peptide ... Thus, comparison
of the tertiary structures of this epitope under various
conditions is of interest to understand its pharmaco-
kinetics.
We have initiated solution NMR studies of
18.5 kDa rmMBP ... [7].
There had been several previous, contradictory predic-
tions of the kind of secondary structure of this segment
of MBP, due to the plethora of experimental conditions,
and the SDSL ⁄ EPR experiments...
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