shaping tumor associated macrophages the role of nf kb

The role of NF kb and histone deacetylase in gene regulation

Ngày tải lên : 14/09/2015, 08:45

... regulators The first phase of activation of NF- κB sets the stage for the second phase of NF- κB activation The second phase of NF- κB activation occurs in the nucleus, which involves NF- κB post-translational ... phosphorylate NF- κB, and the components of the NF- κB signaling pathway The roles of phosphatases in NF- κB signaling pathway is not as well studied as the kinases Li et al elucidated the role of phosphatases ... export the NF- κB-IκBα complex out of the nucleus, therefore the NF- κB-IκBα complex shuttle constantly between the cytoplasm and the nucleus, which leads to basal transcriptional activity of NF- κB...

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báo cáo hóa học:" Sensitization of ovarian cancer cells to cisplatin by genistein: the role of NF-kappaB" doc

Ngày tải lên : 20/06/2014, 07:20

... however the role of genistein in chemo-resistant ovarian cancer cells has not been investigated Therefore, the intent of this study was to evaluate the effect of genistein for sensitization of ovarian ... on the DNA binding activity of NF- κB Genistein inhibits NF- κB DNA binding activity Specifically, the effects of pretreatment followed by the combination treatment were studied in the context of ... demonstrated greater inhibition of NF- κB compared to the treatment of cells with any of the drugs alone (Figure 4) These results suggest that the pretreatment of cells with genistein sensitized...

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báo cáo khoa học: " Recent insights into the role of NF-κB in ovarian carcinogenesis" pot

Ngày tải lên : 11/08/2014, 12:20

... http://genomemedicine.com/content/2/8/56 Page of Table Members of the NF- kB family of proteins Member NF B1 NF B, p105, p50, p50/p105 NF B2 p52 NF B3 RelA, p65 Ligand Other names RelB c-Rel in the highly metastatic ... treated with TWEAK in the presence of the NF- κB inhibitor pyrro lidine dithiocarbamate In another study, which showed that microRNA-9 (miR-9) could control the levels of NF- κB1, the authors [15] ... that inhibition of the NF B pathway through specific inhibition of inhibitor of NF- κB kinase β (IKKβ) can decrease the percentage of viable CAOV3, IGROV1 and A2780 cells In addition, they showed...

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Báo cáo khoa học: Mutagenic probes of the role of Ser209 on the cavity shaping loop of human monoamine oxidase A docx

Ngày tải lên : 30/03/2014, 01:20

... to the active site on incorporating the mutations To further investigate the environment of ﬂavin cofactor in the active site of MAO A, CD spectroscopy was used to monitor the alterations in the ... Ser209 and the structure of human MAO A J Wang et al the Vw of the para-substituent are observed for wildtype and the Ser209 mutant forms of MAO A These data suggest similar structures of the substrate ... from Nandigama et al B on the properties of the substrate binding site of MAO A, suggesting that structural alterations are occurring in the conformation of the cavity shaping loop (Fig 1) Flavin...

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Báo cáo y học: "κ Regulation of NFκB signalling during inflammation: the role of hydroxylases" potx

Ngày tải lên : 09/08/2014, 01:22

... our understanding of the mechanism of hypoxia-induced NF B activity The fact that the inhibitory action of hydroxylases is at the level of the IKK complex through suppression of catalytic activity ... given the body of evidence for NF B target genes contributing to inflammatory signalling [80,81] The targeted delivery of a PHDI in the appropriate inflammatory condition will therefore be of paramount ... hydroxylation of IKKβ at proline 191 has yet to be demonstrated Further work on IKKβ and the inflammatory response supports the theory that hypoxia has the potential to modulate the NF B response to inflammatory...

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Báo cáo y học: "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis" pps

Ngày tải lên : 09/08/2014, 08:23

... to the regulation of TNF-α and IL-1β in the OA synovium (as demonstrated here), it appears unlikely that the neutralisation of either of these cytokines would affect the production of the other ... assessed, by means of specific neutralisation of macrophage-produced TNF-α and IL-1, the contribution of these two proinflammatory cytokines on the production of each other, on other proinflammatory ... overproduction of cytokines and growth factors from the inflamed synovium may play a role in the pathophysiology of OA The low-grade OA synovitis is itself cytokinedriven, although the levels of proinflammatory...

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Báo cáo y học: "The role of tumor necrosis factor-alpha in systemic lupus erythematosus" pdf

Ngày tải lên : 09/08/2014, 10:22

... Given the role of TNF as a strong mediator of inflammation, the high levels of serum TNF in active SLE, and the overexpression in renal tissue with active nephritis, we reasoned that TNF blockade ... with renal inflammation [15] The induction of lupus-like disease by TNF blockers appears to be quite uncommon, with an incidence of 0.5% to 1% [20,25,35], and independent of the type of TNF-blocking ... renal tissue of MRL/lpr/lpr lupus mice and the levels of TNF correlated with the degree of inflammatory organ disease [13,14] Moreover, even in NZB/W mice, there is an increase in renal TNF expression...

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the role of ikkalpha, ikkbeta and nf-kappab in the progression of breast cancer

Ngày tải lên : 22/12/2014, 21:49

... The role of IKKalpha, IKKbeta and NF- kappaB in the progression of breast cancer Lindsay Bennett BSc(Hons), MSc Submitted in fulfillment of the requirements for the degree of PhD Institute of ... immune response, inflammation, proliferation and apoptosis Many of these processes are hallmarks of cancer and NF- κB has been hypothesised to have a role in tumorigenesis The aim of the current study ... activation of the NF- κB dimer [102] Degradation of IκBα means there is no longer a NES in the complex and the NLS of p65 and p50 are unmasked, meaning localisation is then nuclear The NF- κB dimer,...

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EXPLORING THE ROLE OF PHARMACOKINETIC ALTERATIONS IN TYROSINE KINASE INHIBITORS (TKIS) ASSOCIATED TOXICITIES

Ngày tải lên : 09/09/2015, 08:14

... Almost all of the TKIs undergo metabolism by the cytochrome P450 (CYP) family of enzymes, with the CYP3A4 enzyme being the most commonly involved in the metabolism of the majority of the TKIs Therefore, ... toxins The main CYP enzyme, CYP3A4, is responsible for the metabolism of more than 50% of all drugs in the market It is also implicated in the metabolism of almost all of the TKIs Therefore, there ... Genetic variation of drug exposure The tumor or somatic genome, mainly determines the features of the tumor such as its aggressiveness and sensitivity to treatment On the other hand, the patient or...

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Single molecule studies on the role of nucleoid associated proteins in bacterial chromatin

Ngày tải lên : 09/09/2015, 11:26

... the extension of the DNA is ⇠ µm, the image of the bead is near the edge of our observation area and may interfere with the measurement Therefore, we didn’t let the extension of the DNA to go ... the stretching force, A is the persistence length of the polymer, kB is the Boltzmann constant, T is the temperature, z is the measured extension of the polymer, and L is the contour length of ... contains the genetic code of bacteria, assembled by many factors into a compact structure called nucleoid The primary focus of this thesis is on the role of nucleoid -associated proteins in shaping the...

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THE ROLE OF ANNEXIN 1 IN THE REGULATION OF INFLAMMATORY STRESS RESPONSE IN MACROPHAGES

Ngày tải lên : 01/10/2015, 17:27

... NFkB NFkB is a transcription factor involved in the regulation of inflammation and cytokine production NFkB exists in an inactive form bound to IkBa in the cytoplasm The binding of IkB to NFkB ... by NFkB such as IL-1B and TNFα can also regulate the activation of NFkB (Barnes and Karin, 1997) thus amplifying the inflammatory response The termination of NFkB gene expression occurs when IkBα ... suppression of these cytokines in the presence of ANXA1 has been attributed to the lack of activation of the members of the MAPK family – pERK, pP38 and pJNK The absence of ANXA1, on the other hand,...

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The Role of Power

Ngày tải lên : 22/08/2012, 22:07

... Outline  Role of Power  Rules for Using Power Role of Power  Power defined: • Ability or official capacity to exercise control; authority • Ability to influence or control others  Sources of Power ... who are truthful and demonstrate regard for their own outcomes and those of others • Moderately Politicized Area – greater acceptance of behind the scenes tactics so long as the goals of the group are achieved ... Find the Soft Spot  Encourage others to open up • Gain disclosure of something private or personal about your counterpart • Expression of trust  Identify true motivations and sources of objections...

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Circuit theory of finance and the role of incentives in financial sector reform

Ngày tải lên : 24/10/2012, 09:33

... DC: The World Bank) Chernow, Ron, 1997, The Death of the Banker The Decline and the Fall of the Great Financial Dynasties The Triumph of the Small Investor (New York: Vintage Books, a Division of ... to further improve the bank’ risk position s and counterparties, on their side, might consider for them unnecessary to further assess the riskiness of the bank Finally, the inadequacy of the static ... financial infrastructural facilities Enforcement is a key ingredient for the integrity of the financial circuit Very often, poor enforcement, rather than lack of rules, is the cause of financial...

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Facts of Vietnam Freight forwarding industry and the role of Vietnam Freight Forwarders Association (VIFFAS) to the industry in international economic integration processhelpful to Oristar.doc

Ngày tải lên : 27/10/2012, 16:42

... such professional colleagues on the world The Association has the role of coordinating the activities of the members in order to protect the interests of the members and improve the position of Vietnam ... to the realization of the objectives and duties of the Association, may be invited to join the Association as Honorary members In general, this stipulation on the membership in the Statue of the ... expanding With their experiences, they have learned the value of offering quality services In the way of growing, they have also open branches to establish a worldwide presence These companies...

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Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"

Ngày tải lên : 31/10/2012, 15:37

... eradication of the bacteria However, the OR of the A/A genotype for H pylori seropositivity was 0.25 (95% CI 0.09-0.71) So, the Gab1 polymorphism was associated with the low risk of the infection ... diagnosis of cancer In summary, the Gab1 A/A was associated with the low risk of H pylori infection while the G/A and A/A genotypes together may increase the risk for gastric atrophy The biological ... previously that G/G of the PTPN11 gene encoding SHP-2 increased the risk of gastric atrophy among the seropositive subjects [18] The present study examined the association of a polymorphism of Gab1 with...

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Báo cáo y học: "Human toxoplasmosis and the role of veterinary clinicians"

Ngày tải lên : 03/11/2012, 11:06

... where the consequences of infection can be very severe, while the risk of living with one’s beloved cat is practically nill References Angulo FJ, Glaser CA, Juranek DD et al Caring for pets of immunocompromised ... JA Animal -associated opportunistic infections among persons infected with the human immunodeficiency virus Clin Infect Dis.1994;18:14-24 Han K, Shin DW, Lee TY, et al Seroprevalence of Toxoplasma ... and Olsen CW Preventing zoonotic diseases in immunocompromised persons: the role of physicians and veterinarians Emerg Infect Dis 1999; 5: 159-163 http://www.medsci.org ...

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The role of language in adult education and poverty reduction in Botswan

Ngày tải lên : 05/11/2012, 16:27

... and English at the expense of the other languages that exist in the country, the adult language program in Botswana maintains the hegemony and the gap between the poor and the rich, the major and ... improve the quality of life of the poor and rural people adult education programs should include as one of its components the observation and imitation of the artisans and other skilled persons in the ... challenge the hegemony of the majority communities in Botswana 31 In most parts of the world, education is for the most part the preserve of the few (elites) The choice of which language or dialect...

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153 The role of marketing activities to bankcard and actual state of Ngân hàng nông nghiệp và phát triển nông thôn (AgriBank) cards

Ngày tải lên : 03/04/2013, 12:13

... maintaining the flow of funds and information between issuing and acquiring members The exchange of financial information is called clearing The exchange of the actual funds for the transaction and the ... sells the transaction to the acquire and is reimbursed the amount of the sales ticket by the acquirer (4) - The acquirer then summits the ticket to the issuer for payment, via the ICO interchange ... system 9 (5) - The issuer bills the cardholder (6) - Finally, the cardholder repays the issuer for the goods or services originally purchased from the merchant ICO are at the centre of the transaction...

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494 The role of marketing activities to bankcard and actual state of Ngân hàng nông nghiệp và phát triển nông thôn (AgriBank) cards

Ngày tải lên : 08/04/2013, 17:01

... “bộ” “trọn gói” theo nguyên tắc giá gói nhỏ tổng số tiền mua hàng theo phương thức riêng rẽ  Định giá theo nguyên tắc địa lý: cách thức mà doanhnghiệp định giá bán sản phẩm theo nguyên tắc địa ... sản phẩm Bề rộng chủng loại sản phẩm phân giải số lượng mặt hàng thành phần theo tiêu thức định ví dụ theo kích cỡ, theo công suất… Bề rộng chủng loại sản phẩm mục tiêu công ty định phần Những ... trường theo giác độ khác Theo quan điểm Marketing thị trường bao gồm tất khách hàng tiềm ẩn có nhu cầu mong muốn cụ thể sẵn sàng có khả tham gia vào trao đổi để thoả mãn nhu cầu Như vậy, theo khái...

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The role of advertising in society

Ngày tải lên : 16/04/2013, 11:05

... values, others say advertising merely reflects the values of society rather than shaping them They argue that consumers' values are defined by the society in which they live and are the results of ... executives point to the vast array of topics they cover and the investigative reporting they often as evidence of their objectivity It is in their best interest to build a large audience for their publications ... in the other countries, partly due to the limitation of means of communication and citizens’ perception The most popular type of advertising is on TV Following is the advertising price chart of...

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