severe acute adverse cutaneous drug reactions i stevens johnson syndrome and toxic epidermal necrolysis
Chapter 056. Cutaneous Drug Reactions (Part 1) potx
Ngày tải lên :
07/07/2014, 01:20
... induced or exacerbated by prolonged utilization of drugs, e.g., pruritus, pigmentation, nail or hair disorders, psoriasis, and pemphigus These chronic drug reactions are not frequent, but neither ... rare, severe cutaneous reactions to drugs have an important impact on health and on the risk-versus-benefit evaluation of medicines because of significant mortality and sequelae Some populations ... are at increased risks of drug reactions: patients with collagen vascular diseases, bone marrow graft recipients, and those with acute Epstein-Barr virus infection It has also been established...
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Chapter 056. Cutaneous Drug Reactions (Part 2) pps
Ngày tải lên :
07/07/2014, 01:20
... production of specific antibodies for urticarial reactions IMMEDIATE REACTIONS Immediate reactions depend on the release of mediators of inflammation by tissue mast cells or circulating basophilic ... Serum sickness is produced by tissue deposition of circulating immune complexes with consumption of complement It is characterized by fever, arthritis, nephritis, neuritis, edema, and an urticarial, ... through IgE-specific antibodies These reactions are usually manifest in the skin and gastrointestinal, respiratory, and cardiovascular systems (Chap 311) Primary symptoms and signs include pruritus,...
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Chapter 056. Cutaneous Drug Reactions (Part 3) docx
Ngày tải lên :
07/07/2014, 01:20
... effectors—cytotoxic T cells in blistering reactions, chemokines in reactions mediated by neutrophils or eosinophils and from the intensity of stimulation and response GENETIC FACTORS AND CUTANEOUS DRUG REACTIONS ... REACTIONS Specific genetically determined defects in the ability of an individual to detoxify toxic reactive drug metabolites predispose such individuals to the development of drug toxicity It ... (ACE) inhibitors can exacerbate plaque psoriasis, while antimalarials can worsen pustular psoriasis Acne may be induced by glucocorticoids, androgens, and lithium Minocycline and thiazide diuretics...
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Chapter 056. Cutaneous Drug Reactions (Part 3) pps
Ngày tải lên :
07/07/2014, 01:20
... blockers), antidepressants, antithyroid drugs, interferons (IFNs), oral contraceptives, and hypolipidemics Hirsutism Hirsutism is an excessive growth of coarse hair with masculine characteristics in a ... hypertrichosis include anti-inflammatory drugs, glucocorticoids, vasodilators (diazoxide, minoxidil), diuretics (acetazolamide), anticonvulsants (phenytoin), immunosuppressive agents, psoralens, and ... drug after onset of the eruption Warfarin reactions are associated with protein C deficiency Warfarin anticoagulation in heterozygotes for protein C deficiency causes a precipitous fall in circulating...
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Chapter 056. Cutaneous Drug Reactions (Part 5) doc
Ngày tải lên :
07/07/2014, 01:20
... lamivudine, indinavir, and anti-EGFR monoclonal antibodies (cetuximab, gefitinib) Nail Discoloration Some drugs, including anthracyclines, taxanes, fluorouracil, and zidovudine, may induce nail ... dysfunction, and neurologic symptoms Certain drugs, such as NSAIDs, ACE inhibitors, angiotensin II antagonists, and radiographic dyes, may induce urticarial reactions, angioedema, and anaphylaxis in ... of drug- specific antibody Although ACE inhibitors, aspirin, penicillin, and blood products are the most frequent causes of urticarial eruptions, urticaria has been observed in association with...
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Chapter 056. Cutaneous Drug Reactions (Part 7) ppsx
Ngày tải lên :
07/07/2014, 01:20
... HYPERSENSITIVITY SYNDROME Initially described with phenytoin, hypersensitivity syndrome a multiorgan drug- induced reaction—is also known as DRESS and drug- induced hypersensitivity syndrome (DIHS) It ... required STEVENS- JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS SJS and TEN are terms that, most believe, describe the same usually druginduced disorder, which is characterized by blisters and epidermal ... changes in these lesions suggest immune-complex deposition Drugs implicated in vasculitis include allopurinol, thiazides, sulfonamides, other antimicrobials, and several NSAIDs The presence of eosinophils...
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Chapter 056. Cutaneous Drug Reactions (Part 8) potx
Ngày tải lên :
07/07/2014, 01:20
... reaction is pharmacologic, and patients who are sensitive to NSAIDs cannot be identified by assessment of IgE antibody to aspirin, lymphocyte sensitization, or in vitro immunologic testing Other reactions ... β-lactam antibiotics and preventing the risk of anaphylaxis is discussed below ("Management of a Patient with a Drug Eruption") Nonsteroidal Anti-Inflammatory Drugs Most NSAIDs, including aspirin, cause ... In clinical trials, combinations of highly active antiretroviral treatments were frequently associated with ≥10% "drug eruptions." Two drugs, nevirapine and abacavir, have been associated with...
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Chapter 056. Cutaneous Drug Reactions (Part 9) doc
Ngày tải lên :
07/07/2014, 01:20
... may induce urticaria, angioedema, anaphylactic reactions, and serum sickness Alopecia is a common complication of IFN-α A nonspecific highly pruritic "dermatitis" is frequent in patients receiving ... Reaction rates are much lower with nonantibiotic sulfonamides, including diuretics or antidiabetic agents Cross-reactivity between antibiotic and nonantibiotic sulfonamides is, at most, infrequent ... premedication with glucocorticoids and histamine H(1) and H(2) antagonists Glucocorticoids Both systemic and topical glucocorticoids cause a variety of skin changes, including acneiform eruptions,...
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Báo cáo khoa học: " Multifocal Stevens-Johnson syndrome after concurrent phenytoin and cranial and thoracic radiation treatment, a case repor" doc
Ngày tải lên :
09/08/2014, 09:20
... starting the combined brain and spine radiation therapies Since the eruptions occurred first in areas corresponding to the radiation Figure Hematoxylin and eosin staining of palmar biopsy specimen ... radiation therapy (20 Gy in fractions) to his right hip without complications Seven months later, he was treated with palliative radiation therapy (8 Gy in fraction) to his right ribs, again without ... irradiation with concurrent phenytoin administration It is believed that phenytoin induces cytochrome P450 3A and produces oxidative reactive intermediates that are involved in the hypersensitivity...
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R INTE S OF MEDIC REPORTING ADVERSE DRUG REACTIONS DEFINITIONS OF TERMS AND CRITERIA FOR THEIR USE ppt
Ngày tải lên :
07/03/2014, 10:20
... characteristic heliotropic rash Both polymyositis and dermatomyositis are associated with myositic-specific auto-antibodies Infectious myositis (interstitial focal myositis) is caused by such infectious ... be given to exfoliative dermatitis Definition Exfoliative dermatitis is a potentially life-threatening inflammation of the entire skin, characterized by redness of the skin and scaling, with acute ... with drugs include erythema multiforme, StevensJohnson syndrome, and toxic epidermal necrolysis Bullae may also be a feature of photosensitivity reactions and fixed drug reactions In assessing...
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Women and Adverse Drug Reactions Reporting in the Canadian Context pot
Ngày tải lên :
22/03/2014, 11:20
... dose and that requires in-patient hospitalisation or prolongation of existing hospitalisation, causes congenital malformation, results in persistent or significant disability or incapacity, is lifethreatening ... on information it had about the risks associated with cisapride when she died This information – that patients with a number of conditions, including bulimia or anorexia, should not use the drug ... up with the latest scientific discoveries and new technologies, on the one hand, and the new risks and diseases Canadians were increasingly 11 “Direct-to-consumer advertising of prescription drugs”,...
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Phản ứng có hại của thuốc (Adverse Drug Reactions; ADR) pdf
Ngày tải lên :
25/03/2014, 05:20
... 09/10/2004) Liệu pháp insulin làm tăng nguy ung th đ i trực tràng (Hoa Kỳ) Nghiên cứu h i cứu 24.918 bệnh nhân tiểu đờng týp 2, theo d i th i gian năm Có tất 3160 ng i tiêm insulin kéo d i năm, l i 21.758 ... đặc hiệu Cũng gặp báo cáo r i loạn khứu giác statin Trong báo cáo r i loạn vị giác, có trờng hợp dùng simvastatin, pravastatin, atorvastatin, fluvastatin v i cerivastatin Trong trờng hợp nghi ngờ ... vancomycin amikacin: ho i tử cấp tính ống thận (Pháp) Bệnh nhân nữ 72 tu i bị ho i tử cấp tính ống thận sau dùng liều đơn amikacin sau dùng vancomycin để chữa viêm ph i tụ cầu vàng kháng meticillin...
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Phản ứng có hại của thuốc (Adverse Drug Reactions; ADR) docx
Ngày tải lên :
03/04/2014, 00:20
... đợc biết viêm gan ng i dùng d i ngày minocyline không phân biệt đợc v i viêm gan tự miễn; nhiên, ngừng thuốc thờng giúp phục h i hoàn toàn Số báo cáo ADR minocycline g i WHO: 600 trờng hợp r i loạn ... NSAID quanh th i kỳ thụ thai để ngăn ngừa sẩy thai (Theo Brid Med J.: 327; số 7411; 16/8/2003) Ăn bổ sung kẽm nhiều làm tăng nguy ung th tuyến tiền liệt (Hoa Kỳ) i u tra 51.529 nam gi i (tu i ... bổ sung kẽm v i liều cao kéo d i 10 năm, nguy tơng đ i Phản ứng gan v i minocycline (Australia) Trong 28 trờng hợp, minocycline đợc uống để chữa trứng cá; 15/42 bệnh nhân d i 21 tu i Có 25 bệnh...
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Báo cáo y học: " Parkinsonism caused by adverse drug reactions: a case series." pps
Ngày tải lên :
11/08/2014, 00:23
... DIP is indistinguishable from PD [11]; however, Susatia and Fernandez contradicted this in their recent review, suggesting that DIP can be distinguished from PD because tremor and gait instability ... parkinsonism may sometimes persist Such patients may have subclinical parkinsonism and require dopaminergic treatment as with our two patients PD is usually irreversible, but DIP is reversible ... the study US and AI drafted the manuscript, and US, AI and DC were responsible for critical revision of the manuscript US, AI and DC provided administrative, technical and material support All...
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Báo cáo y học: "Management of Critically Ill Patients with Severe Acute Respiratory Syndrome (SARS)"
Ngày tải lên :
03/11/2012, 10:20
... superimposed infections, too rapid tailing of corticosteroids or persistently severe and uninhibited cytokine storm Empirical anti-pseudomonal antibiotics should then be given first If there is ... polyprotein and preventing the replication of viral RNA Ritonavir inhibits lopinavir metabolism thus increasing its serum concentration, but it has no activity against SARS-CoV In a retrospective ... their efficacy is uncertain Tracheostomy is required in patients requiring prolonged mechanical ventilation and ICU stay Strict adherence to infection control guidelines is mandatory in performing...
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Tài liệu COMMUNITY-BASED MANAGEMENT OF SEVERE ACUTE MALNUTRITION doc
Ngày tải lên :
21/02/2014, 21:20
... Proteins Lipids Sodium Potassium Calcium Phosphorus (excluding phytate) Magnesium Iron Zinc Copper Selenium Iodine Vitamin A Vitamin D Vitamin E Vitamin K Vitamin B1 Vitamin B2 Vitamin C Vitamin ... malnutrition Prevention first… Investing in prevention is critical Preventive interventions can include: improving access to high-quality foods and to health care; improving nutrition and health ... interventions aimed at identifying and treating children in all parts of the country and at all times of the year through effective community mobilization and active case finding • Provide training and...
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Báo cáo khoa học: Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization pptx
Ngày tải lên :
23/03/2014, 07:20
... motif is directly involved in N protein selfinteraction [42] However, other evidence indicated that the RS motif interferes with SARS-CoV N protein multimerization but this activity requires its ... phosphorylation of the SARS-CoV N protein Our data provide evidence that phosphorylation of the N protein primarily occurs within its RS-rich motif and may affect its oligomerization, translation inhibitory ... rich in arginine residues and is likely cell cycle-dependent [20,35,36] The avian infectious bronchitis virus N protein indeed interacts with and colocalizes with the nucleolar proteins nucleolin...
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Báo cáo khoa học: On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus pptx
Ngày tải lên :
28/03/2014, 23:20
... helicase mutant is fully active is consistent with the above hypothesis proposing that this amino acid substitution, which is critical for bananin binding, does not interfere in the interaction ... effectively interferes with SARS-CoV ATPase activity by inhibiting helicase activity Furthermore, in a cell culture system of SARS-CoV, bananin inhibited viral replication at a half maximal effective ... that this mutation site is very far from the active site suggests that S259 is located either in an allosteric site of the enzyme or in a critical position for the overall protein flexibility The...
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Báo cáo sinh học: " The Severe Acute Respiratory Syndrome (SARS)-coronavirus 3a protein may function as a modulator of the trafficking properties of the spike protein" docx
Ngày tải lên :
18/06/2014, 22:20
... their interactions with host factors Indeed, it is crucial to determine how this unique pathway benefits replication of the SARS-CoV It is also interesting to note that sequence comparison of isolates ... genetics would certainly reveal more about the interplay between 3a and S during SARS-CoV infection Implication of the hypothesis This hypothesis, if proven, will indicate that the interaction ... understand the different signaling pathways that are important for regulating the trafficking properties of S Indeed, the dilysine endoplasmic reticulum retrieval signal, which is a different...
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