... therefore not surprising that CY administration resulted in a decrease inthe proliferating cell number in both thegastricandduodenal tissues Indeed the decrease in cell proliferation ingastric ... alkylation within the DNA is the N7 position of guanine Alkylation of guanine results in depurination by excision of guanine residues, causing DNA strand breakage through scission ofthe sugar-phosphate ... activity of ODC gene [29], which is involved in polyamine synthesis It is likely that the cell cyclearresting action of CY inthe stomach in this study was due to the activation of p53 and therefore...
... 7-11 The rates ofthe increase in childhood overweight and obesity vary, with England and Poland showing the steepest increases49 12 EN As relatively few risk factors cause the majority ofthe ... consumption of fats, free sugars and salt, of increasing the intake of fruits, vegetables, legumes, grains and nuts, andof performing moderate physical activity during at least 30 minutes a day ... comparable set of indicators for health status, including inthe area of dietary intake, physical activity and obesity IV.4.2 Under the health determinants strand, the Programme is supporting pan-European...
... in ammation induces a state of ‘leptin resistance’ in obese animals and humans resulting in development of hyperleptinemia Similarly, hyperleptinemia is a consequence ofthe development of insulin resistance ... overexpression of ANGPTL6 ⁄ AGF inthe liver of diet-induced obese mice results in elevated ANGPTL6 ⁄ AGF serum levels and amelioration of diet-induced obesity and insulin resistance [14] Taken together, these ... endothelial cells may be a mediator linking smoking to cardiovascular disease in an autocrine or paracrine manner Blocking ANGPTL2 signaling may also be beneficial also in preventing and treating...
... endothelium lining the cavernosal arteries andthe helicine arterioles, as well as the endothelium lining the lacunar spaces ofthe corpus cavernsoum; and (c) the endocrine milieu that regulates the fibroelastic ... disrupter andin uence the endocrine milieu by reducing the levels of luetinizing hormone 5758 (LH) and testosterone resulting in hypogondoropichypogonadism The increased aromatase activity ofthe ... hormone-binding-globulin, leptin, insulin and insulin resistance in obese men Arch Androl 52, 355–361 Wannamethee SG, Shaper AG, Morris RW & Whincup PH (2005) Measures of adiposity inthe identification...
... in Jo, 68% ofthe decrease in Jp, 56% ofthe increase inthe QH2 ⁄ Q ratio, 70% ofthe increase in Dw, 72% ofthe increase inthe ATPin ⁄ ADPin ratio, and 59% ofthe decrease inthe ATPout ⁄ ADPout ... 68% ofthe increase in Dw, 88% ofthe increase inthe ATPin ⁄ ADPin ratio, and 69% ofthe reduction inthe ATPout ⁄ ADPout ratio The exception was the QH2 ⁄ Q ratio, where the response through the ... tended to increase the positive control ofthe ATPin ⁄ ADPin ratio by ATP synthesis andthe negative control by the proton leak The negative control ofthe ATPin ⁄ ADPin ratio by the ANT increased...
... flavonoids, tannin, catechin and alkaloid were found principally in ethanol, n-hexan and chloroform fractions Especially, there is no alkaloid inthe ethylacetate fraction To determine relatively the composition ... Casein Cholesterol Vitamin and minerals Other compounds % 30 35 25 3 Fistly, the body weight of experimental obese mice was determined in conparision with control mice (fed standard diet) The ... drinking water ad libitum + Lot 6: Obese mice fed normal diet and drink water (no treatment) and drinking water ad libitum The results obtained show that the effect of daily repeated oral administration...
... flavonoids, tannin, catechin were found principally inthe ethyl acetate and ethanol fractions In order to determine relatively the composition of natural compounds we used the technique of thin layer ... Vitamin and minerals Other compounds First, the body weight of experimental obese mice was determined in comparison with control mice (fed standard diet) The obtained result was represented inthe ... concentrates /kg) The experimental schema was presented inthe following: The results obtained from the model of experimentally obese mice inthe figure show that the body weights of experimentally...
... for examining the potential bene t of reducing the dumping of untreated wastewater, andthe importance of increasing enforcement in China's industrial zones inthe northern arid parts ofthe country, ... reflecting more particulates inthe air, and is reported as the average reading inthe river basin containing the DSP site The rainfall measure is the average monthly rainfall in millileters inthe ... urban), and two instrumental variables: the average monthly rainfall in millileters inthe basin and output upstream ofthe basin containing the DSP site The F statistic for the joint significance of...
... Preventing Obesity MARKETING TO CHILDREN Since the 1980s, the food and beverage industry has made children and adolescents the targets of intense and specialized food marketing and advertising efforts ... efforts The proliferation of electronic media, the deregulation ofand declining support for public service advertising, andthe booming economy ofthe 1990s all contributed to the transformation of ... children and youth would begin drinking or increase the amount of alcohol they drank before the age of 21 That research points to three important findings: ß Advertising has both immediate and cumulative...
... associated with an increased risk of a variety of other health problems, including the following: Several types of cancer, including cancers ofthe endometrium (lining ofthe uterus), colon and rectum, ... restaurant and are more likely to order a dessert or extra drink if the lighting is dim and/ or the music is soft and pleasant, as is often the case in fine dining establishments On the other hand, ... vitamin D to milk, beginning inthe early 1930s, to prevent rickets andthe enrichment of flours and breads starting in 1938 (made mandatory in 1943) to prevent deficiencies of thiamin, niacin,...
... 60 and 120 postinjection through the tail vein, and glucose levels were measured Determination of plasma insulin and leptin levels Insulin and leptin levels inthe plasma of mice were determined ... catabolism of atherogenic lipoproteins [32,35–37] In this study, we sought to determine the role of ApoE inthe development of diet-induced obesity, glucose intolerance and insulin resistance in vivo ... glucose tolerance and insulin sensitivity To determine the role of ApoE inthe development of obesity-associated insulin resistance and glucose intolerance, we performed the standard glucose tolerance...
... includes the under surface ofthe soft palate, the base ofthe tongue andthe tonsils, the hypopharynx (bottom part ofthe throat) andthe nasopharynx (behind the nose) The most common site of cancer ... on the lip or inthe mouth, but there may also be pain and/ or a lump inthe neck Other symptoms are a white or red patch on the gums, tongue or lining ofthe mouth, and unusual bleeding, pain ... the mouth, lip and tongue (oral cavity), the upper part ofthe throat and respiratory system (pharynx), andthe voice-box (larynx) Other UAT sites include the salivary glands, nose, sinuses and...
... later, the expression of inducible nitric oxide synthase (iNOS) mRNA increased inthe liver Injection of DEP did not induce inflammation or oxidative damage to DNA inthe lungs and aorta Therefore, ... in 2020 (19) It is noteworthy that in many cases, the excess weight of children in developing countries is because of their stunting (15, 20, 21) These findings highlight the need for determining ... that in spite ofthe existing association of NAFLD with the early onset ofthe metabolic and vascular pathogenic changes of atherosclerosis, the evidence for the relationship between NAFLD and...
... of these mice worsened the glucose tolerance and insulin sensitivity ofthe ApoE) ⁄ ) · Ay ⁄ + mice, and triggered obesity, indicating that circulating ApoE is involved in increased adiposity and ... Despite the pivotal role of obesity and dyslipidemia inthe development ofthe metabolic syndrome and heart disease, the functional interactions between adipose tissue andthe lipid and lipoprotein ... establishing that the difference inthe ability of human ApoE3 and murine ApoE to promote obesity in response to a high-fat diet may be the result of intrinsic differences between these two peptides Interestingly,...
... adipocyte and facilitates the expression of multiple proteins regulating insulin sensitivity, including the insulin-dependent glucose transporter GLUT4 andthe insulin-sensitizing hormone, adiponectin ... for our understanding of what controls the expansion of fat mass in different individuals Moreover, it is also important to understand the origins of each ofthe different white and brown depots ... as thermogenesis andthe b-oxidation of lipids [27,28] The gene silencing activity of RIP140 involves an association with additional corepressors, including the NADH-dependent C-terminal-binding...
... the circulatory demands ofthe invading lesion The adipokine leptin is strongly angiogenic [26] and may increase tumor angiogenesis either by directly acting on the endothelium or by increasing ... expansion The importance of maintaining at least remnants of WAT was demonstrated by injecting adipocyte progenitors into the residual adipose depots of lipodystrophic mice: the depots expanded andthe ... In what has become increasingly indicative ofthe metabolic disease potential, the expansion of WAT results in hypoxia and increased levels of HIF-1a that, in turn, lead to an up-regulation of...
... including TNF-a and IL-6 by white adipose tissue (WAT), andthe activation of a network of pro-inflammatory signaling pathways, including the c-Jun NH 2-terminal kinase (JNK) and inhibitor of NF-B ... nerve fibers inthe lamina propria are involved in regulating epithelial transport These nerves form networks within the lamina propria of both crypts and villi with the terminal Lakhan and Kirchgessner ... alterations inthe ENS disrupt normal GI function Since the ENS controls the motility and secretion ofthe bowel these abnormalities indicate the impact of inflammation on neural signaling inthe ENS...
... rib and iliac crest with the subject standing at the end of gentle expiration and expressed in cm [32] All the details ofthe three groups are reported in Table The clinical examination included ... - the values of angle of ankle (AIC index) and knee (KIC index) at the Initial Contact (IC); - the values of ankle dorsiflexion peak during stance (AMSt index) and swing phase (AMSw index) and ... index) andthe peak of knee flexion (KMSw index) during swing; - the values of peak of ankle plantarflexion in stance (AmSt index) andof knee extension (KmSt index) during the gait cycle; - the hip...
... design and gave Page of final approval to the version ofthe manuscript to be submitted All the authors approved the final version ofthe manuscript Competing interests The authors declare that they ... sacroiliac joints, and therefore a higher torque on the L5-S1 joint and discs This possibly increases the shear forces at this level and overload the disc, thus increasing the risk of disk degeneration ... rehabilitative interventions in obese patients should include strengthening ofthe lumbar and abdominal muscles as well as mobility exercises for the thoracic spine and pelvis, in line with previous...
... including TNF-a and IL-6 by white adipose tissue (WAT), andthe activation of a network of pro-inflammatory signaling pathways, including the c-Jun NH 2-terminal kinase (JNK) and inhibitor of NF-B ... nerve fibers inthe lamina propria are involved in regulating epithelial transport These nerves form networks within the lamina propria of both crypts and villi with the terminal Lakhan and Kirchgessner ... alterations inthe ENS disrupt normal GI function Since the ENS controls the motility and secretion ofthe bowel these abnormalities indicate the impact of inflammation on neural signaling inthe ENS...