screening of polymers for amorphous drug stabilization
Methods to improve virtual screening of potential drug leads for specific pharmacodynamic and toxicological properties
... Performance of Ensemble for Hepatic Effects Classification Performance of Base Classifiers in Ensemble Performance of Best Base Classifier Performance of Ensemble for Similar ... necessary for virtual screening of chemical libraries for Lck inhibitors 4.3.4 Evaluation of Prediction Performance Some of the performance measures described in Section 2.6 were calculated for this ... Virtual Screening for Lck Inhibitors 37 39 39 5.1 5.2 5.3 5.4 PI3K Diversity Index Performance of AODE for PI3K Inhibitors Classification Performance of kNN for PI3K...
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R INTE S OF MEDIC REPORTING ADVERSE DRUG REACTIONS DEFINITIONS OF TERMS AND CRITERIA FOR THEIR USE ppt
... Classification of Diseases (ICD)13 helps with reporting the reasons for taking a drug For purposes of drug safety a correct diagnosis and assessment of causality of a suspected ADR are of particular ... common understanding and the uniform use of terms for the monitoring of drug safety The established definitions and basic requirements for the proper use of adverse-drugreaction terms will undoubtedly ... (comments that may be of help to validators of reports of ADRs) Proposed definition of the term (including a list of published definitions) Basic requirements for use of the term (for validating the...
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In Vitro Screening of Plant Resources for Extra-Nutritional Attributes in Ruminants: Nuclear and Related Methodologies pptx
... Tim A McAllister 87 In Vitro Screening of Feed Resources for Efficiency of Microbial Protein Synthesis Harinder P.S Makkar 107 Screening of Plants for Inhibitory Activity Against ... storage of plants for nutritional analysis xi xii Introduction Chapters 3–10 are dedicated to various techniques used for screening a large number of plants and plant compounds for a wide range of ... Geographic Information System (GIS) derived parameters Undertake an expert review of listing of species Germplasm collection of prioritised species and collection of samples for testing of nutrient...
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Báo cáo khoa học: Piezoelectric sensors based on molecular imprinted polymers for detection of low molecular mass analytes potx
... Detection of low molecular mass analytes Y Uludag et al ˘ For all the examples cited above, the binding capacity of the sensor surface is critical to maximize the sensitivity of the sensor for the ... analysis Therefore extra care needs to be taken to remove the template from the polymer and the 3D structure of the polymer should allow for easy regeneration of the template from the polymer for repeated ... amount of a particular drug or any other chemical in body fluids For instance, Tan et al determined the amount of nicotine and paracetamol in human serum and urine [55,58] The detection limit of nicotine...
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Guidelines for the early detection and screening of breast cancer ppt
... detection of cancer 24 Cancer screening 24 Screening for breast cancer 26 Screening approach 26 Guidelines for the early detection and screening of breast ... detection and screening of breast cancer 51 Annex Consensus opinion of the regional task force for developing breast cancer prevention, screening and management guidelines 52 Foreword In ... assessment of regional guidelines for the early detection and screening of breast cancer, and has given special attention to supporting the development of national programmes for the early detection of...
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báo cáo hóa học:" Brazilian Network for HIV Drug Resistance Surveillance: a survey of individuals recently diagnosed with HIV" pot
... the design of the study and performed the statistical analysis LAI and MBGS conceived of the study, participated in its design Page of (page number not for citation purposes) Journal of the International ... maintained undetectable viral loads after one year of follow up With the introduction of new drugs and more potent regimens, the level of efficacy of initial treatment increased substantially in ... 2001, 26:266-273 UK Collaborative Group on Monitoring the Transmission of HIV Drug Resistance: Analysis of prevalence of HIV-1 drug resistance in primary infections in the United Kingdom Br Med J...
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LISTS OF ACCEPTABLE POLYMERS FOR USE IN FOOD PACKAGING APPLICATIONS ppsx
... and thus can be very crystalline For this reason they are often used to make block copolymers with soft rubbery polymers These block copolymers have properties of thermoplastic elastomers 32 33 ... chains of polybutadiene growing out of it Food Packaging Materials These rubbery chains hanging off of the backbone chain some good things for polystyrene Polybutadiene and polystyrene homopolymers ... filed for a patent outside Germany) Tons of new uses for this wonderful waterproof material followed, and PVC was a smash hit the second time around For Nylon 6,6 at a glance, click here! For Nylon...
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Báo cáo khoa học: "Near infrared analysis as a tool for rapid screening of some major wood characteristics in a eucalyptus breeding program" ppsx
... value of 2.0–3.0 is regarded as adequate for rough screening A value of above 3.0 is regarded as satisfactory for screening (for example in plant breeding), values of and upward are suitable for ... the known value of the constituent of interest for sample j, and Np is the number of samples in the prediction set The ratio of performance to deviation (RPD: ratio of the SD of the reference ... coefficient of determination of 0.35 Hence it was of no interest to develop a validation test for this criterion The coefficients of determination for the regressions calculated by comparison of the...
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báo cáo khoa học: " ’It’s risky to walk in the city with syringes’: understanding access to HIV/AIDS services for injecting drug users in the former Soviet Union countries of Ukraine and Kyrgyzstan" ppt
... based on the accounts of HIV/AIDS service clients, frontline providers and stakeholders in the field of HIV/AIDS: • stigmatisation of HIV/AIDS and drugs use; • criminalisation of drugs use; • discriminatory ... service providers reported that police officers commonly arrested drug service clients, confiscated drugs and extracted bribes for possession For clients of needle/syringe exchange services this ... Ukraine, for example, revealed wide scale extortion of bribes, planting of drugs, and in some cases torture or rape of detainees and other human rights violations [54] While recent legislative reform...
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báo cáo khoa học: " Route of administration for illicit prescription opioids: a comparison of rural and urban drug users" pdf
... criteria for MDD than did urban participants (Table 1) Drug Use and Route of Administration Table describes rural and urban nonmedical drug use and the routes of drug administration for each of the drugs ... Route of drug use and its implications for drug effect, risk of dependence and health consequences Drug Alcohol Rev 1998, 17:197-211 15 Xian X, Jun L, Jianling B, Rongbin Y: Epidemiology of hepatitis ... variations in the characteristics of heroin seized in Spain and their relation with the route of administration Spanish Group for the Study of the Purity of Seized Drugs Drug Alcohol Depend 1996, 40:185-194...
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báo cáo khoa học: " The acceptability and feasibility of peer worker support role in community based HCV treatment for injecting drug users" pot
... shown that knowledge of HCV treatment options among injecting drug users is low and that medical support for HCV is often perceived as a low priority in the lives of injecting drug users [17] HCV ... agencies about a broad range of clinical and logistical considerations relating to HCV treatment She talked about the importance of offering practical support, often in the form of transporting clients ... identified the complexity of the peer worker role in this service model (of being both a member of the HLC team and a confidante for the clients), and the need for independent professional clinical...
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Báo cáo khoa học: "Screening of Feral Pigeon (Colomba livia), Mallard (Anas platyrhynchos) and Graylag Goose (Anser anser) Populations for Campylobacter spp., Salmonella spp., Avian Influenza Virus and Avian Paramyxovirus" pot
... protocol: 94 °C for 40 s, 55°C for 20 s and 72°C for 60 s, and by 45 cycles with the following conditions for the avian influenza protocol: 94 °C for 45 s, 58 °C for 45 s and 72°C for 30 s A final ... transcription was performed at 50 ºC for 45 for the avian paramyxovirus detection, and at 55 ºC for 30 for the avian influenza detection Both reactions were followed by inactivation of the reverse transcriptase ... step at 72 °C for 5-10 was performed, followed by chilling to ºC The concentration of Mg2+ in the reactions was 1.5 mM for both protocols, and Qiagen's Q solution was added in the PCR for avian paramyxovirus...
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Báo cáo sinh học: " A tree-based method for the rapid screening of chemical fingerprints" potx
... et al Algorithms for Molecular Biology 2010, 5:9 http://www.almob.org/content/5/1/9 Page of 10 Figure Distribution of number of bits in fingerprints Distribution of the number of bits set in the ... is performed 100 times, and the average query time is presented All experiments are performed with a Smin of 0.9 The three graphs (a) - (c) show the performance of the three bucket types for the ... advantage of: • Convenient online submission References Irwin JJ, Shoichet BK: ZINC: A Free Database of Commercially Available Compounds for Virtual Screening Journal of Chemical Information...
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Báo cáo y học: "Are we ready for therapeutic drug monitoring of biologic therapeutics" pot
... serum drug levels are not measured routinely in these patients Additionally, in patients with drug levels below the therapeutic range, the detection of antibody formation could reveal the reason for ... reveal the reason for these low drug levels Although the effects of immunogenicity have become widely studied for infliximab and adalimumab, comparable studies for other biologicals are lacking ... biological therapeutics Apart from the issue of an elevated risk of side effects, the finding of antibodies against a biological and low or absent drug levels is important and clinically relevant...
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Báo cáo y học: " Discovery of novel targets for multi-epitope vaccines: Screening of HIV-1 genomes using association rule mining" pot
... IH: Data mining in bioinformatics using Weka Bioinformatics 2004, 20:2479-2481 Gewehr JE, Szugat M, Zimmer R: BioWeka – extending the Weka framework for bioinformatics Bioinformatics 2007, 23:651-653 ... generation of tetramer epitope vaccines with epitopes being chosen based on the presence of principal neutralizing determinant [12], (b) the generation of synthetic peptides with prediction of the ... [18] with epitope identification by screening of HIV-1 antigens for peptides that contain the HLA-DR-supertype binding motif [19] However, inherent limitation of in-silico epitope predictions is...
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guide for the use of polymers in concrete
... coalescence or formation of the polymer film The formation of the polymer film retards the loss of water from the concrete thus making it available for hydration of the cement Moist curing of PMC is ... granular-powder forms (35 to 50percent BPO) For ease of handling and safety purposes, the balance of these formulations is generally a plasticizer or inert filler Purer forms of BPO (for example, ... C) because of the rate of hydration of the cement 4.2—PMC polymers 4.2.1 Latexes—The majority of PMC placed today uses a polymer in latex form Latex has been defined as a dispersion of organic...
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identification, design and synthesis of oxygenated hydrocarbon-based carbon dioxide-soluble polymers for chemical and petroleum engineering applications
... biodegradable polymers to form particles that can be used for drug delivery and controlled release.60-63 1.2.4 Scaffolds for Tissue Engineering Applications A shortage of donor tissue limits the number of ... They evaluated a variety of commercially available polymers, amorphous polymers of various molecular weights They also studied linear, weakly associative polymers composed of tri-alkyltin fluoride, ... monomers such as acrylamide and 2-hydroxyethyl acrylate.41 1.2.2 Formation of Polymer Blends The use of scCO2 as a solvent for the formation of polymer blends was pioneered by McCarthy and colleagues...
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synthesis and characterization of novel polymers for functional and stimuli responsive silicon surfaces
... surfaces at 150 °C for 12 h and extracting the physically attached polymers by sonication in toluene for h 119 Figure 3-11: Depiction of the formation of (a) brush regime in the case of linear polymer ... Synthesis of poly(sty-b-styOAc-b-t-BA) (1), B) hydrazinolysis of to 1-OH, C) silylation of 1-OH 141 Scheme 4-2: Synthesis of poly(sty-b-HEA-b-DMAAm) (2) 144 Scheme 4-3: Depiction of the formation of ... Branched Polymers 2.3.1 Introduction In terms of chemical compositions, polymers attached to surfaces include homopolymers (both neutral and charged), mixed homopolymers, block copolymers, random copolymers,...
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DESIGN, SYNTHESIS AND PROPERTIES OF METAL COMPLEXES AND COORDINATION POLYMERS FOR 2+2 PHOTO CYCLOADDITION REACTIONS
... transformation of 3-9 monomer to dimer complex in SCSC manner Figure 3-7 DSC of III-2 3-11 Figure 3-8 3-11 H-NMR spectra of III-2 before & after heating at 220°C for 48 h, showing the formation of ... supervision of Prof Jagadese J Vittal at Department of Chemistry, National University of Singapore, during January 2010 to January 2014 I have duly acknowledged all the sources of information used for ... transformation of 2D interdigitated MOF, V-1.2 5.1-12 to doubly interpenetrated 3D MOF, V-1.3 Figure 5.1- Comparison of PXRD data of V-1.2 & V-1.3 5.1-13 Figure 5.1- 10 A perspective view of a...
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