scientific and clinical research in alzheimer s disease
Báo cáo khoa học: Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease brain doc
... proteins with either polyglutamine or polyalanine expansions in Huntington disease, Huntington related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies ... Foundation, SADF (Insamlingsstiftelsen for ¨ Alzheimer- och Demensforskning), Socialstyrelsens Stiftelser, Stiftelsen for Alderssjukdomar, and Svenska ¨ ˚ Lakaresallskapet ¨ ¨ FEBS Journal 272 ... its N-terminus (Thr56) that subsequently blocks eEF2 binding to ribosomes, resulting in decreased rates of protein synthesis Dephosphorylation of eEF2 relieves its translational restriction and...
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báo cáo hóa học: " Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer''''s disease" pdf
... pathological disease state and investigated brain area, methods of analysis, as well as technical issues The data presented in this study are in agreement with the findings of Yermakova and O'Banion ... Demographic characteristics of the cases used in this study Shown are differences between groups of the cases used in this study [PMI post-mortem interval, SD standard deviation] Braak score for neurofibrillary ... Mueksch B, Boehringer M, Hull M: Interleukin-1beta induces cyclooxygenase-2 and prostaglandin E(2) synthesis in human neuroblastoma cells: involvement of p38 mitogenactivated protein kinase and...
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báo cáo hóa học: " Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer''''s disease" potx
... groups Similar results were obtained when the analysis was carried out using LSS scores as proxy of status (p < 0.025, lowest vs highest LSS scores) As shown in Figure 2, high serum AOC levels predicted ... clinical diagnosis of probable Alzheimer' s disease [10] All participants underwent a physical examination, blood tests and neuroimaging assessments They also underwent cognitive assessments using the ... MMSE scores Figure MMSE AOC Serum scoreslevels in participants grouped according to Serum AOC levels in participants grouped according to MMSE scores Square and circle symbols indicate controls...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... of CAA in leptomeningeal and cortical vessels with few diffuse plaques, severe loss of SMCs, weakening of vessel walls leading to hemorrhage and perivascular microgliosis and astrocytosis The ... aggregation in sporadic AD brain There is now a renewed interest in studying APP processing in sporadic AD brain, and in understanding the mechanisms of Ab truncation and modification Most transgenic ... pathogenesis Therapeutic studies in AD models Access to good animal models is crucial to success in developing disease- modifying therapeutics However, AD neuropathology is incomplete in the Ab-expressing...
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Psychiatric and Cognitive Disorders in Parkinson’s Disease pptx
... Epidemiologic, clinical, and therapeutic aspects of Parkinson s disease Parkinsonism and Parkinson s disease 34 Cognitive deficits in Parkinson s disease 55 Depression in Parkinson s disease 88 Anxiety, ... guidelines, case studies and rating scales will meet the needs of all clinicians working with Parkinson s disease patients Sergio E Starkstein was Assistant Professor of Psychiatry at Johns Hopkins ... the disease itself This subject is further discussed in chapter Clusters of parkinsonian signs and subgroups of the disease A question now arising is whether PD constitutes one single and clinically...
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báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer''''s disease" pptx
... findings to the human disorders, distinct differences remain These models may be appropriate for studying some aspects of a disease process, while less suitable for others To determine the significance ... The PS/APP mouse carries both of these transgenes and has been extensively used as a model for studying processes relating to the formation of SPs Aβ deposition occurs more rapidly in these mice ... Landreth GE: Inflammation, apoptosis, and Alzheimer' s disease Neuroscientist 2002, 8:276-283 Gupta A, Pansari K: Inflammation and Alzheimer' s disease Int J Clin Pract 2003, 57:36-39 Hoozemans...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... global inhibition of src-family tyrosine kinases or inhibition of phosphatidylinositol-3 kinase (PI3K) attenuates ROS production These findings suggest that these kinases are involved in upstream signaling ... http://www.jneuroinflammation.com/content/3/1/30 kinases Lyn and Fyn as well as the tyrosine kinase Syk [30,32,52] Activation of these signaling cascades are linked to the synthesis and secretion of proinflammatory molecules and cytokines ... Despite these promising findings, the use of statins in prospective clinical trials has yielded unsatisfactory results, failing to dramatically improve cognitive function or reduce serum plasma...
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báo cáo hóa học: " Neuroinflammation in Alzheimer’s disease wanes with age" pdf
... microglia is already increased in early pathological stages of AD and in cognitively normal subjects with frequent presence of plaques and tangles [3,4] Clinical studies using positron emission tomography ... cases Page of Discussion In this study, we compared the age-dependent presence of microglia and astrocytes, which is indicative of a neuroinflammatory response, in controls and AD cases We show ... arbitrary units) for controls (open dots) and AD patients (closed dots) Straight lines represent regression lines, with corresponding 95% confidence intervals microglia in young AD cases might reflect...
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THE CLINICAL SPECTRUM OF ALZHEIMER’S DISEASE – THE CHARGE TOWARD COMPREHENSIVE pdf
... subentities, making a clear definition very difficult The majority of AD researchers assume Risk Factors for Disease Progression in Alzheimer' s Disease a linear slope, but some investigators also suggest ... Cardiovascular disease risk factors and progression of Alzheimer s disease Dement Geriatr Cogn Disord., 27(3), 240-246 Risk Factors for Disease Progression in Alzheimer' s Disease 13 Adak, S. , Illouz, ... can be re-sampled repeatedly, allowing for longitudinal assessment of gene dysregulation at different disease stages This could assist in making diagnoses, tracking the disease course and evaluation...
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Báo cáo y học: "Phenomenology and management of cognitive and behavioral disorders in Parkinson''''s disease. Rise and logic of dementia in Parkinson''''s disease" pptx
... different diseases, and others have given its name to diseases differing essentially from it" [1] For instance, dementia with Lewy bodies and Parkinson 's disease are one or two disorders? [37-39] This ... precipitating factors common in these ages, and, finally addressing dementia itself So, the diagnostic process in patients with PD and suspected dementia involves two steps: the diagnosis of dementia and ... comments and suggestions References The marked cholinergic deficits in patients with DLB and PD dementia suggest the efficacy of Acetylcholinesterase inhibitors in these diseases, possibly even...
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Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E pptx
... neurological, psychiatric and neuropsychological assessments were reviewed in a consensus conference comprised of neurologists, psychiatrists, and neuropsychologists Based on this review all participants ... cognitive skills remained stable Increased age was associated with lower scores in all cognitive domains while increased education was associated with higher scores APOE-4 was not associated with ... education, and ethnic background were included as covariates in subsequent analyses The GEE analyses yields beta values which represent associations between a factor score and variables included in the...
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PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx
... cognitive functioning Cognitive screening includes using validated screening instruments, such as the MMSE, and brief bedside assessments Cognitive screenings are usually sensitive to significant cognitive ... toward scan interpretation that integrates the visual and quantifying information present in clinical PET scans Visual Assessment Systematic visual examination of a clinical brain PET scan involves ... parkinsonism in DLB differs from Parkinson s disease by being more often symmetric, with less pronounced tremor (if any) Hallucinations are also more prominent in Parkinson s disease than in DLB...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: genetic and clinical studies from patients ppt
... 50 years to 85% at age 70 years in an initial family-based study, but varied in subsequent reports, depending on sample size, study design, inclusion of probands in the analysis and methods of ... pars compacta with the presence of eosinophillic, intracytoplasmic and proteinaceous inclusions termed as Lewy bodies and dystrophic Lewy neurites in surviving neurons [2] For many decades, the ... interactions with substrates and ⁄ or regulatory proteins Preliminary studies suggest that it may lead to decreased kinase activity and be pro-apoptoptic under cellular stresses [12,41] The clinical...
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báo cáo hóa học: " Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer''''s disease" potx
... analysis, data analysis and presentation and assisted with perfusions and animal care; OY performed immunohistochemistry and image analysis; DC assisted with the design of the study and manuscript ... memory loss in a mouse transgenic model of Alzheimer' s disease J Neurosci 2002, 22:6331-6335 Selkoe DJ, Schenk D: Alzheimer' s disease: molecular understanding predicts amyloid-based therapeutics Annu ... technical assistance, and K Pisalyaput for careful reading of the manuscript References Competing interests Charles Glabe and Rakez Kayed are consultants for Kinexis, Inc and Scott Webster is an employee...
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báo cáo hóa học: " ELISA measurement of specific non-antigenbound antibodies to Ab1-42 monomer and soluble oligomers in sera from Alzheimer’s disease, mild cognitively impaired, and noncognitively impaired subjects" pptx
... encouraging results were obtained in two clinical trials in which IvIg was administered to AD patients [22,23] and a multi-site phase trial is in progress In our ELISA studies we found that in addition ... differences, and the small sample sizes used in some studies In previous ELISA studies comparing these antibodies in AD subjects vs normal controls, only Moir et al [3], Gruden et al [14,15], and Nath ... with this approach Methods Serum samples Serum samples were obtained from the Rush Alzheimer s Disease Center (Chicago, IL) from individuals whose diagnosis on the basis of post-mortem clinical...
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báo cáo hóa học: " Osteoarthritis accelerates and exacerbates Alzheimer’s disease pathology in mice" ppt
... Bonotis K, et al: Systemic immune aberrations in Alzheimer s disease patients J Immunol 2008, 193:183-187 Holmes C, et al: Systemic inflammation and disease progression in Alzheimer disease Neurol ... how is joint osteoarthritis linked to AD pathology? Numerous clinical and animal reports in the past showed an increase in circulating pro-inflammatory cytokines in the serum of patients and small ... Massive gliosis induced by interleukin-6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition FASEB 2004, 24:548-559 19 Shaftel SS, et al: Sustained...
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Báo cáo y học: " Interrelated modulation of endothelial function in Behcet''''s disease by clinical activity and corticosteroid treatmen" ppt
... unchanged during the following days Clinical assessment and vascular studies were repeated on day The present study was conducted, using both case-controlled cross-sectional and prospective interventional ... years) who presented at disease relapse while not receiving corticosteroid treatment were studied prospectively Subsequent to their clinical assessment, these patients underwent vascular studies ... control individuals and in patients with Behçet 's disease (BD) divided according to the receipt (+) or nonreceipt (-) of corticosteroid treatment and the clinical disease status Unless otherwise stated,...
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Báo cáo y học: " Research In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of β-amyloid plaques associated with Alzheimer''''s disease" doc
... been classified into two types, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), on the basis of distinct substrate specificities and inhibitor sensitivities AChE (EC 3.1.1.7) is a key ... pose was evaluated by considering the RMSDs values, docking scores and similarity scores The selected re-docked pose was further evaluated by its interactions and energetic analysis to investigate ... changes that occur upon ligand binding It was the goal of this docking and scoring evaluation to investigate as systematically and exhaustively as possible the current state of the art in docking and...
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Báo cáo y học: "Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer''''s disease" pot
... polymorphism and certain clinical phenotypes, such as measures of disease severity or responsiveness to medications In doing this, we would be able to indirectly associate the splicing event with key clinical ... regardless of disease state, and not if they failed solely in the control or diseased brain tissue structure, interactions Brain tissue was ground in liquid nitrogen (mortar and pestle) Tissue powder ... elucidating which of these events translate into clinically significant changes Materials and methods Brain tissue samples This study was approved by the Joint Research Ethics Committee of the Institute...
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Tài liệu Alzheimer’s Disease and Other Dementias doc
... Psychological Disorders Alzheimer s Disease and Other Dementias Psychological Disorders Addiction Alzheimer s Disease and Other Dementias Anxiety Disorders Child Abuse and Stress Disorders Depression ... Chelsea House books are available at special discounts when purchased in bulk quantities for businesses, associations, institutions, or sales promotions Please call our Special Sales Department in ... Huntington s disease, alcohol-induced dementia, and head trauma Dementia can also be caused by infections to the brain and hereditary diseases like Wilson s disease Huntington s disease is an involuntary...
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