... attack (15) The present clinical trial evaluated thesafetyandefficacyof UC -II inthetreatmentofthe knee in OA patients Materials and Methods Study Design This clinical trial (Human Clinical ... in this study were standard for OA and are widely used and recognized as reliable, accurate, and relevant WOMAC scores were determined, at screening, and baseline, as well as at days 30, 60 and ... Peal A, Alvey M, Simms C, Curtsinger A, Gupta RC, Canerdy TD, Goad J, Bagchi M, Bagchi D Therapeutic efficacyandsafetyofundenaturedtypeIIcollagen singly or in combination with glucosamine...
... cervical to thoracic tracheal area Coughing and dyspnea disappeared andthe dogs resumed normal activity Stent implantation is a minimally invasive, effective, easy and brief procedure that can ... (b) intratracheal placement of self expandable nitinol stent with flare ends ina dog with tracheal collapse Collapsed trachea is extended and sustained (white arrow) Intratracheal nitinol stent ... treatmentof tracheal collapse ina dog J Am Vet Med Assoc 2004, 225, 1217-1221 10 Moritz A, Schneider M, Bauer N Management of advanced tracheal collapse in dogs using intraluminal self-expanding...
... Techasathit W, Sonjai A, Suwanagool S: Safetyandefficacyofa simplified fixed-dose combination of stavudine, lamivudine and nevirapine (GPO-VIR) for thetreatmentof advanced HIV-infected patients: ... combinations, Nevirapine, EFV: Efavirenz, d4T: Stavudine, 3TC: Lamivudine, ART: Antiretroviral therapy, OIs: Opportunistic infections, AST: Aspartate aminotransferase, ALT: Alanine aminotransferase ... study SL participated inthe design ofthe study SS participated inthe design ofthe study and statistical analysis Acknowledgements The authors would like to thank all the attending staffs and physicians...
... first Pain was assessed with a six-point Pain Intensity (PI) scale, in which was no pain, was mild pain, was moderate pain, was severe pain, was very severe pain, and was worst possible pain If the ... study involved bradycardia, cerebral infarction, oedema, hypotension and intracranial haemorrhage inthe remifentanil group, raised ICP inthe fentanyl group, and bradycardia and raised ICP inthe ... Karabinis et al and sedation beyond day 3, propofol was discontinued and replaced with midazolam in accordance with local transitioning protocols The infusion rates of fentanyl and morphine and...
... all of these laboratories andthe electrocardiogram were repeated at the end of study participation All females had a urine pregnancy test performed at screening and at week or at termination of ... than the standard ANOVA method [44] The baseline and each post-baseline visit were included inthe model as the dependent variables In addition, a CDRS-R "response" rate was prospectively defined ... amphetamines, opiates, cannabinoids, cocaine, and phencyclidine Also, at the study physician's discretion, a blood ethanol screen was also able to be obtained at additional study visits if there was...
... (hearing loss alone in three, facial numbness and hearing loss in one, vocal cord paralysis and hearing loss in one, and temporary imbalance and/ or vertigo in one) In 26 patients in whom hearing ... RFAH conceived and prepared the manuscript MSM and OMF participated inthe design ofthe study All authors read and approved the final manuscript Competing interests The authors declare that they ... otorrhea, hemorrhage, bruit, andthe presence ofa middle ear mass Significant ear pain is uncommon Involvement ofthe inner ear produces vertigo and sensorineural hearing loss [11] Cranial nerve involvement...
... unwinding collagen fibril inside the cell Sections through several planes of more than 50 cells were examined for each treatment CII, stained and imaged at the same gain and offset levels as the ... which the level of intracellular CII dropped, probably due to terminal lysosomal transport and degradation IIcollagen (CII) by macrophages The effect of inhibitors of uptake on the intracellular ... inhibitors of uptake Pretreatment of macrophages with cytochalasin D or amiloride reduced accumulation of CII in fractions and (Figure 4c) Monodansylcadaverine and filipin had no effect on CII internalization...
... arthritic DBA/1 and B6 mice revealed that, in early arthritis (up to weeks after onset), there was a similar degree of inflammatory cell infiltration inthe two strains In contrast, in late arthritis ... stained with haematoxylin and eosin Inthe early stages of CIA, inflammatory infiltrates were found in both the DBA/1 (Figure 2a) and B6 (Figure 2b) joints However, at late stages of disease, ... (Margate, Kent, UK) The phenotype ofarthritis was milder in B6 mice than in DBA/ mice, with less swelling anda more gradual increase in clinical score Histological assessment ofthe hind paws...
... efficacyof an oral tolerance approach for RA To evaluate theefficacyandsafetyof CCII in RA patients further, we treated two groups of RA patients with oral CCII or MTX ina randomized, doubleblind, ... ofefficacy were made at baseline and repeated 12 and 24 weeks later Efficacy variables included [21,22] pain, and pain intensity was assessed by visual analogue scale (VAS) of (no pain) to 10 ... models, including arthritis CII is the most abundant structural protein of human cartilage The cartilage within the joint caused mainly damage of autoimmunity in patients with RA CII autoimmunity may...
... antibodies against bovine typeIIcollagen (CII) and human CII Scatter plot ofthe levels of IgG antibodies against human CII and bovine CII in sera of patients with rheumatoid arthritis (RA; n = ... = of bovine typeIIcollagenin patients with rheumatoid arthritis= 34) and 96), psoriatic serum of antibodies against CB10 (a) and (RA; (b) in normal human arthritis (PsA; n 33), collagenin ... Mechanisms of disruption ofthe articular cartilage surface in inflammation Neutrophil elastase increases availability ofcollagentypeII epitopes for binding with antibody on the surface of articular...
... Annals of General Psychiatry 2009, 8:16 thetreatmentof acute mania, the approval of quetiapine andthe olanzapine-fluoxetine combination against acute bipolar depression andthe approval of ... Sharma A, Kovalick LJ, Reeves RA: Pharmacokinetics and tolerability of intramuscular, oral and intravenous aripiprazole in healthy subjects andin patients with schizophrenia Clin Pharmacokinet ... efficacyof aripiprazole against acute mania and they report that the separation from placebo occurred as early as days to They also provide some support for its efficacy against mixed episodes and...
... Infecciosas, Hospital Universitario Infanta Cristina, Badajoz, Spain Authors’ contributions Conception, design, analysis, interpretation ofthe data, drafting ofthe article and obtaining of funding: LFLC ... Community of Andalusia, and conducted according to the principles contained inthe Declaration of Helsinki All patients gave an informed consent The patients’ inclusion was censored in May 2007 to allow ... maintenance therapy [23,24] We are aware that the open-label characteristics ofthe study, the heterogeneity ofthe analyzed population andthe lack of available genotypic resistance tests in...
... analysis Data were entered into a computerized database and analyzed with a statistical package (STATISTICA; StatSoft, Inc) The descriptive summary of data included mean ± standard deviation and 95% ... Postoperative protocol After surgery, all patients were treated with intravenous heparin and amiodarone With reconvalescence ofthe patient, anticoagulation (warfarin or coumadin) and antiarrhythmic ... therapy (amiodarone 200 mg/d) were switched to oral medication and maintained for months After months continuance of oral anticoagulation was determined on basis ofthe CHADS2 score In case of...
... reports the results of post hoc analyses ofa 24-week maintenance study of olanzapine LAI [2] examining the potential association between olanzapine LAI dose and several safetyandefficacy parameters ... Statistical Analyses The primary objective of these post hoc analyses was to examine the potential relationship between different olanzapine LAI doses and changes insafetyandefficacy parameters ... treated with oral olanzapine have found an association between olanzapine plasma concentrations and changes in some metabolic parameters [3,4], as well as differences in changes inefficacy and...
... Poulton and colleagues [65] more than 60 years ago, and seven years ago the first meta-analysis appeared, showing theefficacyof CPAP inthetreatmentof ACPE [10] Since then, several RCTs comparing ... using any device) and medical therapy compared with standard medical therapy alone; use of NPPV (with any device) and medical therapy compared with standard medical therapy alone; or use of CPAP ... NPPV and SMT versus SMT alone; and NPPV and SMT versus CPAP and SMT Secondary aims were to analyze the impact of patients' baseline hypercapnia on theefficacyof CPAP and NPPV and to test a common...
... from sites in North America, Thailand and Australia, between 2002 and 2005 Study material or placebo was administered ina 100 mL bag of normal saline Addition of IV ibuprofen to the bag for dilution ... and MA made substantial contributions to the conception and design ofthe study, acquisition of data andthe interpretation of data PM and PW drafted the manuscript and PM, JP, KG, PW and MA revised ... Page of 13 Figure Mean ibuprofen concentrations (hour to 4), by treatment group and randomization stratum Ina secondary analysis of efficacy, theefficacyof IV ibuprofen was analyzed by assessing...
... is at the medial side ofthe orbit, and is the smallest andthe innermost part ofthe orbicularis oculi The palpebral portion raises the eyelid and controls the involuntary action of blinking The ... lines and drooping nasal tip Bunny lines refer to the wrinkles on the lateral part ofthe nose In some patients, the wrinkles also exist on the dorsal part ofthethe procerus, the nasalis and ... injection.31 Anatomy The masseter is the largest and strongest muscle functioning in mastication Its superficial portion originates from the zygomatic arch and inserts into the ramus ofthe mandible and the...
... shut-off temperature is ≤40°C Evaluation of replication of viruses in AGMs andefficacy against challenge AGMs in groups of two to four animals at a time were inoculated intranasally (i.n.) and intratracheally ... increase the overall stability ofthe virus by increasing the total number of attenuating mutations present inthe vaccine candidate To generate the two live attenuated HPIV1 vaccine candidates, ... laboratory is developing a live attenuated virus vaccine for HPIV1 for intranasal administration to infants and young children The intranasal route of administration is needle-free and has the...
... immunological mechanisms that may advance our understanding of biological pathways in non-clinical populations The presence ofType D personality may also be associated with health-related problems inthe ... reactivity [11] Type D was also associated with a differential activity ofthe amygdala in reaction to fearful versus neutral face and body expressions Emotion-evoked activation ofthe amygdala ... systolic and diastolic blood pressure Page of 10 reactivity [11], and dampened heart rate reactivity during experimental stress Type D was also associated with a decreased activity inthe amygdala in...
... excretion of albumin and protein was measured before (day 1), during (days and 14), andand 14 days after HGF administration Repeated doses of rh-HGF induced an increase in urinary albumin excretion in ... Proc Natl Acad Sci USA 1994, 91:4357-4361 Morishita R, Aoki M, Hashiya N, Makino H, Yamasaki K, Azuma J, Sawa Y, Matsuda H, Kaneda Y, Ogihara T: Safety evaluation of clinical gene therapy using ... miniature swine, six to seven months of age, and male Wistar rats, seven weeks of age, were obtained from Japan Farm (Kagoshima, Japan) and Charles River Laboratories Japan Inc (Yokohama, Page...