roles of security manager in an organization
Tài liệu Báo cáo khoa học: Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus doc
Ngày tải lên :
19/02/2014, 07:20
... alanine scanning of the
L-CDR3 and H-CDR3 loops of antibody mAb4E11.
This scanning allowed us to identify the residues of
these loops that contributed to the energetics and kinet-
ics of the interaction ... systematic
scanning of the CDR3 loops of mAb4E11 by mutagen-
esis of their residues into alanine (Ala scanning). The
affinities of the purified mutant Fab fragments of
mAb4E11 for its antigen were ... Thorn KS (1998) Anatomy of hot spots in
protein interfaces. J Mol Biol 280, 1–9.
32 DeLano WL (2002) Unraveling hot spots in binding
interfaces: progress and challenges. Curr Opin Struct
Biol...
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Báo cáo khoa học: Roles of conserved arginines in ATP-binding domains of AAA+ chaperone ClpB from Thermus thermophilus pptx
Ngày tải lên :
06/03/2014, 00:20
... exam-
ine the roles of the conserved arginines, Arg322 (P2)
and Arg323 (P1) of AAA-1, and Ar g747 (P1) of AAA- 2,
and determined that the arginines of TClpB are not
involved in nucleotide binding ... these three arginines in TClpB.
By combining an arginine mutation with the WalkerA
mutation in the other AAA+ module, we tested the
roles of the arginines in ATP binding and hydrolysis in
each module. ... arginines are not involved in
nucleotide binding
To examine the roles of conserved arginines, we gener-
ated three mutants of TClpB: R322A [1R ⁄ A(P2)],
R323A [1R ⁄ A(P1)], and R747A (2R⁄ A). In...
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Báo cáo khoa học: Flexible nets The roles of intrinsic disorder in protein interaction networks potx
Ngày tải lên :
07/03/2014, 21:20
... Biology and Bioinformatics, Indiana University
School of Medicine, Indianapolis, IN, USA
2 School of Informatics, Indiana University – Purdue University Indianapolis, IN, USA
3 Laboratory of Statistical ... interaction with Cdk2 and
cyclin A: 1, domain 1 interacting with
cyclin A; 2, a linker helix involved in binding
both cyclin A and Cdk2; 3, domain 2 inter-
acting with Cdk2 [122]. Blue and dark yellow
horizontal ... capable of bind-
ing many different partners.
An interesting consequence of the capability of ID
proteins and regions to interact with different binding
partners is the potential for polymorphism in...
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Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf
Ngày tải lên :
15/03/2014, 00:20
... one-third of all solid tumors
[20]. During cancer progression, increased shedding of
the membrane-anchored ligands of EGFR, including
heparin-binding EGF (HB-EGF), transforming growth
factor (TGF)-a and ... Shedding of membrane-anchored ligands of EGFR
(HB-EGF, TGF-a and amphiregulin)
ADAM10 Shedding of E-cadherin
MMP-9, -2, -14 Activation of TGF-b
MMP-7 (anchored to CD44) Shedding of HB-EGF
Cancer ... their
main roles focus on ectodomain shedding and nonpro-
teolytic functions, such as binding to adhesion mole-
cules, integrins and interacting with phosphorylation
sites for serine ⁄ threonine and...
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Báo cáo khoa học: Different roles of functional residues in the hydrophobic binding site of two sweet orange tau glutathione S-transferases pdf
Ngày tải lên :
15/03/2014, 09:20
... of microgram quantities of protein
utilizing the principle of protein-dye binding. Anal
Biochem 72, 248–254.
40 Laemmli UK (1970) Cleavage of structural proteins
during the assembly of head of ... PEI and PKI mutants were obtained by replacing
Arg89 of GSTU1 (REI) with Pro89, and Glu117 of
the PEI mutant with Lys117, respectively. Steady-state
kinetic analysis of purified RKI and RKV mutants
showed ... induction of
distinct glutathione transferases of wheat by xenobiotics
and by pathogen attack. Plant Physiol 102, 1193–1201.
17 Dean JD, Goodwin PH & Hsiang T (2005) Induction
of glutathione S-transferase...
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Báo cáo khoa học: Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1 pot
Ngày tải lên :
17/03/2014, 09:20
... of alanine
or glutamine for Glu182 blocks binding of PDP1 and
PDP1c to the L2 domain. As can be seen in Fig. 2A, a
distinct pocket exists in the center of this set of residues.
Binding of PDP1c-Ca
2+
to ... higher
rates of phosphorylation of the E2-bound E1. Binding of a kinase
dimer to a lipoyl domain containing a reduced lipoyl group fosters a
further increase in kinase activity (PDK* state). Binding of ... by the L1 domain of E2 and L3 domain of E3BP
(Fig. 1) and reduction and acetylation of the lipoyl groups
of these domains enhance PDK4 activity. PDK1 binds to
the L1 and L2 domains of E2 (Fig....
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The Roles of the Aesthetic in Mathematical Inquiry doc
Ngày tải lên :
30/03/2014, 16:20
... pattern emerging in a sequence of numbers; a point of coincidence found
in a group of lines; a large change resulting from a small variation; a finite real
thing proved by an infinite, possibly ... particularly attuned to things analogous, he also
wants to and enjoys finding analogies—they are aesthetically pleasing to him. The
wealth of analogies evident in his initiation into triangle geometry satisfies ... playing is aesthetic insofar as the mathematician is framing an
area of exploration, qualitatively trying to fit things together, and seeking patterns
that connect or integrate. Rather than being...
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báo cáo hóa học:" Functional bracing for delayed union of a femur fracture associated with Paget''''s disease of the bone in an Asian patient: a case report" pot
Ngày tải lên :
20/06/2014, 04:20
... reported incidence of 3-4% in the adult
population [1-3]. Interestingly, it is extremely rare in
Africa and Asia, and rarely occurs in Japanese individuals
[3-6].
Although the etiology of Paget's ... Guidelines for diagnosis and
management of Paget's disease of bone in Japan. J Bone Miner Metab
2006, 24:359-367.
7. Kanis JA: Pathophysiology and treatment of Paget's disease of bone ... and KS have been involved in drafting the manuscript.
All authors read and approved the final manuscript.
Author Details
1
Department of Orthopaedic Surgery, Gifu University Graduate School of...
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báo cáo hóa học:" Unicameral bone cyst of the lunate in an adult: case report" docx
Ngày tải lên :
20/06/2014, 04:20
... patient and wrote the
manuscript. MS and TA participated in writing and design of the manuscript.
They also drafted the manuscript. All authors read and approved the final
manuscript.
Conflict of interest ... M, Oka Y: Cystic lesion in carpal bone. Hand Surg 2000, 5:25-32.
6. Athanasian EA: Aneurysmal bone cyst and giant cell tumor of bone of
the hand and distal radius. Hand Clin 2004, 20:269-81.
7. ... [3]. The main indication for surgical inter-
vention is to prevent or treat a pathological fracture
[1,3].
In our case herein, in dications for surgery were clini-
cal history of pain and radiographic...
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Summary phd thesis in philosophy roles of the government in the integration of economic growth with ecological environment protection in vietnam nowadays
Ngày tải lên :
14/07/2014, 13:34
... capacity of management and control of behaviors of individuals and
organizations in economic activities with the aiming of protecting and recovering
the ecological environment.
In terms of methodology, ... plays an important role in
issuing the undertakings, policies, laws and organizing, building the team of
professional staff that is in charge of performing the management of resources and
environment. ... team of professional staff by planning,
training and developing skilled staff and Government officials. Then, there will be
a team of skilled staff, ensuring the continuing hierarchy in terms of...
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Different roles of functional residues in the hydrophobic binding site of two sweet orange tau pps
Ngày tải lên :
07/08/2014, 01:20
... of microgram quantities of protein
utilizing the principle of protein-dye binding. Anal
Biochem 72, 248–254.
40 Laemmli UK (1970) Cleavage of structural proteins
during the assembly of head of ... PEI and PKI mutants were obtained by replacing
Arg89 of GSTU1 (REI) with Pro89, and Glu117 of
the PEI mutant with Lys117, respectively. Steady-state
kinetic analysis of purified RKI and RKV mutants
showed ... induction of
distinct glutathione transferases of wheat by xenobiotics
and by pathogen attack. Plant Physiol 102, 1193–1201.
17 Dean JD, Goodwin PH & Hsiang T (2005) Induction
of glutathione S-transferase...
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- 385
- 0
Báo cáo toán học: "Dense Packings of Equal Disks in an Equilateral Triangle: From 22 to 34 and Beyond" pptx
Ngày tải lên :
07/08/2014, 06:20
... packings, the distance of the
disk center to the boundary of this enclosing triangle is the distance to the line between bonds
with the left side of the triangle and disk 24, and is 0.0317185 of ... compute and report d(n)to15significantdecimal
digits.
Disk packings in equilateral triangles differ from those in squares or circles in that for
triangles there are an in nite number of values of n ... absence
of gravitation and friction, the disks move along straight lines, colliding with each other and the
region walls according to the standard laws of mechanics, all the time maintaining a...
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Báo cáo lâm nghiệp: "Canopy structure and spatial heterogeneity of understory light in an abandoned Holm oak woodland" pps
Ngày tải lên :
07/08/2014, 16:20
... mean height of individual Holm
Tab le I. Mean and standard deviation (SD) of canopy height, number
of stems and basal area for the 900 1-m
2
sampling points of the study
plot, and mean and standard ... (tree- and
shrub-dominated zones) are indicated on the map. Distances shown in the axes are in m.
vegetation in many current Mediterranean ecosystems, where
abandoned woodlands and shrublands develop ... Madrid, Spain.
Mean elevation of the zone is 640 m a.s.l. and it experiences a dry,
continental, Mediterranean weather with a mean annual tempera-
ture of 14.8
◦
C and an annual precipitation of 420...
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Báo cáo lâm nghiệp: "Effects of soil mechanical treatments combined with bramble and bracken control on the restoration of degraded understory in an ancient beech forest" pptx
Ngày tải lên :
07/08/2014, 16:20
... Statsoft Inc., STATISTICA (data analysis software system), version
6, Statsoft Inc., Tulsa, 2001.
[59] Stieperaere H., Fransen K., Standaardlijst van de Belgische
vaatplanten, met aanduiding van ... variables in the Pteridium stand. Harrow
did not have any effect on the considered soil parameters. Both
disc and rotary ploughing induced an overall lowering of soil
nutrient index and soil compaction, ... trails and haul roads on understory plant richness and compo-
sition in management forest landscapes in Upper Michigan, USA,
For. Ecol. Manage. 175 (2003) 509−520.
Soil mechanical treatments in...
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