role of oxidative stress in parkinsons disease
báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
Ngày tải lên :
19/06/2014, 22:20
... use of vitamin E and vitamin C in combi-
nation reduced the prevalence and incidence of AD in an
elderly population; however, the use of either of these
vitamins alone had no effect [110]. Finally, ... utility of anti-inflammatory drug
therapies in the treatment of AD.
Microglia are the principle immune effector cells in the
brain and represent approximately 5–10% of all glia
found in the brain. ... complex leads to the
initiation of complex signaling events leading to protein
tyrosine phosphorylation and activation of the src-family
kinases Lyn and Fyn as well as the tyrosine kinase Syk
[30,32,52]....
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The role of sentence stress in enhancing english speaking competence of HPU english majors
Ngày tải lên :
17/03/2014, 16:12
... you.
8. The role of sentence stress in enhancing English speaking competence.
Sentence stress is the governing stress in connected speech. All words have
their individual stress in isolation. ... 1997:190).
27
The pattern of stress in this sentence is stressed – unstressed – stressed –
unstressed – stressed – unstressed, with equal number of alternating stressed
and unstressed syllables. ... must distinguish between four levels of stress: major
sentence stress, major word stress, minor word stress and unstressed.
Thus, in the sentence: “I walked home in the rainstorm”.
‗I‘, in ,...
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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
Ngày tải lên :
09/08/2014, 06:22
... ageing.
Conclusion
This study provides insight into the involvement of oxidative
stress in the pathogenesis of OA from the viewpoint of oxi-
dative stress induced genomic instability, especially tel-
omere ... Our findings
clearly show the presence of oxidative stress in degenerat-
ing cartilage, and the resultant telomere erosion and dys-
function of chondrocytes in vitro and in vivo, suggesting a
role ... degeneration
in cartilage.
The findings of the present study suggest that cumulative
oxidative stress leads to a decrease in antioxidative capac-
ity in articular cartilage, resulting in chondrocyte...
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx
Ngày tải lên :
18/02/2014, 14:20
... calcium-independent
phospholipase A
2
participates in ER stress- induced
INS-1 insulinoma cell apoptosis by promoting cera-
mide generation via hydrolysis of sphingomyelins by
neutral sphingomyelinase. ... should have a key role in our under-
standing of the mechanisms of the disease. We propose
that pathology data will, in most cases, be more
insightful than clinical data in defining the disease.
This ... data
suggesting that some of the genes involved in the
genetics of Lewy body disease, have in common the
fact that they impinge on ceramide metabolism. One
shortfall of the present theory is the lack of...
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Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx
Ngày tải lên :
21/02/2014, 03:20
... important role in protection of neuronal cells
against stress- induced apoptosis [26]. In accordance with
these findings, ischemia/reperfusion in the rat forebrain
induces the expression of HSP105/110 ... activation of p38 induced by
oxidative stress, we further examined whether its activation
is responsible for the induction of apoptosis in F9 cells using
SB202190, a potent inhibitor of p38. As shown in ... mitogen-activated protein kinase
(p38). Furthermore, oxidative stress- induced apoptosis was
suppressed by SB202190, a potent inhibitor of p38, in F9
cells. These findings indicated that the activation of p38...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
Ngày tải lên :
07/03/2014, 12:20
... depolarization of in situ mitochondria by
oxidative stress parallels a decrease in NAD(P)H level
in nerve terminals. Neurochem Int 36, 483–488.
61 Chinopoulos C & Adam-Vizi V (1999) Depolarization
of in ... imposing a continuous load of
calcium to the neuron. The turning point upon which
the cell looses the ability to buffer the incoming calcium
resulting in an abrupt, sustained and irreversible
increase ... element binding protein, iso-
citrate dehydrogenase is an RNA-binding protein, while
kgd2p is a mitochondrial DNA binding protein [81–84].
Mitochondria from different brain regions contain
different...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
Ngày tải lên :
23/03/2014, 07:20
... oxidative stress- induced changes in
D. discoideum development. Interestingly, oxidative stress resulted in PARP
activation within 5 min that was inhibited by benzamide. Oxidative stress-
induced ... to oxidative stress
and the role of PARP during development. We used hydroxylamine (HA)
to induce in situ generation of H
2
O
2
and monitored the effect of
benzamide, a PARP inhibitor, on oxidative ... an
important role under oxidative stress [21]; however,
there is no report on the role of PARP in D. discoideum
development. We have investigated the role of PARP in
D. discoideum development by inhibiting...
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Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
Ngày tải lên :
18/06/2014, 16:20
... cell
activity of several LOX inhibitors, including aesculetin (a
nonselective LOX inhibitor), MK886 (an inhibitor of the
5-LOX-activating protein), zileuton (a 5-LOX inhibitor),
baicalein (a 12/15-LOX inhibitor), ... apoptosis. In fact, ROS-induced oxidative stress
and cell death play important roles in the efficacy of many
antineoplastic agents [13,14].
To investigate whether oxidative stress is involved in
the ... treatment of H460 cells with 1 μM of NSC-
741909 induced cluster formation of MKP1 and MKP7 at
all time points examined (2 - 8 h after the treatment) (Fig.
1A, B), suggesting that oxidative stress...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
Ngày tải lên :
19/06/2014, 22:20
... that a full dose of
indomethacin alone despite a significant reduction in
brain inflammation had only a marginal effect on brain
oxidative stress in the Tg2576 mice [16]. This finding sug-
gests ... implicating both oxidative
stress and inflammatory mechanisms in AD pathogenesis.
Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3
Effect of indomethacin plus ... brain sections from mice on placebo or receiving indomethacin plus vitamin EFigure 6
Representative pictures of brain sections from mice on placebo or receiving indomethacin plus vitamin E.
Indomethacin
Vitamin...
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báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers" pptx
Ngày tải lên :
20/06/2014, 00:20
... response of the organism to particle-induced oxida-
tive stress. The observed increase of reducing species in
urine would mirror an increased level in blood originat-
ing from a response to oxidative ... only 10% of urate is excreted in the urine (the
remaining 90% being recirculated by the renal system
[3]), an increase of this antioxidant in blood will also
lead to an increase in urine. The ... been
reported to increase the serum levels of uric acid in
North Carolina police officers [4]. A similar increase of
plasma antioxidants in response to an increased oxid a-
tive stress was observed in newborns...
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Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
Ngày tải lên :
07/08/2014, 17:22
... PM10
suggesting that PM2.5 induced more oxidative stress than
PM10. In the single strand breakage assay using pBR322
DNA, the ratio of changed form II/total plasmid DNA (form
F
ig. 10. RT-PCR analysis of ... analysis of Nrf-2
No remarkable change of expression level in Nrf-2,
proteins related with many transcriptional and anti -oxidative
stress enzyme, was observed in the groups of three
concentration of ... Expression of Nrf2 protein in the PM2.5
-
and PM10
-
t
reated rat lung epithelial cell was determined by Weste
rn
B
lotting. The lower shows the ratio of Nrf2/actin usi
ng
c
alculatging by densitometor....
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Báo cáo khoa học: " Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application" pps
Ngày tải lên :
07/08/2014, 23:22
...
significantly reduced (p ＜ 0.05) in all groups compared to
the control group. Similar finding have been reported in
other study during oxidative stress [24]. No significant
changes in GST activity was ... resistant
strain of insect [38]. GST levels were also increased
significantly after 30 days of exposure to protect RBCs
from oxidative damage. Further significant decreases in
GSH levels in our study ...
oxidative damage [16]. Increased activity of GST was
reported in Drosophila melanogaster after insecticide
exposure [27]. Elevated GSTs were reported in
Nilaparvata lugens, a pyrethroid insecticide...
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Báo cáo lâm nghiệp: "Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings" pot
Ngày tải lên :
08/08/2014, 00:22
... 5D).
Anaplerotic fixation of CO
2
by PEPC increased in re-
sponse to O
3
in both groups of seedlings (Figs. 5E–5H) dur-
ing the growing season. The level of activity decreased in
the neoformed flush of the episodic ... by immersing
the tubes for 5 min in boiling water. The colorimetric determination
of NO
2
−
was done by mixing 0.25 mL of incubation medium with
0.25 mL 0.02% N-(1-Naphtyl) ethylenediamine and ... preformed flush, consisting of preformed leaves and
the second flush as neoformed flush consisting of neoformed leaves
as described by Gregory [18].
2.1.2. Harvesting of seedlings
Seedlings were randomly...
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Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
Ngày tải lên :
09/08/2014, 01:23
... sVEGFR-1.
Endothelium injury is critical in SSc and is suspected to
occur early in the disease process. Circulating sVCAM-1 is
a recognised marker of disease activity and a possible
marker of disease severity ... production, including
hypoxic conditions and stimulation by transforming growth
factor, CD40 ligand, interleukin 1, or interleukin 6 [10]. Oxi-
dative stress also promotes angiogenesis [13]. The link
between ... the
concentration of VEGF or sVEGFR-1. Our results suggest
that nifedipine can ameliorate endothelium injury in SSc
and that VEGF signalling may by impaired in this disease
without implication of the sVEGFR-1.
Endothelium...
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Báo cáo y học: "Role of interleukin-7 in degenerative and inflammatory joint diseases" potx
Ngày tải lên :
09/08/2014, 10:23
... study of Long and colleagues contributes
to our knowledge on the broad range of IL-7/IL-7R-driven
pathways. In addition to its role in inflammation driven joint
destruction, and its potential role ... potential role in T cell-driven bone loss in
the absence of prominent inflammation, direct harmful effects
on cartilage can be added to the list of catabolic properties of
IL-7. In this respect, ... is a
target of interest for the treatment of rheumatic diseases such
as rheumatoid arthritis, osteoporosis and OA.
Competing interests
The authors declare that they have no competing interests.
References
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