role of oxidative stress in breast cancer
The role of prion protein in breast cancer cell metabolism
... higher in normal breast cell line (MCF10A) than breast cancer cell lines (MCF7, SK-BR-3, and MDA-MB-231) Proliferation rate in breast cancer cell lines Up-regulation of p53 in breast cancer cell lines ... overview of the role of PrP in breast cancer metabolism in the study model Picture showing different lactate production in normal and cancer situation Schematic overview of the role of PrP in cancer ... the finding of early markers for therapeutic intervention that has disease modifying effect, in hope of bringing down death due to breast cancer In addition, the contribution of PrP to breast cancer...
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The role of sentence stress in enhancing english speaking competence of HPU english majors
... to this kind of stress in referring, proclaiming, and reporting utterances Tonic stress is almost always found in a content word in utterance final position Consider the following, in which the ... clear to you The role of sentence stress in enhancing English speaking competence Sentence stress is the governing stress in connected speech All words have their individual stress in isolation When ... 34 8.1 Final intonation 36 8.1.1 Rising-falling intonation 36 8.1.2 Rising intonation 37 8.2 Non-final intonation 39 8.2.1 Rising-falling intonation...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... use of vitamin E and vitamin C in combination reduced the prevalence and incidence of AD in an elderly population; however, the use of either of these vitamins alone had no effect [110] Finally, ... gp91phox and an increase in p47phox protein expression in monocytes primed with INFγ [59] Figure Activation of the Rac GTPase Activation of the Rac GTPase GTP-binding of the Rac protein confers an ... src-family tyrosine kinases or inhibition of phosphatidylinositol-3 kinase (PI3K) attenuates ROS production These findings suggest that these kinases are involved in upstream signaling cascades responsible...
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Báo cáo y học: "Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function" pptx
... Conclusion This study provides insight into the involvement of oxidative stress in the pathogenesis of OA from the viewpoint of oxidative stress induced genomic instability, especially telomere ... Our findings clearly show the presence of oxidative stress in degenerating cartilage, and the resultant telomere erosion and dysfunction of chondrocytes in vitro and in vivo, suggesting a role ... and maintenance of GAG content in articular cartilage in tissue culture Interestingly, treatment of cultured cartilage with an antioxidative agent not only inhibited GAG loss but also maintained...
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Báo cáo khoa học: "An ultrasonographic evaluation of skin thickness in breast cancer patients after postmastectomy radiation therapy" docx
... measurements of each of the nine points of irradiated skin were compared with corresponding points of non-irradiated skin by using a t-test This test determined the significance of differences ... measurement points taken in patients with Grade Figure Erythema and dry desquamation seen in Grade grade 4) showed a convincing trend of an increased probability of thinning in the skin thickness ... variation in skin thickness in the conservatively managed breast This finding suggests a need to use the same examination point when performing serial and comparative examinations The results of this...
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Báo cáo y học: " Identification of fusion genes in breast cancer by paired-end RNA-sequencing" potx
... fusions In breast cancer, recurrent gene fusions have only been identified in rare subtypes, such as ETV6-NTRK3 in secretory breast carcinoma [12] and MYB-NFIB in adenoid cystic carcinoma of the breast ... the inhibition of apoptosis [29,30] IKZF3 is located at the most common telomeric breakpoint of the ERBB2amplicon [31] Interestingly, our preliminary analysis of clinical breast cancers shows ... splicing at the fusion junction, suggesting fusion junction diversity (Figure 2) VAPB-IKZF3 fusion is required for the cancer cell phenotype In order to gain insight into the functional role of...
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báo cáo khoa học: " Microarray-based analysis of microRNA expression in breast cancer stem cells" doc
... verification Haematoxylin and eosin (H&E) staining and immunohistochemical staining are shown on pathology sections of tumors implanted in NOD/SCID mice In a, b and c, the staining showed a single cell type ... be one of the causes of high expression of the drug-metabolising enzyme CYP1B1 in cancerous tissues [14] Finally, as a tumor suppressor in breast cancer cells, miR-17-5p regulates breast cancer ... Ras-GAP binding proteins (G3BP) Oncogene 2007, 26(29):4209-4215 27 French J, Stirling R, Walsh M, Kennedy HD: The expression of Ras-GTPase activating protein SH3 domain-binding proteins, G3BPs, in...
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Báo cáo khoa học: " The effect of methyl sulphonyl methane supplementation on biomarkers of oxidative stress in sport horses following jumping exercise" doc
... combined with vitamin C (Vit C), on training -induced decrease of reduced Effect of methyl sulphonyl methane (MSM), alone or combined with vitamin C (Vit C), on training -induced decrease of reduced ... combined with vitamin C (Vit C), on training -induced increase of lipid Effect of methyl (LPO) levels Effect of methyl sulphonyl methane (MSM), alone or combined with vitamin C (Vit C), on training ... by increases in lipid peroxidation, glutathione oxidation, and oxidative protein damage [28] In our study exercise induced an increase in cellular oxidative stress (as shown by the increase in...
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Role of stathmin 1 in colorectal cancer metastasis and chemo resistance
... about 10% of all cancer incidence and mortality in 20132 Consistent with trends in developed countries, CRC is the most frequent cancer in Singapore, accounting for 14% to 18% of all cancer incidence ... 2005-20093 Colorectal cancers usually begin as non-cancerous polyps in the inner lining of the colon or rectum4 Over many years, adenomatous polyps in the dysplasic colon may develop into pre-neoplastic ... of kDa These cell line models are used in subsequent investigations to elucidate the functional role of STMN1 in colorectal cancer metastasis Expression of endogenous STMN1 and/or STMN1-DDK in...
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CHARACTERIZING ROLES OF ANNEXIN 1 IN BREAST CANCER DEVELOPMENT BY MASS SPECTROMETRY BASED QUANTITATIVE PROTEOMICS
... points out the potential of ANXA1 playing a non-trivial role in breast cancer However, its specific role in breast cancer initiation and progression remains unclear 1.3: Models for breast cancer ... expression in breast carcinomas, its role in breast cancer initiation and progression remains unclear The study presented here seeks to characterize ANXA1 in initiation and tumorigenesis of breast cancer ... effect of ANXA1 on the proliferation of tumor-derived cell lines The status of ANXA1 in certain clinical cancer tissues has been tabulated in Table Table 1: The status of ANXA1 in clinical cancer...
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Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
... apoptosis In fact, ROS-induced oxidative stress and cell death play important roles in the efficacy of many antineoplastic agents [13,14] To investigate whether oxidative stress is involved in the ... decreased protein levels of MKP1, one of MAP kinase phosphatases that inactivate JNK and p38 MAP kinases [2] Interestingly, NSC-741909 induced an increase of MKP1 mRNA expression in both time- ... several LOX inhibitors, including aesculetin (a nonselective LOX inhibitor), MK886 (an inhibitor of the 5-LOX-activating protein), zileuton (a 5-LOX inhibitor), baicalein (a 12/15-LOX inhibitor),...
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Heregulin enhanced tyrosine phosphorylation in breast cancer cells role of PP2A in HER 2 eu oncogenic signalling
... 1.1.3 Breast cancer Incidence of breast cancer Classification of breast cancer Aetiology of breast cancer 1 1.2 1.2.1 1.2.2 1.2.3 1.2.4 1.2.5 1.2.6 HER-2/neu-positive breast cancer Definition Clinical ... XVI Chapter Introduction CHAPTER INTRODUCTION 1.1 Breast cancer 1.1.1 Incidence of breast cancer Breast cancer is the second leading cause of cancer deaths in women today after lung cancer and ... frequent cancers affecting Singapore women, 2003-2007 Breast cancer is the top cancer type affecting the women in Singapore Data extracted from Singapore Cancer Registry, Interim Report: Trends in Cancer...
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Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx
... activation of p38 induced by oxidative stress, we further examined whether its activation is responsible for the induction of apoptosis in F9 cells using SB202190, a potent inhibitor of p38 As shown in ... determine the effects of Hsp105a on JNK and p38 signalling pathways, we examined the activation of JNK and p38 in F9 cells by oxidative stress As shown in Fig 6A, JNK was not activated in control ... hydrogen peroxide In contrast, hydrogen peroxide-treatment induced marked activation of JNK within 30 in S23 cells, but not in S3 cells Therefore, the enhancement of the oxidative stress- induced JNK-activation...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... increase in the amount of ROS [21]; (b) loss of cytochrome c impairs the flow of electrons in the respiratory chain inducing overreduction of the complexes, favouring the generation of ROS [16,17,22]; ... element binding protein, isocitrate dehydrogenase is an RNA-binding protein, while kgd2p is a mitochondrial DNA binding protein [81–84] Mitochondria from different brain regions contain different ... buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase in [Ca2+]c, probably coincides with the cleavage of the exchanger (but see [164]) Therefore, inhibition of the,...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... with larger fruits PARP involvement during oxidative stress- induced developmental changes in D discoideum To determine the role of PARP in oxidative stressinduced developmental changes, D discoideum ... important role under oxidative stress [21]; however, there is no report on the role of PARP in D discoideum development We have investigated the role of PARP in D discoideum development by inhibiting ... to investigate the long-term effects of PARP inhibitors for two successive generations n=3 Fig Effect of PARP inhibition during oxidative stress- induced growth changes in D discoideum Under oxidative...
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báo cáo hóa học:" Optical imaging of the peri-tumoral inflammatory response in breast cancer" docx
... p-value less than 0.05 Injection of free DiD resulted in no increase in fluorescent intensity within the tumor at any time point post-infusion Figure labeling (a) Optical imaging of DiD-labeled cells ... intravenous injection of DiD-labeled monocytes (a) In vivo optical imaging of a control FVB/n mouse after (a) In vivo optical imaging of a control FVB/n mouse after intravenous injection of DiD-labeled ... innate immune cells during breast cancer progression Breast Cancer Res 2007, 9:212 Balkwill F, Charles KA, Mantovani A: Smoldering and polarized inflammation in the initiation and promotion of...
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Báo cáo hóa học: " In vivo evidence of htid suppressive activity on ErbB-2 in breast cancers over expressing the receptor" potx
... reacting with the murine receptor resulted in a faint stain of the cytoplasm and rarely in staining of the membrane of the tumor cells (Figure 3B) In the more advanced 30 weeks tumors the staining ... characterized by positive staining ranging from moderate to intense staining In the context of the potential association of htid expression with the biology of human breast cancers of different subtype ... analysis Page of 13 revealed elevated htid expression in 81% of the luminal A type tumors (Figure 1A), in 20% of the cases of the luminal B type over expressing ErbB-2 and in 18% of tumors diagnosed...
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báo cáo hóa học: " Responsiveness of the EQ-5D in breast cancer patients in their first year after treatment" ppt
... quality -of- life measurement in randomized clinical trials in breast cancer – taking stock Journal of the National Cancer Institute 2003, 95(4):263-281 Montazeri A: Health-related quality of life in breast ... and Treatment of Cancer QLQC30: a quality -of- life instrument for use in international clinical trials in oncology J Natl Cancer Inst 1993, 85(5):365-376 Bottomley A, Aaronson NK: International ... clinical trial investigating several follow-up strategies for curatively treated breast cancer patients [10] to address whether the EQ-5D is responsive to changes in HRQoL in a population of breast...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... that a full dose of indomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidative stress in the Tg2576 mice [16] This finding suggests that ... indomethacin plus vitamin Effect of1 brain oxidative stress E supplementation on Effect of indomethacin plus vitamin E supplementation on markers of brain oxidative stress Total cerebral cortex homogenates ... presence of vitamin E significantly reduced two independent markers of oxidative stress injury in both brain regions Thus, neocortex and hippocampus levels of iPF2α-VI (a reliable biomarker of lipid...
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