role of microenvironment on gene expression angiogenesis and microvascular function in tumors

Báo cáo y học: "Genomic analysis of the relationship between gene expression variation and DNA polymorphism in Drosophila simulans" pps

Ngày tải lên : 14/08/2014, 20:22

... on gene feature length and levels of expression intensity Expression intensity was determined based on overall average expression for a gene on the chip In males, the average gene expression intensity ... UTRs, introns, and so on) together with expression variation measured using Affymetrix gene expression arrays (see Materials and methods) to examine the relationship between expression variation and ... population genetic factors influencing expression variation Two population genetic models for explaining local variation in heterozygosity are hitchhiking effects of linked beneficial mutations and...

14
390
0

Báo cáo sinh học: "Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells" doc

Ngày tải lên : 19/06/2014, 08:20

... Figure Involvement of p38 MAPK in ethanol induction of ISRE transcription and Stat1 serine phosphorylation Involvement of p38 MAPK in ethanol induction of ISRE transcription and Stat1 serine phosphorylation ... signaling and increased HCV replication in the presence of IFN Inhibition of Jak-Stat signaling may involve ethanol perturbation of IFN-α induced changes in membrane fluidity, inhibition of IFN binding ... actions of IFN-α, involving inhibition of IFN-α induced Stat1 tyrosine phosphorylation Analysis of the effects of chronic ethanol administration on basal and IFN-α induced signaling responses is...

12
379
0

báo cáo hóa học:"Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells" potx

Ngày tải lên : 20/06/2014, 04:20

... Figure Involvement of p38 MAPK in ethanol induction of ISRE transcription and Stat1 serine phosphorylation Involvement of p38 MAPK in ethanol induction of ISRE transcription and Stat1 serine phosphorylation ... signaling and increased HCV replication in the presence of IFN Inhibition of Jak-Stat signaling may involve ethanol perturbation of IFN-α induced changes in membrane fluidity, inhibition of IFN binding ... actions of IFN-α, involving inhibition of IFN-α induced Stat1 tyrosine phosphorylation Analysis of the effects of chronic ethanol administration on basal and IFN-α induced signaling responses is...

12
499
0

Báo cáo y học: "Cell culture and passaging alters gene expression pattern and proliferation rate in rheumatoid arthritis synovial fibroblasts" pdf

Ngày tải lên : 12/08/2014, 12:20

... evaluation and interpretation of data IHT was involved in evaluation and interpretation of data JG was involved in preparation of the synovial tissue for RASF isolation JSt was involved in preparation ... preparation of the synovial tissue for RASF isolation SG was involved in evaluation and interpretation of data JSc was involved in evaluation and interpretation of data, structural organziation of the ... http://arthritis-research.com/content/12/3/R83 Page of 10 Figure Changes in gene expression during passaging (a) The changes in gene expression increase substantially during passaging of the cells in all fibroblast...

10
483
0

Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc

Ngày tải lên : 08/03/2014, 08:20

... conserved transcription factor-binding sites Using a combination of cis-element mutagenesis and the expression of dominantnegative inhibitors of transcription factors that bind to these cis-elements, ... p38 signaling in the activation of CREB via MSK1 Role of RhoA and p38 kinase in the activation of Cyr61/CCN1 promoter Fig Immunoblot analyses of RhoA activation and p38 MAP kinase, CREB and MSK1 ... abrogated Cyr61/CCN1 gene expression induced by S1P indicating a preponderant role of RhoA signaling in Cyr61/CCN1 gene expression Similarly, treatment of the cells with latrunculin B, a speciﬁc agent...

14
415
0

Báo cáo khoa học: Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-b1 induced murine tissue inhibitor of metalloproteinases-1 gene expression docx

Ngày tải lên : 16/03/2014, 18:20

... superinduction of PMA-induced Timp-1 expression, appears unique The effects of HDAC inhibitors on Timp-1 gene expression can be reiterated in transient transfection of Timp-1 promoter-containing ... acetylation of Ets1 are also unknown, but of future interest, as mutation of the Ets binding motif (m4) results in both a loss of protein binding and the TSA superinduction of Timp-1 Eleven NAD-independent ... induction and TGF-b1 inducing a slower more sustained stimulation of the gene [25] The effect of TSA on both PMA- and TGF-b1induced Timp-1 expression is evident as early as h after addition of...

15
347
0

Báo cáo y học: "Passage and reversal effects on gene expression of bovine meniscal fibrochondrocytes" pdf

Ngày tải lên : 09/08/2014, 10:21

... protein gene expression profiles of meniscal fibrochondrocytes The x-axis refers to the passage number, and the y-axis to protein gene expression profiles of meniscal fibrochondrocytes the gene expression ... terminate the reaction Gene expression efficiency and abundance The efficiency of the PCR reactions was determined by taking dilutions of standard samples run in duplicate (1:1, 1:10, 1:100 and ... protein coating In fact, both protein coatings induced a further downregulation of collagen II expression by about 50% or more at most passage time points Interestingly, even the no coating control...

12
349
0

báo cáo khoa học: "ShRNA-mediated gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF-7 in vitro" pptx

Ngày tải lên : 10/08/2014, 10:21

... consequence of ER activation appears to be alterations in transcriptional activity and expression profiles of target genes A number of genes, including cyclinD1, are regulated by ER alpha[7] In ... ShRNA-mediated gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF7 in vitro Journal of Experimental ... MTA1 gene silence and consequentially recover the protein expression of ER alpha, resulting in increase sensitivity of antiestrogens, as well as suppress the protein expression of MMP-9 and cyclinD1...

11
281
0

Báo cáo y học: "Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects" docx

Ngày tải lên : 11/08/2014, 17:20

... Authors' contributions KC, BH and SW conception and design, analysis and interpretation of data, drafting the manuscript JS, IL and JD acquisition of data, analysis and interpretation of data RY and ... Effects of individual AP drugs on gene expression are shown with fold change and 95% confidence intervals Effects of individual AP drugs on gene expression are shown with fold change and 95% confidence ... population [69] Also, clinical information available on each patient is often incomplete, and so unknown clinical covariates may either confound or confuse many of the gene expression findings [26,28]...

15
518
0

báo cáo khoa học: " The impact of bisphosphonates on the osteoblast proliferation and Collagen gene expression in vitro" ppsx

Ngày tải lên : 11/08/2014, 20:20

... determine the effects of zoledronate, ibandronate and clodronate on cyclin D1 gene expression As shown in figure 1, treatment of human hip bone osteoblast [hOB] cells with ibandronate, zoledronate ... classic Nitrogen-containing biophosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras Originally published in Volume 7, number ... AA: Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro Proc...

6
245
0

Sequential effects of a high fat, calorie dense diet or a high fiber diet on gene expression, body weight and associated metabolic responses in c57 BL6J mice

Ngày tải lên : 12/09/2015, 08:20

... CONTAINING PSYLLIUM HUSK ON BODY WEIGHT, PLASMA LIPIDS AND HEPATIC GENE EXPRESSION LEVELS Introduction 119 Results 120 Discussion 139 CHAPTER CONCLUSIONS AND FUTURE RECOMMENDATIONS Conclusions ... feeding and insulin, and its role is mainly responsible for the regulation of fatty acid synthesis (Horton et al., 2002) On the other side of the equation of energy balance is energy production ... 5% reduction in total cholesterol and 7-8% reduction in LDL-cholesterol and these reductions are sustained in the long term (Anderson et al., 2000 a; Anderson et al., 2000 b) In relation to obesity,...

228
231
0

Báo cáo y học: "Effect of antibodies on the expression of Plasmodium falciparum circumsporozoite protein gene"

Ngày tải lên : 02/11/2012, 10:14

... reactions, demonstrating that there was no gDNA contamination PCR reaction triplicates showed no major differences among them and expression levels of the internal control were similar in the ... multiplication and invasion, suggesting that CSP is likely to be involved indirectly on erythrocyte invasion The immune localisation of the CS-like protein described by Cochrane et al [12] only found ... 20µl containing the following primer concentrations: ldh (0.3mM -fwd, 0.05mM-rev), csp (0.1mM -fwd, 0.3mM-rev) Each reaction contained 1µl of cDNA template Amplification and detection of specific...

4
524
0

Báo cáo khoa học: Efﬁcient inhibition of b-secretase gene expression in HEK293 cells by tRNAVal-driven and CTE-helicase associated hammerhead ribozymes doc

Ngày tải lên : 08/03/2014, 08:20

... this expression system is of interest for endogenous generation of siRNA and activation of the RNAi effect in human cells [45] Studies on an inhibition of BACE gene expression by endogenously generated ... less than 5% of the control BACE mRNA expression in the cells transfected with lipofectin only (NO) and lysed after 48 h increase of the BACE mRNA level because of the lower expression of ribozyme ... transfection As controls, only lipofectin (NO) or lipofectin and an empty plasmid (EM) were used The level of the RT/PCR products was determined under co-ampliﬁcation conditions 36 h after transfection...

9
434
0

The role of pictures in improving health communication: A review of research on attention, comprehension, recall, and adherence doc

Ngày tải lên : 14/03/2014, 21:20

... effects of incorporating pictures on understanding medication instructions among 60 low-literate respondents in South Africa Subjects were randomly assigned to experimental and control groups and ... providing a context for organizing information in the text—which is consistent with Morrow et al.’s [23] study of comprehension of medication instructions discussed above In discussing the use of ... LW Effects of labeling techniques on memory and comprehension of prescription information in young and old adults J Gerontol 1990;45:166–72 [34] Winograd E, Smith AD, Simon EW Aging and the picture...

18
919
0

Báo cáo khoa học: Inhibition of urokinase receptor gene expression and cell invasion by anti-uPAR DNAzymes in osteosarcoma cells pot

Ngày tải lên : 16/03/2014, 22:20

... fraction of untreated control Statistical evaluation showed that the effect of Dz720 in inhibition of Saos-2 cell invasion was signiﬁcant as shown by ***P < 0.01 reduction in in vitro invasion of ... Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer ... al Inhibition of uPAR by DNAzymes all of which contribute to focal proteolysis and regulation of wound healing, angiogenesis, and metastasis [5] Of the components of the uPA system, uPAR is of...

11
315
0

Báo cáo khoa học: Selenium affects biosilica formation in the demosponge Suberites domuncula Effect on gene expression and spicule formation pot

Ngày tải lên : 30/03/2014, 20:20

... 150 200 250 the amino acids glutamine, lysine and histidine at the N-terminus and the nonpolar amino acid proline and the hydroxy amino acids serine and threonine at the C-terminal border 3842 ... formation in sponges and in turn skeleton formation in these animals The ﬁnal interesting ﬁnding for the biotechnological application of silicatein, especially with respect to the understanding of ... level of transcription was surprising In vertebrates the expression of all 3846 Fig 11 In uence of selenium on the size of silica aggregates, formed in vitro Recombinant silicatein was incubated in...

15
346
0

Báo cáo hóa học: " cDNA targets improve whole blood gene expression profiling and enhance detection of pharmocodynamic biomarkers: a quantitative platform analysis" ppt

Ngày tải lên : 18/06/2014, 16:20

... mitigation technology, then by the Page of 12 amount of globin spike -in Expression ratios between brain and liver containing samples were derived within a given globin concentration and mitigation ... in the literature of ex vivo gene expression profiling as well as experiments looking at the SAHA-induced expression profiling [31,33-37] The latter generally rely on the isolation of PBMCs in ... participated in the expression profiling assays and participated in the ex vivo dosing study DA participated in the expression profiling assays and participated in the ex vivo dosing study HC...

12
585
0

báo cáo hóa học: " The effect of consequent exposure of stress and dermal application of low doses of chlorpyrifos on the expression of glial fibrillary acidic protein in the hippocampus of adult mice" pptx

Ngày tải lên : 20/06/2014, 00:20

... effects of gestational exposure to cholinotoxicants nicotine and CPF, alone and in combination, showed increased GFAP expression in offspring in the CA1 sub-field of the hippocampus, and white ... AM, Abou Donia MB: Inhibition of cholinesterase enzymes following a single dermal dose of chlorpyrifos and methyl parathion, alone and in combination, in pregnant rats J Toxicol Environ Health ... of consequent exposure of stress and dermal application of low doses of chlorpyrifos on the expression of glial fibrillary acidic protein in the hippocampus of adult mice Journal of Occupational...

9
451
0

Báo cáo toán học: " Effects of internal low-dose irradiation from 131 I on gene expression in normal tissues in Balb/c mice" ppt

Ngày tải lên : 20/06/2014, 21:20

... Mukherjee S, Sainis KB, Deobagkar DD: Comparative analysis of gene expression profiles in BALB47;c and C57BL47;6 strains of mice in response to low-dose ionising radiation using microarray Int J Low ... mechanisms of radiation-induced microvascular damage in normal tissues Int J Radiat Oncol Biol Phys 2004, 58:420-426 Mahmoud-Ahmed AS, Atkinson S, Wong CS: Early gene expression profile in mouse brain ... Gius D: Distinct effects of ionizing radiation on in vivo murine kidney and brain normal tissue gene expression Clin Cancer Res 2006, 12:3823-3830 Uehara Y, Ito Y, Taki K, Nenoi M, Ichinohe K, Nakamura...

14
347
0

Báo cáo khoa học: "Comparative evaluation of phenobarbital-induced CYP3A and CYP2H1 gene expression by quantitative RT-PCR in Bantam, Bantamized White Leghorn and White Leghorn chicks" ppsx

Ngày tải lên : 07/08/2014, 18:21

... ces 003 rof C 27 ta noisnetxe lanif dna ces 09 rof C 27 pmet noisnetxe ,ces 54 rof C 06 pmet gnilaenna ,ces 54 rof C 49 ta noitarutaned ,ces 06 rof C 49 ta noitarutaned laitini ,sgniwollof eht ... 301-79 ,47 ,6991 locamrahP loisyhP J naC sdnuopmoc cinegoniryhprop fo noitartsinimda ovo ni eht gniwollof noitavitcani dna edimihtetulg dna ,latibrabonehp ,enosahtemaxed yb noitcudni :snoitalyxordyh ... enosahtemaxed fo ydobitna lanolconom a yb noitcedonummI eneg 1H2PYC eht fo noitcudni BP stibihni yllacificeps 684-UR taht dnuof osla saw ti dna setycotapeh oyrbme nekcihc ni latibrabonehp yb decudni ylhgih...

7
291
0