role of inflammation and oxidative stress mediators in gliomas
báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
Ngày tải lên :
19/06/2014, 22:20
... a subset of NSAIDs
(e.g. ibuprofen, flurbiprofen, indomethacin) reduced
brain inflammation and Aβ levels in addition to the dep-
osition of Aβ in brain [13,14]. Despite this evidence, and
the ... that a full dose of
indomethacin alone despite a significant reduction in
brain inflammation had only a marginal effect on brain
oxidative stress in the Tg2576 mice [16]. This finding sug-
gests ... implicating both oxidative
stress and inflammatory mechanisms in AD pathogenesis.
Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3
Effect of indomethacin plus...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
Ngày tải lên :
07/03/2014, 12:20
... imposing a continuous load of
calcium to the neuron. The turning point upon which
the cell looses the ability to buffer the incoming calcium
resulting in an abrupt, sustained and irreversible
increase ... by proteins resi-
ding in both the inner and outer mitochondrial
membrane, that is activated by mitochondrial Ca
2+
overloading and other factors including oxidative stress
[88,89]. In neurons ... for a role of Trp proteins in the oxidative
stress- induced membrane conductances of porcine
aortic endothelial cells. Cardiovasc Res 42, 543–
549.
236 Wehage E, Eisfeld J, Heiner I, Jungling E,...
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Báo cáo khoa học: Yeast oxidative stress response Influences of cytosolic thioredoxin peroxidase I and of the mitochondrial functional state pot
Ngày tải lên :
16/03/2014, 14:20
... a
DNA-binding protein that binds to elements in the
vicinity of Yap1 binding site [52]. Alternatively, the
increased reducing power of tsa1 mutant, achieved by
the expression elevation of GSH1, ... (2001) Role of the glutathione ⁄ glutaredoxin
and thioredoxin systems in yeast growth and response
to stress conditions. Mol Microbiol 39, 533–541.
5 Collinson EJ & Grant CM (2003) Role of yeast ... carriers are involved in oxidative
stress during heat stress in Saccharomyces cerevisiae.
Mol Cel Biol 21, 8483–8489.
17 Guo J & Lemire BD (2003) The ubiquinone-binding site
of the Saccharomyces...
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Báo cáo khoa học: Expression of CYP2E1 increases oxidative stress and induces apoptosis of cardiomyocytes in transgenic mice pdf
Ngày tải lên :
22/03/2014, 16:20
... A rapid and sensitive method for
the quantitation of microgram quantities of protein
utilizing the principle of protein-dye binding. Anal
Biochem 72, 248–254.
CYP2E1 causes apoptosis of cardiomyocytes ... College, Beijing, China
2 Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Institute of Laboratory Animal
Science, Chinese Academy of Medical ... overexpression of CYP2E1 both in vivo
and in vitro is associated with several cellular markers
of oxidative stress, including products of lipid peroxi-
dation (e.g. 4-hydroxynonenal and malondialdehyde),
as...
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Báo cáo khoa học: Photodynamic treatment and H2O2-induced oxidative stress result in different patterns of cellular protein oxidation ppt
Ngày tải lên :
23/03/2014, 15:21
... (1999)
Photodynamic crosslinking of proteins. Kinetics of the FMN-
and rose bengal-sensitized photooxidation and intermolecular
crosslinking of model tyrosine-containing N-(2-hydroxypropyl)
methacrylamide ... modifica-
tions of the side chains of amino acids within a protein. In
particular, the side chains of cysteine, histidine, methionine,
tryptophan and tyrosine are susceptible to ROS-induced
modifications ... Western
blotting are shown in (A) and (B). Silver
stainingisshownin(C )and( D)inblue
superimposed with the spots of oxidized pro-
teins shown in red. Protein labels: 1, a-tubulin;
2, b-tubulin;3,actin;4,PDI;5,BiP;6,
GRP58.
4862...
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Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
Ngày tải lên :
26/10/2012, 09:07
... synthase. The increased
activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased
and effective recycling of citrulline to arginine in anoxia, making nitric ... findings of NO involvement in pathophysiol-
ogy of hypobaric hypoxia in brain (42-43). In this
study the increased activity of NOS in anoxia may
represent predominantly the nNOS form. In inflam-
matory ... reperfusion damage in brain.
The increased activities of AS and AL indicate the
effective recycling of citrulline to arginine and suggest
a functional role to citrulline –NO cycle enzymes in
anoxia....
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
Ngày tải lên :
19/02/2014, 13:20
... involved in fosfomycin
binding, and in view of the multitude of interactions, it was
assumed that deletion of a single interaction would not lead
to a complete loss of fosfomycin binding. Therefore ... fosfomycin binding due to charge–charge
repulsions. Most interestingly, the uncharged valine side
chain completely abolishes fosfomycin binding in the
absence of UDPNAG. Clearly, UDPNAG binding creates
additional ... UDP-N-acetylmuramic acid) (A) and inactivation mechanism of MurA by
fosfomycin as a result of the covalent linkage between Cys115 of MurA and fosfomycin (B).
Ó FEBS 2004 Lysine 22 and arginine 120 in MurA (Eur....
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Tài liệu Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking pdf
Ngày tải lên :
21/02/2014, 00:20
... periods of times (0–60 min)
at 37 °C. The concentration of the biotinylated Ig remaining
on the cell surface was then quantified by measuring the
binding of [
125
I]Streptavidin. In the absence of ... image.
Ó FEBS 2003 Role of cleavage and shedding in TSHR function (Eur. J. Biochem. 270) 3491
Role of cleavage and shedding in human thyrotropin receptor function
and trafficking
Myle
`
ne Quellari
1
, ... five amino acids of the
extracellular domain and devoid of any tag was not
functional [27], while a mutant containing four amino acids
of the ectodomain and including a rhodopsine tag was
found...
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The Role of Small and Large Businesses in Economic Development doc
Ngày tải lên :
06/03/2014, 19:20
... recruiting large
enterprises with tax breaks, financial incentives, and other induce-
ments. Instead, they are relying on building businesses from the ground
up and supporting the growth of existing ... growth from the second quarter of 2000 into job
classes using beginning size of firm, mean size of firm over the period,
and end size of firm. If the beginning size of the firm is used to classify
firms, ... efficient at innovation. Small firms
are the great innovators in some industries, while large firms are the
great innovators in others. Moreover, small and large businesses interact
in innovative...
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Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
Ngày tải lên :
07/03/2014, 04:20
... buffer A in 15 min, followed by a linear
gradient down to 5% buffer A in 2 min. 5% buffer A was
held for an additional 2 min and followed by a linear
gradient up to 95% buffer A in 6 min.
Determination ... °C: loading 5% buffer B, after
5 min linear gradient up to 95% buffer B in 37 min, and
then holding 100% buffer B for 5 min. The product was
identified by UV detection at 215 nm and by on-line
ESI-MS ... domain is one of the
few ACPs in which valine replaces isoleucine (I) or
leucine (L) in the conserved sequence. To determine
whether DptF is the putative partner of DptE, we
expressed dptF using...
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