... prosthesis inserted into the portal vein andthe inferior vena cava ofthein vivo rabbit model Figure Diagram of silastic H-shaped prosthesis inserted into the portal vein andthe inferior vena cava of ... arterial and portal venous vascular networks ofthe rabbit liver: theroleofadenosine Eur J Pharmacol 1997, 320:139-144 Mathie RT, Alexander B: Theroleofadenosineinthe hyperaemic response ofthe ... relating the readings to the wet weight ofthe liver, determined at the end of each experiment The "buffering capacity" ofthe HA was expressed in % as: [Increase in HA flow / Decrease in PV...
... appearances ofthe polyp The most serious problem in PJS is an increased risk of cancer inthe gastrointestinal tract The occurrence of cancer inthe gastrointestinal tract has been reported in 20-25% of ... mucosa, with a focus of well-differentiated adenocarcinoma Hematoxylin and eosin staining (objective 10 ×) Figure Pedunculated duodenal polyp measuring 15 mm in diameter inthe second part ofthe ... Figure Histological examination showed findings suggestive of a hamartoma without malignant components Hematoxylin and eosin staining (objective 10 ×) or sex ofthe patient, or the location, size...
... therapy was initiated on Day eight The hematocrit percentages and creatinine levels were measured at the indicated days The changes in hematocrit and creatinine levels correlated well withthe progression ... raises the possibility that the early use of EPO may have facilitated the recovery of renal function In combination withthe experimental data, our findings then support the notion that EPO, administered ... provided clinical information and critically reviewed the content ofthe paper EF interpreted patient data andthe literature and critically reviewed the content ofthe paper All authors read and approved...
... peroxidase–H2O2 systems in later stages during the oxidation of indolequinone precursors of eumelanin and benzothiazinylalanine precursors of pheomelanin [5–10] Of considerable interest are recent ... enhance pigment formation by regulating Fig Comparison ofthe modes of action of tyrosinase and peroxidase in converting tyrosine to dopaquinone Inthein vitro tyrosinase-mediated assays conducted, ... oxidized with catalase than without catalase These catalase-inhibited oxidations of DOPA and dopamine strongly implicate the involvement of H2O2 inthe diphenolase activity of tyrosinase Insufficient...
... problems with social and family life, and is positively associatedwith having enough time to spend in these areas, irrespective ofthe type of work schedule This finding accords withthe locus ofcontrol ... consisted of general information regarding the purpose ofthe study and their personal access code for completing the questionnaire The data were collected within the same two-week period in August ... shiftwork-related internal locus ofcontroland engaging coping strategies would be associatedwith lower levels of reported problems with social and domestic life, irrespective ofthe type of work schedule In...
... Determination ofthe arthritic index: Each paw was evaluated on the basis of a 4-point ordinal scale: – no visible signs, – edema/erythema of a single joint or digit; – edema/erythema of joints; ... on the inhibition of GSK3 pathway Effect of2 Effect of RIAA on the inhibition of GSK3 pathway (A) GSK-3α was incubated with RIAA (0, 5, 25 and 50 μg/ml) andthe kinase activity was determined ... IκB and causes the degradation ofthe complex, which permits the dissociation and nuclear translocation of NF-κB p50/p65 NF-κB inthe nucleus binds to DNA and activates inflammatory genes and...
... nucleolar and ribosomal biology Inthe second part ofthe study, the identified proteins are subjected to phylogenetic profiling, thereby providing insights into the evolution ofthe nucleolus and ... for the karyopherins alpha and beta (KAP95, SRP1) The Uso1p-related myosin-like protein (MLP1) is linked to the interior side ofthe nuclear envelope and nuclear pore It is proposed to act inthe ... PRP3 and PRP4, the U2A snRNP protein LEA1, the U2 components PRP9 and HSH49, the U5 snRNP protein PRP8, andthe Sm core proteins SMX2 and SMD3 Furthermore, we predict the nucleolar localization of...
... (MHRA) and Commission on Human Medicines (CHM) ofthe UK andthe Food and Drugs Administration (FDA) ofthe US therefore weigh the potential benefits of a drug against the harms, on the basis ofthe ... clean-up The clean-up include correcting misspellings of names of drugs and adverse events, finding all descriptions inthe data that point to the same adverse event and recoding them into the Medical ... (2009) of another study withthe same duration as above but focusing on ADRs occurring after hospitalization, involving one hospital and two ofthe authors ofthe above report (including others), the...
... differences inthe sizes ofthe genotype-specific bands The type-specific primers were designed on the basis ofthe conserved nature of those sequences within a genotype and on the basis of their poor ... conflicting results in this context In a study ofchronic carriers in which, surprisingly, 50% ofthe patients were infected with genotype A strains and 50% were infected with genotype D strains, ... patients infected with genotype D strains had more severe chronic liver disease In contrast, Gandhe et al [27] could not find that genotype D influenced the outcome ofchronic HBV infection in Indian...
... differences inthe sizes ofthe genotype-specific bands The type-specific primers were designed on the basis ofthe conserved nature of those sequences within a genotype and on the basis of their poor ... conflicting results in this context In a study ofchronic carriers in which, surprisingly, 50% ofthe patients were infected with genotype A strains and 50% were infected with genotype D strains, ... patients infected with genotype D strains had more severe chronic liver disease In contrast, Gandhe et al [27] could not find that genotype D influenced the outcome ofchronic HBV infection in Indian...
... [32] According to PONDRề predictions, the positions of PC sequences inthe SPs in Table were, withthe exception ofthe globular protein riboavin-binding protein (RBP), disordered, and had disordered ... describe the binding isotherms obtained previously for the b-casein 125 phosphopeptide in this pH range, andthe same model was adapted to t the binding isotherm of OPN 1149 measured at pH 7.0 The ... osteopontin C Holt et al details ofthe model are provided in Doc S3 (see Supporting information) The Ca2+ binding isotherm of OPN 1149 was determined by measuring the concentration of free Ca ions with...
... understanding ofthe roles of these co-repressor complexes and thereafter their roles in disease In summary cigarette smoke exposure reduced HDAC2 activity andthe expression of mSin3a and Mi-2α in ... mSin3a and Mi-2 co-repressor complexes or their rolein disease The reduction in mSin3a expression inthe lungs of cigarette smoke-expose mice may reduce the capacity for the regulation of pro -inflammatory ... a roleinthechronic enhanced inflammation in diseases seen inthe lungs of COPD Cigarette smoke-exposure induces a relatively glucocorticoid unresponsive inflammatory response inthe lungs of...
... understanding ofthe roles of these co-repressor complexes and thereafter their roles in disease In summary cigarette smoke exposure reduced HDAC2 activity andthe expression of mSin3a and Mi-2α in ... mSin3a and Mi-2 co-repressor complexes or their rolein disease The reduction in mSin3a expression inthe lungs of cigarette smoke-expose mice may reduce the capacity for the regulation of pro -inflammatory ... a roleinthechronic enhanced inflammation in diseases seen inthe lungs of COPD Cigarette smoke-exposure induces a relatively glucocorticoid unresponsive inflammatory response inthe lungs of...
... Conclusions, including the results ofthe November 2001 Workshop Management Framework - Introd uced Marine Pests Management capabilities and approaches APEC andthe MRCWG have a rolein liaising with ... Within APEC little is known on the introduction of marine pests Little practical information on measures to prevent introductions Lack of knowledge in what individual countries are doing ... NACA to enhance the effectiveness of existing instruments within APEC Institutional arrangements for managing the marine environment is fragmented in most economies Baseline surveys to identify...
... binding ligand Sodium ions may still bind to the N373L mutant through coordination to the other ligands ofthe binding site (center I), but the binding becomes much weaker as emphasized by the ... translocation of H+ across the membrane [3,13,14] An essential feature inthe proposed mechanism is the binding of Na+ ions from the cytoplasm at D203 and S382 including sites and their delivery into the ... carboxylation ofthe biotin group and binding ofthe carboxybiotin to the OadB site This step (Fig 4A,D) is supposed to restore the original conformation withthe channel opening to the cytoplasmic...
... as the development of offshore financial centers and off-balance-sheet methods of financing); • the diminishing effectiveness of traditional controls due to financial innovation (including the ... to being changed and enforced inthe interest ofthe regulated industry, rather than inthe interest ofthe economy at large General laws, on the other hand, tend to be more immune and therefore ... 1980s Inthe case of S&Ls the insurance premium was set by statute in 1950 at 1/12 of 1% ofthe assessable deposits and was the same for all insured institutions regardless ofthe riskiness of their...
... neurons inthe brainstem and hypothalamus, and induce neuroendocrine and behavioral responses Food intake also activates the brainstem and hypothalamus, resulting inthe termination of meals andthe ... SP9155) Decrease in vasopressin release Increase inthe release of ACTH, oxytocin, vasopressin and prolactin Increase inthe release of ACTH, oxytocin and prolactin ? ? No effects Increase [52,53] ... hypothalamus The administration of RFRP increases Fos expression inthe hypothalamic paraventricular nucleus andin hypothalamic oxytocin neurons, and facilitates the release of ACTH and oxytocin into the...
... correlated withthe breaking of cambial dormancy (Little and Wareing, 1981Moreover, ABA content increases again in reactivating cambium, for example, inthe trunk of Pinus contorta (Savidge and Wareing, ... peaking in late summer is rather incidental and drought-induced During winter, a decrease inthe ABA level, often associatedwith an increase in conjugated ABA, is frequently reported, but these ... inactivation of auxin receptor and carrier proteins Later on, the breaking of rest may occur when the conditions of active membrane trans- port are regained Is abscisic acid (ABA) involved inthe regulation...
... University inthe late 1960s which showed that the performance of a staging laparotomy altered the stage of disease in 42% of cases, up regulating in 28% and down regulating in 14% of cases [2] The ... baseline against which the effects of chemotherapy may be judged The aim of this study was to examine whether the 21st century surgeon still has a role to play inthe diagnosis and management of ... perihepatic and perisplenic in addition to retroperioneal lymphadenopathy Thus upper gastrointestinal surgeons with training in these techniques may have an increasing roleinthe diagnosis of lymphomas...
... determine factors associatedwith incident HIV and sexually transmitted infections (STIs) inthe postpartum period The information on determinants for HIV is intended to contribute in improving ... recruitment and activation of HIV susceptible inflammatory cells The inflammation and ulceration increases HIV shedding inthe genital tract, thus the HIV infectiousness [10,11] HSV- and syphilis ... sector andthe main income generating activities are tourism, trading and agriculture The present study was conducted inthe two largest primary health care clinics, Majengo and Pasua These clinics...