... congruent withthe definition of each ofthe subtypes.These results are consistent withthe clinical profile definitions of burnout syndrome. In addition, they assist the recognition of distinct profiles ... and that the “worn-out” profile is asso-ciated withthe cumulative effect over time of the characteristics of an organisation. The recognition of these variables will assist the process of clinical ... clinical profiles. We h aveseen that the “frenetic” profile is highly associated with the number of hours per week dedicated to work, that the “underchallenged” profile is related withthe type of occupation...
... the topographical loss of cartilage in the different subregions ofthe knee and theassociated risk factors. Moreover, the impact ofthe location and rate of cartilage loss on the evolution of ... meniscal tear in the lateral com-partment, and to a lesser extent the WOMAC stiffness. The riskfactorsassociatedwiththe loss of cartilage volume in the central subregions ofthe medial compartment ... time as the disease progressed. The relationshipbetween the worsening in the WOMAC scores withthe loss of cartilage on the central portion ofthe tibial plateau is intrigu-ing. The level of significance...
... modernization associatedwiththedevelopmentofthe knowledge-based economy in the Province of Thua Thien Hue in the near future.2.2. Research tasks With the above objectives, the thesis has the following ... material wealth and the spirit of service to society. With this approach ofthe thesis, the concept of human resources fully reflects the aspects: 1) The quantity criteria of human resources, ... growth ofthe capacity to endure the pressure of work and creative energy as well as the structure ofthe labor force must be consistent withthe growth rate of technical infrastructure and the...
... None ofthe patients, independently ofthe tumor site, age, the abuse of predisposing carcinogens, or the presence of other kinds of tumors, carried the CHK2 1100delC variant.Conclusions: The ... impact on thedevelopment of SCCHN.BackgroundHea d and neck cancer is the fifth most common cancer in the world [1]. The tumor suppressor p53 is stronglyinvolved in the carcinogenesis of these ... analysis of exon 10 ofthe CHK2 gene wasperformed for all patients. However, none of the patients showed the presence ofthe 1100delC variant.DiscussionNone ofthe investigated 91 patients with...
... such as the mesothelium, the coelomic epithelium ofthe ovary, the nonpigmentedepithelium of ciliary processes, the d istal convolutedtubule ofthe kidney, and the choroid plexus ofthe brain.All ... Immunohistochemical expression of CA12 was highly associatedwiththe histologic grade of cervical cancer. Lack of CA12 expression was associatedwith PD histology, with an odds ratio of 3.9 (P = 0.01). ... 4).DiscussionInourstudy,wediscoveredthatCA12expressionwasstrongly associatedwith histologic grades ofthe cervical cancer. As CA12 and histologic grade were significantly associated with each other, we then examined whetheran applica tion of combined...
... revealedthat over-expression ofthe three proteins was signifi-cantly associatedwiththe genesis and progression of CRC. The functional implications ofthe alterations in the levels of these proteins are ... role in thedevelopment and progression of CRC. Further functional and clinical analysis of the proteins is necessary to elucidate their precise role in the process of CRC and the formation of metastases.Experimental ... prognostic variables. The evaluation of carcino-embryonic antigen in serum has not fulfilled the prom-ise of a simple test that would offer early diagnosis of colon cancer. A number of other, less well-explored,potential...
... transfer of phVEGF165[37]. The hypothesis thatVEGF might have dual functions in the pathogenesis of SSc, with positive effects on the vascular system but with negative effects on thedevelopmentof ... patients with limited SSc.According to the hypothesis that the angiogenic effects of VEGF are inhibited by a concomitant increase of angio-static factors, another strategy for the treatment of ischemic ... [41]. The inverse association of endostatin with giant capillariesand microhemorrhages and ofthe higher levels of endo-statin in patients with avascular areas argue for a role of endostatin in the...
... preconditions the power ofthe pre-sented results for the -173 G/C SNP and the -794 (CATT)nmicrosatellite was 98% and 87%, respectively. The linkagedisequilibrium ofthe two loci was assessed withthe ... Table 3 shows the genotype and allele distribution of both polymor-phisms in the three groups. The carriage ofthe allele -173C was significantly associatedwith carriage ofthe -794CATT7 ... on the fraction of non-surviving patientsand on the genotype relative risks the statistical power of the significant associations were 81%, 96% and 91%,respectively. The relative risks of -173...
... findings and the relief of his chest pain after stopping the cayenne pepper pills support the role of capsaicin in thedevelopmentof coronary vasospasm through increased sympathetic stimulation. ... myocytes, an effect that is associatedwiththe inhibition of potassium currents [8,9]. Coronary vasospasm and acute myocardial infarction (AMI) associatedwiththe use of topical capsaicin patches ... [14,15]. These substances exaggerate the vasospastic activity of other drugs, enhance endothelial dysfunction, increase platelet aggregation, increase sympathetic activity, and decrease the myocardial...
... the urban and rural areas of Oyo state with a viewto identify thefactors that are associatedwith mental ill-ness in the general population at the community level. The overall prevalence of ... whofound out that the larger the size ofthe family the lower the quality of child upbringing. This may lead to delin-quent behavior among the children and increased mentalstress on the care providers ... when there istransition into adulthood and self autonomy. This mayexplain the higher morbidity rates [23]. The study underlines the effect of family structure on the mental health ofthe population....
... to the loss of disc collagen andGAGs. The lack of effect on GAG synthesis furthervalidates the importance ofthe degradative component of the remodeling cycle in relaxin's modulation of ... determined the effects of relaxin with or without β-estradiol on the modulation of MMPs injoint fibrocartilaginous explants, and assessed the contribution of these proteinases to the loss of collagen ... tissue.In this study we determined the effects of relaxin with orwithout β-estradiol on the modulation of MMPs, andassessed the contribution of these proteinases to the changes in collagen and glycosaminoglycan...
... expressed throughout the entire cardiac crescent early in the developing heart. With thedevelopmentofthe heart, Tbx5 is asymmetricallyexpressed in the heart. Expression of Tbx5 in the ventricu-Figure ... HDACactivities through the intervention ofthe transcription of HDAC genes. More likely, valproate inhibits HDAC activi-ties directly by binding withthe active site ofthe enzyme asother HDAC inhibitors ... malformationduring heart development. Further studies are on the way toexplore the down-stream activities after the valproate-enhanced expression of these transcriptional factors in the developing heart.ConclusionOur...