relationship of molecular and cellular defects to clinical features
The relationship of psychological and personality factors to post concussive symptoms (PCS) in mild traumatic brain injury (MTBI) patients
Ngày tải lên :
16/10/2015, 15:38
... evidence of injury and non-injury factors pertinent to the expression and maintenance of PCS The injury factors or neurogenic factors comprise of MTBI severity which is determined by GCS, LOC and ... contributions of these factors, particularly the role of non-injury factors has not been comprehensively investigated This thesis sought to elucidate the role of injury and non-injury factors in PCS and ... strongly linked to the duration of PCS experienced and the interaction of the MTBI afflicted individual with the demands of daily life 14 CHAPTER 3: INJURY AND NON-INJURY FACTORS IN PCS AND PPCS The...
- 131
- 432
- 0
Tài liệu Báo cáo khoa học: Molecular and cellular specificity of post-translational aminoacyl isomerization in the crustacean hyperglycaemic hormone family docx
Ngày tải lên :
18/02/2014, 11:20
... Hep-DS2 and HepDW4 were added to the standard mixture as standards Figure 2B shows that the elution time of Hep-dW4 is identical to that of the VIH II fragment By MALDI-TOF MS, the mass of this ... configuration of the tryptophan at the fourth position Characterization of cell types in relation to CHH and VIH isomers To study the distribution of CHHs and VIHs in the X organ cells, immunohistochemical ... of CHH- and VIH- expressing cells, in relation to isomers, was investigated by immunohistochemistry and immunocytochemistry, using antisera specific to each epimer Confocal examination of in toto...
- 13
- 687
- 0
molecular and cellular biology of neuroprotection in the cns - christian alzheimer
Ngày tải lên :
08/04/2014, 12:51
... Role of Reactive Oxygen Species in Excitotoxicity 16 Role of Nitric oxide and other Reactive Nitrogen Species in Excitotoxicity 19 Excitotoxicity, Calcium Loading and Apoptosis ... administration of BOAA is known to induce the features of lathyrism in nonhuman primates105 and application of BOAA to cell cultures results in cell death with structural features of excitotoxicity106 ... excitotoxicity came with the understanding that neurons can die by apoptosis In response to excitotoxicity the neuron activates apoptosis i.e., dismantling of itself including DNA, cytoskeleton,...
- 518
- 930
- 0
Báo cáo sinh học: "Molecular and cellular correlates of the CIITA-mediated inhibition of HTLV-2 Tax-2 transactivator function resulting in loss of viral replication" pot
Ngày tải lên :
18/06/2014, 22:20
... inactivation of Tax-2 leading to the inhibition of HTLV-2 retrovirus replication Further studies of subcellular localization unveiled the co-localization of Tax-2 and CIITA both in the cytoplasm and the ... co-localization of the two molecules in cytoplasmic and nuclear subcellular compartments Moreover and of particular importance, interaction with CIITA makes Tax-2 molecules prone to migrate to cytoplasm ... amounts (0.2 μg) of pLTR-II-Luc and pcTax2 V5.(0.05 μg) vectors and in the absence or presence of increasing amounts (0.5-1 μg) of vectors coding for Flag-tagged CIITA wt (pfCIITA 1-1130) and fragments...
- 9
- 493
- 0
o cáo hóa học:" Molecular and cellular correlates of the CIITA-mediated inhibition of HTLV-2 Tax-2 transactivator function resulting in loss of viral replication" potx
Ngày tải lên :
20/06/2014, 04:20
... inactivation of Tax-2 leading to the inhibition of HTLV-2 retrovirus replication Further studies of subcellular localization unveiled the co-localization of Tax-2 and CIITA both in the cytoplasm and the ... co-localization of the two molecules in cytoplasmic and nuclear subcellular compartments Moreover and of particular importance, interaction with CIITA makes Tax-2 molecules prone to migrate to cytoplasm ... amounts (0.2 μg) of pLTR-II-Luc and pcTax2 V5.(0.05 μg) vectors and in the absence or presence of increasing amounts (0.5-1 μg) of vectors coding for Flag-tagged CIITA wt (pfCIITA 1-1130) and fragments...
- 9
- 405
- 0
Báo cáo y học: "4th meeting of the EU research network EUROME: From the identification of genes and cellular networks in murine models of arthritis to novel therapeutic intervention strategies in rheumatoid arthritis, London, UK, 9 March 2004" pot
Ngày tải lên :
09/08/2014, 01:23
... activation, as well as expression of antiapoptotic proteins Bcl-2 and members of the inhibitor of apoptosis family (cIAP-1, XIAP and survivin, which directly bind to and inhibit caspases), was strikingly ... http://arthritis-research.com/content/6/4/155 either T helper (Th) or Th2 effector cells The goals of this arm of EUROME are to identify genes and pathways involved in this differentiation of DCs and to set up an ex vivo–in vivo cell therapy ... will be transferred into CIA mice to ameliorate the autoimmune process On the basis of the previous finding of a differential impact of Th1 and Th2 cells on the function of bone marrow-derived...
- 4
- 288
- 0
MOLECULAR AND CELLULAR MECHANISMS LEADING TO SIMILAR PHENOTYPES IN DOWN AND FETAL ALCOHOL SYNDROMES
Ngày tải lên :
24/08/2014, 10:37
... buffer was added to samples with 50 µL of buffer added to blank To those controls; 15, 7.5, 3.75, and 1.88 µL of BSA protein was added respectively to samples to have a total of 50 µL of sample with ... to study the possible expression or effects of high occurrence of apoptosis in craniofacial precursors and a possible cause of distinct DS phenotypes 1.3.5 Expression of Activated Akt in DS and ... Integrity and Copyright Disclaimer Title of Thesis/Dissertation: Molecular and Cellular Mechanisms Leading to Similar Phenotypes in Down and Fetal Alcohol Syndromes For the degree of Master of Science...
- 80
- 396
- 0
Molecular and cellular functions of the alternatively spliced isoforms of GDNF receptor complex in neuronal differentiation
Ngày tải lên :
09/09/2015, 10:13
... variants of GDNF family ligands and receptors is suggestive of a new paradigm where a limited number of ligands and receptors generate pleiotropic effects through differential expression and combinatorial ... Regulation and function of GFRα and co-receptor isoforms in neurogenesis 159 9.2.4 Functions of miRNA in GFL signaling and neurogenesis 159 CHAPTER 10 MATERIALS AND METHODS 161 10.1 Ligands and Chemicals ... The combinatorial interactions of GFLs, GFRα and RET receptor isoforms provides a new paradigm that allows a single ligand to exert a plethora of biological effects xi List of Figures and Tables...
- 192
- 425
- 0
Studies on the molecular and cellular mechanisms underlying the process of learning and memory formation body
Ngày tải lên :
09/09/2015, 18:55
... activation of A1 adenosine receptors, removal of adenosine tone by A1 receptor antagonists, genetic deletion of A1 receptors or application of adenosine-degrading enzymes is proved to enhance ... form excitatory synaptic contacts to the dendrites of granule cells in dentate gyrus: axons from the medial and lateral entorhinal cortices innervate the middle and outer molecular layers of dentate ... expression of the MFs LTP is due to increasing release of presynaptic glutamate, and requires the activation of PKA as well as the downstream targets of PKC and PKA Several substrates of PKA have...
- 164
- 361
- 0
Studies on the molecular and cellular mechanisms underlying the process of learning and memory formation
Ngày tải lên :
09/09/2015, 18:55
... different molecular mechanisms involved in amygdala-related cuedor tone-dependent fear conditioning xi List of Tables Table 4.1 Average concentrations and standard errors of Fe Cu and Zn in different ... the mossy fibers………………………………… 1.1.2 Histology of Mossy fiber pathways……………………………………… 1.1.3 Anatomic plasticity of the mossy fibers…………………… 1.2 Plasticity of the mossy fibers……………… .9 1.2.1 ... learning and memory……………………………………… 19 1.3.1 Role of mossy fibers plasticity in learning and memory 19 1.3.2 Species and strains difference in mossy fibers…… 21 1.4 Significance of studies…………………………………………...
- 14
- 274
- 0
Application of Hydrothermal Reaction to Biodegradability Improvement of Refractory Pollutants: Structural Conversion of Di- and Trichloroacetic Acid to Biodegradable Products
Ngày tải lên :
05/09/2013, 08:40
... can be seen from the - 221 - Journal of Water and Environment Technology, Vol.1, No.2, 2003 results of TOC and DOC In case of TCAA, more than 70 % of TOC and CODCr were mineralized within as ... section 3.1 and 3.2 3.4 Relationship between TOC reduction and BOD improvement Figure shows the relationship between TOC reduction and BOD improvement of products obtained from CAAs at 250 oC and MPa ... glycolic acid and decomposition of glycolic acid to other organic acids were reported [11] Based on the results of ion chromatography, attached recalcitrant chlorine atoms of DCAA and TCAA were...
- 8
- 643
- 0
Sensibility study of flooding and drying issues to the operating conditions in PEM fuel cells
Ngày tải lên :
05/09/2013, 14:58
... International Journal of Energy and Environment (IJEE), Volume 1, Issue 1, 2010, pp.1-20 16 Qtot = Ptot vtot Ach R Top (25) So, the cathode velocity is: vtot = Qtot R Top Ptot Ach (26) A high total pressure ... mixture in the channel vtot (m.s-1) is computed in each slice using the relationship (20) P (20) Qtot = tot vtot Ach R Top where Ach is the channel area (m2) and Ptot the total pressure in the ... anode All these results are of great interest to the improvement of water management in PEMFC They lead to a better understanding of how to use the operating parameters to control the cell internal...
- 20
- 571
- 0
A contrastive analysis of grammatical and semantic features of words and idioms related to hearing in english and vietnamese
Ngày tải lên :
26/11/2013, 13:31
... how to use them in Vietnamese features of WIRHs in English and - to describe semantic features of WIRHs English and Vietnamese - to provide a brief account of grammatical-semantic similarities and ... semantic features of words and idioms related to hearing in English b, Metonymy and in Vietnamese require collecting corpora of literature work and Harris thinks that metonymy is another form of metaphor ... grammatical features and semantic features of words and idioms related to hearing in English and Vietnamese However, there are some aspects that should be study to 24 have more profound and through...
- 13
- 1.3K
- 3
Tài liệu LoopStar® 711 Leveraging a Full Suite of Ethernet and TDM Services to Cost-Effectively Utilize Fiber Networks doc
Ngày tải lên :
10/12/2013, 19:15
... Leveraging a Full Suite of Ethernet and TDM Services to Cost-Effectively Utilize Fiber Networks Ethernet and Legacy Services for True Convergence Providers of all sizes and types are worried about ... 100FX (SFP) • CLI management interfaces - RS-232 - 10/100 • In-band or out -of- band • SNMP • FTP to download multiple software images and configurations • LoopStar 700 intelligent management Ethernet ... 19” and 23” rack mount brackets, console cable, license for basic software and documentation LPS-711-AC L1 Web Site: www.adc.com From North America, Call Toll Free: 1-800-366-3891 • Outside of...
- 4
- 405
- 0
Tài liệu Applications of Robotics and Artificial Intelligence to Reduce Risk and Improve Effectiveness pdf
Ngày tải lên :
13/12/2013, 01:15
... of transmitting power and control to the hand If standards were defined, quick-change mechanisms and a family of hand grippers and robot tools would rapidly become available The development of ... APPLICATIONS OF ROBOTICS AND ARTIFICIAL INTELLIGENCE • • • • how to capture and deploy knowledge and duties of the operations, intelligence, logistics, and fire-support officers into operations, ... logistics, and fire-support expert systems to aid these officers; how to automate screening messages and establishing priorities to reduce information overload; how to integrate the operations of the...
- 276
- 593
- 0
Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface pdf
Ngày tải lên :
18/02/2014, 11:20
... those of neighboring cells, and their cytoplasmic components are linked to accessory proteins (e.g zonula occludens proteins and cingulin), forging a connection to the actin cytoskeletons of endothelial ... insulin, transferrin and leptin, to cross the BBB [13] Molecular basis of brain angiogenesis and barriergenesis Hypoxia and the hypoxia-inducible factor system As an embryo develops and its structure ... thought to contribute to BBB permeability by mediating cellular communication between the endothelium and pericytes or astrocytes Pericyte- and astrocyte-derived soluble factors seem to contribute to...
- 14
- 580
- 0
Tài liệu Báo cáo khoa học: Lipopolysaccharide-evoked activation of p38 and JNK leads to an increase in ICAM-1 expression in Schwann cells of sciatic nerves ppt
Ngày tải lên :
18/02/2014, 18:20
... similar to the non-myelinating glia of the CNS SCs can be induced to produce cytokines and chemokines, to express major histocompatibility complex (MHC) class II molecules and adhesion molecules, and ... the presence of cytokines Natural ligands of ICAM- 1and LFA-1 are expressed on the surface of T and B lymphocytes, natural killer cells, monocytes, macrophages and granulocytes [33], and interaction ... phosphorylated ERK, p38 and JNK (p-ERK, p-p38 and p-JNK) and total ERK, p38 and JNK (tERK, tp38 and tJNK) (B) The ratio of phosphorylated to total ERK (p44 ⁄ 42), p38 and JNK at each time point The data...
- 11
- 519
- 0
TEXTBOOK OF Hepatology From Basic Science to Clinical Practice doc
Ngày tải lên :
06/03/2014, 09:21
... MD FRACP Director of Gastroentrology and Hepatology Austin Hospital Melbourne, Vic, Australia Vicente Arroyo MD Professor of Medicine Director of the Institute of Digestive and Metobolic Diseases ... Professor of Medicine University of Toronto Toronto, ON, Canada J Michael Henderson MD Department of General Surgery The Cleveland Clinic Foundation Cleveland, OH, USA Jens H Henriksen MD Professor of ... periportal and centrilobular cells and matrix can also help to explain the regional distribution of lesions and susceptibility of cells to certain hepatotoxicants Not only hepatocytes have gradients of...
- 2.2K
- 3.8K
- 7
Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx
Ngày tải lên :
06/03/2014, 22:21
... accumulation of forms of the mutant proteins that were of lower apparent molecular mass and of similar size to the unglycosylated form of the wild-type protein (see Fig 2B for single mutants and Fig ... end of an a-helical region of the HFE a1 domain (V100 and W103A) as being of particular importance for TfR1 interactions [16,17,20] The effect of HFE binding to TfR1 is to lower the affinity of ... cells and is now recognized as a key regulator of iron homeostasis in the body Hepatocellular hepcidin mRNA levels have been shown to be regulated by HFE, and are altered in haemachromatosis...
- 16
- 538
- 0