regulation of fluid and electrolyte balance in hypertension

Ceftriaxone-induced up-regulation of cortical and striatal GLT1 in the R6/2 model of Huntington’s disease pps

Ngày tải lên : 10/08/2014, 05:21

... capable of overcoming a deficit in GLT1 function It is interesting in this regard that palmitoylation, a process by which proteins are inserted into cellular membranes [20], is reduced in HD mice, including ... WTs and R6/2s indicate saline treatment, and WTc and R6/2c indicate ceftriaxone treatment N refers to number of animals per group Genotype and CAG repeat length We used PCR for genotyping and ... blocking buffer Protein loading was normalized using b-tubulin immunoblotting as a loading control Chemiluminescent detection of HRP (SuperSignal West Pico; Pierce) was followed by exposure of...

5
380
0

Regulation of navigation and vessel-source pollution in the Northern Sea Route - Article 234 and state practice

Ngày tải lên : 01/11/2013, 09:20

... 15 of the Economic Zone Edict; Arts and 15 of the Environmental Edict; and Art 11 of the Decree of the Council of Ministers of the USSR, June 1990, ‘On Measures of Securing the Implementation of ... within the inland waters, territorial sea or EEZ adjoining the USSR northern coast and that it includes seaways suitable for guiding vessels in ice Due to the vagueness concerning leading in Article ... the mandatory prescription of leading in ‘other regions’, as well as from Article 7(1) which states that the NSRA will determine the beginning and end of the navigational period taking into account,...

23
555
0

Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc

Ngày tải lên : 16/02/2014, 09:20

... role of AP-2a and AP-2e in chondrogenesis Overview of the differentiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin and eosin-stained section of an ... tumorigenesis and genetic diseases [47] Most analyses of the regulation of AP-2 and the interactions of the transcription factor with binding partners, as well as of the regulation of target gene ... proline-rich and glutamine-rich N-terminus, which is important for transactivation, is shown in yellow, and contains the PY-motif (green) The helix–span–helix domain at the C-terminus shown in...

9
642
0

Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx

Ngày tải lên : 07/03/2014, 01:20

... contains an N-terminal domain harboring activation function 1, a central DNA-binding domain (DBD) and a C-terminal ligandbinding domain (LBD) containing activation function [67–70] Upon binding androgens, ... Actin and ABPs in transcription regulation B Zheng et al Table Role of nuclear actin-binding proteins interacting with the androgen receptor AR, androgen receptor; LBD, ligand-binding domain ... Direct a-actinin-2 ()) Bundling proteins Coactivator Supervillin NLS F-actin- and membraneassociated scaffolding protein Filamin NLS? Cross-linking proteins Filamin A NLS? Cross-linking proteins Transgelin...

17
573
0

Báo cáo khoa học: Huntington’s disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription pptx

Ngày tải lên : 23/03/2014, 07:20

... containing inositol lipids and stabilizes the growth factor receptor tyrosine kinases by increasing their half-life following ligand induced endocytosis Such interaction affects cell growth and ... caspase-8-mediated pathway Rybp also interacts with ubiquitin-binding protein, procaspase-8, procaspase-10, and the HIPPI interactor apotin Interaction of HIPPI with Rybp is involved in murine neural development, ... resulting in aggregates ⁄ neuronal intranuclear inclusions Aggregates ⁄ neuronal intranuclear inclusions are observed in cell models, brains of transgenic animals, and post-mortem brains of HD...

9
492
0

Báo cáo Y học: Molecular characterization of MRG19 of Saccharomyces cerevisiae Implication in the regulation of galactose and nonfermentable carbon source utilization pdf

Ngày tải lên : 31/03/2014, 08:20

... monitored in MIG1 disruption (Fig 10, lane and 2) and wild-type (Fig 10, lane and 4) strains bearing multiple copies of MRG19 and grown in the presence of glucose (Fig 10, lane and 3) and glycerol ... digesting with SalI and ﬁlling in with dNTPs and the resulting plasmid was named p19C-S This construct was expected to induce a protein of 49 kDa To determine subcellular localizations of Mrg19p, ... gal80mrg19 strains Cells were grown to D600 of 0.5 in synthetic complete medium containing glycerol plus lactate and galactokinase activity was determined as described in Materials and methods MRG19...

11
499
0

Báo cáo y học: "T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFκB: implications for rheumatoid arthritis" docx

Ngày tải lên : 09/08/2014, 08:23

... transcription factor NFκB, in order to gain insight into the regulation of chemokines at sites of inflammation Materials and methods Isolation of peripheral blood monocytes and lymphocytes Human monocytes ... RANTES and MCP-1 was unaffected (Figure 2c) This inverted pattern of utilization of NFκB for the T-cell contact-dependent induction of CC and CXC chemokines in monocytes is surprising and indicates ... factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines J Biol Chem 1990, 265:21128-21133 42 Wood LD, Richmond A: Constitutive and cytokine-induced expression of...

10
456
0

Báo cáo y học: "Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4" pot

Ngày tải lên : 09/08/2014, 14:22

... attenuation of autoimmunity Herein we present data on the regulation of IL17 responses by the Th1 cytokine IFN-γ and the Th2 cytokine IL-4 in CIA treatments Hematoxylin and eosin staining of paws ... Goldman M, Berg WB van den: Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis Protective effect of interleukin-4 and interleukin-10 treatment on cartilage destruction ... provide insight into the heterogeneity of systemic as well as joint-specific immune events underlying inflammatory arthritis Another intriguing finding was the significant level of IL-4 in the...

15
388
0

báo cáo khoa học: " Genetic and transformation studies reveal negative regulation of ERS1 ethylene receptor signaling in Arabidopsis" pot

Ngày tải lên : 12/08/2014, 03:21

... measurement of mutants respectively carrying and lacking ERS2 (C) phenotype and (D) hypocotyl measurement of etiolated seedlings of ers1-2 etr2 ein4, ERS1p:ERS1 ers1-2 etr2 ein4, and etr2 ein4 Error ... alterations in the expression of the remaining receptor genes (Figures 2C, 2D, and 2E) Notably, ETR1 expression in etr2 ein4 ers2 was identical to that in ers1-2 etr2 ein4 ers2 and ers1-3 etr2 ein4 ers2 ... a numerically larger value of t air: seedlings germinated in air; AVG: seedlings germinated in the presence of AVG ein4 ers2 ers1 etr2 ers2 exhibited early flowering and rosette growth ceased...

14
175
0

Báo cáo y học: " Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus" doc

Ngày tải lên : 12/08/2014, 12:20

... producing T cells, including CD4 + and DN T cells, have been found in lupus nephritis In addition, IL17 gene expression was detected in T cells infiltrating the kidneys and in urine sediments of ... Page of 10 Figure Plasma levels of Th17-driving cytokines and IL-10 in patients with SLE and healthy controls Plasma levels of Th17-polarizing cytokinesg(IL-1b, IL-6, IL-21, TGF-b, and IL-23) and ... underlying our findings is yet to be determined, it appears that factor(s) involved in balancing Th17 and Th1 cell responses as well in producing IL-6 are dysregulated in SLE Our data offer a...

10
443
0

Báo cáo y học: "Oxygen-sensing mechanisms and the regulation of redox-responsive transcription factors in development and pathophysiology" ppsx

Ngày tải lên : 12/08/2014, 18:20

... (blocked arrows) of different stages in the proposed pathway are indicated Genistein is an inhibitor of tyrosine protein kinase and competitive inhibitor of ATP in other protein kinase reactions; ... signaling and proinflammatory cytokines [13,14,16–18] This review is primarily concerned with discussing the recent understanding of redox signaling and gene regulation, the role of oxygenation in ... nucleus, pull NF-κB off DNA, and export NF-κB back to its resting state in the cytoplasm Thick lines indicate the activating pathway; thin lines indicate the inactivating pathway IκB-independent pathways,...

27
342
0

Báo cáo y học: "Fluid balance as a biomarker: impact of fluid overload on outcome in critically ill patients with acute kidney injury" potx

Ngày tải lên : 13/08/2014, 11:22

... 100]) at the time of initiation of continuous RRT (CRRT) to be associated with lower survival, independent of severity of illness This finding was further confirmed in two additional investigations ... studies, provide compelling evidence that attention to fluid balance and prevention of volume overload, in particular in AKI, may be an important and underappreciated determinant of survival These ... from early initiation of CRRT to prevent fluid accumulation and overload in critically ill children, once initial fluid resuscitative management has been accomplished Few clinical investigations,...

3
270
0

Báo cáo y học: " Signaling and regulation of G protein-coupled receptors in airway smooth muscle" ppsx

Ngày tải lên : 13/08/2014, 13:20

... relaxation of methacholine-induced bronchoconstriction, but an increase in GRK activity, and GRK2 and GRK5 expression in the lung [112] This is an intriguing finding and suggests that inflammation ... chain phosphorylation caused by: 1) an imbalance of GPCR-derived signals; and 2) increased expression and activity of myosin light chain kinase (MLCK) associated with inhibited myosin light chain ... for examining agonist-induced changes in stiffness of cultured ASM cells that has provided useful information linking regulation of GPCR signaling with ASM contractile state [23] Interestingly,...

23
363
0

Báo cáo y học: "Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease" potx

Ngày tải lên : 13/08/2014, 13:20

... hepatocytes In support of the role of TNFα as a key mediator in the stimulation of hepatocellular proliferation, recent findings suggest that down -regulation of the iron-binding protein lactoferrin (LF) ... the AF2 ligand-dependent activation domain The amino-terminal A/B domain contains the AF1 ligand-independent activation domain The D domain consists of a highly flexible hinge region and non-rodent ... MAP-kinase mediated phosphorylation of Ser112 of mouse PPARγ2 lowers transcriptional activity [14,15] The ligand binding domain (LBD), or E/F domain of PPARs, is responsible for ligand-binding and...

15
437
0

Báo cáo y học: "Global analysis of alternative splicing regulation by insulin and wingless signaling in Drosophila cells" ppt

Ngày tải lên : 14/08/2014, 21:20

... Activation of insulin and wingless signaling pathways in Drosophila S2 cells Figure Activation of insulin and wingless signaling pathways in Drosophila S2 cells (a) Schematic representation of the insulin ... changes in alternatively spliced mRNA isoforms induced by insulin and wingless Figure Numerous changes in alternatively spliced mRNA isoforms induced by insulin and wingless (a) Features of microarray ... Insulin regulates alternative splicing of protein kinase C beta II through a phosphatidylinositol 3-kinasedependent pathway involving the nuclear serine/argininerich splicing factor, SRp40, in...

14
271
0

gjerstad & smith - rethinking housing bubbles; the role of household and bank balance sheets in modeling economic cycles (2014)

Ngày tải lên : 01/11/2014, 18:18

... underlying economic analysis and policy? 1.3 Balance Sheet Recessions: A Missing Perspective In our view, the prominent role of balance sheets is the missing link in answering these questions and ... has joint appointments in the Argyros School of Business and Economics and the School of Law at Chapman University, and he is part of a team that created and runs the Economic Science Institute ... 6in × 9in Top: 0. 5in Gutter: 0.87 5in CUUS2122-FM CUUS2122/Gjerstad ISBN: 978 521 19809 January 31, 2014 15:25 Rethinking Housing Bubbles The Role of Household and Bank Balance Sheets in Modeling...

310
471
0

FUNCTION AND REGULATION OF CALCIUM INDEPENDENT PHOSPHOLIPASE a2 IN THE ATTENUATION OF PAIN IN MICE

Ngày tải lên : 09/09/2015, 08:15

... maprotiline and another TCA, amitriptyline Antidepressant treatment reduced pain behavioral responses indicating antinociceptive effect of maprotiline and amitriptyline treatment in a model of inflammatory ... sometimes 2.1 Orofacial pain Orofacial pain is defined as “pain within the structures of the oral cavity and face, usually of a diffuse pattern” (Zwemer, 1998) Orofacial pain includes pain disorders ... previously, brain imaging of iPLA2-deficient mice also revealed reduced DHA signaling and metabolism, supporting the role of iPLA2 in generating DHA in the brain (Basselin et al., 2010) Both DHA and EPA...

232
396
0

A numerical study of heat and mass transfer in porous fluid coupled domains

Ngày tải lên : 12/09/2015, 21:13

... Forchheimer term f fluid fluid fluid part i, j grid node number in x and y directions in inlet int interface line in reactor interface interface value l east, west, north, and south point of control ... electronic cooling, ceramic processing, and overland flow during rainfall In thermal insulation engineering, an appreciable insulating effect is derived by placing porous material in the gap between ... NUMERICAL STUDY OF HEAT AND MASS TRANSFER IN POROUS -FLUID COUPLED DOMAINS CHEN XIAOBING (B Eng., University of Science and Technology of China) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHYLOSOPHY...

286
532
0

Role of p73 in regulation of cell death specific role in mitotic cell death and potential regulation of caspase 2s

Ngày tải lên : 13/09/2015, 21:21

... with each other (Irwin and Kaelin, Jr., 2001) Each of them consists of a N-terminus trans-activation domain, a central DNA binding domain and a C-terminus regulatory domain (Illustration 1) All ... during mitosis, thus allowing chromatids to separate during anaphase towards opposing poles In the cells, the spindle checkpoint is kept active through the binding of inhibitory proteins BubR1 and ... protein ubiquitination in a highly specific manner (Rossi et al., 2005) This regulation depends on the binding of p73 through its proline rich domain to the WW domain of Itch Knockdown of Itch...

238
205
0

Ontogeny and hormonal regulation of alpha amylase gene expression in seabass larvae, lates calcarifer

Ngày tải lên : 17/09/2015, 17:20

... domain (DBD) bind to a GRE in a cooperative manner (Fig.1.5), in which binding of the first molecule enhances binding of the second (Dahlman-Wright, et al., 1991) Studies of the binding of GR DBD ... major actions of cortisol in fish: regulation of the hydromineral balance and energy metabolism Its effects include stimulation of protein catabolism, gluconeogenesis and hyperglycemia in response ... observed in some fishes The relationship of endocrine and exocrine pancreatic cells, distribution of islets, presence or absence of principal islet and distribution of cell types within the islet...

195
215
0