regulating the anabolic catabolic balance of articular cartilage
báo cáo hóa học:" Study of the collagen structure in the superficial zone and physiological state of articular cartilage using a 3D confocal imaging technique" pptx
... of the durability of the AC This is consistent with the fact that loss of the most superficial layer of AC accelerates worn off AC [13] Also, the similarity of the collagen structure in the cartilage ... to rapid wear of the AC, and consequently reduction of the loading capacity of AC as a result of progressive release of proteoglycans from the cartilage [22] Therefore, study of the 3D collagen ... the source of the tensile property of the articular surface for wearing and shearing resistance Particularly, the structure of the interwoven collagen bundles is ideal for resistance of the tensile...
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Báo cáo y học: "Ultrasound properties of articular cartilage in the tibio-femoral joint in knee osteoarthritis: relation to clinical assessment (International Cartilage Repair Society grade)" pptx
... 2, cartilage with lesions extending to 50% of the depth of the cartilage; and grade 4, severely abnormal cartilage ... decrease in the speed of sound in degraded cartilage [7,25,26] The speed of sound is dependent on the cartilage water content, and an increase of water content induces the decrease of the speed of sound ... stiffness of rabbit articular cartilage: an examination of the superficial collagen-rich zone of cartilage Osteoarthr Cartil 2006, 14:784-792 Swann AC, Seedhom BB: The stiffness of normal articular cartilage...
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Báo cáo y học: "Role of hypoxia-inducible factor 1alpha in the integrity of articular cartilage in murine knee joints" potx
... degeneration of the articular cartilage and osteophyte formation (Figures 2b,d,f and 3a,b) The formation of osteophytes was present at the margins of the articular surface in all joint compartments The articular ... were observed in the medial compartment, with massive loss of the cartilage substance and meniscal tissue to the point of complete loss of cartilage tissue with exposure of the subchondral bone ... of articular cartilage tissue and degeneration of the menisci The cartilage of the lateral compartment and the patellofemoral joint was affected with fibrillation and fissuring There were also...
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Báo cáo y học: "Ultrasound has the potential to detect degeneration of articular cartilage clinically, even if the information is obtained from an indirect measurement of intrinsic physical characteristics" pdf
... evaluation of living human cartilage of the elbow and knee during mosaicplasty for osteochondritis dissecans of the elbow: an in vivo study Am J Sports Med 2008, 36:2345-2353 Page of (page number ... Ultrasound properties of articular cartilage in the tibio-femoral joint in knee osteoarthritis: relation to clinical assessment (International Cartilage Repair Society grade) Arthritis Res Ther 2008, 10: ... Y, Tomita N, Ikeuchi K: Measurement of the mechanical properties of regenerated articular cartilage using wavelet transformation In Tissue Engineering for Therapeutic Use Edited by Ikada Y, Umakoshi...
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Báo cáo y học: "Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability" pptx
... osteochondral defects The purpose of the current study is to analyze the effect of this agonist on articular cartilage in a model of traumatic degeneration Methods: The model of traumatic degeneration ... when the transgene is expressed in articular cartilages of postnatal mice[6] Moreover, inhibitors of MMP-13 prevent the degradation of articular cartilage[ 5, 7] Chondrocytes also produce anabolic ... enhances the growth of chondrocytes[18, 19] and promotes the regeneration of articular cartilage in rabbits with cartilage defects[19] In the current study, we investigate the effect of an EP2...
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Báo cáo y học: "More intrinsic parameters should be used in assessing degeneration of articular cartilage with quantitative ultrasound" doc
... thickness both can contribute to the change of the interval Although the authors did discuss the effect of swelling on the speed of sound, they neglected to address the fact that thickness could ... Noncontact measurement of material properties US patent issued No 7124636 Oct 24 2006 Acknowledgments The works of the authors in the field of ultrasound assessment for articular cartilage were supported ... transducer (incidence angle of ultrasound beam), and curvature of the tissue surface besides the tissue state The echo duration can be affected by the characteristics of ultrasound transducer,...
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Báo cáo lâm nghiệp: "Variation of stomatal resistance with leaf age in Quercus petraea: effect on the soil-water balance of an oak forest" pot
... achieved their covered with a dense net of hairs (Fig 3, 1a and 2a); 2) as the leaf matures, all stomates end their development and hairs progressively disappear (Fig 3, 1b and 2b) The decrease ... epidermal resistance after the leaf has reached its full size may thus be attributed to both stomatal development and a decrease in boundary layer resistance development They are References Nizinski ... de Fontainebleau Ann Sci For 46, 173-186 Nizinski J & Saugier B (1989b) A model of transpiration and soil-water balance for a mature oak forest Agric For Meteorol in press budding ...
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Báo cáo y học: "Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis" pptx
... and across the width of the tibial plateaux A significant loss of proteoglycan was evident in the superficial cartilage of both the LTP (Fig 1d, e) and, to a lesser extent, the MTP of the meniscectomized ... elevation in synthesis [17,18] Degradation of the ECM is also elevated in these early stages in OA Eventually, the biosynthetic machinery of the chondrocyte is unable to keep up with the anabolic demands ... occur in the articular cartilage in the ovine lateral meniscectomy model of OA [22,23,33] The present study extends these earlier investigations by examining the expression of a number of important...
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Báo cáo y học: " Major biological obstacles for persistent cell-based regeneration of articular cartilage" pps
... Although proof of principle has been provided that implanted chondrocytes can contribute to structural cartilage repair, the origin of cells persisting at the repair site, whether these are the originally ... for cartilage repair is especially detrimental because of the associated inflammatory response, which interferes with chondrogenesis and the integrity of the cartilage matrix The avoidance of ... the lack of cell supply in cartilage, major cell loss in cartilage and neo -cartilage will inevitably lead to tissue failure, as chondrogenic cells are the only source of matrix synthesis in theses...
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Báo cáo y học: "Bonding of articular cartilage using a combination of biochemical degradation and surface cross-linking" pdf
... cross-sections of cartilage blocks were stained for GAGs Compression In the absence of treatment with cross-linking agents, neither just laying the cartilage blocks together nor compressing them (to 83% of ... load, in the order of 0.1 N, was attributed to swelling of the cartilage In contrast, for the oversized G2 cartilage blocks, a compressive load of N resulted from mechanical fixing by the stamp ... prior surface degradation for either of the two geometries Based on these results, the following experiments investigating the effects of the different combinations of degrading and cross-linking...
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Báo cáo y học: "More intrinsic parameters should be used in assessing degeneration of articular cartilage with quantitative ultrasound" ppt
... thickness both can contribute to the change of the interval Although the authors did discuss the effect of swelling on the speed of sound, they neglected to address the fact that thickness could ... Noncontact measurement of material properties US patent issued No 7124636 Oct 24 2006 Acknowledgments The works of the authors in the field of ultrasound assessment for articular cartilage were supported ... transducer (incidence angle of ultrasound beam), and curvature of the tissue surface besides the tissue state The echo duration can be affected by the characteristics of ultrasound transducer,...
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A role for chondroitin sulfate proteoglycan in regulating the survival and growth of neural stem cells
... 15 of gestation On the left, the embryo is cut sagittally through the midline; the right view looks down upon the dorsal surface of the embryo (B) The movements of the epiblast cells through the ... invaginations of the mesoderm along the primitive streak results in the formation of the notochord, a column of cells that extend along the anterior-posterior axis of the embryo and defines the midline of ... margins of the neural plate (farthest from the notochord) (C) Once the edges of the neural plate meet in the midline, the neural tube is complete The mesoderm adjacent to the tube then thickens...
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Báo cáo y học: "A second-generation autologous chondrocyte implantation approach to the treatment of focal articular cartilage defects" ppsx
... at the site of implantation, which should promote integration between the neo -cartilage and the surrounding host articular cartilage tissue A critical feature of the technology is the use of ... example, the exact cell density per volume of the construct was not given, and neither were details of the pre-surgery culture expansion of chondrocytes It would have been helpful to present these ... osteoarthritis is clearly required to test the applicability of the BioSeed-C procedure for larger sized cartilage repair of osteoarthritic lesions Further development of the technology described here to...
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Báo cáo y học: "Anabolic and catabolic responses of human articular chondrocytes to varying oxygen percentages" ppt
... evolution of cartilage damage following alteration of the oxygen levels and to assess the effect of possible therapeutic targets The observed pro -anabolic and anti -catabolic effects of low oxygen ... While the importance of HIF-1a in modulating the expression/synthesis of cartilage- specific genes was recently addressed [28-46], the involvement of this factor in the oxygendependent modulation of ... O2 after the Phase I differentiation culture (Figure 2D, E) Expression of catabolic mediators We then investigated the possible role of oxygen percentage in modulating the expression of catabolic...
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Báo cáo y học: "The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies" pdf
... controlling the clonality of surface zone chondrocytes [51] In fact, in both species the Notch receptor is present in the chondrocytes of the surface zone of the articular cartilage Consistent with these ... in the deeper layers of cartilage, thus promoting osteochondral ossification One of the most relevant hypotheses is that Notch may act as an on/off switch, either enabling maturation of the articular ... pathway The first described Notch activation cascade consists of a series of cleavages leading to the release of the intracellular domain of the receptor, which interacts in the nucleus with the transcription...
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Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf
... Chondrocytes regulate the enzymatic breakdown of the extracellular matrix, thereby maintaining the equilibrium between synthetic and degradative processes in the cartilage [1] Therefore, the metabolic ... Evaluation of articular cartilage after experimentally induced osteoarthritis (A) Photomicrographs of articular cartilage (B) The evaluation of osteoarthritis in the right and left joints of dogs ... and the hypoxic inhibition of cartilage and chondrocyte degeneration Results Macroscopic and radiographic examination of the articular cartilage after experimentally induced OA Articular cartilage...
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Báo cáo " Balance of rice for the Mekong Delta - Viet Nam to 2050 in terms of industrialization and climate change '''' doc
... 3.2 Analysis the changes of elements in the model In the original script of the model using actual values of the elements obtained from the secondary resources from the provinces and the primary ... the strategy of the population in the future is to stabilize population size, improve the quality of human resources According to the calculation of the study is to reduce the rate of population ... in the study was obtained from the Department of Agriculture and Rural Development, Department of Statistics, Department of Planning and Investment, Department of Science and Technology of the...
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báo cáo hóa học: " Participation of MCP-induced protein 1 in lipopolysaccharide preconditioning-induced ischemic stroke tolerance by regulating the expression of proinflammatory cytokines" pdf
... generated the figures, and wrote the manuscript JW did parts of the animal surgery JW, YS, LW, EB performed the experiments PEK provided advice in the design of the study and in interpreting of data ... quantified using the Image J software Infarct volume was expressed as a percentage of the contralateral hemisphere There were 10 mice in each group Brain Edema Measurement The mice were anesthetized ... whether there is loss of LPS preconditioning-induced ischemic stroke tolerance in MCPIP1 knockout mice and whether such effects involve regulation of expression of proinflammatory cytokines Furthermore...
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báo cáo hóa học:" Fourier-transform infrared anisotropy in cross and parallel sections of tendon and articular cartilage" pptx
... comparison, the isotropic nature of the amide II component in the parallel sections of cartilage' s radial zone implies that the long axis of the fibrils in the radial zone of the cartilage is ... parallel to the long axis of the block; consequently, the regular and parallel sections of tendon have the fibrils running parallel in the plane of the sections The cross sections of the tendon, ... increment of the analyzer's angle in the 0° – 180° angular space For the analyzer angle 0°, the long axis of the collagen fibrils is parallel to the x-axis of the x-y moving stage of the Infrared...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25