... with waiver of written informed consent (# 09-953). Red bloodcell transfusion characteristicsPacked redbloodcell units were obtained from the blood bank (St. John’s Mercy Medical Center). None ... Meiselman HJ: Redbloodcell deformability insepsis. Am J Respir Crit Care Med 1998, 157:421-427.38. Hurd TC, Dasmahapatra KS, Rush BFJ, Machiedo GW: Redblood cell deformability in human and experimental ... treatment of severe sepsis and septicshock. N Engl J Med 2001, 345:1368-1377.36. Powell RJ, Machiedo GW, Rush BFJ: Decreased redblood cell deformability and impaired oxygen utilization during...
... transfusion.Epidemiology of anemiaandredblood cell transfusion in the ICU Anemia is common in ICU patients and appears early inthe ICU course [1]. In an observational, multicenter,cohort study in Scotland, 25% ... ofallogeneic redblood cells–a systematic review. Transfus Med 2003,13:275-285.86. Amin M, Fergusson D, Wilson K, Tinmouth A, Aziz A, Coyle D, Hebert P: Thesocietal unit cost of allogenic redblood cells ... Cohen H, Lilleyman J: Reducing adverse events in blood transfusion. Br J Haematol 2005, 131:8-12.doi:10.1186/2110-5820-1-43Cite this article as: Lelubre and Vincent: Redbloodcell transfusion inthe...
... to these results in human red cells, it is interesting to note that PC istotally absent in the red cells of sheep and is reduced markedly in camels, and inthe red cells of rats it is significantly ... and 1993) Cellular and molecular biology of redblood cell membrane proteins in health and dis-ease. Semin. Hematol. 29: 229À319, and 30:1À283.70 Lux, S. E., Palek, J. (1995) Disorders of red ... red cells from the biophysicalstandpoint. He published his renouned monograph of The Mammalian Red Cell and the Properties of Hemolytic Systems in 1934 and then in a revised form Hemolysisand...
... of red cells. Hence, a logical, time-honored classification of anemias comprises three groups: decreased production of red cells, increased destruction of red cells, and acute blood loss. Red ... of anemia in these two groups of patients are quite different, and they will be considered separately. Hemolytic Anemias Anemias due to increased destruction of red cells, or hemolytic anemias ... Red cell destruction and acute loss, both associated with increased reticulocyte production, are covered in this chapter. Redcell production defects are discussed in Chaps. 98, 99, and 100....
... corpuscular volume (MCV) in the blood count. On the blood smear this is reflected in the presence of macrocytes; there is also polychromasia and sometimes nucleated red cells. In most cases a bone ... level of 340 g/L, i.e., about 5 mM) goes hand in hand with the gradual loss of cellular organelles and of biosynthetic abilities. In the end the erythroid cell undergoes a process that has features ... sign is hemoglobinuria, often associated with hemosiderinuria and an Chapter 101. Hemolytic Anemias andAnemia Due to Acute Blood Loss (Part 2) Table 101-2 General Features of Hemolytic...
... HAs is an increased redcell turnover. The gold standard for proving that the life span of red cells is reduced (compared to the normal value of about 120 days) is a redcell survival study, ... sometimes referred to as aplastic crisis. Inherited Hemolytic Anemias There are three essential components in the red cell: (1) hemoglobin, (2) the membrane-cytoskeleton complex, and (3) the ... Chapter 101. Hemolytic Anemias andAnemia Due to Acute Blood Loss (Part 3) Figure 101-1 cause considerable iron loss, needing replacement....
... Hemolytic Anemias andAnemia Due to Acute Blood Loss (Part 5) Hemolytic Anemias Due to Abnormalities of the Membrane-Cytoskeleton Complex The detailed architecture of the redcell membrane ... dimer of α-spectrin and β-spectrin. The membrane is physically linked to the cytoskeleton by a third set of proteins (including ankyrin and the so-called band 4.1 and band 4.2), which thus ... toward both the outside and the inside of the cell. Other proteins are tethered to the membrane through a glycosylphosphatidylinositol (GPI) anchor, and they have only an extracellular domain. These...
... Hemolytic Anemias andAnemia Due to Acute Blood Loss (Part 6) Peripheral blood smear from patients with membrane-cytoskeleton abnormalities. A. Hereditary spherocytosis. B. Hereditary elliptocytosis, ... L Luzzatto, in J Gribben and D Pravan (eds): Molecular Hematology, 2d edition. Oxford, Blackwell, 2005; with permission.] Table 101-3 Inherited Diseases of the RedCell Membrane-Cytoskeleton ... forms. ANK1 8p11.2 Ankyrin HS (dominant) May account for majority of HS. SLC4A1 17q21 Band 3 (anion channel) HS (dominant) Mutations of this gene may account for ~25% of HS. ...
... Chapter 101. Hemolytic Anemias andAnemia Due to Acute Blood Loss (Part 7) Clinical Presentation and Diagnosis The spectrum of clinical severity of HS is ... one hand, as in many other HAs, the spleen itself is a major site of destruction; on the other hand, transit through the splenic circulation makes the defective red cells more spherocytic and ... structure of the redcell is abnormal. Instead, when one of the enzymes is defective, the consequences will depend on the precise role of that enzyme in the metabolic machinery of the red cell, which,...
... apoptosis and may have implications on the pathophysiology and diagnosis of various diseases involving redblood cells. Key words: redblood cell, gene expression analysis Introduction Human erythrocytes ... human redblood cells Sveta Kabanova1 *, Petra Kleinbongard1 *, Jens Volkmer1, Birgit Andrée2, Malte Kelm1, Thomas W. Jax1,3,4 1. Department of Medicine, Division of Cardiology and ... regulation, and metabolism 1. It was shown, that both the rate and extent of transcription in mature erythrocyte nuclei from chicken 3 and newt 4 were much reduced as compared to reticulocytes...