reciprocal regulation of endothelin 1 and nitric oxide relevance in the physiology and pathology of the cardiovascular system
Báo cáo khoa học: "Immunohistochemical study of constitutive neuronal and inducible nitric oxide synthase in the central nervous system of goat with natural listeriosis" potx
... nNOS and iNOS in neurons increased when bacterial encephalitis occurred This is the first study of NOS expression in the goat brain with listeriosis The involvement of iNOS in bovine and caprine ... encephalomyelitis J Vet Sci., 2000, 1, 11 -17 11 Moncada, S., Palmer, R.M.J and Higgs, E.A Nitric oxide: physiology, pathophysiology, and pharmacology Pharmacol Rev., 19 91, 43, 10 9 -13 4 12 Murphy, S., Simmons, ... Wu, J., Lin, Q., Lu, Y., Willis, W.D and Westlund, K.N Changes in nitric oxide synthase isoforms in the spinal cord of rat following induction of chronic arthritis Exp Brain Res 19 98, 11 8, 457-465...
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Báo cáo y học: " HIV-1 Accessory Protein Vpr: Relevance in the pathogenesis of HIV and potential for therapeutic interventio" ppsx
... negative Page 18 of 20 14 6 14 7 14 8 14 9 15 0 15 1 15 2 15 3 15 4 15 5 15 6 15 7 15 8 15 9 16 0 16 1 16 2 16 3 16 4 16 5 regulator of apoptosis in a human lymphoblastoid T cell line: possible implications for the pathogenesis ... overshadowing Vpr? Retrovirology 2 010 , 7:35 13 1 Casey L, Wen X, de Noronha CM: The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase Cytokine 2 010 , 51: 1-9 ... 272:2 213 4-2 213 9 36 Gorlich D, Henklein P, Laskey RA, Hartmann E: A 41 amino acid motif in importin-alpha confers binding to importin-beta and hence transit into the nucleus Embo J 19 96, 15 :18 10 -18 17...
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The role of hydrogen sulphide in the cardiovascular system emphasis on haemorrhagic shock
... Mechanisms of action of H2S .27 1. 2.5 H2S and the cardiovascular system 28 1. 2.6 H2S and inflammation 32 1. 2.7 H2S and the nervous system 35 1. 2.8 H2S and the gastrointestinal ... and aminoguanidine on MAP and HR in haemorrhagic shock 11 1 5.2.6 Effect of PAG on organ damage & inflammation in haemorrhagic shock 11 1 5.3 Discussion 11 6 5.3 .1 H2S formation in haemorrhagic ... .11 6 5.3.2 Use of CSE inhibitors in haemorrhagic shock 11 7 5.3.3 H2S and nitric oxide in haemorrhagic shock .11 8 5.3.4 Use of glibenclamide in haemorrhagic shock 11 9 5.3.5...
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Role of hydrogen sulfide in the cardiovascular system implications for treatment of cardiovascular diseases
... hypertension 15 0 The mechanism for the anti-hypertensive effects involve inhibition of the renin-angiotensin system (RAS) 15 1, attenuation of vascular remodeling 15 2 and activation of KATP channels 18 1. 4 ... -Preservation of endothelial function 13 2 2 011 12 4 2 011 11 2 2 011 Table 1. 3 H2S effects against various heart failure models (Source: Self-drawn) 1. 3.3 Effect of H2S on blood vessels The effect of H2S ... on intact cells in the LV sections Figure 5 .1 Triple-staining of mast cells, renin and cell nucleus in human mast cells (HMC -1. 1) Figure 5.2 Forskolin stimulated renin release from HMC- 1. 1 into...
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Báo cáo y học: "Gender-based reciprocal expression of transforming growth factor-β1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis" ppsx
... reflect the state of the acrolein-injured bladder Given the interplay of regulatory influences operating in the production of NO, TGF- 1 and other pro-inflammatory cytokines in bladder inflammation, ... TGF- 1 in the urine of both males and females (with the possible exception of the 10 -h time point in untreated male rats), suggesting that there is an elevation in the expression of total TGF- 1 and ... by NIH grant NIDDK RO1-DK 06 613 8 and NIDRR grant H133E070024 References 10 11 12 13 14 15 Competing interests The authors declare that they have no competing interests 16 17 Hu RQ, Mehter H, Nadasdy...
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Báo cáo y học: " The anti-inflammatory effects of the tellurium redox modulating compound, AS101, are associated with regulation of NFB signaling pathway and nitric oxide induction in macrophages" doc
... inhibition of two steps in the NFB pathway by modifying specific cysteine residues in IKKa and in the p50-subunit resulting in the inhibition of nuclear translocation and DNA-binding to the iNOS promoter ... evidence, and given the inhibitory effect of AS1 01 on NFkB activation at h, the lack of modulation of the NFkB pathway by AS1 01 at h, concomitantly with the inhibition of iNOS at that time point, ... AS1 01 We show that AS1 01 is an effective inhibitor of LPS-stimulated iNOS expression and NO secretion in RAW264.7 macrophages The mechanism by which AS1 01 inhibits the expression of these inflammatory...
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Báo cáo khoa học: Transport of L-arginine and nitric oxide formation in human platelets pdf
... transport of the cationic amino acids lysine, arginine and ornithine at the basolateral membrane of the polar epithelial cells in the intestine and renal tubules LPI is caused by mutations in the SLC7A7 ... cationic amino acids are present on the trans-side of the membrane Moreover system y+L is inhibited by L-leucine in the presence, but not in the absence of Na+ The small inhibition of L-arginine in ux ... neutral amino acid transport [16 ], several experiments in the absence of Na+ were performed L-Leucine was ineffective on + L-arginine in ux in the absence of Na , confirming the presence of the system...
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Báo cáo khoa học: Nitric oxide formation from the reaction of nitrite with carp and rabbit hemoglobin at intermediate oxygen saturations pdf
... 80 10 0 12 0 14 0 16 0 18 0 60 80 10 0 12 0 14 0 16 0 18 0 SO2 = 65% 14 0 12 0 12 0 10 0 10 0 80 80 60 60 40 40 20 20 0 20 40 60 80 10 0 12 0 14 0 F 16 0 SO2 = 78% 14 0 16 0 18 0 20 G 16 0 40 16 0 14 0 14 0 SO2 = 10 0% ... 80 10 0 12 0 16 0 18 0 16 0 18 0 16 0 14 0 SO2 = 10 0% 12 0 12 0 [ATP]/[Hb] = 10 0 10 0 80 80 60 60 40 40 20 20 14 0 Concentration (àM) 14 0 oxyHb metHb HbNO deoxyHb 0 20 40 60 80 10 0 Time (min) 12 0 14 0 16 0 18 0 ... (min) 20 40 60 80 10 0 12 0 14 0 16 0 Time (min) Fig Time-dependent changes in the concentrations of oxygenated hemoglobin, methemoglobin, nitrosylhemoglobin and deoxygenated hemoglobin during the...
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Báo cáo khoa học: "Enhanced expression of constitutive and inducible forms of nitric oxide synthase in autoimmune encephalomyelitis" pdf
... [40] In conclusion, our results showed that the three isoforms of NOS including nNOS, eNOS, and iNOS were increased in the initiation of EAE and suggested that the brain cells including neurons and ... B and C, 13 2 A: TUNEL and hematoxylin, B: TUNEL and either rabbit anti-GFAP, C: TUNEL and rabbit and ED1 Immunohistochemical localization of nNOS, eNOS, and iNOS in EAE In the spinal cords of ... anti-nitrotyrosine (1 : 10 0 in dilution, Upstate Biotechnology Inc., NY) The finding of nitrotyrosine (NT) indicates the generation of peroxynitrite and the potential damage of proteins by nitration...
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Báo cáo y học: "Ex vivo effects of flavonoids extracted from Artemisia herba alba on cytokines and nitric oxide production in Algerian patients with Adamantiades-Behcet''''s disease" pptx
... that the overexpression of either inducible NO and proinflammatory cytokines might be intimately involved in the pathogenesis and the evolution of ABD [12 , 42] An increase in the concentration of ... strong inhibition on Th1-mediated inflammatory processes involving the regulation of the synthesis of inflammatory cytokines (IL-2 TNF-, IL -1) and chemokines (CXCL8, CXCL10, CCL2) The effect of flavonoùds ... vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production Eur J Pharmacol 2002, 446 :18 719 4 19 Vernin G,...
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Báo cáo y học: "Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration: a prospective, controlled animal experiment" docx
... cytotoxicity, and induction of vascular and epithelial hyperpermeability [17 ,18 ] The expression of eNOS may be induced by calcium-dependent binding of calmodulin via proinflammatory cytokines or by serine ... Akt, and inhibition of the PI3-K and Akt pathway or mutation of the Akt site on eNOS protein (at serine 1, 177) attenuated the serine phosphorylation and prevented the activation of eNOS [19 ] We ... blocked in Akt mutant mice (Figures and 5) Findings in other studies support our findings that neutrophil infiltration and the development of acute lung injury involve the PI3-K and Akt pathway in...
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Báo cáo y học: "Involvement of nitric oxide (NO) in cough reflex sensitivity between non-sensitized and OVA-sensitized guinea pigs" pptx
... 0.8 16 .8 ± 5.6 ONO1 714 : 0 .1 mg/kg 1. 09 ± 0 .12 74.5 ± 4.3 6.2 ± 1. 5 1. 4 ± 0.4 17 .9 ± 4.7 ONO1 714 : 0.3 mg/kg 0.88 ± 0.09 76.0 ± 2 .1 5.3 ± 3.3 1. 5 ± 0.5 17 .7 ± 1. 6 Control 2.63 ± 0.26 24 .1 ± 3 .1 2.5 ... effect of ONO1 714 on the coughs induced by the 10 -4 M aerosolized capsaicin solution in non-sensitized and OVA-sensitized guinea pigs In non sensitized guinea pigs, the number of coughs was not influenced ... guinea pigs were divided into three groups: control (normal saline) group and groups receiving the selective iNOS inhibitor ONO1 714 at doses of 0 .1 and 0.3 mg/kg (n = for each group) ONO1 714 (1S,5R,6R,7R)-7-chloro-3-imino-5methyl-2-azabicyclo...
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Báo cáo y học: " A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus" pptx
... of cDNA Bandsa cDNA Density WT 65R+74V 65R+74I p-values 1- 6 11 53 ± 10 3.0 11 25 ± 79.0 11 52 ± 10 2.0 0.38b, 0.49c 7 -12 13 75 ± 80.5 12 82 ± 82.5 13 32 ± 72.5 0.237d 13 -18 15 45 ± 10 0.0 13 09 ± 89.0 15 49 ... 0. 016 d 19 -24 15 92 ± 94.5 12 02 ± 10 2.5 14 97 ± 70.5 0.007d 25-30 31- 36 15 21 ± 76.5 14 83 ± 76.5 10 59 ± 10 9.0 854 ± 74.0 13 21 ± 56.5 10 18 ± 68.5 0. 010 d 0.023d 37-42 14 10 ± 46.0 655 ± 65.0 789 ± 10 9.5 ... Lys65 and Arg72, main-chain-NH groups of residues 11 3 and 11 4 along with two Mg+ ions are involved in coordinating the incoming triphosphate In the process, Arg72 donates hydrogen bonds to the...
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Báo cáo y học: " Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease" ppsx
... 31. 10 .19 89 m 216 6 1, 5 0,52 03 .11 .19 89 05.04 .19 87 m m 10 0 2 617 213 5 25 35 1, 4 1, 6 0, 71 0, 71 06 .10 .19 84 f 93 983 75 34 0,83 24 .10 .19 88 Respiratory Research 2009, 10 :11 0 17 .10 .19 80 f 83 214 3 35 14 ... 0,27 27.02 .19 91 f 3,4 0,29 25 .11 .19 88 17 . 01. 1985 f f 80 18 55 2059 25 30 2,8 1, 5 0,30 0,32 14 .06 .19 88 f 75 2222 25 14 2 ,1 0,32 09.03 .19 84 f 12 85 1, 9 0,33 25.05 .19 90 m 2536 0, 71 0,40 11 78 14 25 Diagnosis ... Qp:Qs Rp:Rs 26 .12 .19 90 f 75 24 17 7,2 0, 01 28.03 .19 91 20. 01. 1985 f m 424 388 0,08 0 ,10 20.03 .19 84 20 .10 .19 87 m f 16 0 968 1, 6 3,9 0 ,11 0 ,15 m 83 294 60 11 2,9 0,24 12 .08 .19 88 f 10 0 2400 30 22...
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Báo cáo y học: "Atrial natriuretic peptide infusion and nitric oxide inhalation in patients with acute respiratory distress syndrome" ppt
... concentration of ANP, but only a modest increase in the arterial concentration during the infusion of ANP Since ANP was infused on the venous side of the circulation, these findings suggest that most of the ... difference between the occurrence of the first particle and all the following particles The product of CO and MTT is the volume between the site of injection and the site of detection The DST can be ... 1. 7 17 .1 ± 1. 6 19 .8 ± 3.0 14 .5 ± 0.9 0 .14 NS 0 .15 PaO2/FiO2 (kPa) A–a gradient (kPa) Qs/Qt (%) 17 .7 ± 1. 4 41. 9 ± 3.9 35.7 ± 2.0 19 .7 ± 1. 1 40.4 ± 3.6 32.8 ± 2.7 0.07 < 0.05 0 .11 NS, P > 0.2 The...
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Báo cáo y học: " Proinflammatory role of inducible nitric oxide synthase in acute hyperoxic lung injury" pot
... L-arginine by two main isoforms of the NO synthase: the constitutive and the inducible isoform [20] The NOS enzymes are complex homodimeric proteins consisting of a N-terminal oxygenase domain, ... capable of inducing nitration of tyrosine in proteins, for example the reaction of myeloperoxidase with hydrogen peroxide Therefore, increased nitrotyrosine staining is considered as an indicator of ... cytological and biochemical analyses, and writing and preparation of the manuscript MD and FK participated in the direction of the study as well as in writing and preparation of the manuscript...
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Role of nitric oxide in wound healing facilitatory effects of nitrosoglutathione a nitric oxide donor on the extracellular matrix deposition characteristics of wound healing
... 1. 1 .1. 3 Biological agents 1. 1 .1. 3 .1 Growth factors 1. 1 .1. 3.2 Enzymes 1. 1 .1. 3.3 Gene therapy 1. 1 .1. 3.4 Miscellaneous 1. 1.2 Pitfalls in Current Wound Management i Contents 1. 2 Page 1. 2 .1 Rate of ... Abbreviations used in text xix Summary xxi Introduction 1. 0 The problem statement 1. 1 Current concepts in wound management 1. 1 .1 Therapeutic agents in wound healing 1. 1 .1. 1 Dressings 1. 1 .1. 2 Pharmacological ... contraction 1. 2.2 Collagen content 1. 2.3 Biomechanical strength Physiology of wound healing 10 1. 3 .1 Phases of wound healing 1. 3 Quantitative indicators of wound healing 11 1. 3 .1. 1 Coagulation and Inflammation...
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Environmental Injustice and Human Rights Abuse: The States, MNCs, and Repression of Minority Groups in the World System pptx
... 213 ,620 1 0 1 0 0 0 0 0 0 0 0 0 0 13 0 28 0 1 0 0 0 20 31 13 0 0 1 0 31 24 0 0 0 0 0 0 15 14 0 0 0 0 0 0 11 0 1 0 2 0 0 15 10 9 32 37 2 24 4 2 0 98 19 4 TOTALS 248,0 41 22 11 94 84 44 14 14 4 413 ... Philippines 94 Saint Lucia 98 Senegal 10 2 Solomon Islands 10 6 Sudan 11 0 Thailand 11 4 Turkey 11 8 Uruguay 12 2 Zaire Human Ecology Review, Vol 8, No 1, 20 01 Angola Bahrain 11 Benin 15 Brazil 19 Cambodia ... (Per capita) 19 80 19 96 19 80 19 96 U.S U.S U.S U.S U.S./U.K U.S U.S 10 7.5 7.6 n.a 18 3.4 39.8 2.5 6.4 12 9.9 23.0 n.a 273.4 65.3 4.7 12 .9 3.8 0 .1 n.a 1. 5 1. 4 1. 1 1. 1 3.7 0.2 1. 9 1. 7 1. 7 1. 4 1. 6 U.S U.S...
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