receptor interactions of parathyroid hormone and parathyroid hormone related protein
Báo cáo y học: "Differential expression of copper-associated and oxidative stress related proteins in a new variant of copper toxicosis in Doberman pinscher" potx
... Quantitative Real-Time PCR of apoptosis and cell proliferation related genes Quantitative Real-Time PCR of apoptosis and cell proliferation related genes mRNA levels of non-copper associated subclinical ... Healthy controls Protein precision marker 10 kDa Figure Western blot analysis of the metallothionein proteins Western blot analysis of the metallothionein proteins Immunoreactive bands of total metallothionein ... The Netherlands) Q-PCR of oxidative-stress proteins, copper metabolism and other related signaling molecules Q-PCR was performed on a total of 17 genes involved in oxidative stress and copper...
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Báo cáo y học: " Expression of parathyroid hormone-related protein during immortalization of human peripheral blood mononuclear cells by HTLV-1: Implications for transformation" pps
... necrosis factor β, parathyroid hormone- related protein (PTHrP), macrophage inflammatory protein- 1α (MIP-1α) and receptor activator of nuclear factor-κB ligand (RANKL) that directly and/ or indirectly ... Silvestrini A, et al.: Human parathyroid hormone- related protein and human parathyroid hormone receptor type are expressed in human medulloblastomas and regulate cell proliferation and apoptosis in medulloblastoma-derived ... interleukin-1 and parathyroid hormonerelated protein production on adult T-cell leukemia cells in vitro Blood 1995, 86:2257-2267 Dunbar ME, Wysolmerski JJ, Broadus AE: Parathyroid hormonerelated protein: ...
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Interactions of Chemical Variations and Biocide Performance at Paper Machines potx
... errors in demanding biocide dosing 15 THE OBJECTIVE AND THE OUTLINE OF THE STUDY The objective of this work was to study the interactions of microbial activity, biocide usage and - creation and chemical ... the DLVO (Derjaguin and Landau, Verwey and Overbeek) theory (Derjaguin and Landau 1941; Verwey and Overbeek 1948) The theory explains how particles in aqueous system interact and how different ... of the system and further the flocculation and coagulation Figure illustrates how different forces attract and repulse the particles, what is the effect of salt concentration, and what kind of...
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Design for aesthetics: interactions of design variables and aesthetic properties pdf
... reference (frontal, profile, median) comparative size and spacing of features • degree of symmetry of arrangements of objects about centre of mass, major axes and planes of references of the whole product ... dimension of one object (or feature) and that of another A number of standard good proportion exist (e.g the golden section) Areal and volumetric refers to similar relations in the areas and volumes of ... coverage and variations of • complementary and opponent colours • different luminance intensity, hue, or saturation degree of asymmetry about centre of mass, major axes, and planes of reference...
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interactions of yeasts, moulds, and antifungal agents how to detect resistance
... including candidal esophagitis and hepatosplenic candidiasis; for severe candidiasis including candidemia, endophthalmitis, and osteomyelitis; and for treatment of aspergillosis, cryptococcosis, and ... drugs for treatment of chromoblastomycosis 1.2.4 Spectrum of Activity The spectrum of activity of 5-FC includes most species of Candida (except for C krusei) and C neoformans and Saccharomyces ... is little use of miconazole outside of treatment of dermatophyte infections, cutaneous Candida infections, and tinea versicolor With the advent of new azoles and echinocandins that offer more broad-spectrum...
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The study of interactions of transmembrane receptors and intracellular signaling proteins in live cells by fluorescence correlation and cross correlation spectroscopy
... characteristics of FPs and fusion FPs Chapters and focus on the interactions between ErbB receptors Chapter describes the study of the interactions between ErbB receptors before ligand stimulation ... properties of EGFP in CHO cells 64 Fig 4.2 Image and ACFs of PMT-EGFP expressed in CHO cells 67 Fig 4.3 Image and ACFs of EGFR-EGFP expressed in CHO cells 69 Fig 4.4 Images and ACFs of EYFP, mRFP and ... numerous proteins that bind to a protein of interest, and result in the availability of the cloned genes encoding identified binding proteins The major limitation of Y2H is that target proteins...
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In vivo aspects of potential stereospecific drug interactions of oral warfarin and rutin in rats
... for the constant support and encouraging ii words of Assoc Prof Go Mei Lin, Assoc Prof Paul Ho, Assoc Prof Chan Sui Yung, Assoc Prof Lim Lee Yong, Assoc Prof Chan Lai Wah and Dr Shanthi I want to ... and activation of a number of structurally unrelated compounds (56) It is responsible for numerous drug interactions and is inducible by a number of structurally unrelated drugs and xenobiotics ... metabolites of warfarin not appear to contribute to the activity of the drug But metabolite estimation helps in understanding the source of variation and mechanism of interaction of drugs with...
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Tài liệu Báo cáo khoa học: Glycation of low-density lipoprotein results in the time-dependent accumulation of cholesteryl esters and apolipoprotein B-100 protein in primary human monocyte-derived macrophages docx
... consists of two related processes ) oxidation of protein- bound sugars (from glycation), and oxidation of free glucose and its products Both processes can generate radicals that modify LDL, and hence ... The time course of cellular uptake of LDL-derived lipid and protein has been characterized, as well as the subsequent turnover of the apoB protein It is shown that both lipid and protein are taken ... manner, via scavenger receptor SR-A- and CD36-mediated processes, and that the uptake of lipid and protein occurs in synchrony Furthermore, it is shown that both lipid and modified protein accumulate...
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báo cáo hóa học: " The possible link between the elevated serum levels of neurokinin A and anti-ribosomal P protein antibodies in children with autism" pot
... living cells and starting apoptosis, a defect in the synthesis of apolipoprotein B resulting in accumulation of lipids inside the cell, and downregulation of the total protein synthesis P proteins ... levels of neurokinin A and CARS in autistic patients, P < 0.001 This may indicate that the extent of the elevation of serum neurokinin A was closely linked to the degree of the severity of autism ... levels of neurokinin A and anti-ribosomal P protein antibodies were found in 57.1% and 44.3%, respectively of autistic children There was significant positive correlations between serum levels of...
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Báo cáo y học: "Canakinumab relieves symptoms of acute flares and improves health-related quality of life in patients with difficult-to-treat Gouty Arthritis by suppressing inflammation: results of a randomized, dose-ranging study" ppt
... role-physical score of 35.0 and PCS value of 34.2 for a population with a Page 10 of 13 mean age of 59 years and experiencing 0.6 flares per month [18], while Strand et al reported reductions of 30 to 32 ... PS, DR, VM and UA, and data were gathered and analyzed by Novartis All authors vouch for the accuracy of the data and the analysis, and contributed to the interpretation of the data and were involved ... impact on acute Gouty Arthritis and the risk of recurrent flares, but also because of the possible role of elevated CRP and SAA levels and IL-1b in the development of cardiovascular disease [52-54]...
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Báo cáo y học: " Alterations in the expression of DEAD-box and other RNA binding proteins during HIV-1 replication" potx
... Further study of the interactions of EIF4G1, CBP80 and EIF4A1 may thus be important in elucidating Rev function and viral RNA export, as well as the synthesis of viral proteins While some of the differentially ... expression profiles of genes encoding DDX18 and DDX39, which were up regulated during viral latency and during latency and early lytic replication Panel D shows the expression profile of genes encoding ... initiation and may also be involved in mediating nuclear export of RNA In addition, genes encoding other proteins involved in nucleic acidprotein interactions were also upregulated, such as members of...
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Báo cáo khoa học: Interactions of ultraspiracle with ecdysone receptor in the transduction of ecdysone- and juvenile hormone-signaling pdf
... ultraspiracle and ecdysone receptor in hormone signaling Fig Effect of treatment with hormones, and of receptor expression, on activation of the DR1JHECore reporter promoter (A) Activation of the DR1JHECore ... a single protein DR1 1579 Interaction of ultraspiracle and ecdysone receptor in hormone signaling A B C F Fang et al D Fig Binding of ultraspiracle (USP) to DR1 motif and to ecdysone receptor ... Interaction of ultraspiracle and ecdysone receptor in hormone signaling Nuclear hormone receptors play key roles in metazoan development, metabolic homeostasis, and response to xenobiotics Some of these...
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Báo cáo khoa học: Proper targeting and activity of a nonfunctioning thyroid-stimulating hormone receptor (TSHr) combining an inactivating and activating TSHr mutation in one receptor pptx
... corresponds to the major unliganded form of the receptor; the active conformation capable of promoting GDP/GTP exchange on the G -protein is achieved by a fraction of the unliganded receptors only, but ... 5-isothiocyanate and PI Fluorescence emission of fluorescin 5-isothiocyanate and PI from single cells were separated and measured using the standard optics of the FACSort The CELLQUEST software program ... the I486M and 33-fold for the P639S The combination of the two activating TSHr mutations produced a receptor which Ó FEBS 2003 Fig RSCA of single and double mutant receptors for cAMP (A) and IP...
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Báo cáo khoa học: Thyroid hormone induces the expression of 4-1BB and activation of caspases in a thyroid hormone receptor-dependent manner pptx
... assay One thousand cells of HeLaTR and FRTL were cultured in 100 lL of the medium in the presence or absence of T3 and Z-VAD-FMK at 37 °C for 48 h At the end of the culture, 20 lL of CellTiter ... T3, but that of PSG7 is modulated during both early and late responses We also examined the expression of TRAF1 and TRAF2 because they interact and regulate the function of the 4-1BB proteins to ... involvement of 4-1BB-L in the activation of caspases by T3 The biological significance of the modulation of PSG7, fmfc and BMP-6 expression by T3 also awaits additional studies Up-regulation of 4-1BB and...
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CHEMICAL AND BIOLOGICAL CHARACTERIZATION OF TRACE AMOUNT OF SEX HORMONE RECEPTOR ACTIVE COMPOUNDS IN PROSTATE CANCER RELATED BIOLOGICAL SAMPLES
... Development and Validation for Simultaneous Detection and Quantitation of A4, T and DHT 40-41 2.1.1 Materials 2.1.2 Experimental 2.1.2.1 Preparation and Extraction of Calibration Standards and Quality ... Development and Validation Simultaneous Detection and Quantitation of E1 and E2 for 77-78 3.1.1 Materials 3.1.2 Experimental 3.1.2.1 Preparation and Extraction of Calibration Standards and Quality ... 110-111 4.2.1.4.2 Denaturation of Proteins and Sample Loading 4.2.1.4.3 Transfer of Bands from Gel to Membrane and Addition of AKR1C3 Antibody 4.2.1.4.4 Addition of Secondary Antibody for AKR1C3...
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Báo cáo khoa học: Regulation of luteinizing hormone receptor mRNA expression by mevalonate kinase – role of the catalytic center in mRNA recognition potx
... 293T cells and RNA electrophoretic mobility shift analysis was performed with 10 lg of cytosolic S100 protein and [32P]-labeled LHR mRNA binding protein site (LBS) in the presence of ATP and mevalonate ... 9A, the active site of the enzyme is located at the interface of the N- and C-terminal domains of the monomer The adenosine base of ATP is bound at the base of the left-handed b–a–b fold, where ... using 0.6 M Bq of [35S]methionine in the presence of 10 lg of S100 protein from 293T cells transfected with wild-type MVK (wtmvk) and all the single (A) and double (B) mutants of rat MVK All...
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Báo cáo khoa học: Molecular characterization of gonad-inhibiting hormone of Penaeus monodon and elucidation of its inhibitory role in vitellogenin expression by RNA interference pptx
... the left and right of the sequences show the coordinate of nucleotides and amino acids in corresponding lines The full-length cDNA encoding the putative GIH of P monodon was composed of 861 nucleotides ... color, and light gray depicts the conservative changes The percent identity of the pro- and mature sequences between Pem-GIH and other hormones was shown on the right to the C-terminus of the ... min, and allowed to cool to room temperature The remaining DNA template and singlestranded RNA in solution were digested with DNaseI and RNaseA at 37 °C for h The proteins, free nucleotides and...
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Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx
... manner of EGF binding On the other hand, chimeras 4111-1 and 4411-1, generated by the replacement of domain I and of domains I and II, respectively, of ErbB-1 by the corresponding domain(s) of ErbB-4, ... ErbB-1 and EGF, using a heterobifunctional reagent, showed that the N- and C-terminal parts of the ligand are cross-linked to domains I and III, respectively, of the receptor [19,22] The b sheet of ... cognate–ligand interaction of ErbB-1 Nevertheless, the 125I-labeled EGF bindings of 4111-1 and 4411-1 were appreciably smaller than those of 1111-1, 1111-4, and 1114-4, indicating that domain I of ErbB-1...
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Báo cáo Y học: Effect of coenzymes and thyroid hormones on the dual activities of Xenopus cytosolic thyroid-hormone-binding protein (xCTBP) with aldehyde dehydrogenase activity potx
... linear with time and protein Determination of NAD content The content of NAD (the sum of its reduced and oxidized forms) in Xenopus tissues was determined according to the method of Nisselbaum & ... microgram quantities of protein utilizing the principle of protein- dye binding Anal Biochem 72, 248–254 24 Scatchard, G (1949) The attractions of proteins for small molecules and ions Ann NY Acad ... the presence of NAD+ [29] We therefore examined the effects of the substrate (retinal), product (retinoic acid), coenzymes (NAD+ and NADH), related dinucleotides (NADP+ and NADPH) and a typical...
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Báo cáo y học: "Diurnal secretion of growth hormone, cortisol, and dehydroepiandrosterone in pre- and perimenopausal women with active rheumatoid arthritis: a pilot case-control study" ppt
... Board of the National Institute of Diabetes and Digestive and Kidney Diseases and the National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health (NIH), and ... Sensitivity and intra- and interassay coefficients of variation (CVs) of the GH assay were 0.1 ng/ml and 2.8% and 7.5%, respectively Corresponding values for the cortisol assay were 0.9 µg/dl and 4.4% and ... independent of the use of exogenous glucocorticoids Most reports indicate that circulating levels of cortisol and dehydroepiandrosterone (DHEA) are normal, and not elevated, in the setting of increased...
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