reactions to drug delivery systems
Drug Delivery Systems
Ngày tải lên :
25/10/2013, 08:20
... for Drug Delivery Systems Drug delivery systems modify the kinetics or the location of the escape of the drug from the medicine Tables 15.1 and 15.2 provide generic reasons for using drug delivery ... to use nanotechnology and biological mimicry to create drug delivery systems that penetrate into 15.6 Examples of Biodegradable Polymer Drug Delivery Systems Under Development articular cartilage ... numerous types of protein drug [21–23] 15.6 Examples of Biodegradable Polymer Drug Delivery Systems Under Development 15.6.1 Polyketals Polyketal-based drug delivery systems are under development...
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Chemical Aspects of Drug Delivery Systems pptx
Ngày tải lên :
28/03/2014, 10:20
... salt, to more complex drug delivery systems involving enzymatic breakdown of a formulation component or particle coating to effect drug release', to the delivery of drugs containing liposomes to ... stability Chemical Aspects of Drug Delivery Systems Table Routes of administration and general classification of drug delivery systems ROUTES OF ADMINISTRATION DRUG DELIVERY CLASS ORAL SOLIDS (e.g ... sites has led to the development of alternative drug delivery systems, which attempt to address the requirements of rate and extent of drug release, and thereby absorption Delivery systems include...
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THE CHEMISTRY OF DRUG DELIVERY SYSTEMS (hoá học các hệ dẫn truyền thuốc)
Ngày tải lên :
18/04/2014, 15:37
... Liposomes as drug delivery systems Polymers and polymeric systems for drug delivery Dendrimers for drug delivery GENERALITIES OF DRUG DELIVERY DRUG DELIVERY SYSTEM Definition: A drug delivery system ... Topical (local) drug delivery systems: drugs are delivered locally to the target organ/tissue without entering the systemic circulation Systemic drug delivery systems: drugs are delivered to ... Targeted drug delivery systems: deliver drug to a desired body location, organ, tissue, specific cells… Controlled-release drug delivery systems: preprogramed drug release By the route of delivery: ...
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nanoparticulate drug delivery systems, 2007, p.382
Ngày tải lên :
04/06/2014, 14:47
... define drug- delivery systems of a certain size range Reflecting this trend of size definition, Nanoparticulate Drug Delivery Systems is a worthy attempt to bring together a wide range of drug- delivery ... finding a place in drug discovery as well as NPDDS (27–31) DRUG- DELIVERY SYSTEMS An ideal drug- delivery system possesses two elements: the ability to target and to control the drug release Targeting ... Christopher T Rhodes 41 Specialized Drug Delivery Systems: Manufacturing and Production Technology, edited by Praveen Tyle 42 Topical Drug Delivery Formulations, edited by David W Osborne and Anton...
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Báo cáo hóa học: " Nanotechnology-based drug delivery systems" pdf
Ngày tải lên :
20/06/2014, 00:20
... binds to the cytoplasmic receptors and the subsequent drug- receptor complex is transported to the nucleus resulting in the expression of certain genes that control cell proliferation [14] These drug- loaded ... Nanoparticles can be used in targeted drug delivery at the site of disease to improve the uptake of poorly soluble drugs [8,9], the targeting of drugs to a specific site, and drug bioavailability A schematic ... attributed to their small size, reduced drug toxicity, controlled time release of the drug and modification of drug pharmacokinetics and biological distribution Too often, chemotherapy fails to cure...
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Báo cáo hóa học: " The application of carbon nanotubes in target drug delivery systems for cancer therapies" docx
Ngày tải lên :
20/06/2014, 22:20
... Raman and photoluminescence, afford additional advantages for tracking and real-time monitoring of drug delivery efficacy in vivo Intracellular drug delivery To study the cellular drug delivery, ... molecular transporter in drug delivery Page 14 of 22 Drug delivery targeted to lymphatic system Many cancers metastasize through lymphatic canal The drug delivery systems targeted to the lymphatic system ... the lymphatic system Drug delivery targeted to tumor To deliver anticancer drugs into cancer focus is the prerequisite for the drugs to develop their effects However, some drugs cannot arrive...
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Ophthalmic Drug Delivery Systems - part 1 pptx
Ngày tải lên :
10/08/2014, 00:20
... Christopher T Rhodes Specialized Drug Delivery Systems Manufacturing and Production Technology, edited by Praveen Tyle Topical Drug Delivery Formulations, edited by David W Osborne and Anton H ... from simple solutions to novel delivery systems such as biodegradable polymeric systems, corneal collagen shields, iontophoresis, and viral and nonviral gene delivery systems, to name a few An increase ... new medications to be used effectively, and for those now available to provide maximal benefit, improvements in ocular drug delivery are essential Drug delivery is no less vital than drug discovery...
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Ophthalmic Drug Delivery Systems - part 2 pdf
Ngày tải lên :
10/08/2014, 00:20
... local drug delivery to the eye generally provides direct access to the site of action and, in most cases, substantially reduces systemic exposure and toxicity, systemic administration of drugs to ... of the intraocularly absorbed drug was due to local topical application and not to redistribution from plasma The mechanism by which drugs may be locally delivered to the posterior segment from ... aqueous to between 20 and 60 minutes for most drugs (8) Due to rapid loss of drug from the precorneal region, less than 10%, and more typically less than 1– 2%, of a topical dose is absorbed into...
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Ophthalmic Drug Delivery Systems - part 4 doc
Ngày tải lên :
10/08/2014, 00:20
... compounds added to the perfusate diffuse out into the tissue Therefore, the technique can be used not only to monitor the extracellular concentrations of the analyte, but also to deliver drugs to a specific ... 1993 10 Ohtori, A., and Tojo, K In vivo/in vitro correlation of intravitreal delivery of drugs with the help of computer simulation Biol Pharm Bull 17:283–290, 1994 11 Tojo, K., and Ohtori, A Pharmacokinetic ... important to consider if toxicity to the retina and other tissues is to be avoided The mean calculated vitreous concentration 24 hours after an intravitreal injection varied by up to a factor of...
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Ophthalmic Drug Delivery Systems - part 5 doc
Ngày tải lên :
10/08/2014, 00:20
... inhibitor to chitosan is another strategy to improve drug delivery (62,63) However, due to the limited amounts of enzymes in the precorneal area, this strategy may not be beneficial in ocular drug delivery ... and evaluation of ocular drug delivery systems II OCULAR ANATOMY AND PHYSIOLOGY RELEVANT TO THE NONCORNEAL ROUTE The ocular anatomy and physiology relevant to ocular drug delivery was reviewed by ... for rational design of drug delivery systems for therapeutic agents that are poorly absorbed across the cornea or require delivery to posterior segment of the eye Drug delivery across the conjunctiva...
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Ophthalmic Drug Delivery Systems - part 6 docx
Ngày tải lên :
10/08/2014, 00:20
... contribute significantly to drug penetration into intraocular tissues for some drugs Second, drug entering the eye via the cornea enters the aqueous humor and provides high drug levels to the anterior ... to the practical design of drugs and drug delivery systems for ocular therapy Noncorneal delivery is not a panacea and will probably have niche utility in ocular drug delivery The greatest potential ... segment of the eye Iontophoretic delivery of anti-inflammatory drugs into the eye has been examined in human and various animal models and offers a viable alternative to topical or systemic administration...
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Ophthalmic Drug Delivery Systems - part 8 docx
Ngày tải lên :
10/08/2014, 00:20
... OCULAR DELIVERY OF PEPTIDE AND PROTEIN DRUGS Peptides and proteins may be instilled into the eye for local/topical use Instillation of a topical dose of a drug to the eye leads to absorption of a drug ... targeting to pulmonary endothelium, J Pharm Sci., 79:978 72 O’Donnell, M (1990) Novel approaches to the development of peptide bronchodilator drugs Presented at Respiratory Drug Delivery II, Keystone, ... survival of existing photoreceptors Replacing photoreceptors that have degenerated Restoring functional synaptic connections between the photoreceptors and inner neural retinal cells to maintain the...
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Ophthalmic Drug Delivery Systems - part 9 pot
Ngày tải lên :
10/08/2014, 00:20
... degeneration in the mouse due to high levels of visible light has been shown to be dependent on the activation of transcription factor AP-1 leading to apoptotic cell death of photoreceptors (44) Grimm et ... the systemic delivery of genes does not reach, to a satisfactory level, the ocular tissues, most gene therapy agents (except for gene delivery to surface corneal epithelium) need to be administered ... glaucomatous neurons die by apoptotic cell death, the use of gene therapy agents targeted to the ganglion cells via intravitreal or via brain delivery has been found to be promising Delivery...
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Ophthalmic Drug Delivery Systems - part 10 ppt
Ngày tải lên :
10/08/2014, 00:20
... therapeutics: drug delivery and targeting Adv Drug Delivery Rev., 18:115–131 167 J W Jaroszewski, and J S Cohen (1991) Cellular uptake of antisense oligodeoxynucleotides Adv Drug Delivery Rev., ... assessments (3) D Orphan Drug Act The Orphan Drug Act of 1983 was enacted to provide incentives for the research and development leading to market availability of drugs to treat rare diseases Only ... the first to obtain marketing approval for the drug and rare disease The Act also encourages early availability of orphan drugs through open protocols, allowing patients to be added to ongoing...
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Ophthalmic Drug Delivery Systems - part 1 ppsx
Ngày tải lên :
10/08/2014, 03:20
... Christopher T Rhodes Specialized Drug Delivery Systems Manufacturing and Production Technology, edited by Praveen Tyle Topical Drug Delivery Formulations, edited by David W Osborne and Anton H ... from simple solutions to novel delivery systems such as biodegradable polymeric systems, corneal collagen shields, iontophoresis, and viral and nonviral gene delivery systems, to name a few An increase ... new medications to be used effectively, and for those now available to provide maximal benefit, improvements in ocular drug delivery are essential Drug delivery is no less vital than drug discovery...
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Ophthalmic Drug Delivery Systems - part 4 pdf
Ngày tải lên :
10/08/2014, 03:20
... compounds added to the perfusate diffuse out into the tissue Therefore, the technique can be used not only to monitor the extracellular concentrations of the analyte, but also to deliver drugs to a specific ... 1993 10 Ohtori, A., and Tojo, K In vivo/in vitro correlation of intravitreal delivery of drugs with the help of computer simulation Biol Pharm Bull 17:283–290, 1994 11 Tojo, K., and Ohtori, A Pharmacokinetic ... important to consider if toxicity to the retina and other tissues is to be avoided The mean calculated vitreous concentration 24 hours after an intravitreal injection varied by up to a factor of...
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Ophthalmic Drug Delivery Systems - part 7 docx
Ngày tải lên :
10/08/2014, 03:20
... Local Injectable Systems When the vitreous cavity is targeted for drug delivery, topical, systemic, or subconjunctival drug delivery prove unsatisfactory due to their inability to target the action ... Nanoparticles in Ocular Drug Delivery 455 compared to the free drug, but the drug levels with the former remained constant for 14 days, unlike the free drug The drug concentration diminished to undetectable ... route of drug delivery to the eye is topical Drug- loaded microparticulate systems are suspended in aqueous or nonaqueous medium and instilled typically in the cul-de-sac of the eye, wherefrom drug...
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