prognostic factors in adult acute lymphoblastic leukemia all

báo cáo khoa học: "Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics" ppsx

... was 19 months in the absence of MLL-PTD and 7.75 months in its presence [37] In general, the majority of studies indicate that MLL-PTD is poor prognostic indicator in NC-AML including median survival ... contains a DNA-binding and transcriptional repression domain, can suppress the expression of the wild-type allele by an unknown mechanism Interestingly, the silencing of wild-type MLL in blasts positive ... C-terminal CEBPα mutations in approximately 15% to 20% of AML [42] The mutant proteins act in a dominant-negative manner to block DNA binding and transactivation of granulocyte target genes resulting...

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Relapse prediction in childhood acute lymphoblastic leukemia by time series gene expression profiling

Danh mục: Cao đẳng - Đại học

... typically involving grouping genes with correlated expressions into bins and then selecting representatives from each bin, have also been used One of the more interesting recent developments in ... effects of the training data, and result in prediction failures In contrast, unsupervised learning targets on classifying cases in a dataset into several subgroups by evaluating the major variance ... RELATED WORK 18 informative genes most closely correlated with AML -ALL distinction in 38 known samples (27 ALL and 11 AML) during the training stage The built predictor is then tested in 34 new samples,...

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báo cáo khoa học: "Persistence of TEL-AML1 fusion gene as minimal residual disease has no additive prognostic value in CD 10 positive B-acute lymphoblastic leukemia: a FISH study" doc

Danh mục: Báo cáo khoa học

... clinical significance of TEL-AML1 as MRD in CD 10 positive ALL is needed to determine how to best integrate TEL-AML1 testing into routine patient care Abbreviations ALL: Acute lymphoblastic leukemia; ... factors and is rearranged in a wide variety of hematological malignancies In particular, TEL is fused to the platelet-derived growth factor receptor β in CMML, to the ABL tyrosine kinase in acute ... frequency of MRD positivity is high after induction and decreases gradually during consolidation and maintenance phase being in some genes 88% during early induction to 13% at week 52 [19] If MRD...

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báo cáo hóa học: " Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia" potx

Danh mục: Hóa học - Dầu khí

... assess the HRQOL in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical characteristics on HRQOL Methods Setting Indonesia is ... n = 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment); proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive ... childhood acute lymphoblastic leukemia (ALL) in developed countries are about 80%, the survival rates in developing countries are often less than 35% In our previous study the overall even-free...

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báo cáo hóa học: " Impaired sleep affects quality of life in children during maintenance treatment for acute lymphoblastic leukemia: an exploratory study" pdf

Danh mục: Hóa học - Dầu khí

... findings and provide more detailed information on the relationship between sleep and QoL, and on factors affecting sleep in pediatric ALL and in children with cancer in general Abbreviations ALL: ... Health-related quality of life during post-induction chemotherapy in children with acute lymphoblastic leukemia in remission: An influence of corticosteroid therapy Int J Oncol 1997, 11(2):333-339 ... frequently been used in pediatric oncology studies [22,32-34] and includes subscales with age-specific questions for determining problems in relevant areas during cancer treatment such as pain, nausea,...

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báo cáo hóa học:" Health-related quality of life assessment in Indonesian childhood acute lymphoblastic leukemia" docx

Danh mục: Hóa học - Dầu khí

... assess the HRQOL in childhood acute lymphoblastic leukemia (ALL) patients in Indonesia and to assess the influence of demographic and medical characteristics on HRQOL Methods Setting Indonesia is ... n = 42 in the non-intensive phase), ** self-reports (n = 22 in intensive treatment and n = 24 in non intensive treatment); proxy-reports (n = 31 in intensive treatment and n = 33 in non intensive ... childhood acute lymphoblastic leukemia (ALL) in developed countries are about 80%, the survival rates in developing countries are often less than 35% In our previous study the overall even-free...

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Báo cáo khoa học: "Mitochondrial DNA alterations of peripheral lymphocytes in acute lymphoblastic leukemia patients undergoing total body irradiation therapy" ppt

Danh mục: Báo cáo khoa học

... irradiation; IR, ionizing radiation; HVR2, hypervariable region 2; nDNA, nuclear DNA; ALL, acute lymphoblastic leukemia; MGB, minor groove binder; ROS, reactive oxygen species; Competing interest: The ... lymphoblastic leukemia (ALL) patients undergoging total body irradiation (TBI) precondionting as human beings in vivo irradiation model The advantage of using this model lies in full view of in vivo microenvironment, ... differentiate into two major populations immediately: apoptotic population usually containing relative high CD level and thus being sensitive to apoptosis, while surviving population containing relatively...

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báo cáo khoa học: " Plasma levels of leptin and soluble leptin receptor and polymorphisms of leptin gene -18G A and leptin receptor genes K109R and Q223R, in survivors of childhood acute lymphoblastic leukemia" docx

Danh mục: Báo cáo khoa học

... insulin and leptin receptors are located in key brain areas, such as the hypothalamic arcuate nucleus In some cells of hypothalamus, leptin and insulin activate both JAK-STAT and PI3K signaling ... may be the reason of leptin resistance The closed-loop leptin/insulin feedback makes the GH/insulin/leptin relations understandable [30,31] According to Link et al leptin might serve as a good ... assay Levels of leptin and leptin soluble receptor were measured using commercially available EIA kits (R&D Systems, Inc., USA) Genotyping All patients underwent genotyping, and in 77 cases good...

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báo cáo khoa học: "SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines" ppsx

Danh mục: Báo cáo khoa học

... del(9)(q34.11q34.13) in patients with T-cell acute lymphoblastic leukemia (T -ALL) [4] It has also been reported in a single case of acute myeloid leukemia (AML) [5] SETNUP214 positive T -ALL patients ... expressed in myeloid leukemias [7,8] Conclusion We demonstrated the presence of the SET-NUP214 gene in the T -ALL cell line LOUCY and in the AML cell line MEGAL by genomic sequencing In both cell lines, ... SET-NUP214 screening in cell lines SET-NUP214 screening in cell lines SET-NUP214 expression screening performed with a SET exon forward primer and a NUP214 exon 18 reverse primer Cell lines LOUCY and...

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báo cáo khoa học: "Analysis of the expression pattern of the BCL11B gene and its relatives in patients with T-cell acute lymphoblastic leukemia" doc

Danh mục: Báo cáo khoa học

... showed that the inhibition of BCL11B expression by siRNA selectively inhibited proliferation and effectively induced apoptosis in human T-cell acute lymphoblastic leukemia (T -ALL) cell lines (Jurkat, ... solid tumors [26] Additionally, our findings indicated no significant difference in SPP1 gene expression in the TALL group Comprehensive analysis revealed that T -ALL occurred in the presence of BCL11B, ... four genes of interest in the healthy controls Discussion Increasing numbers of translocations involving the BCL11B locus [8,10,11] or high levels of BCL11B mRNA expression in most T -ALL cases [8,12]...

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Báo cáo y học: "Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man: a case report." doc

Danh mục: Báo cáo khoa học

... transforming in undifferentiated leukemia [3,5] and one report of Ph negative T -ALL in a patient receiving treatment [6] TMZ is an oral alkylating agent that is now known to be active against a ... methylates guanines in DNA at the O6 position, causing base-pair mismatch Unsuccessful cycles of mismatch repair eventually lead to breaks and permanent nicks in the daughter strand, preventing mitotic ... [10] All alkylating agents are considered to carry a five to ten percent mutagenic risk potential for development of myeloid leukemia, but not for lymphoblastic leukemia TMZ is a new alkylating...

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Báo cáo y học: "Acute lymphoblastic leukemia subsequent to temozolomide use in a 26-year-old man: a case report" potx

Danh mục: Báo cáo khoa học

... transforming in undifferentiated leukemia [3,5] and one report of Ph negative T -ALL in a patient receiving treatment [6] TMZ is an oral alkylating agent that is now known to be active against a ... methylates guanines in DNA at the O6 position, causing base-pair mismatch Unsuccessful cycles of mismatch repair eventually lead to breaks and permanent nicks in the daughter strand, preventing mitotic ... [10] All alkylating agents are considered to carry a five to ten percent mutagenic risk potential for development of myeloid leukemia, but not for lymphoblastic leukemia TMZ is a new alkylating...

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Báo cáo y học: " Challenges in implementing individualized medicine illustrated by antimetabolite therapy of childhood acute lymphoblastic leukemia" ppt

Danh mục: Báo cáo khoa học

... and outlined in numerous publications, but in spite of extensive research within almost all areas of medicine, few outcome predictors are implemented in routine clinical decision-making [2] Hence, ... during-infusion may improve the cure rates [16], pharmacogenetically improved dosing of MTX could potentially reduce the inter-individual variations in MTX pharmacokinetics with a reduction in ... NOPHO ALL- 92 and ALL- 2000 studies of childhood acute lymphoblastic leukemia Leukemia 2010, 24:345-354 Schmiegelow K, Bjork O, Glomstein A, et al: Intensification of mercaptopurine/methotrexate maintenance...

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CLINICAL EPIDEMIOLOGY OF ACUTE LYMPHOBLASTIC LEUKEMIA - FROM THE MOLECULES TO THE CLINIC docx

Danh mục: Sức khỏe giới tính

... of the population mixing studies had failed to find an increase in a symptomatic infection in adults or children, paralleling the increase in leuke‐ mia incidence Considering that there are viruses ... hypotheses concerning an infectious origin of childhood leukemia ‘Population mixing’ hypothesis by Kinlen In early 1980, an unusual increase in the incidence of childhood leukemia was observed in young ... Identifying the Etiology of Acute Lymphoblastic Leukemia in Children http://dx.doi.org/10.5772/52716 [37] Infante-Rivard C, Krajinovic M, Labuda D, Sinnett D Childhood acute lymphoblastic leukemia...

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báo cáo khoa học: "Gastrointestinal stromal tumors: correlation between symptoms at presentation, tumor location and prognostic factors in 47 consecutive patients" pot

Danh mục: Báo cáo khoa học

... develop through all the GI tract: 50-70% in the stomach, 25-30% in the small intestine, 5-10% in the colon-rectum, < 5% in the esophagus, the remaining may arise within the omentum or within the peritonel ... Carney JA: Gastrointestinal stromal tumors in Carney triad are different clinically, pathologically, and behaviorally from sporadic gastric gastrointestinal stromal tumors: findings in 104 cases ... considered as indications for adjuvant therapy Histological processing was obtained with formalin fixation followed by paraffin inclusion, μm sectioning, and staining with hematoxylin and eosin Morphologic...

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báo cáo khoa học: "Prognostic factors in patients with node-negative gastric cancer: an Indian experience" pdf

Danh mục: Báo cáo khoa học

... of various prognostic factors influencing the disease-free survival (DFS) was performed using log-rank test Factors identified to be significant in univariate analysis were included in the multivariate ... according to the UICC TNM guidelines [15] and were included in the analysis Patients with carcinoma -in- situ were excluded from the study, since the risk of nodal metastasis is very low in these ... Using reverse transcription polymerase chain reaction assay, Wu et al [29] detected micrometastasis in 20% of patients who were determined to be node negative on routine hematoxylin-eosin stains...

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Báo cáo khoa học: "Prognostic factors in primary adenocarcinoma of the small intestine: 13-year single institution experience" ppt

Danh mục: Báo cáo khoa học

... Primary malignant tumors of the small bowel are rare These are mainly adenocarcinomas followed in decreasing order by carcinoid tumors, non-Hodgkin lymphomas, gastrointestinal stromal tumors, melanomas, ... a small bowel tumor, and five patients Table 1: Initial symptoms of the patients N (%) Nausea/vomiting Abdominal pain Melena Weight loss Anemia Palpable abdominal mass Dyspepsia complaints Intestinal ... entities In the United States, the incidence of all types of small bowel cancer is estimated to be approximately In concordance with other reports, adenocarcinomas located in the small bowel,...

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Báo cáo khoa học: "Evaluation of clinical, laboratory and morphologic prognostic factors in colon cancer" ppsx

Danh mục: Báo cáo khoa học

... of the previous studies were often intriguing and conflicting [4,5] Actually, most studies investigating prognostic factors for large bowel cancers did not distinguish between the subpopulation ... Takahashi I: Increase in both CEA and CA19.9 in sera is an independent prognostic indicator in colorectal carcinoma J Surg Oncol 2006, 94:132-137 Blomqvist L, Torkzad MR: Whole-body imaging with ... significant factors in multivariable analysis Mulcahy et al [15] found a trend for prognostic significance of vascular invasion in rectal but not in colonic cancers Accordingly, in our experience...

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báo cáo khoa học: "The frequency of NPM1 mutations in childhood acute myeloid leukemia" doc

Danh mục: Báo cáo khoa học

... University of Athens in Greece Cytogenetic analysis Cytogenetic investigations were performed by karyotyping G-banding analysis in all patients Additionally, interphase fluorescence in situ hybridization ... TCTG-tandem duplication in NPM1exon 12 Leukemia 2007, 21:366-367 Rau R, Brown P: Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukemia: towards definition of a new leukemia entity ... provided samples and clinical data and F.T-S coordinated the study, participated in its design and contributed to writing All authors read and approved the final manuscript Competing interests The authors...

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Báo cáo y học: " Precursor B-cell acute lymphoblastic leukemia presenting as obstructive jaundice: a case report" pdf

Danh mục: Báo cáo khoa học

... rare presentation of acute lymphoblastic leukaemia in an adult JOP 2010, 11:72-74 Takamatsu T: Preferential infiltration of liver sinusoids in acute lymphoblastic leukemia Rinsho Ketsueki 2001, ... change in his medications and was tolerating his aspirin, sitagliptin, fosinopril, metformin and repaglinide without reported side effects His physical examination was significant for pallor, ... biopsy of the liver showing small to medium-sized lymphoblasts infiltrating the hepatic parenchyma Page of Figure Bone marrow biopsy showing lymphoblastic infiltration instructions to follow up...

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