processing mapping and grouping of short read data

Báo cáo y học: "The functional spectrum of low-frequency coding variation" pot

Ngày tải lên : 09/08/2014, 23:20

... (at BC), and a combination of the MAQ [11] and SSAHA2 [12] mapping programs (at BI) (Materials and methods) Alignment post -processing Mapped reads were filtered to remove duplicate reads resulting ... Pilot and the Low Coverage Sequencing Pilot, enabling quality control and performance comparisons Data processing and variant analysis Two separate and complementary pipelines (Materials and methods; ... molecular methodologies and informatics methods for high-throughput data collection and data analysis Although it is not a main focus of our manuscript, development and refinement of the DNA capture...

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Báo cáo khoa học: Supramolecular calsequestrin complex Protein–protein interactions in chronic low-frequency stimulated muscle, postnatal development and ageing pot

Ngày tải lên : 08/03/2014, 10:20

... isoform of the Ca2+-ATPase; mAb IID8 against the slow SERCA2 isoform of the Ca2+-ATPase, and mAb IIG12 to muscle triadin) and Upstate Biotechnology, Lake Placid, NY, USA (pAB to the RyR1 isoform ... self-aggregation of triadin [27], the 94 kDa band of the fast isoform is often accompanied by high-molecular-mass bands in fast-twitch muscle (Fig 2E) The decreased relative density of fast triadin ... the fast isoforms of CSQ, TRI and the RyR1 (Fig 3E,G,H) The disproportionate weakening of immuno labeling of the RyR1 band in stimulated muscle ﬁbers is probably due to a combination of factors,...

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Báo cáo y học: "Association of the T+294C polymorphism in PPAR δ with low HDL cholesterol and coronary heart disease risk in women"

Ngày tải lên : 31/10/2012, 17:03

... Treatment of obese rhesus monkeys with GW 501516, a selective PPARδ agonist, led to a significant improvement of metabolic traits characterized by a rise of HDL and lowering of LDL, triglycerides, and ... N, Ballantyne CM, Gotto AM, Marian AJ Effects of PPARα, γ and δ haplotypes on plasma levels of lipids and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein ... clinic again and it is the lipid values and biometric data obtained at this visit which were used for statistical analysis in this study The presence of chd was assessed by medical records and/ or self-reported...

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iec 60439-1 low-voltage switchgear and controlgear assemblies - type-tested and partially ty

Ngày tải lên : 25/12/2013, 11:00

... standard values can be given 4.3 Rated short- time withstand current (I cw ) (of a circuit of an ASSEMBLY) The rated short- time withstand current of a circuit of an ASSEMBLY is the r.m.s value of ... impulse withstand voltage (U imp ) (of a circuit of an ASSEMBLY) The peak value of an impulse voltage of prescribed form and polarity which the circuit of an ASSEMBLY is capable of withstanding without ... (I n ) (of a circuit of an ASSEMBLY ) 45 4.3 Rated short- time withstand current (I cw) (of a circuit of an ASSEMBLY ) 45 4.4 Rated peak withstand current (I pk ) (of a circuit of an ASSEMBLY...

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iec 60439-2 low-voltage switchgear and controlgear assemblies - particular requirements for busba

Ngày tải lên : 25/12/2013, 11:05

... degree of protection of IP5X shall be tested according to category of 13.4 of IEC 60529 Busbar trunking systems having a degree of protection of IP6X shall be tested according to category of 13.4 of ... Temperature rises of conductors and corresponding parts of the enclosure shall be recorded and checked with thermocouples located in the centre of each busbar trunking unit and adjacent joints and shall ... part of the test report and shall be recorded in the immediate vicinity of the centre of the busbar trunking run under test, at the same level and at a distance of approximately m from one of the...

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iec 60439-3 low-voltage switchgear and controlgear assemblies - particular requirements for iow-v

Ngày tải lên : 25/12/2013, 11:06

... parts of the ASSEMBLY and the protective circuit by inspection or by resistance measurement Short- circuit withstand strength of the protective circuit 8.2.4.2 Verification of short- circuit withstand ... Verification of temperature rise limits 3' b) Dielectric properties 8.2.2 Verification of dielectric properties C) Short circuit withstand strength 8.2.3 Verification of short circuit withstand strength ... Degree of protection 8.2.7 Verification of degree of protection 6* h) Construction and marking 8.2.9 Verification of construction and marking 1* i) Impact strength 8.2.10 Verification of impact...

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iec 60439-4 low-voltage switchgear and controlgear assemblies - particular requirements for assem

Ngày tải lên : 25/12/2013, 11:07

... 60439-4 d) Type and rated current of the unit (and the frequency in the case of a.c.) e) Rated operational voltages (see 4.1.1) f) Short- circuit withstand strength (see 7.5.2.1) g) Degree of protection ... ground compatible with the radius of curvature of the largest cable that may be connected to the ACS 7.2.5 Lifting and handling devices of ACS Lifting rings and/ or handles (or any other equivalent ... Jerification of dielectric properties by test :type test) short- circuit withstand strength 8.2.3 Jerification of the short- circuit withstand strength by test (type test) Sffectiveness of the protective...

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iec 60439-5 low-voltage switchgear and controlgear assemblies - particular requirements for assem

Ngày tải lên : 25/12/2013, 11:08

... 4628-3:1982, Paints and varnishes - Evaluation of degradation of paint coatings Designation of intensity, quantity and size of common types of defect - Part 3: Designation of degree of rusting IS0 ... of the test of 8.2.9.3 of this standard, the door(s) of the CDC shall be locked at the commencement of the test and remain locked for the duration of the test 8.2.9.1 8.2.9.1.1 Verification of ... manufacturer and shall be sufficient to pass the appropriate tests of 8.2.1 of this standard Add at end of third paragraph: l h e mechanical properties of a CDC shall comply with 8.2.9 of this standard...

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LOW FREQUENCY IGBT CONVERTER FOR CONTROL EXCITING FORCE OF ELECTROMAGNETIC VIBRATORY CONVEYORS

Ngày tải lên : 03/01/2014, 19:15

... load change compensation of EVCD and oscilloscopic records of characteristic values (EVA current, EVA voltage and displacement of vibratory trough) Fig.7 The influence of refrence current change ... displacement of EVCD; (a)-output displacement and EVA current, (b)-detail of interval I , (c)-detail of interval II In the simulation is set to the value of the resonant frequency of the mechanical ... value of Ym1 =0.1mm i.e vibratory width value of Y(p-p)1 =0.2mm in which the amplitude of EVA current was Im1 =280mA In the moment of time t=2.5s is setting sudden increase of reference value of...

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Tài liệu Social networking sites and our lives doc

Ngày tải lên : 18/02/2014, 00:20

... the use of SNS since 2009, and interest surrounding how the use of these services influences people’s offline and online relationships, we revisit this issue with new data on the extent of social ... 79% of American adults said they used the internet and nearly half of adults (47%), or 59% of internet users, say they use at least one of SNS This is close to double the 26% of adults (34% of ... variation in the frequency of use of SNS Facebook and Twitter are used much more frequently by their users than LinkedIn and MySpace Some 52% of Facebook users and 33% of Twitter users engage with...

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Tài liệu Báo cáo Y học: Interaction of decorin with CNBr peptides from collagens I and II Evidence for multiple binding sites and essential lysyl residues in collagen pot

Ngày tải lên : 21/02/2014, 15:20

... spectra of a recombinant decorin puriﬁed in the absence of chaotropic agents, with the exception of the wavelength of the minimum (215–216 instead of 218 nm) and very different to the spectrum of ... (number of residues) and melting temperature of the trimeric species of CNBr peptides The bottom two lines indicate the N ﬁ C direction with a length scale (in residues) and the banding pattern of ... of 200 lL of M HCl and subjected to hydrolysis and Hyp quantitation [38] The percentage of protein adsorbed to the wells was found to be 15.1% ± 3.0 for CNBr peptides, 9.4% ± 0.6 for type I and...

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Google Sites and Chrome For Dummies pptx

Ngày tải lên : 06/03/2014, 11:20

... directly to the site Office Live’s big brothers, Groove and SharePoint, offer additional features for larger companies but also require expensive servers and software To use Office Live Workspace, ... Google Sites and Chrome Blackboard and Moodle Blackboard (www.blackboard.com) and Moodle (www.moodle.org) are both great tools for teachers to keep track of classes, handouts, quizzes, and grades ... expensive servers and software All you need is an Internet connection and a Web browser, either of which you could get free at your public library, if you wanted All of your pages, wikis, and files are...

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Providing and Funding Financial Literacy Programs for Low- Income Adults and Youth pot

Ngày tải lên : 06/03/2014, 19:20

... curriculum consists of eight lessons, including hands-on activities, which can stand alone or be taught as part of a series It is written for those with elementary math and reading levels Lessons ... differences between a broker and banker, the threat of predatory lenders, how to budget, and what the entire process of home ownership entails Take the cultural and logistical needs of program participants ... hands-on curriculum included a variety of breakout activities and encouraged participants to track personal expenses and develop a family budget Over the two-year duration of the project, 50 of...

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Google Sites and Chrome For Dummies potx

Ngày tải lên : 06/03/2014, 23:20

... directly to the site Office Live’s big brothers, Groove and SharePoint, offer additional features for larger companies but also require expensive servers and software To use Office Live Workspace, ... Google Sites and Chrome Blackboard and Moodle Blackboard (www.blackboard.com) and Moodle (www.moodle.org) are both great tools for teachers to keep track of classes, handouts, quizzes, and grades ... expensive servers and software All you need is an Internet connection and a Web browser, either of which you could get free at your public library, if you wanted All of your pages, wikis, and files are...

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Báo cáo khoa học: Identiﬁcation of the amniotic ﬂuid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms docx

Ngày tải lên : 07/03/2014, 00:20

... representation of the susceptibility to proteolytic degradation of IGFBP-1 isoforms The y-axis shows the percentage of the ratio between the spot area of the degraded and that of the untreated ... fraction and the last eluting fraction, VI, displayed a very similar mobility to that of fraction V A 5 B Mass determination of the IGFBP-1 isoforms The molecular mass of the six IGFBP-1 isoforms ... for the presence of nine disulﬁde bonds involving the 18 cysteine residues of the polypeptide chain Analysis of peak II yielded a molecular mass of 25 332 Da and the increase of 80 Da over the...

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Báo cáo khoa học: Biochemical characterization of USP7 reveals post-translational modiﬁcation sites and structural requirements for substrate processing and subcellular localization pptx

Ngày tải lên : 07/03/2014, 05:20

... with Ub-K-peptide-TAMRA Processing of ubiquitin synthetic substrates by USP7-FL and domain deletion variants Evaluation of the hydrolysis of Ub-AMC and Ub-KTAMRA by USP7-FL and its domain deletion ... proteolysis of USP7 variants in the presence and absence of ubiquitin SDS ⁄ PAGE (4–20% gradient gels) showing the limited proteolysis of native USP7-FL and variants thereof by trypsin over time with and ... Coomassie stained and major bands were excised and eluted in order to perform N-terminal sequencing Tandem afﬁnity puriﬁcation and mass spectrometric analysis of USP7 N-terminal and C-terminal TAP-tagged...

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LOW INTEREST RATES AND HIGH ASSET PRICES: AN INTERPRETATION IN TERMS OF CHANGING POPULAR MODELS doc

Ngày tải lên : 17/03/2014, 08:20

... of interest rates (both nominal and real) and the level of asset prices in the world Next, I will consider some aspects of the public’s understanding of the economy, including common understandings ... policy alone entails a “very costly short- run tradeoff” in increased unemployment and lost output But the rise of inflation led to a sense of alarm, and the failure of other measures to control inflation ... ratio and the actual was only 0.309 and the ratio of the standard deviation of the theoretical dividend-price ratio and the actual dividend-price ratio was only 0.58 (The latter is a suggestion of...

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Báo cáo Y học: SMAP-29 has two LPS-binding sites and a central hinge docx

Ngày tải lên : 17/03/2014, 23:20

... Dtriﬂuoroethanol, and were placed in Kontes Model 240 NMR tubes A standard set of DQFCOSY, TOCSY and NOESY spectra were collected at 25 °C on a Varian 500 MHz instrument (University of Iowa College of Medicine ... used Processing of NMR data Spectra were processed using the VNMR 6.1B software package The apodization for DQFCOSY spectra consisted of a 0.158-s Gaussian function, shifted by 30°, in f-2 and ... had an EC50 of 7.1 lm, the inability of SMAP-29 [6–25] to bind LPS was not simply attributable to the shorter length Because SMAP-29 [1–18] and SMAP-29 [9–29] had EC50 values of 49 lM and 143 lM,...

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Environmental Health Criteria 238 EXTREMELY LOW FREQUENCY FIELDS docx

Ngày tải lên : 22/03/2014, 16:21

... collaborating centres and by RAD Unit staff These included Prof Paul Elliot, Imperial College of Science, Technology and Medicine, UK, Prof Maria Stuchly, University of Victoria, Canada, and Prof Bernard ... existing pooled and meta-analyses of adult leukaemia and brain tumour studies and of cohorts of occupationally exposed individuals Medium Development of transgenic rodent models of childhood leukaemia ... version of the various chapters, including Prof Paul Elliot, Prof Maria Stuchly, and Prof Bernard Veyret, the members of the Working Groups and the members of the Task Group Special thanks go to Dr...

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High-Impact, Low-Frequency Event Risk to the North American Bulk Power System ppt

Ngày tải lên : 30/03/2014, 09:20

... granularity and quality of metrics used to measure and report on the emergence and spread of pandemic vectors and related illness These measures should incorporate or be tailored to meet the needs of ... comprised of hundreds of thousands of miles of high-voltage transmission lines, over 150 Balancing Authority Areas, and millions of digital controls Conducting regular patrols of the entire grid and ... miles of high-voltage transmission lines, thousands of generation plants, and millions of digital controls.4 More than 1,800 entities own and operate portions of the system, with thousands more...

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