procapsid assembly maturation nuclear exit dynamic steps in the production of infectious herpesvirions

Tài liệu Báo cáo khoa học: Final steps in the catabolism of nicotine Deamination versus demethylation of c-N-methylaminobutyrate doc

Ngày tải lên : 19/02/2014, 07:20

... other members of the polyamine oxidases, the FAD cofactor was noncovalently bound to the apoprotein and the C-terminal ﬁngerprint sequence SGGCY of monoamine oxidases, with C being the cysteine ... protein with an N-terminal extension reading MSPIHHHHHHLVPRGSV The ﬁrst amino acid of mao is valine (underlined V in the one letter amino acid code) The protein eluted from the nickel-chelating ... expression of these genes depends on the presence of nicotine in the growth medium and we have determined the enzyme activities of the proteins Our results demonstrate the presence of two pathways of...

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POTENTIAL CONFLICT OF INTEREST IN THE PRODUCTION OF DRUG COMPENDIA doc

Ngày tải lên : 09/03/2014, 00:20

... conflict of interest in mind 21 Relevant information for assessing potential conflict of interest includes the identification of the sponsor, determination of whether an independent team reviewed the ... remaining two areas – conflict of interest leading to biased selection of evidence, and bias in the interpretation of evidence – fall within the domain of the compendia publishers and under the ... Two of these areas – conflict of interest in evidence sources, and conflict of interest in the process of making study data available – lie beyond the control of the compendia publishers The...

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Báo cáo khoa học: Cooperation of two carotene desaturases in the production of lycopene in Myxococcus xanthus pot

Ngày tải lên : 16/03/2014, 05:20

... resulting from the heterologous expression of crtIa in E coli (strain FD6 in Table 1), indicates that CrtIb is acting at one or two of the last dehydrogenation steps in lycopene production, after the ... insertion in crtE or in crtB of the carB operon prevents the accumulation of 4308 Fig The absence of CrtIa blocks the cis-to-trans isomerization of phytoene (A) Absorption spectra in hexane of ... dehydrogenase The requirement in M xanthus for two CrtI-type proteins to carry out the four dehydrogenation steps involved in converting phytoene to lycopene is atypical in the biogenesis of carotenoids The...

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Báo cáo khoa học: Predicting the substrate speciﬁcity of a glycosyltransferase implicated in the production of phenolic volatiles in tomato fruit pptx

Ngày tải lên : 28/03/2014, 23:20

... alcohol in the binding pocket In clusters and 3, the ring is oriented ‘inside’, towards the conserved core of the binding pocket, but in cluster 2, it is oriented towards the long loop covering the ... cannot explain the observed preference for the b-isosalicin production determined by NMR The main difference between the conformation clusters lies in the position of the aromatic ring of salicyl ... within the vicinity of the active site, therefore signiﬁcantly reducing the size and accessibility of the acceptor binding pocket (Fig S6) In SlUGT5, this tyrosine is replaced by a phenylalanine...

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output and efficiency in the production of business and economics majors

Ngày tải lên : 03/06/2014, 02:08

... spent on the teaching staff, making the efficiency of the “labor” component of educational production a main subject of study The introduction of non-school inputs into the production process ... production, the form of the production function, the variance of choices, the underlying decision rules for determining choices, and the accuracy of measuring inputs Becker (2004) suggests the use of ... assess the effect of different educational inputs on the production of academic business knowledge An overview of the inputs and outputs used in the literature, as well as a summary of the main conceptual,...

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Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx

Ngày tải lên : 20/02/2014, 23:20

... suppression of respiration during hypoxia In the absence of differential regulation of a speciﬁc nuclear gene coding for the subunits of CytOX, changes in the microenvironment of the cell may induce ... the effects of hypoxia on the steady state levels of nuclear genome encoded CytOX IV and Vb mRNAs There was no change in the levels of these mRNAs in macrophages at h of hypoxia, the time point ... and alters the expression of the two nuclear genome coded isoforms of CytOX V [10,32] The regulation of genes CytOX5a and CytOX5b, coding for the two isofoms Va and Vb, parallels that of genes...

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Dynamic Planet Mercury in the Context of Its Environment docx

Ngày tải lên : 06/03/2014, 19:20

... OBJECTIVES The objectives of Bepi Colombo focus on obtaining the kind of coverage necessary to fill in particular gaps in our knowledge of planet Mercury (Grard et al, 2000) Determining the nature of the ... showing the mission timeline, with extensive use of the gravitational assist technique developed for Mariner 10 during the five year cruise, and the first orbiting of Mercury during the nominal ... core, decouples the inner core from the crust, then the moment of inertia of the crust may be determined separately It is possible to determine anomalies, or lateral inhomogeneities in the mantle,...

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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx

Ngày tải lên : 07/03/2014, 01:20

... actin is associated with rDNA genes, and microinjection of anti-actin Ig into the nuclei of HeLa cells inhibits pre-rRNA synthesis in vivo [25,34] The interaction of NM1 with actin in the initiation ... actin-binding site located in the hnRNP U C-terminus and associate with the phosphorylated C-terminal domain of Pol II [43] Injection of a peptide acting as a competitive inhibitor of protein–protein ... enhances its activity in the presence of androgen The interaction between the N- and C-termini of the AR does not affect gelsolin FXXFF binding to AR LBD, indicating that the gelsolin FXXFF motif has...

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Mastering the Ultimate High Ground -Next Steps in the Military Uses of Space pptx

Ngày tải lên : 15/03/2014, 18:20

... logic of this evolution until no doubt exists in the minds of Congress or the public that the Air Force mission lies in space, as the mission of the Army is on the ground and the mission of the ... space systems increasingly emerged from the black world of secrecy into the light of day Indeed, one could go further yet by observing that, in fact, there were three schisms in the Air Force ... throughout the Air Force The increasingly contentious issue of where stewardship for space belonged within the Air Force was finally forced into the open in 1987 when the Secretary of the Air Force...

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Mastering the Ultimate High Ground - Next Steps in the Military Uses of Space docx

Ngày tải lên : 29/03/2014, 15:20

... logic of this evolution until no doubt exists in the minds of Congress or the public that the Air Force mission lies in space, as the mission of the Army is on the ground and the mission of the ... space systems increasingly emerged from the black world of secrecy into the light of day Indeed, one could go further yet by observing that, in fact, there were three schisms in the Air Force ... throughout the Air Force The increasingly contentious issue of where stewardship for space belonged within the Air Force was finally forced into the open in 1987 when the Secretary of the Air Force...

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Three Years After - Next Steps in the War on Terror potx

Ngày tải lên : 29/03/2014, 20:20

... failure of imagination,” in the words of the 9/11 Commission, or the “groupthink,” in the words of those who looked at our intelligence on weapons of mass destruction in Iraq The issues also include ... the suffering of the devout, the atrocities committed against Muslims, the injustice of the situation in Muslim communities, the humiliation inflicted on the faithful Recruiting stresses the opportunities ... by the Queen Sofia Center for the Study of Violence in Valencia, Spain He is editor -in- chief of Studies in Conflict and Terrorism, the leading scholarly journal in the field, and a member of the...

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Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identiﬁed substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf

Ngày tải lên : 29/03/2014, 21:20

... are involved in the transmission of mechanical signals to signaling pathways In the M line, mechanical stimulation activates the interaction of a protein complex with the kinase domain of titin, ... pathway and an increase in muscle ﬁber apoptosis [8] The participation of NF-jB signaling in the pathogenesis of LGMD2A is therefore an interesting possibility The ﬁndings obtained in the present ... the binding to titin by improving the accessibility of the titin-binding domain Interestingly, the importance of CARP interaction for its function was recently demonstrated in a FEBS Journal...

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Báo cáo khóa học: Protein assembly of photosystem II and accumulation of subcomplexes in the absence of low molecular mass subunits PsbL and PsbJ pdf

Ngày tải lên : 30/03/2014, 13:20

... (2003) Dynamic interaction between the D1 protein, CP43 and OEC33 at the lumenal side of photosystem II in spinach chloroplasts: evidence from lightinduced cross-linking of the proteins in the donor-side ... missing There seems to be no tight mutual control in the assembly of the three OEC proteins Although the binding of PsbO apparently occurs ﬁrst [48] and may be a prerequisite for the assembly of ... is critical in providing proper docking sites, either directly or indirectly, by modifying the conformation of PSII on the lumenal side, making efﬁcient binding of PsbQ and PsbP of the OEC possible...

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handbook of biochemical kinetics a guide to dynamic processes in the molecular life sciences

Ngày tải lên : 01/04/2014, 10:21

... contain high concentrations of actin ﬁlaments as well as other actin-binding proteins, including Ͱ-actinin, vinculin, zyxin, paxillin, and talin Microinjection of the FEFPPPPPTDE peptide into uninfected ... monomers The afﬁnity of a capping protein can be readily determined as the concentration of capping protein needed to inhibit the initial rate of dilutioninduced disassembly of polymer containing ... by assembly of actin-based motor complexes from a battery of regulatory proteins These include capping proteins, severing proteins, sequestering proteins, bundling and cross-linking proteins,...

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Báo cáo hóa học: " Influence of the training set on the accuracy of surface EMG classification in dynamic contractions for the control of multifunction prostheses" potx

Ngày tải lên : 19/06/2014, 08:20

... from all the others Including the dynamic portion in the training set increases substantially the number of windows available for each class, and so the unbalance between the sizes of the two ... when dynamic portions are included in the training set is not likely related to the inclusion of the dynamic part Rather, it is more likely due to the unbalance of size during the learning process, ... by involving the transitions between all the combinations of active classes in the learning process This would however increase the amount of training data and training time significantly making...

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Báo cáo khoa học: "The micronucleus frequency in cytokinesis-blocked lymphocytes of cattle in the vicinity of a nuclear power plant" ppt

Ngày tải lên : 07/08/2014, 20:23

... tnalp rewop raelcun a raen detacol slamina neewteb stnuoc eht ni dnuof saw ecnereffid tnacifingis oN slamina eht fo etats lacigoloib lareneg eht etaulave ot demrofrep saw sisylana lacilototameH aera ... noitidda ni ,eroferehT snosaer lacihte suoivbo rof elbissopmi era snamuh ni serusopxe latnemnorivne level-wol ,cinorhc fo stceffe eht fo snoitagitsevni tceriD dleif eht ni deviecer evah smsinagro taht ... eht gnissessa rof elbatius si slamina larutlucirga ni snoitarreba lamosomorhc fo gnirotinom ehT tnemnorivne eht ni )snegotsalc rehto dna( sedilcunoidar ot erusopxe level-wol ,cinorhc morf ksir...

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Báo cáo khoa học: "The role of Bcl-xL and nuclear factor-kB in the effect of taxol on the viability of dendritic cells" ppsx

Ngày tải lên : 07/08/2014, 23:22

... effects of Bax might be minimized in the DCs during the treatment of taxol, 48 h NF-κB is closely involved in the survival and maturation of DCs [11,17,20] To investigate further the mechanisms of ... taxol increased the expression of the anti-apoptotic protein Bcl-xL, and increased the mobilization of p65 subunit molecules into the DC nucleus Furthermore, we found that the inhibition of NF-κB ... However, the taxol concentration used was critical for the level of cytokine production; μg/ml of taxol induced only marginal production of these cytokines These results suggest that taxol enhances the...

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Báo cáo y học: " Tumour necrosis factor-α stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-κB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b" doc

Ngày tải lên : 09/08/2014, 07:20

... investigate whether the effect of SN50 interfered at the level of Cyp7b activity or expression, we also analyzed the influence of SN50 on the TNF-α-induced increase in Cyp7b Available online http://arthritis-research.com/content/7/6/R1271 ... activity We further investigated a putative role for MAPKs in the TNFα-induced increase in Cyp7b activity by using the MEK1 inhibitor PD98059 and the p38 inhibitor SB203580 The p38 inhibitor (SB203580) ... localized in the cytoplasm (Fig 1d) Incubation of FLS with TNF-α strongly increased the presence of NF-κB in the nucleus This nuclear translocation of NF-κB was inhibited by SN50 (Fig 1d) PSI inhibited...

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Báo cáo y học: "Enhanced expression of mRNA for nuclear factor κB1 (p50) in CD34+ cells of the bone marrow in rheumatoid arthritis" potx

Ngày tải lên : 09/08/2014, 07:20

... examine whether the elevation of NFκB1 mRNA expression parallels the elevation of NFκB1 protein expression in bone marrow CD34+ cells The protein expression of NFκB1 was evaluated by staining of permeabilized ... mRNA in the six bone marrow CD34+ cells (Figure 3) The results indicate that the elevation of NFκB1 mRNA leads to the increase in NFκB1 protein expression Relevance of expression of NFκB1 mRNA in ... C-reactive protein (CRP) levels in RA patients (Figure 5) The data thus indicate that the upregulation of NFκB1 mRNA in bone marrow CD34+ cells is independent of the activity of the systemic inflammation,...

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Báo cáo khoa học: " Hepatitis C Virus entry: the early steps in the viral replication cycle" ppt

Ngày tải lên : 12/08/2014, 04:21

... on the function of these proteins, in vivo, in the tightening of skin [104], the blood brain barrier [105], myelin sheets and Sertoli cell layers [106], and the epithelial in the inner ear [107], ... with other transmembrane proteins and regulate post-ligand binding events, including integrinmediated adhesion strengthening The c-terminus of CD81, CD151, and other tetraspanins meet the criteria ... glycoprotein E2 bind CD81 and not other members of the tetraspanin family [36] Binding of E2 occurs at the CD81 LEL and binding of E2 to CD81, or infections with HCVpp or HCVcc, are inhibited...

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