pro inflammatory cytokines and memory functioning in humans

Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt

... detrimental effects of OGD in vitro by releasing glutamate in excess, indicating that the increase in 2-AG levels that was observed by these authors following OGD may protect dopaminergic neurons through ... activate TRPV1 channels both in vitro and in vivo and to upregulate genes involved in proin ammatory ⁄ microglialrelated responses [43,99,100] In addition, AEA can induce an acute release of NO ... midbrain slices (7 min) Rat cortiscostriatal slices (30 min) Hippocampal slices (15 min) eCB levels ⁄ CB-R expression CB-R activation Protection Protection Protection Protection Toxicity Protection...

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Báo cáo khóa học: Collectins Players of the innate immune system docx

Danh mục: Báo cáo khoa học

... conglutinin interact with this receptor, while binding could be inhibited using C1q and C1q collagen stalks, demonstrating that the collectin collagen domain is involved in receptor binding [56,213] ... contain repeating saccharide units, thereby representing ligands for collectin binding In several studies, the inability of collectins to bind to certain bacterial strains, correlated with increased ... SP-D bind signal regulating protein a (SIRPa; a transmembrane protein involved in signal transduction) through their CRDs to initiate a signaling pathway that blocks proinﬂammatory mediator production...

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Paradoxical roles of the immune system during cancer development docx

Danh mục: Sức khỏe giới tính

... characterized by chronic infiltration of innate immune cells in the stromal tissue25,26 (FIG 2) Interestingly, the profile of infiltrating inflammatory cells in skin is distinct from that in cervix — pre-malignant ... development is probably a consequence of their inherent capacity to produce both pro- inflammatory T-helper-1 cytokines and anti -inflammatory T-helper-2 cytokines7 4; therefore, the nature and balance ... gene-expression programmes in initiated neoplastic cells, culminating in altered cell-cycle progression and increased survival Inflammatory cells positively influence tissue remodelling and development...

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Cancer of the Brain and Other Central Nervous System doc

Danh mục: Sức khỏe giới tính

... Huong Do, and William Cheng for their assistance in preparing this chapter 12 Gurney JG, Smith MA, Bunin GR Chapter III: CNS and Miscellaneous Intracranial and Intraspinal Neoplasms In: Ries ... Spinal meninges, C720 - Spinal Cord and C721 - Cauda equine and OTHER: C723 Optic nerve, C724 - Acoustic nerve, C725 - Cranial nerve, NOS, C728 - Overlapping lesion of brain and CNS and C729 – ... Brain Stem, C718 - Overlapping lesion of brain and C719 - Brain, NOS For other CNS cancers, primary site of tumor is classified as the following: BRAIN: C700 - Cerebral meninges, C709 - Meninges,...

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Báo cáo khoa học: Modulation of the endocannabinoid system by focal brain ischemia in the rat is involved in neuroprotection afforded by 17b-estradiol pdf

Danh mục: Báo cáo khoa học

... [pmolÆ(mg protein) ] 35 ± 30 ± FAAH activity [pmolÆmin)1Æ(mg protein))1] 820 ± 80 884 ± 90 NAPE-PLD activity [pmolÆmin)1Æ(mg protein))1] 22 ± 25 ± CB1 receptor binding [fmolÆ(mg protein))1] 190 ... arachidonic acid and ethanolamine [5] Taken together, AEA, its congeners and the proteins that bind, synthesize or transport them form the ‘endocannabinoid system’ [6] In the brain, endocannabinoids act ... effect of MCAo-induced brain insult on AEA regional level, metabolism, and receptor binding and expression The putative neuroprotective action of agonists and antagonists of cannabinoid receptors...

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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx

Danh mục: Báo cáo khoa học

... Binding speciﬁcities of the sialoadhesin family of I-type lectins Sialic acid linkage and substructure requirements for binding of myelinassociated glycoprotein, Schwann cell myelin protein, and ... Western blotting for SHP proteins To determine if the cytoplasmic domain of siglec-10 binds SHP-1 and SHP-2 in cell lysates, 10 mg of GST fusion protein tyrosine phosphorylation were incubated with ... Emt and ZAP-70 kinases or left untreated, and incubated with cell lysate GST proteins and associated proteins were recovered by binding to glutathione– Sepharose, separated by SDS/PAGE, and analyzed...

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brain facts a primer on the brain and nervous system - the society for neuroscience

Danh mục: Sinh học

... dopaminecontaining neurons release dopamine into speciﬁc brain areas that include a special portion of the nucleus accumbens Cocaine and amphetamines produce their intense feelings of euphoria by increasing ... peptides Heroin injected into a vein reaches the brain in 15 to 20 seconds and binds to opiate receptors found in many brain regions, including the reward system Activation of the receptors in the ... factor in spinal cord development is a secreted protein called sonic hedgehog that is similar to a signaling protein found in ﬂies The protein, initially secreted from mesodermal tissue lying beneath...

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Design of a near infrared spectrophotometry brain imaging system

Danh mục: Tự động hóa

... OF A NEAR INFRARED SPECTROPHOTOMETRY BRAIN IMAGING SYSTEM BY SUKNEET BASUTA Electrical and Biomedical Engineering Faculty Advisor: Prof Doyle Electrical and Biomedical Engineering Project Report ... stimulation, and intense thinking, it is also able to measure muscle activity Keywords: near-infrared spectroscopy, brain activity, functional monitoring and imaging, imaging, optical imaging ii Acknowledgements ... of a Near Infrared Spectrophotometry Brain Imaging System BY SUKNEET BASUTA Electrical and Biomedical Engineering Design Project (4BI6) Department of Electrical and Computer Engineering McMaster...

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scientific american - 1993 09 - special issue - life, death, and the immune system

Danh mục: Toán học

... bloodstream, interleukin-6 reaches the liver, causing it to secrete mannosebinding protein The binding stimulates the B cell to proliferate and to secrete antibodies ANTIBODY LIVER MANNOSEBINDING PROTEIN ... mannose-binding protein (center ) Antibodies produced and ingest bacteria Second, macrophages that meet bacteria can secrete interleukin-6, a protein that in turn stimulates the liver Interleukin-6 instructs ... earning a B.A in chemistry and, in 1969, an M.D degree He trained in medicine at Peter Bent Brigham Hospital in Boston and in immunology at the National Institute for Medical Research in England,...

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báo cáo hóa học:" Angiostatin anti-angiogenesis requires IL-12: The innate immune system as a key target" docx

Danh mục: Hóa học - Dầu khí

... angiostatin receptors identified to date include cell surface ATP synthase, angiomotin and various integrins (see [4] for review) Angiomotin appears to be involved in VEGF signaling in vitro and angiomotin ... [1,2] Angiostatin and related forms consisting of the first 1–5 kingles in plasminogen (here termed collectively AST) is generated by the action of diverse proteases, including metalloproteases (MMP2, ... software and normalized to the expression of the house-keeping gene β-actin Data were obtained from independent experiments done in triplicate Results Angiostatin (AST) in an angiogenic setting using...

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Báo cáo sinh học: " Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" docx

Danh mục: Điện - Điện tử

... vaccine In Proceedings of the tenth Conference 5–7 November 1996 Faculty of Veterinary Medicine, Assiut Univrsity, Egypt; 1996:111-118 Trinchieri G: Interleukin-12 and the regulation of innate ... inhibits the generation of immunological memory necessary to immunity in subsequent exposure [2] Interestingly, both inactivated and attenuated SPPV showed significant increase in the IL-10 production ... antiviral process [16,26] In addition, inducing apoptosis in a significant number of antigen-presenting cells [20] as well as inducing IL-10 release that has the capacity to impair the initiation...

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Báo cáo hóa học: " Effectiveness of a Wii balance board-based system (eBaViR) for balance rehabilitation: a pilot randomized clinical trial in patients with acquired brain injury" ppt

Danh mục: Hóa học - Dầu khí

... patient to play in standing or in sitting position to improve balance control in both conditions In standing position the patients are required to maintain their soles on the WBB In sitting position, ... only in the field of motor domain [47] but also in those processes involving perceptual learning [48] and cognitive recovery [49] According to these principles, the greatest effects of training in ... Patients Stud Health Tech Informat 2010, 154:61-66 Young W, Ferguson S, Brault S, Craig C: Assessing and training standing balance in older aldults: A novel approach using the ‘Nintendo Wii’ Balance...

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Báo cáo hóa học: " Brain-Computer Interface Controlled Functional Electrical Stimulation System for Ankle Movement" doc

Danh mục: Hóa học - Dầu khí

... transitions to idling state (pink block) during the training procedures revealed that the EEG power in the μ, b and low-g bands were responsible for encoding the differences between idling and dorsifiexion ... K, Yoshinobu T: Development of Brain-Computer Interface (BCI) System for Bridging Brain and Computer In 13th International Conference on Biomedical Engineering, Volume 23 of IFMBE Proceedings Edited ... mapping at high-b band (two-Hz bin centered at 29 Hz) for subject B Values close to +1 and -1 indicate brain areas of importance for classifying EEG data into idling and dorsifiexion classes Since...

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báo cáo hóa học: " Application of a hybrid wavelet feature selection method in the design of a self-paced brain interface system" pptx

Danh mục: Hóa học - Dầu khí

... Tsujimoto H, Inokuchi S: Studies of input speed of word inputting system using event-related potential Proc 20th Int Conf IEEE Engineering in Medicine and Biology Society Hong Kong, China 1998, ... for direct brain interfaces – rethinking the definition of asynchronous and synchronous Proc of HCI Int Conf Las Vegas, USA 2005 Birch GE, Lawrence PD, Hare RD: Single-trial processing of event-related ... follows For each subject, IC and NC epochs were randomized and divided into training, validation and test sets The training set was used to train the classifier, and the validation set was used...

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báo cáo hóa học: " Expression of innate immune complement regulators on brain epithelial cells during human bacterial meningitis" docx

Danh mục: Hóa học - Dầu khí

... are dramatically increased in the CSF enhancing the influx of inflammatory cells into the ventricle and increasing complement biosynthesis and promoting activation [11,16,17] Critically, the epithelial ... meningitis cases Rehydrated paraffin wax sections of human choroid plexus in normal and meningitis cases immunostained with antisera to inflammatory cells and to membrane regulators proteins ... Rabbit anti-CD35 Weak staining is detected on Kolmer cells in normal sections (i) but a strong staining is noticed in meningitis epithelia and infiltrating PMNs (j) k and l, Rabbit anti-CD59 Normal...

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báo cáo hóa học: " Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice" doc

Danh mục: Toán học

... stages of brain injury The significant findings of increased T cell infiltrate into the injury site, increased levels of IL-2, prolonged neuronal death surrounding the injury site and increased ... mice after brain injury and may explain the differences observed in T cell infiltration in MT-I/II-/- mice Conclusions MT-I/II expression is increased in the brain after brain injury which suggests ... brain does not coincide with observed differences in neuron death and T cell infiltration in wild type and MT-I/II-/- mice Circulating leukocyte numbers in wild type and MT-I/II-/mice after brain...

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báo cáo hóa học:" Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" doc

Danh mục: Hóa học - Dầu khí

... vaccine In Proceedings of the tenth Conference 5–7 November 1996 Faculty of Veterinary Medicine, Assiut Univrsity, Egypt; 1996:111-118 Trinchieri G: Interleukin-12 and the regulation of innate ... inhibits the generation of immunological memory necessary to immunity in subsequent exposure [2] Interestingly, both inactivated and attenuated SPPV showed significant increase in the IL-10 production ... antiviral process [16,26] In addition, inducing apoptosis in a significant number of antigen-presenting cells [20] as well as inducing IL-10 release that has the capacity to impair the initiation...

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Báo cáo sinh học: "Parasite immunomodulation and polymorphisms of the immune system" ppsx

Danh mục: Báo cáo khoa học

... receptor-ligand specificities; those loci in red italic type are loci encoding cytokines, transcriptional regulators and cell surface molecules that are generally polymorphic in promoter, intronic and ... greatest variability included some encoding cytokines controlling both innate immune responses (such as the IL-1 family) and adaptive Th2 responses (such as IL-4 and IL-4R) Strikingly (in terms of the ... with gastrointestinal helminth infection in a wild wood mouse population [2] Shown are, clockwise from top left, Leishmania mexicana protozoal promastigotes (L Prieto-Lafuente); Candida albicans...

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Báo cáo sinh học: "Beyond toxicity: aryl hydrocarbon receptor-mediated functions in the immune system" docx

Danh mục: Báo cáo khoa học

... tryptophan metabolites as well as intrinsic factors such as prostaglandin subtypes, lipoxin A4, bilirubin and others [11] It remains to be seen how such endogenous AhR ligands influence various components ... differentiation of TH17 cells, and more importantly, in inducing them to secrete the cytokine interleukin (IL)-22 (a cytokine implicated in the defense of mucosal barriers) AhR-dependent induction of IL-22 ... which produce early in ammatory responses; and TREG cells, which inhibit the responses of the other cell types and are thought to provide protection from autoimmune disease IFN, interferon; IL, interleukin,...

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Báo cáo khoa học: "The use of crossreactive monoclonal antibodies to characterize the immune system of the water buffalo (Bubalus bubalis)" pdf

Danh mục: Báo cáo khoa học

... containing either 50 µl of PBS-HS (negative control) or µg of mAb in 50 µl of PBS-HS and incubated for 30 minutes at 4oC Cells were washed times (800 × g/3 min) in PBS-HS, then incubated in the ... 20 minutes) using Lympho-paque (density 1.086: Nycomed AS; Oslo, Norway) Mononuclear cells banding at the interface were collected and washed once (500 × g/10 min) in phosphate-buffered saline ... appearance varies, but it is prominently expressed following days of stimulation with Con A It is constitutively expressed on CD8+ cells in the intestine and mammary gland [23] (and unpublished) ACT3...

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