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PRINCIPLES OF CLINICAL PHARMACOLOGY Second Edition potx
... effective use of medicine can be traced back at least to RudolphBucheim (1820–1879), who has been credited with1 PRINCIPLES OF CLINICAL PHARMACOLOGY, SECOND EDITION 20 Principles of Clinical Pharmacology Therefore, ... basic principles of clinical phar-macology currently are being applied in the process of drugdevelopment.Journals Clinical Pharmacology and TherapeuticsBritish Journal of Clinical Pharmacology Journal ... 6 Principles of Clinical Pharmacology TABLE 1.1 Status of Renal Function in 44 Patients withDigoxin ToxicityaSerum creatinine(mg/dL)No. of patients with CLCR of Percentage of group50...
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CRC Desk Reference of Clinical Pharmacology SECOND EDITION doc
... designation of Chester Fritz DistinguishedProfessor of Pharmacology and of Clinical Neuroscience, thehighest honor bestowed by the University of North Dakota.8 DESK REFERENCE OF CLINICAL PHARMACOLOGY For ... July of 1999, he was appointed professorand chairman of the Department of Pharmacology and Tox-icology at the University of North Dakota School of Med-icine and Health Sciences. In September of ... Gilman Professor of Pharmacology and EpidemiologyYale University School of MedicineNew Haven, ConnecticutAlfred M. Freedman, M.D.Professor and Chairman of PsychiatryDirector of Psychiatric...
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ABC OF CLINICAL GENETICS, THIRD EDITION pot
... havepersonal experience of the condition, several groups now offerthe help of professional care advisors. In the UK there is anextensive network of support groups for a large number of individual inherited ... Molecular confirmation of diagnosis in affected relative • Discussion of clinical and genetic aspects of condition, and impact on familyPatient requests test(interval of severalmonths suggested)Pre-test ... indicating non-paternity and affecting therisk of recurrence for future pregnancies.acg-03 11/20/01 7:14 PM Page 12ABC OF CLINICAL GENETICS, THIRD EDITION acg-fm 11/21/01 9:03 AM Page iparent...
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Chapter 005. Principles of Clinical Pharmacology (Part 1) pps
... Chapter 005. Principles of Clinical Pharmacology (Part 1) Harrison's Internal Medicine > Chapter 5. Principles of Clinical Pharmacology Principles of Clinical Pharmacology: Introduction ... accompaniment of drug therapy, this is not the case. The goal of this chapter is to describe the principles of clinical pharmacology that can be used for the safe and optimal use of available ... of the target molecule itself or of variability in the broad biologic context in which the drug-target interaction occurs to achieve drug effects. Two important goals of the discipline of clinical...
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Chapter 005. Principles of Clinical Pharmacology (Part 2) ppt
... P-glycoprotein, the product of the normal expression of the MDR1 gene. P-glycoprotein is expressed on the apical aspect of the enterocyte and on the canalicular aspect of the hepatocyte (Fig. 5-3); ... from the site of administration (Fig. 5-2). The extent of absorption may be reduced because a drug is incompletely released from its dosage form, undergoes destruction at its site of administration, ... aInhibitors affect the molecular pathway, and thus may affect substrate. bClinically important genetics variants described. A listing of CYP substrates, inhibitors, and inducers is maintained at http://medicine.iupui.edu/flockhart/table.htm....
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Chapter 005. Principles of Clinical Pharmacology (Part 3) docx
... intravenous infusion, plasma concentrations at steady Chapter 005. Principles of Clinical Pharmacology (Part 3) Clinical Implications of Altered Bioavailability Some drugs undergo near-complete ... a typical intravenous dose of verapamil is 1–5 mg, compared to the usual single oral dose of 40–120 mg. Administration of low-dose aspirin can result in exposure of cyclooxygenase in platelets ... tissues, the volume of distribution can be far greater than any physiologic space. For example, the volume of distribution of digoxin and tricyclic antidepressants is hundreds of liters, obviously...
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Chapter 005. Principles of Clinical Pharmacology (Part 4) ppsx
... Chapter 005. Principles of Clinical Pharmacology (Part 4) Clinical Implications of Drug Distribution Digoxin accesses its cardiac site of action slowly, over a distribution phase of several ... unbound (free) drug can distribute to sites of pharmacologic action, drug response is related to the free rather than the total circulating plasma drug concentration. Clinical Implications of Altered ... prevent elimination by very rapid (t1/2 of seconds) uptake into erythrocytes and endothelial cells before the drug can reach its clinical site of action, the atrioventricular node. Plasma...
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Chapter 005. Principles of Clinical Pharmacology (Part 5) doc
... effect of the drugs, it may produce severe agonist–mediated effects (such as hypertension or tachycardia) if the blocking drug is abruptly withdrawn. Chapter 005. Principles of Clinical Pharmacology ... site of action, it alters the function of that molecular target, with the ultimate result of a drug effect that the patient or physician can perceive. For drugs used in the urgent treatment of ... accumulation of active metabolites. Commonly, the clinical effect develops as a downstream consequence of the initial molecular effect the drug produces. Thus, administration of a proton-pump...
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Tài liệu McGraw.Hill - Brealey & Myers - Principles of Corporate Finance, 6th Edition Slides docx
... Cost of Capital Principles of Corporate FinanceBrealey and Myers Sixth Edition Chapter 241Short Cutsw Sometimes there are shortcuts that make itvery easy to calculate the present value of ... Financial OfficerComptrollerTreasurer22Opportunity Cost of CapitalExampleYou may invest $100,000 today. Depending on thestate of the economy, you may get one of threepossible cash payoffs:140,000110,000$80,000PayoffBoomNormalSlumpEconomy000,110$3000,140000,100000,80C ... YearsFV of $110% Simple10% Compound20Rate of Return Rulew Accept investments that offer rates of returnin excess of their opportunity cost of capital.ExampleIn the project listed below,...
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Tài liệu The GALE ENCYCLOPEDIA of ALTERNATIVE MEDICINE THIRD EDITION doc
... theintestines of patients who have undergone an ileos-tomy (removal of a pouch at the end of the smallintestine) and restorative complete colectomy (removal of all four parts of the colon). ... tolerateacidophilus.KEY TERMSCandidiasis—Any of a variety of infections causedby fungi of the genus Candida.Complete colectomy—The surgical removal of allfour parts of the colon.Crohn’s disease—An immune ... cNultyFreelance WriterSt.Charles, ILLeslie MertzMedical Writer, BiologistKalkaska, MIGALE ENCYCLOPEDIA OF ALTERNATIVE MEDICINE, 3rd EDITION xxiThe GALEENCYCLOPEDIA of ALTERNATIVEMEDICINETHIRD...
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