principles of cancer genetic counseling and genetic testing

báo cáo khoa học: " Platinum resistance in breast and ovarian cancer cell lines Niels Eckstein" pptx

Ngày tải lên : 10/08/2014, 10:21

... first-line anti -cancer drugs in a broad variety of malignancies, for instance: ovarian cancer, testicular cancer and non small cell lung cancer Cisplatin is inactive when orally administered and, thus, ... A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes Cancer Cell 2006, 10:515-27 Wang D, Lippard SJ: Cellular processing of platinum anticancer drugs ... of the ovary and testicular cancer when treated with cisplatin for which they show extraordinary Figure Structure formulas of platinum-complexes Cisplatin, Carboplatin, and Oxaliplatin Cis- and...

11
373
0

Báo cáo khoa học: "Giant breast tumors: Surgical management of phyllodes tumors, potential for reconstructive surgery and a review of literature" potx

Ngày tải lên : 09/08/2014, 07:22

... CCP, GG and MIL helped with writing and editing BR and MTM helped with researching, writing, and editing GN performed, reviewed, and interpreted all the pathology slides and reports GG and WC ... treatment and prognosis of patients with phyllodes tumor of the breast: an analysis of 170 cases Cancer 1996, 77:910-16 Page of (page number not for citation purposes) World Journal of Surgical ... time of presentation The skin of the breast was blue at the apex of the mass, and the nipple was massively enlarged and excoriated (Fig 1) On initial presentation, there was no evidence of skin...

8
276
0

báo cáo hóa học:" Emerging role of microRNAs in diagnosis and treatment of various diseases including ovarian cancer" pdf

Ngày tải lên : 20/06/2014, 07:20

... expression of miR-181a, miR-181b, and miR-213 in OVCA cell lines results in resistance to doxorubicin and gemcitabine and increased expression of miR-99b and miR-14 leads to docetaxel and paclitaxel ... for cancer treatment Using data from miRNA profiling and knowledge of familial history of a certain diseases will help in developing miRNA-based personalized therapy Detailed understanding of ... same standard therapies, a more effective course of treatment could be targeted towards specific histotypes of various cancers Page of (page number not for citation purposes) Journal of Ovarian...

9
440
0

Báo cáo y học: "2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema" pdf

Ngày tải lên : 08/08/2014, 21:20

... in-hospital and home use of expensive and potentially toxic treatments, track outcomes (both beneficial and adverse), and develop and meet Standards of Care for HAE Page 10 of 13 c accesss to and support ... University of Manitoba, Winnipeg, Manitoba, Canada 31University of Auckland, Auckland, New Zealand 32Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA 33Department of Clinical ... patient perspective of HAE management and to help reflect on the development of comprehensive care clinics, home therapy programs, and overall management of HAE The Canadian and Canadian Hungarian...

13
718
0

Báo cáo khoa học: "Outcomes of resection and non-resection strategies in management of patients with advanced colorectal cancer" doc

Ngày tải lên : 09/08/2014, 04:21

... in a local copy of the Association of Coloproctology of Great Britain and Ireland colorectal cancer database All patients underwent colonic imaging (Barium enema or colonoscopy), and staging with ... confirmed by 71% of elective surgery patients having an ASA status of I or II and a median age of 72 The elective operative mortality of 14% is high but given the small number of patients in this ... colorectal cancer, as survival is comparable to that of resection and without the burden of a stoma Further studies are required to assess the impact of advances in surgical oncology on QoL and survival...

7
327
0

Báo cáo khoa học: "Surgical management of giant Brunner''''s gland hamartoma: case report and literature review" ppsx

Ngày tải lên : 09/08/2014, 04:21

... Hematoxylin and Eosin and viewed Histopathological Appearance of a Giant Brunner's Gland Histopathological Appearance of a Giant Brunner's Gland Hamartoma stained with Hematoxylin and Eosin and viewed ... Discussion Brunner's glands are alkaline-secreting glands located in the submucosal layer of the duodenum The majority of Brunner's glands are located in the first portion of the duodenum, with ... second and third portions of the duodenum BGH follow this distribution, as a series of 27 patients with BGH found 70% in the duodenal bulb, 26% in the second portion of the duodenum, and 4% in...

4
323
0

Báo cáo y học: "Non-invasive neurosensory testing used to diagnose and confirm successful surgical management of lower extremity deep distal posterior compartment syndrome" potx

Ngày tải lên : 10/08/2014, 10:20

... branches of the tibial nerve (Figures and 2) The anterior lateral dorsum of the foot and the dorsal web-space between the first and second toe – the usual distribution of the superficial peroneal and ... complete release of the deep distal posterior compartments and return of normal tibial nerve function Page of (page number not for citation purposes) Journal of Brachial Plexus and Peripheral Nerve ... with of the of the Pressurenerve branch of the Measurement of the use discrimination inSpecified Sensory is Measurement of point discrimination in great toe which is in the distribution of the...

6
334
0

Báo cáo y học: " Intricacies in the surgical management of appendiceal mucinous cystadenoma: a case report and review of the literature" ppt

Ngày tải lên : 11/08/2014, 12:20

... calcification, extensive areas of fibrosis and patchy acute and chronic non-specific inflammation were also seen in the wall of the appendix No significant cytological atypia or invasion of the appendiceal ... ascertain the safety profile of the approach we employed Systematic work-up and follow-up of patients with mucinous cystadenoma of the appendix should be undertaken because of the reported association ... Intricacies in the surgical management of appendiceal mucinous cystadenoma: a case report and review of the literature Journal of Medical Case Reports 2010, 4:129 Page of ...

4
427
0

Báo cáo y học: " Surgical management of abdominal compartment syndrome; indications and techniques" potx

Ngày tải lên : 13/08/2014, 23:20

... major source of morbidity is associated with the management and complications of the open abdomen Management of the open abdomen In view of the complicated and often fatal outcome of patients ... careful management and better understanding of the open abdomen, there is a high risk of persistent open abdomen requiring split-thickness skin grafting and delayed reconstruction of the abdominal ... selection of the technique has to be individualized and based on common sense and weighing the pros and cons of each technique The midline laparostomy is relatively safe, easy to perform and nearly...

5
272
0

Association analysis of genetic variation of estrogen related candidate genes in breast and endometrial cancers

Ngày tải lên : 09/09/2015, 17:58

... calibration Use of standardized laboratory procedures Training and competency assessment of staff Type of primary antibody and second antibody Type of antigen retrieval and test reagents Use of standardized ... 7.2 Subtypes of breast and endometrial cancer 23 7.3 Determination of ER phenotype and reliability of testing .25 7.4 Genetic polymorphisms in Estrogen Receptor .29 7.5 Candidate gene ... Many genetic studies have suggested that breast cancer and endometrial cancer are common, heterogeneous and polygenetic diseases, and it is unrealistic to expect that the genetic variance of these...

158
422
0

The functional investigation of forkhead factor FOXQ1 in human breast and colon cancers

Ngày tải lên : 10/09/2015, 15:51

... Epidemiology of breast cancer 6 1.2.2 Internal structure of mammary gland 6 1.2.3 Subtypes of breast cancer 9 1.2.4 Treatment of breast cancer 11 1.3 Colorectal cancer ... with basal-like breast cancer in terms of genetic makeup and tumor behavior Overall, triple-negative and basal-like breast cancer accounts for 12-17% of all types of breast cancer (Cleator, Heller ... Breast cancer 1.2.1 Epidemiology of breast cancer Breast cancer is currently the most leading cancer among women with an estimated 1.38 million new cancer cases diagnosed in 2008 (23% of all cancers),...

255
378
0

Báo cáo y học: "surgical Management of Hidradenitis Suppurativa"

Ngày tải lên : 26/10/2012, 08:57

... treatment and incision and/ or surgical removal of the abscesses and fistulas are usually futile.1,14 The success of medical therapies, however, often is limited because of the indolent and recurrent ... that lack of personal hygiene and utilization of inadequate treatment modalities result in severe and widely disseminated lesions that affects the quality of life and general health status of the ... inguinal, and perineal regions after wide excision of the diseased areas and elevation and advancement of the skin flaps Primary closure is primarily preferred by non-plastic surgeons and inadequate...

8
512
1

Báo cáo y học: "Management of HCV Infection and Liver Transplantation"

Ngày tải lên : 31/10/2012, 17:08

... because of the patient's often poor performance status, their increased susceptibility to infection and rejection, and the presence of anemia and renal dysfunction that lessen the tolerability of ... combination of pegylated interferon alpha-2b and ribavirin have resulted in end -of- treatment and sustained virological response rates ranging from 27-64% and 0-36%, respectively [24,25] Treatment of recurrent ... M, Seaberg E Impact of immunosuppression and acute rejection on recurrence of hepatitis C: results of the National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation...

5
491
0

Surgical management of spasticity

Ngày tải lên : 01/11/2013, 10:20

... Conservation of one-third to one-fifth of the fibres of each branch is sufficient to avoid loss of motor function and amyotrophy Comparing the results of stimulation of the distal and proximal parts of the ... flexors and extrinsic finger flexors, is indicated for spasticity in the wrist and the hand – the aim being to open the hand and improve prehension As the fascicular organization of the median and ... lateral and central bundles formed by the nociceptive and myotatic fibres, as well as the excitatory medial part or the TL and the upper layers of the dorsal horn Right: Principles of the technique of...

21
372
0

Tài liệu Report on The Management of Non-Muscle-Invasive Bladder Cancer ppt

Ngày tải lên : 14/02/2014, 21:20

... Only Randall G Rowland, M.D Professor and Director Division of Urology University of Kentucky Chandler Medical Center Lexington, Kentucky The Bladder Cancer Clinical Guidelines Panel consists of ... Members of the European Organization for Research and Treatment of Cancer Genitourinary Group A prospective European Organization for Research and Treatment of Cancer Genitourinary Group randomized ... of low-grade Ta bladder cancers Guideline: Intravesical instillation of either BCG or mitomycin C is recommended for treatment of CIS and for treatment after endoscopic removal of T1 tumors and...

68
425
1

Tài liệu Carrots, Sticks, and Promises: A Conceptual Framework for the Management of Public Health and Social Issue Behaviors docx

Ngày tải lên : 18/02/2014, 02:20

... understanding of and accommodate the target's MOAs and the trade-off of free choice and externalities The potential for success of the three sets of tools is derived from the target's assessment of ... short- and long-run self-interest (e.g., "buy my brand and you will be better off," "buy my brand and you will feel better about yourself") In public health and social issues, managers often ask ... 7, and 8; and members of 4, 7, and may be managed by allowing them the opportunity and/ or ability to share in the benefits P7 returns to a consideration of the importance of self-interest and...

14
780
0

Tài liệu NASA’S MANAGEMENT OF MOON ROCKS AND OTHER ASTROMATERIALS LOANED FOR RESEARCH, EDUCATION, AND PUBLIC DISPLAY doc

Ngày tải lên : 18/02/2014, 05:20

... origin and evolution of the solar system and the nature and distribution of life, NASA loans astromaterial samples to researchers worldwide To inspire the next generation of explorers and inform ... for loans of astromaterials for classroom examination and study The Curation Office manages the loans and makes lunar and meteorite education disks available to teachers 10 NASA’s Office of Communications ... Exhibits and Education Programs The Office manages about 140,000 lunar samples, 18,000 meteorite samples, and about 5,000 solar wind, comet, and cosmic dust samples As of March 2011, over 26,000 of...

46
466
0

Tài liệu Alcohol-use disorders: diagnosis, assessment and management of harmful drinking and alcohol dependence docx

Ngày tải lên : 21/02/2014, 11:20

... Alcohol dependence affects 4% of people aged between 16 and 65 in England (6% of men and 2% of women), and over 24% of the English population (33% of men and 16% of women) consume alcohol in a ... assessment and management of harmful drinking and alcohol dependence in adults and in young people aged 10–17 years This is one of three pieces of NICE guidance addressing alcohol-related problems and ... and seeking help, and the limited availability of specialist alcohol treatment services in some parts of England Additionally, alcohol misuse is under-identified by health and social care professionals,...

51
475
0

The management of harmful drinking and alcohol dependence in primary care potx

Ngày tải lên : 08/03/2014, 14:20

... directory of alcohol services and accommodation should be developed for the benefit of NHSScotland staff, patients and their families, friends and carers n 35 THE MANAGEMENT OF HARMFUL DRINKING AND ... (including in the elderly), tremor of the hands and tongue, and excessive capillarisation of the facial skin and conjunctivae.16,17 The exact association between these signs and actual heavy drinking ... INTRODUCTION 1.4 STATEMENT OF INTENT This guideline is not intended to be construed or to serve as a standard of medical care Standards of care are determined on the basis of all clinical data available...

44
381
0

Báo cáo khoa học: Gonadotropin-releasing hormone and ovarian cancer: a functional and mechanistic overview docx

Ngày tải lên : 16/03/2014, 04:20

... GnRH-I agonists and antagonists have been reported to inhibit the migration and invasion of prostate cancer, breast cancer and epidermoid carcinoma cells [65–67] Also, breast cancer cell invasiveness ... actions of GnRH in tumor cells and the agonistic effects of GnRH antagonists in cancer cells is still controversial Grundker and co-workers have compared the GnRH responsiveness of SKOV-3 and EFO-27 ... understanding of MAPK activation by GnRH analogs in cancer cells is rather limited In ovarian cancer OVCAR-3 cells and placental cancer JEG-3 cells, we have demonstrated biphasic activation of ERK...

16
311
0