practice embedded research— moving from research to practice to policy and back again
beyond the ivory tower international relations theory and the issue of policy relevance
... inject some rigor into these processes.6 For these reasons, both theorists and practitioners seek a clear and powerful understanding of cause and effect about policy issues, in order to help them diagnose ... prevent theorists’ research agendas from becoming arid or trivial This book therefore has two objectives: to elaborate and justify the reasoning that leads to these conclusions, and to illustrate ... has veered too far from substance and too close to scholasticism As in other fields driven by a concern with real-world developments, SIR research has been motivated by both internally- and externally-driven...
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Báo cáo hóa học: " Research Article Regularity Criterion for Weak Solutions to the Navier-Stokes Equations in Terms of the Gradient of the Pressure" docx
... 1.8 then u is smooth Berselli and Galdi 11 have extended the range of r and s to 2/r 3/s and 3/2 < s ≤ ∞ When s ∞, Chen and Zhang 12 also see Fan et al 13 refined it to the following condition: ... H Kozono and Y Taniuchi, “Bilinear estimates in BMO and the Navier-Stokes equations,” Mathematische Zeitschrift, vol 235, no 1, pp 173–194, 2000 17 J Chen and X Zhu, “A note on BMO and its application,” ... Pure and Applied Mathematics, vol 41, no 4, pp 437–458, 1988 6 Journal of Inequalities and Applications H Sohr and W von Wahl, “On the regularity of the pressure of weak solutions of Navier-Stokes...
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MORPHOGENESIS THE CELLULAR AND MOLECULAR PROCESSES OF DEVELOPMENTAL ANATOMY pptx
... the book, my policy has been to give key historical articles to the major contributions and to cite sufficient contemporary reviews and papers to guide the reader who would like to pursue his ... with which to embark on a research career I have not always succeeded in this aim because some tissues are hard to investigate and the data from their study seem contradictory and hard to explain ... anlagen grow out towards the head ectoderm; when they meet it, they and the contacted ectoderm interact to form eyes Neural-crest cells migrate laterally and anteriorly into the head to form neural,...
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The future of internal audit is now Increasing relevance by turning risk into results pot
... initiatives to key business risks and key operational and financial priorities Make sure that processes, methodologies and tools are up to date, that internal audit has the industry and functional ... internal auditors to have the ability to team with management and business units on relevant business issues They also expect internal audit resources to have deep sector knowledge and business ... strategy — Auditor survey respondent Key learning: Use thematic audits to put issues into perspective relative to risk for stakeholders seeking to understand the implications and insights the...
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Báo cáo khoa học: Non-enzymatic developmental functions of acetylcholinesterase – the question of redundancy docx
... syntaxins, ligatin, proto-oncogene receptor tyrosine kinase Mer, perlecan and the LDL receptor Of these, only Mer, perlecan and LDL receptor are expressed during migration and differentiation Searches ... system) and collagen IV, which interact and selfassociate to form a scaffold to which other ECM components, such as nidogen ⁄ entactin, fibronectin and perlecan, bind [27] ECM molecules tend to be ... observed to bind to a heterogeneous group of molecules, including proteins (NCAM, slit proteins, laminin, fibronectin and the thrombospondins) and growth factors [members of the fibroblast growth factor...
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báo cáo hóa học: " The role of interleukin-12 in the heavy metal-elicited immunomodulation: relevance of various evaluation methods" potx
... ranging from 0.63 to 0.97 and from 0.7 to 0.9 under stimulation by mAb or hkSE, respectively Considering the mean values of the measured cytokines, r values ranged from 0.93 to and from 0.59 to 0.71 ... light 12:00-hr dark cycle, and allowed free access to food and water Rooms were maintained at 22°C and 40–60% humidity Cytokine analysis using cytometric bead array Serum cytokine levels were determined ... phagocytic cells and to some degree by B cells It is considered to date the most critical factor for skewing the immune response towards a Th1 type, and thereby exerts a substantial stimulatory influence...
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Authority leadership marketing making content the cornerstone of customer engagement and relevance
... need to prime their pipelines and upsell and cross-sell customers with credible, strategic content Companies, both global and emerging, realize the need to use content to drive brand relevance and ... product features and functions, speeds and feeds, and deals and deployments In today’s multi-channel, searchoriented media landscape, corporate buyers, specifiers, and influencers tend to tune out ... knowledge capital and authority leadership come from effective market engagement, real-time customer feedback and listening, primary research, media analytics, as well as regular monitoring and mining...
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Báo cáo sinh học: "On the relevance of three genetic models for the description of genetic variance in small populations undergoing selection" docx
... loci, IM and SFM depart from FFM only after 20 generations, while for 10 loci, they both depart from FFM as early as generation and with loci, IM and SFM depart from FFM after generations and 6, ... to the genetic variance of the selected trait were assumed to be identical in the preceding comparisons To test the robustness of the results with respect to this assumption, and following Lande ... algorithm, initiated by Hospital [8] and developed by Fournet et al [7], uses the Monte-Carlo principle and provides the mean values and standard deviations for genetic mean and variance over time a 2.2...
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báo cáo khoa học: " Field transcriptome revealed critical developmental and physiological transitions involved in the expression of growth potential in japonica rice" potx
... AP2-EREBP-, and CCAAT-family genes MADS-, NAC-, and CCAAT- family genes tend to express mainly in endosperm, and the expression of MADS genes were induced at early stages of seed development (from to ... transcription factors maybe key regulators in the differentiation of lemma and palea Diurnal and growth stage-specific gene expression The transcriptomes of vegetative organs at daytime and nighttime ... spectrophotometer (NanoDrop) and checked for quality using an Agilent 2100 Bioanalyzer (Agilent Technologies, Palo Alto, CA, USA) One-color spike-mix was added to the total RNA prior to the labeling...
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báo cáo khoa học: " Developmental localization and the role of hydroxyproline rich glycoproteins during somatic embryogenesis of banana (Musa spp. AAA)" ppt
... derived against extensins from rice [42] Monocot barley and rice protoplasts contain JIM19 and JIM20 extensin-like epitopes [41,43], while there were both similarities and differences to the labelling ... http://www.biomedcentral.com/1471-2229/11/38 Background Plant cell wall and the cytoskeleton control plant polarity and morphogenesis [1,2] They determine cell shapes and control the fate of cells during cell differentiation To better ... (Figure 3g and h) Again, negative controls showed only very negligible unspecific signal (Figure 3i and 3j) An overview of immunolabelling of JIM11 and JIM20 epitopes in different cell types and embryogenic...
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báo cáo khoa học: " Integration of tomato reproductive developmental landmarks and expression profiles, and the effect of SUN on fruit shape" pot
... controlling tomato fruit shape, reveals a region of the tomato genome prone to DNA rearrangements Genetics 2004, 168:2127-2140 Jensen WA: Botanical Histochemistry: Principles and Practice San ... doubled from anthesis to days post anthesis (dpa), and then further doubled at and 10 dpa, respectively (Fig 6) Cell number across the pericarp increased from 10 at anthesis to 17 at dpa, and reached ... fifth landmark and occurred between 10 and 12 dpa (Fig 7E and 7F) highlighting the beginning of cotyledon growth The 13–16 dpa embryo was torpedo shape, marking the sixth landmark (Fig 7G and 7H)...
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Báo cáo y học: "spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response" doc
... compared to neutrophils and their precursors The IL-17 receptor A is highly expressed in hematopoietic cells [26] Whether the positive staining of neutrophils and MPO+ precursor cells is due to autocrine ... significant differences compared to RA patients, OA patients or healthy controls with regard to PB and compared to RA with regard to SF These results confirm our immunohistological analysis of the bone ... to results obtained from patients with RA (PB and SF) and controls (PB) Additionally, we performed an extensive analysis of IL-17+ cells in bone specimens from AS patients To our knowledge, this...
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Báo cáo khoa học: "Clinical review: Tokyo – protecting the health care worker during a chemical mass casualty event: an important issue of continuing relevance" ppt
... decontaminated This risk varies from country to country, and depends on factors as varied as the extent to which physicians are involved at the site of such emergencies and the range of medical care ... decontamination process However, chemical weapons monitors are expensive and they require skill to operate and maintain Moreover, the addition of monitoring to the decontamination process risks reducing ... learned from the Tokyo incident, the effectiveness of the emergency services and their response to such an incident can be improved by addressing issues related to the decontamination of victims and...
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Báo cáo y học: " HIV-1 Accessory Protein Vpr: Relevance in the pathogenesis of HIV and potential for therapeutic interventio" ppsx
... occurred due to the secretion of these products from cells trafficking to the kidneys or due to other inflammatory cytokines produced in these cells due to the expression of these products Vpr and immune ... would be to employ specific cytokines or cellular kinase inhibitors One candidate, TNF-related apoptosis-inducing ligand (TRAIL), has been shown to cause HIV-1 infected macrophages to undergo ... shown to increase reactive oxygen species production in microglia and neuroblastoma cell lines, to lower ATP, to lower plasma membrane Ca2+ ATPase (PMCA) protein levels, and increase cytoplasmic...
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Báo cáo y học: "Advances in understanding the regulation of apoptosis and mitosis by peroxisome-proliferator activated receptors in pre-clinical models: relevance for human health and disease" potx
... ligands is understood sufficiently to permit us to conclude that this is not relevant to humans However, the genes that are activated by PPARα ligands to regulate apoptosis and mitosis remain to ... Rolfe M and Roberts RA Role for tumor necrosis factor alpha receptor and interleukin-1 receptor in the suppression of mouse hepatocyte apoptosis by the peroxisome proliferator nafenopin Hepatology ... 165 Yamamoto Y, Nakajima M, Yamazaki H and Yokoi T Cytotoxicity and apoptosis produced by troglitazone in human hepatoma cells Life Sci 2001, 70:471-482 166 Boelsterli UA and Bedoucha M Toxicological...
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Báo cáo y học: "Relevance of laboratory testing for the diagnosis of primary immunodeficiencies: a review of case-based examples of selected immunodeficiencies" doc
... Spectratyping -molecular, FC NK cytotoxicity (spontaneous killing, ADCC, IL-2-stimulated and PHA stimulated cytotoxicity) Radioactive method, FC CD8 T cell cytotoxicity - mitogen-stimulated, antigen-specific ... manifestations such as autoimmunity, neoplasia, and congenital anomalies of organs and/ or skeleton Therefore, the traditional role of the laboratory has been to provide supportive data to a largely clinical, ... such as Phytohemagglutinin (PHA), Pokeweed mitogen (PWM) and Concanavalin A (Con A), and antigens, such as Candida albicans (CA) and Tetanus toxoid (TT) to ascertain T cell immune competence in PIDs...
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Báo cáo y học: "The organisation of the stress response, and its relevance to chiropractors: a commentary" pdf
... necrosis factor (TNF)-A, interferon (IFN)-Y and interleukin-12 (IL-12), and to stimulate the production of anti-inflammatory cytokines such as IL-10, IL-4 and transforming growth factor (TGF)B ... Stress hormones, proinflammatory and anti-inflammatory cytokines and autoimmunity Ann N Y Acad Sci 2002, 966:290-303 Harbuz M: Neuroendocrine function and chronic inflammatory stress Exp Physiol ... These systems project to association cortices, such as the parieto-temporo-occipital and prefrontal, and then to the transitional cortex, including entorhinal, parahippocampal and perirhinal areas...
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Báo cáo sinh học: "The use of retroviral vectors for gene therapy-what are the risks? A review of retroviral pathogenesis and its relevance to retroviral vector-mediated gene delivery" pptx
... receptor resulting in massive erythroid proliferation and splenomegaly [34] However, p55 does not bind to the active site of the Epo receptor and the Epo receptor is not used as the receptor for ... [58] and maedi/visna virus (MVV) [59] For CAEV and MMV viral infection of macrophages seems to induce an inflammatory response involving macrophages and CD4+ and CD8+ T cells It is this inflammatory ... with oncogenic retroviral vectors and the protocol used was designed to enhance transduction by using multiple cytokines to stimulate division of PHSC This is likely to induce many genes involved...
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AN INVESTIGATION INTO THE USE OF PRESENTATION-REFLECTION ASSIGNMENTS IN THE AMERICAN STUDIES SYLLABUS AT ULIS-VNUH: RELEVANCE AND EFFICACY AS PERCEIVED BY LECTURERS AND STUDENTS Nghiên cứu về việc Sử dụng Bài tập Thuyết trình-Viết Thu hoạch trong Bộ môn H
... All monitors then forwarded this form to their class' members, who later returned the filled forms to their respective monitor All monitors packed the forms together and sent back to the researcher ... interpretation and discussion in the next chapter Responses from the open-ended question were taken into analysis in tandem with data from interviews to shed light into the more in-depth issues Due to the ... other hand, seemed to be less radical and rather soft-handed About teachers, and other factors that related to the either or both of the assignments Students, when looking at teachers to make...
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Gradient enhanced plasticity and damage models addressing the limitations of classical models in softening and hardening
... shape functions for displacement u and nonlocal parameter λ Finally, we express dσ and dλ in terms of dε and dλ (see Appendix B) and substitute them into Eq (2.21) to get the tangent stiffness matrix ... load-displacement graphs with the same shear band thickness 25 Fig 2.14: Effective plastic strain profiles for α cr = 4.44 x10 −3 m where (from top to bottom) m is 1.1, 1.25 and respectively 26 The material ... weight to the local component It is reported that this “over-nonlocal” approach is required to simulate a mesh independent shear band for some material models (Di Luzio and Bazant, 2005; Grassl and...
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