... meta-analysis of the use of typical antipsychotic agents inbipolardisorder J Affect Disord 2001, 65(1):85-93 Hunter J, Schmidt F: Methods of Meta-Analysis: Correcting error and bias in Research findings ... usefulness of aripiprazole against the psychotic symptoms during the acute manic/mixed and maintenance phases ofbipolar illness, however there are specific issues the clinician should have in mind, ... evidence inbipolardisorder Expert Opin Pharmacother 2007, 8(7):1001-1009 McIntyre RS, Woldeyohannes HO, Yasgur BS, Soczynska JK, Miranda A, Konarski JZ: Maintenance treatment inbipolar disorder: ...
... protein isoforms contain a DNA- binding homeodomain, two LIM domains, which participate in protein-protein interactions, and a carboxyl terminus (C-terminus) trans-activation domain The DNA- binding ... examining the interactions of methyl-binding proteins with chromatin modifiers, including HDACs and co-repressor complexes confirmed cross-talk between DNAmethylation and chromatin in regulating ... leucine-rich acidic nuclear protein LH luteinizing hormone LHX3 LIM homoeodomain LHX4 LIM homoedomain LIM Lin11,Isl-1, Mec-3 MBD methyl-CpG binding domain protein MBP methyl CpG binding protein...
... is growing interest in characterizing QoL inbipolardisorder populations, and determining the impact of treatment interventions upon life quality The scientific quality of research in this field ... assessed several domains of functioning Studies using scales that examined single domains of QoL (for example, those assessing solely social or occupational functioning, or single-item scales such ... study assessing QoL inbipolar depression, one performed in a Turkish sample of interepisode patients, one conducted in a sample of patients attending a mental health service in Italy, one in recently...
... concerning bipolar depression or the maintenance phase The use and usefulness of antidepressants inbipolardisorder is controversial because of the risk of inducing Fountoulakis et al Annals of ... double-blind, randomized comparison of the efficacy and safety of intramuscular injections of olanzapine, lorazepam, or placebo in treating acutely agitated patients diagnosed with bipolar mania J Clin ... Bowden CL: Maintenance of response following stabilization of mixed index episodes with olanzapine monotherapy in a randomized, double-blind, placebocontrolled study ofbipolardisorder J Affect...
... Membrane protein-1 (LMP-1) induced production of Interleukin-8, as in the case of nasopharyngeal carcinoma[7] Although such relationship was not established in CD, it may explain the results of our ... cases into groups, with one that EBER signals were mainly localized in the germinal centers and another one having signals mainly in inter-follicular areas There are 12 cases having EBER signal in ... are 12 cases having EBER signal in areas of germinal centers and cases having signals in inter-follicular areas In the group of EBV localized within germinal centers (GC-EBV), patients tend to...
... functioning Furthermore possible inflammation processes involved inbipolar depression will be investigated The design enables us to assess changes in a wider spectrum of cytokines as a function of ... considerations of measuring disability inbipolar disorder: validity of the Multidimensional Scale of Independent Functioning Bipolar Disord 2007, 9(1-2):3-10 47 Akiskal HS, Akiskal KK, Haykal RF, Manning ... Rating is independent of whether the symptom is regarded as being drug-induced or not Probability of the causal relationship (or lack of it) of each item to the medication in question is indicated...
... of treating bipolardisorderin the California Medicaid (Medi-Cal) program J Affect Disord 2002, 71(1-3):131-139 Blanco C, Laje G, Olfson M, Marcus SC, Pincus HA: Trends in the treatment ofbipolar ... studies can provide important insights into the outcomes of clinical practice in real-world settings, where dosing, titration and concomitant medications are not constrained by trial protocols Such ... address outcomes following adding, switching, or discontinuing antipsychotics, which may be common in this population The analysis of such complex treatment patterns within claims data may be...
... of bud in phase B (20×) (o) DAPI labelling of nuclei of bud in phase B (20×) (p) 5-mdC labelling of bud in phase B (20×) species In the first place a sudden fall in the percentage of global methylation ... 1: tubulin and AcH4 of bud in phase A; Lane 2: tubulin and AcH4 of bud in phase B; Lane 3: tubulin and AcH4 of bud in phase C; Lane 4: tubulin and AcH4 of bud in phase D Marker bands are indicated ... opposite profiles in every phase, indicating that H4 deacetylation and DNAmethylation cooperate in restructuring chromatin during floral development in azalea Discussion The floral transition in azalea...
... evolutionary origin of imprinting are still unclear but in plants, imprinting may be the consequence of global epigenetic reprogramming during sexual reproduction Introduction of imprinting In plants ... maintenance of the imprinted status of PHE1 in endosperm 26 2.4 Genomic imprinting and RNA-directed DNAmethylation Maintenance ofDNAmethylation at cis-elements defines the mono-expression of ... genes are silenced by DNA methyltransferase MET1 in the vegetative tissue Maintain ofDNAmethylation is also required for silencing of imprinted genes in pollen Whereas DNAmethylation was actively...
... protein E2 is a 45 kD protein consisting of an N-terminal region of about 200 amino acid containing an activation domain, a hinge region and a C-terminal DNA binding domain of about 70 amino acids ... methylated CpG binding proteins; green lollipops, methylated CpGs The repressive signals ofDNAmethylation can be interpreted in two ways The methylationofDNA directly affects the binding of some ... 1997) Of all imprinted genes discovered, it is believed that parental origin specific methylation plays a role either in establishing or maintaining the imprint 10 The maintenance of imprinting...
... Comparison of the DNA gyrase inhibitory activity of HN with those of ciprofloxacin, LL-37 and ampicillin (an antibiotic acting as an inhibitor of cell wall synthesis) indicated that the inhibitory ... bactericidal effects of H4-(86–100) and ciprofloxacin were completed within 30 min, as incubation of the cells for a longer period (2 h) in the presence of increasing concentrations of the compounds ... penetrating their membrane and binding to the DNA without inducing cell lysis In the present study, HNr and H4-(86–100), like the quinolone antibiotic ciprofloxacin, displayed rapid (within 30 min;...
... these three arginines in TClpB By combining an arginine mutation with the WalkerA mutation in the other AAA+ module, we tested the rolesof the arginines in ATP binding and hydrolysis in each module ... stabilization of the hexameric form, but not for the ATP-induced motion of the middle domain Results The conserved arginines are not involved in nucleotide binding To examine the rolesof conserved arginines, ... the rolesof the arginines in individual AAA+ modules were not elucidated The role of the other conserved arginine (P2) in AAA-1 was also unclear Here, we investigated in detail the rolesof these...
... and 1L8Q (DnaA) The AAA+ domains of both proteins are shown in cyan with ADP indicated in red The helix-turn-helix (HTH)-containing DNA binding domain of DnaA is in green and the winged helix ... position of the origin of replication in Pyrococcus, providing the first experimental proof of a localized origin of replication in the archaea [52] Interestingly, in a situation reminiscent of that in ... structures of DnaA [59] and Orc1 ⁄ Cdc6 proteins [60,61] As can be seen in Fig 4, both proteins possess N-terminal AAA+ domains and C-terminal DNA binding domains (DBDs) In DnaA, the DBD contains a...
... Cleavage of IGF-binding proteins Shedding of membrane-anchored ligands of EGFR (HB-EGF, TGF-a and amphiregulin) Shedding of E-cadherin Activation of TGF-b Shedding of HB-EGF Proliferation Cleavage of ... overexpressed in more than one-third of all solid tumors [20] During cancer progression, increased shedding of the membrane-anchored ligands of EGFR, including heparin-binding EGF (HB-EGF), transforming ... molecules, integrins and interacting with phosphorylation sites for serine ⁄ threonine and tyrosine kinases, thus contributing to cancer development [11] Rolesof MMPs in cancer progression During development...
... quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72, 248–254 40 Laemmli UK (1970) Cleavage of structural proteins during the assembly of head of ... or heterodimers of subunits ranging from 23 to 30 kDa in size Subunits of all known GST structures exhibit a two-domain fold, the N-terminal domain and C-terminal domain, including the highly ... arrangement of these elements is usually bababba, similar to the thioredoxin fold of other GSH-binding or cysteine-binding proteins The H-site is entirely helical, with a variable number of a-helices,...
... acetyl-transferase-catalyzing inner domain E3BP domains: L3, N-terminal lipoyl domain; B, E3 binding domain; I, inner domain which associates with the inner domain of E2 Dotted connections indicate binding interactions ... domains and their binding interactions E2 subunit domains: L1, N-terminal lipoyl domain; L2, inner lipoyl domain; B, E1 binding domain; I, oligomer-forming, acetyl-transferase-catalyzing inner ... blocks binding of PDP1 and PDP1c to the L2 domain As can be seen in Fig 2A, a distinct pocket exists in the center of this set of residues Binding of PDP1c-Ca2+ to this region may be reinforced...
... a significant increase in expression level in an in vivo system lacking DNAmethylation [14] These data suggested that DNAmethylation had no role in regulating gene expression during development ... frequent targets ofmethylationin a mixed cell population such as tumor DNA This may have even more potential than existing DNAmethylation biomarkers In addition, studying DNAmethylation for ... mechanisms involved in tissue differentiation are unknown Intragenic DNAmethylation is known to be capable of altering the chromatin structure and elongation efficiency in mammalian cells, depleting...
... pattern emerging in a sequence of numbers; a point of coincidence found in a group of lines; a large change resulting from a small variation; a finite real thing proved by an infinite, possibly ... by influencing the discernment of features in a situation, and thereby directing the thought patterns of the inquirer According to Dewey’s theory of inquiry (1938), the heuristic function of ... beliefs, and values—some of the elements of the affective domain (Goldin, 2000)—that are intertwined with aesthetic responses The three rolesof the aesthetic in mathematical inquiry that I have identified...
... inbipolardisorder Neural correlates ofbipolardisorder and rumination Research into neural correlates ofbipolardisorder has increased dramatically in the last few decades with advances in ... deficit in inhibiting selffocus These hypotheses provide interesting lines of investigation that might be pursued in future neuroimaging studies Conclusions and future directions The mind inbipolar ... functioning, including attentional setshifting [65, 66], planning ability [67] and decision making [66, 67], researchers consistently find deficits in executive functioning in mania And the finding...
... organizing, building the team of professional staff that is in charge of performing the management of resources and environment Strengthening the government’s rolesin the management of resources ... sustainability of the society This includes: maintaining the social equality, eradicating the poverty and using the development indicators of people as the first objective of the development 2.2 ROLES ... strengthening the rolesof the government in the incorporation of the economic growth with ecological environment protection 2.2.3 Rolesof the government in performing the inspection, checking and...