pharmacological models of parkinson s disease in rodents

báo cáo hóa học: " Gait dynamics in mouse models of Parkinson''''s disease and Huntington''''s disease" doc

Ngày tải lên : 19/06/2014, 10:20

... ~8 weeks, ~10 weeks, ~12 weeks, and ~13 weeks Discussion Gait disturbances are characteristic of Parkinson' s disease, Huntington 's disease, and amyotrophic lateral sclerosis Gait reflects several ... cycle timing in Parkinson' s disease and Huntington 's disease Mov Disord 1998, 13:428-437 Blin O, Ferrandez AM, Serratrice G: Quantitative analysis of gait in Parkinson patients: increased variability ... and processing 20 21 22 References Salarian A, Russmann H, Vingerhoets FJ, Dehollain C, Blanc Y, Burkhard PR, Aminian K: Gait assessment in Parkinson' s disease: toward an ambulatory system for...

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Báo cáo khoa hoc:" Exclusion of PINK1 as candidate gene for the late-onset form of Parkinson''''s disease in two European populations" pps

Ngày tải lên : 11/08/2014, 08:20

... epidemiology of Parkinson' s disease in the county of Rogaland, Norway Movement Disorders 1995, 10:541-549 Larsen JP, Dupont E, Tandberg E: Clinical diagnosis of Parkinson' s disease Proposal of diagnostic ... variant was not associated with late-onset PD in our study These findings correspond to previously published data of no leading association of other coding SNPs within the PINK1 gene and PD [13] In ... patients and controls were determinated by using DHPLC analyses (WAVE® system, Cheshire, UK, using software Wavemaker 4.1) according to established procedures Statistical analyses SNP frequencies...

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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx

Ngày tải lên : 15/02/2014, 01:20

... discussions References Thomas B & Beal MF (2007) Parkinson s disease Hum Mol Genet 16 Spec No 2, R183–R194 Devine MJ & Lewis PA (2008) Emerging pathways in genetic Parkinson s disease: tangles, ... oxidative stress in Parkinson disease pathogenesis Nat Clin Pract Neurol 4, 600–609 Lesage S & Brice A (2009) Parkinson s disease: from monogenic forms to genetic susceptibility factors Hum Mol ... displayed quantitative differences, regardless of whether or not a-synuclein was overexpressed (Fig 2, insets; black versus white bars) Dopamine-responsive proteins were involved in protein synthesis,...

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Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf

Ngày tải lên : 23/03/2014, 04:20

... mechanisms of many disease processes and will continue to impact our understanding of disease pathogenesis This minireview will examine the previous studies of genes for ROCO or LRRK2 homologs in slime ... early-onset Parkinson s disease caused by mutations in PINK1 Science 304, 1158–1160 29 Lee SB, Kim W, Lee S & Chung J (2007) Loss of LRRK2 ⁄ PARK8 induces degeneration of dopaminergic neurons in Drosophila ... enhanced sensitivity to endoplasmic reticulum stress induced by tunicamycin, a speciﬁc inhibitor for N-linked glycosylation Interestingly, this enhanced sensitivity is suppressed in mutant worms with...

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báo cáo hóa học: " Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson''''s disease" potx

Ngày tải lên : 19/06/2014, 22:20

... A link between TNF family receptors and caspases in Parkinson' s disease Neurology 2002, 58:308-310 Knott C, Stern G, Wilkin GP: Inflammatory regulators in Parkinson' s disease: iNOS, lipocortin-1, ... reaction in response to the neurotoxin Discussion Regular intake of nonaspirin NSAIDs (and high dose of aspirin) has been reported to be associated to a 45% lower risk of PD in large cohorts [22] In ... tracersdays measured6-OHDA lesion of dopamine terminal loss and inflammaA) Using A) Using micro-PET and selective radioactive tracers we measured in vivo the extent of dopamine terminal loss and inflammatory...

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báo cáo hóa học: " Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer''''s disease" potx

Ngày tải lên : 19/06/2014, 22:20

... of increased levels of cytokines in the brains of Alzheimer 's disease patients, and in transgenic mouse models of Alzheimer 's disease [10-12] However, all these reports have focused on a small ... brain slices was assessed using the Bioplex cytokine multi-array system Cytokine levels were not significantly elevated in PS1 brain slices compared to control slices, indicating that the PS1 Page ... brain slice cultures from transgenic mouse models of Alzheimer 's disease, and to further relate this increase to the level of Aβ present in the brain Another purpose of our study was to determine...

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báo cáo hóa học: " Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson''''s disease" pptx

Ngày tải lên : 19/06/2014, 22:20

... attenuates MPTP-induced loss of THpositive neurons and neuronal terminals in the nigrostriatal system Because of possible unintended confounding effects associated with oral administration of COX-2 inhibitors ... loss instead of a loss of TH expression To determine whether valdecoxib could prevent not only MPTP-induced loss of SNpc dopaminergic neurons but also the loss of striatal dopaminergic fibers, ... death This study suggests that COX-2 plays an important role in the secondary activation of microglia, in the progression of the inflammatory response, and in the progressive loss of the dopaminergic...

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báo cáo hóa học: " CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson’s disease" pot

Ngày tải lên : 19/06/2014, 22:20

... various stimuli is impaired in the older groups, especially in PD patients, implying an intrinsic abnormality of CD200-CD200R signalling in PD brain Interestingly, CD200R expressed in human beings ... model of prion disease [70] All of these findings suggest that CD200CD200R signalling plays an important role in the pathogenesis of neurological disorders, including PD Previously, we always used ... Biology, Institute of Health Science, Shanghai Institutes of Biological Sciences (SIBS), Chinese Academy of Science (CAS) & Shanghai Jiao Tong University School of medicine, 225 South Chong Qing Road,...

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Quantitative evaluation of motor function before and after engraftment of dopaminergic neurons in a rat model of Parkinson''''s disease ppt

Ngày tải lên : 10/08/2014, 05:21

... pathogenesis of gait hypokinesia in Parkinson' s disease Brain 1994, 117(Pt 5):1169-1181 Morris ME, Iansek R, Matyas TA, Summers JJ: Stride length regulation in Parkinson' s disease Normalization strategies ... Performance scoring system in the analysis of Parkinson gait NeuroRehabilitation 2002, 17:255-262 Paquet JM, Auvinet B, Chaleil D, Barrey E: Analysis of gait disorders in Parkinson' s disease assessed ... grafting exogenous cells may provide better long-term results Stem cells are viewed as a possible source of neurons for cell-based therapies of neurodegenerative disorders, such as Parkinson' s disease...

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Tài liệu THERAPEUTICS of PARKINSON’S DISEASE and OTHER MOVEMENT DISORDERS docx

Ngày tải lên : 14/02/2014, 17:20

... in these positive symptoms of PD ANIMAL MODELS OF PARKINSON S DISEASE AND PARKINSONISM Early animal models of PD were based on lesions of midbrain areas in monkeys (Poirier et al., 1975) These ... Interestingly, loss of function mutations in 12 PARKINSON S DISEASE AND PARKINSONISM PINK1 in Drosophila causes male sterility, muscle wasting, dopaminergic neuronal degeneration, and increased ... misfolds, oligomerizes and aggregates, is resistant to UPS-mediated degradation and PARKINSON S DISEASE AND PARKINSONISM PARKINSON S DISESASE Sporadic Autosomal Dominant SYN LRRK2 UCH-L1 GENES...

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Surgical Treatment of Parkinson’s Disease and Other Movement Disorders pot

Ngày tải lên : 05/03/2014, 23:20

... this time 3.2 Dyskinetic Disorders In disorders associated with dyskinesias, basal ganglia output is thought to be reduced, resulting in disinhibition of thalamocortical systems and dyskinesias ... development of a variety of movement disorders These diseases are conventionally categorized into either hypokinetic disorders, such as Parkinson s disease, or hyperkinetic disorders such as hemiballism ... disorders The most serious shortcoming of the aforementioned scheme of parkinsonian pathophysiology is, perhaps, that changes in the spontaneous discharge patterns, and the responses of basal...

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An Atlas of PARKINSON’S DISEASE AND RELATED DISORDERS pdf

Ngày tải lên : 14/03/2014, 22:20

... these nuclei may be responsible for the bradykinesia seen in patients with Parkinson' s disease (Figure 2) Parkinson s disease Any discussion of the clinical characteristics of Parkinson' s disease ... Posture in early Parkinson s disease ©2004 CRC Press LLC Figure 11 Posture in later-stage Parkinson s disease Figure 12 Parkinson s disease: Impaired fist clenching Figure 13 Parkinson s disease: ... index ISBN 1-85070-943-2 Extrapyramidal disorders Atlases Parkinsonism Atlases Movement disorders Atlases I Title II Series [DNLM: Parkinson Disease atlases Basal Ganglia Diseases atlases Movement...

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An Illustrated Pocketbook of Parkinson''''s Disease and Related Disorders pot

Ngày tải lên : 14/03/2014, 22:20

... PARKINSON S DISEASE Figure Parkinson s disease: substantia nigra showing depletion of tyrosine hydroxylase (immunostained for tyrosine hydroxylase) Courtesy of S. E.Daniel, The Parkinson s Disease ... ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 11 Posture in later-stage Parkinson s disease AN ILLUSTRATED POCKETBOOK OF PARKINSON S DISEASE Figure 12 Parkinson s disease: impaired fist ... disease Any discussion of the clinical characteristics of Parkinson s disease must take into account the inaccuracies of clinical diagnosis In a successive series of 100 patients with a clinical...

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ETIOLOGY AND PATHOPHYSIOLOGY OF PARKINSON''''S DISEASE pot

Ngày tải lên : 27/06/2014, 19:20

... Etiology and Pathogenesis of Parkinson s Disease Taku Hatano and Nobutaka Hattori Chapter Genetics of Parkinson Disease 15 Celeste Sassi Chapter Parkin and Parkinson s Disease 47 Shiam-Peng Tay, Grace ... variants at the same loci increase susceptibility for PD in the general population Genetics of Parkinson Disease 17 18 Etiology and Pathophysiology of Parkinson' s Disease Genetics of Parkinson Disease ... Distruption of the Ca2+ homeostasis has recently been Genetics of Parkinson Disease 31 proposed of a possible cause of selective vulnerability of dopaminergic neurons in PD Associated SNPs in the BST1...

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Báo cáo y học: "Manifestations of Ollier’s disease in a 21-year-old man: a case report" pdf

Ngày tải lên : 11/08/2014, 14:20

... erosion, extension of the tumor into soft tissues or irregularity or indistinctness of the surface of the tumor A whole-body bone scan obtained hours after intravenous injection of 20 mCi (740 ... criteria [6] In our case, as there was no cortical destruction or soft tissue extension, the histopathological diagnosis of benign lesions was reliable Retrospective assessment of our patient ... problems caused by limb-length discrepancy, as lesions frequently involve the femur or tibia [2] Malignant changes in Ollier s disease may occur in adult patients [2] As dysplasia progresses, there...

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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx

Ngày tải lên : 18/02/2014, 14:20

... intracellular cholesterol trafﬁcking Transferase activity ATPase Dopamine transmission and synaptic vesicle dynamics Protein kinase Gaucher s disease ⁄ Parkinson s disease in heterozygotes Neurodegeneration ... DES, desaturase; GALC, galactosylceramidase; GBA, glucosylceramidase; GCS, glucosylceramide synthase; SMS, sphingomyelin synthase; SMse, sphingomyelinase; SPT, serine palmitoyl transferase Yellow ... calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase Biochemistry...

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Báo cáo khoa học: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract Implications for Parkinson’s disease docx

Ngày tải lên : 16/03/2014, 11:20

... as salsolinol [23] In line with the suggested role of ADHs and ALDHs in protection against toxic insults, mRNAs encoding these enzymes have previously been identiﬁed in tissues forming a physiological ... epithelial lining, might induce a-synuclein misfolding and aggregation in speciﬁc neurons of the intestinal neuronal plexuses and possibly also reach the central nervous system The mammalian ADHs (EC ... human tissues, and that this has implications for how to interpret the role of the studied enzymes in health and disease Results The distribution and relative intensity of expression of the Adh1,...

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báo cáo hóa học:" Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson''''s disease" doc

Ngày tải lên : 18/06/2014, 15:20

... References 10 Twelves D, Perkins KS, Counsell C: Systematic review of incidence studies of Parkinson' s disease Movement Disord 2003, 18:19-31 Olanow CW, Goetz CG, Kordower JH, Stoessl AJ, Sossi V, Brin ... was subjected to HPLC assay Figure HPLC analysis of the synthesis and release of DA by RPE cells HPLC analysis of the synthesis and release of DA by RPE cells.(A) HPLC analysis of standard of ... used for the analysis of other data via the SPSS 10.0 soft packages (SPSS Inc., USA) The criterion for statistical significance was set at p < 0.05 Results RPE-CM protects against rotenone and...

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Báo cáo hóa học: " Reduction of freezing of gait in Parkinson’s disease by repetitive robot-assisted treadmill training: a pilot study" doc

Ngày tải lên : 19/06/2014, 08:20

... Fahn S: Motor blocks in Parkinson s disease Neurology 1992, 42(2):333-339 Hong M, Earhart GM: Rotating treadmill training reduces freezing in Parkinson disease: preliminary observations Parkinsonism ... freezing of gait in parkinsonism, proposed working definition, and setting the stage Mov Disord 2008, 23(2) :S4 23-425 Backer JH: The symptom experience of patients with Parkinson s disease J Neurosci ... severity to assess changes after an intervention using videotaped sessions of five 10-meter walks including turns A previous study reported the directionally restricted effects of gait training...

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