pharmacokinetics in patients with impaired renal function—study design data analysis and impact on dosing and labeling guidance 1998
Báo cáo y học: "Surgery of secondary mitral insufficiency in patients with impaired left ventricular function" pps
Ngày tải lên :
10/08/2014, 10:20
... examination (range 53 – 100 month) and in one patient was lost to follow-up Discussion Surgical treatment in patients with SMI and considerably impaired LV function had been identified as an indicator ... Sudden death (9 months) Pneumonia with sepsis (25 and 27 months) Stroke (26 months) Intestine perforation, peritonitis (2 months) Cerebral bleeding (17 months) Unknown (30 months) 14 1 1 Page ... replacement with CABG and in one a combination of MV repair, CABG and TV repair Redo's and prolonged cross-clamping times Figure (MVR) – Meier survival curve in (HTX) Kaplan and heart transplantation patients...
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báo cáo hóa học:" Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma" pot
Ngày tải lên :
18/06/2014, 15:20
... Abbreviation: ND, not detected initially designed to determine the impact of combination treatment on objective response rate since there is a welldefined, consistent response for IL-2 alone [1,2] ... Neurologic Confusion Syncope 3 12 Pulmonary Dyspnea Renal Elevated creatinine Oliguria 3 22 88 Systemic Fatigue data The corresponding author had full access to all data and the final responsibility ... IL-2 in patients with metastatic RCC In order to take advantage of IL-2 during the contraction phase of the immune response, we designed an exploratory trial in which an initial vaccination was...
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Báo cáo y học: "Persistence with anti-tumour necrosis factor therapies in patients with psoriatic arthritis: observational study from the British Society of Rheumatology Biologics Register" pps
Ngày tải lên :
09/08/2014, 14:20
... presented in Table The leading cause of drug discontinuation for infliximab was infusion reactions (7.4% of patients receiving infliximab, ~30% of all infliximab discontinuations for AEs) Other common ... univariate and multivariate analyses examining predictors of drug overall discontinuation, discontinuation due to inefficacy and discontinuation due to AEs For overall discontinuation, the multivariate ... associated with drug discontinuation of the first course of anti-TNF therapy Separate models were developed for overall discontinuation, for discontinuation due to inefficacy and for discontinuation...
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Báo cáo y học: " Exhaled volatile organic compounds in patients with non-small cell lung cancer: cross sectional and nested short-term follow-up study" pptx
Ngày tải lên :
12/08/2014, 18:21
... Authors' contributions DP: substantial contribution to conception and design, acquisition of data, analysis and interpretation of data, involved in drafting the articles PC: substantial contribution ... interpretation of data, involved in drafting the articles MG: substantial contribution to conception and design, statistical analysis and interpretation of data, involved in drafting the articles ... contribution to conception and design, collection of samples, revision of the draft critically for important intellectual content MC: substantial contribution to conception and design, analysis and interpretation...
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Báo cáo y học: "A positive fluid balance is associated with a worse outcome in patients with acute renal failure" ppsx
Ngày tải lên :
13/08/2014, 11:22
... care ARF, Timewith late-onset dailyacute renal failure (ARF), with early-onset unit stay in patients without acute renal failure (ARF), with early-onset ARF, and with late-onset ARF Analysis of ... the patients into two groups according to urine output and treatment with RRT In oliguric patients and in patients treated with RRT, mean fluid balance was significantly more positive than in non-oliguric ... rate in patients with delayed-onset ARF compared with Another interesting finding in the present study is that outcome among patients treated with RRT was better when RRT was started early in the...
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Báo cáo y học: "Intra-abdominal hypertension due to heparin induced retroperitoneal hematoma in patients with ventricle assist devices: report of four cases and review of the literature" pdf
Ngày tải lên :
10/08/2014, 09:22
... http://www.cardiothoracicsurgery.org/content/5/1/108 implantation, necessitating reoperation in up to 60% of cases irrespective of device used or indication for insertion Spontaneous retroperitoneal hematoma (SRH) on the other hand ... hand is a distinctive clinical entity, most commonly seen in association with patients with anticoagulation therapy, bleeding abnormalities, and haemodialysis [7,8] and may represent one of the ... significantly increases intrathoracic pressure resulting in extrinsic compression of the pulmonary parenchyma and development of pulmonary dysfunction [23,24] Increased intrapleural pressures resulting...
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Báo cáo sinh học: "Bactericidal activity of oxacillin and glycopeptides against Staphylococcus aureus in patients with endocarditis: Looking for a relationship between tolerance and outcome" doc
Ngày tải lên :
12/08/2014, 17:20
... of in vitro testing MICs and MBCs were determined at the IDD of Perugia under blinded conditions according to CLSI guidelines [16-18] 1) Oxacillin: Cefoxitin disk diffusion using Muller-Hinton ... the institutional ethical committee of Perugia and Bergamo All activity was conducted in accordance with the Declaration of Helsinki, and national and institutional review board Associations among ... vancomycin 10, teicoplanin and in therapy was not known Beta-lactam or glycopeptide antimicrobials were administered in combination with rifampin or an aminoglycoside, or a quinolone or a combination...
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Báo cáo y học: "A comparison of continuous and bi-level positive airway pressure non-invasive ventilation in patients with acute cardiogenic pulmonary oedema: a meta-analysis" potx
Ngày tải lên :
12/08/2014, 23:23
... Proportion of patients with hospital mortality and requiring intubation, new onset acute myocardial infarction, duration of noninvasive ventilation needed Allocation concealment adequate; not blinded; ... Proportion of patients with hospital mortality and requiring intubation, duration of noninvasive ventilation needed Allocation concealment not clear; not blinded; no loss to follow up; analysis by intention ... Proportion of patients with hospital mortality and requiring intubation, the duration of noninvasive ventilation needed and hospital length of stay Allocation concealment adequate; study not blinded;...
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Báo cáo khoa học: "Relationship of cognitive function in patients with schizophrenia in remission to disability: a cross-sectional study in an Indian sample" pps
Ngày tải lên :
08/08/2014, 23:20
... programming requiring temporal organization, maintenance and execution of successive action), conflicting instructions (tests sensitivity to interference, where verbal commands conflict with visual ... manuscript including extensive revision of interpretation and discussion of the results AN and RRP reviewed the methodology, contributed to recruiting patients, confirming the diagnosis and interpretation ... 20 RK was involved in the conceptualization of the study, literature review, recruiting patients, data collection, statistical analysis and interpretation of results PBM was involved in review...
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Báo cáo y học: "Reduced number and impaired function of circulating progenitor cells in patients with systemic lupus erythematosus" pot
Ngày tải lên :
09/08/2014, 10:20
... ELISA, using a matched antibody pair and recombinant protein as standard from R&D Systems (Oxon, UK) After incubation and binding of biotinylated antibodies, the color reaction was performed with ... Schleicher and Schuell, Dassel, Germany) Nonspecific protein binding was blocked using PBS with 0.1% Tween 20 and 5% bovine serum albumin (Sigma) After incubation with anti-caspase (Cell Signaling Technology, ... condition with chronic or recurrent inflammation Reduced mobilization and increased apoptosis, resulting in a shorter half-life of CPCs, can result from chronic exposure to inflammatory cytokines...
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Báo cáo y học: "Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study" pdf
Ngày tải lên :
09/08/2014, 14:22
... Figure DNA and α-actinin Baseline binding data for binding to nucleosomes, double-stranded DNA and α-actinin On each graph, absorbance ratios of the 30 normal controls and the 16 patients with lupus ... significant actinin DNA (dsDNA), (b) nucleosomes and α-actinin and (c) dsDNA and αCorrelation between binding to (a) nucleosomes and double-stranded DNA (dsDNA), (b) nucleosomes and α-actinin and (c) ... time point, urine was tested for protein/creatinine ratio (PCR), and serum was tested for albumin and creatinine in the routine clinical laboratory Statistical analysis was carried out on three...
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Báo cáo y học: "Respiratory symptoms and disease characteristics as predictors of pulmonary function abnormalities in patients with rheumatoid arthritis: an observational cohort study" pps
Ngày tải lên :
12/08/2014, 14:21
... 88%) and impaired diffusing capacity in 31 patients (19.8%) Impaired diffusion in conjunction with restriction or obstruction was observed in 16 of those latter subjects, while the remaining 15 patients ... competing interests Authors' contributions DAP participated in the study design, data collection and analysis as well as in writing and editing the manuscript JTG performed statistical analyses and ... We conclude that, beyond smoking, factors such as positive RF and anti-CCP antibodies and ongoing corticosteroid treatment may, in combination with pulmonary symptoms, identify individuals in...
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Báo cáo y học: "The association between microvascular and macrovascular endothelial function in patients with rheumatoid arthritis: a cross-sectional study" pdf
Ngày tải lên :
12/08/2014, 17:21
... function in healthy individuals have reported mixed findings, with some reporting an association between microvascular and macrovascular endothelial-dependent function [22,23] and others reporting ... be used interchangeably in this population Assessments of both vascular beds may provide more meaningful clinical information on vascular risk in RA, but this needs to be confirmed in long-term ... and JVVZ participated in the design of the study and helped with data analysis and drafting the manuscript All authors read and approved the final manuscript Competing interests The authors declare...
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Báo cáo y học: "Pituitary-adrenal function in patients with acute subarachnoid haemorrhage: a prospective cohort study" ppsx
Ngày tải lên :
13/08/2014, 11:23
... participated in analysis and interpretation of data and in revising the critically manuscript References Authors' contributions SB, AU and TK participated in study conception, acquisition of data, analysis ... corticoid-binding (SAH) and control patients with subarachnoid haemorrhageglobulin (CBG) concentration in Evolution of corticoid-binding globulin (CBG) concentration in patients patients with subarachnoid ... analysis and interpretation of data, drafting the manuscript and critically revising it ER participated in study conception, analysis and interpretation of data, drafting the manuscript and critically...
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Báo cáo y học: "Phenotype changes and impaired function of dendritic cell subsets in patients with sepsis: a prospective observational analysi" ppsx
Ngày tải lên :
13/08/2014, 18:22
... and TLR9 agonist-induced cellular responses in MDCs and PDCs in patients with sepsis In line with previous findings, we found increased IL-10 levels in septic patients at baseline and at day 28 ... expression on circulating monocyte and dendritic cell subsets in patients with sepsis at baseline and at day 28 compared with healthy controls Monocyte and dendritic cell subsets were stained and ... [46] In addition to defects in cytokine transcription and translation, reduced monocytic cytokine production in sepsis may result from impaired post-translational processes involved in cytokine...
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Báo cáo y học: "Effects of positive end-expiratory pressure on respiratory function and hemodynamics in patients with acute respiratory failure with and without intra-abdominal hypertension: a pilot study" docx
Ngày tải lên :
13/08/2014, 19:20
... II, duration of mechanical ventilation prior to inclusion and outcome for patients included in normal and increased IAP groups All patients were studied within one week from ALI/ARDS onset We ... at baseline or in response to PEEP Discussion intra-abdominal hypertension (dotted bars) Effect of PEEP on IAP in patients with normal IAP (shaded bars) and intra-abdominal hypertension (dotted ... small PEEP-induced increase in IAP is in keeping with previous findings by de Keulenaer and colleagues [37] Gattinoni and colleagues [7] reported a reduction in the Estat, RS, Estat, L and Estat,...
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Study the serum erythropoietin, ferritin and transferrin concentration in patients with end stage renal disease undergoing hemodialysis
Ngày tải lên :
10/06/2016, 10:39
... body's iron stores and the serum EPO in patients with ESRD 4.2.2 Serum iron, ferritin and TSAT in patients with ESRD and their relations with some clinical and laboratory parameters * Serum iron, ... Erythropoietin, ferritin levels and TSAT in patients with end-stage renal disease Serum EPO in patients with end-stage renal disease -The mean serum EPO concentration in patients with ESRD was ... (TSAT) in patients with end-stage renal disease (ESRD) indicated chronic hemodialysis To assess the change of concentration of erythropoietin , ferritin and TSAT in patients with end-stage renal...
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báo cáo hóa học:" Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14.18-IL2) in patients with metastatic malignant melanoma" docx
Ngày tải lên :
18/06/2014, 15:20
... post -dosing decrease in GD2 staining, and increase in S100 staining intensity and in CD8+ T cell infiltration The EMD 273063-induced intratumoral lymphocytic infiltrates displayed increased staining ... approaches for introducing IL2 into the tumor environment include injection of the cytokine intratumorally [17] and administering intratumoral injections of adenovirus encoding IL2 [18] In the later ... statistical analysis AK participated in the study design and coordination SDG participated in the study design and coordination OK participated in the study design and coordination and helped...
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Báo cáo hóa học: "Multicenter phase II study of matured dendritic cells pulsed with melanoma cell line lysates in patients with advanced melanoma" potx
Ngày tải lên :
18/06/2014, 16:20
... cutaneous lesions (concomitant changes in pigmentation and nodularity) with continued dosing Resection of two nodules at weeks 24 and 36 showed no evidence of viable melanoma; it was consistent with a ... studies in single institutions, frequently without pre-defined parameters for quality control of the DC manufacturing procedures The methods for DC generation, maturation and administration to patients ... Lesions in the skin and subcutaneous tissues, evaluable only by physical examination and not detected using imaging studies, were considered measurable if adequately recorded using a camera with...
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Báo cáo hóa học: " Effects of pegylated G-CSF on immune cell number and function in patients with gynecological malignancies" doc
Ngày tải lên :
18/06/2014, 16:20
... (Th2) cytokine production [3] In humans, G-CSF increases interleukin (IL)-4 release and decreases interferon (IFN)-g production [4], induces immune modulatory genes in T cells, including the Th2 ... responses in vitro Interestingly, monocytes from patients given pegfilgrastim induced T-cell proliferation to a similar extent as immunogenic DC In line with this, T-cell proliferation in response ... corresponding to the day after drug discontinuation (Figure 2B) Because FoxP3 + Treg cells are heterogeneous in humans and FoxP3-expressing cells have been detected both within CD4+CD25+ and within...
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