pharmaceutics and compounding issues in new drug development and marketing
Báo cáo y học: "Equipoise, design bias, and randomized controlled trials: the elusive ethics of new drug development" docx
... one meeting in one medical specialty, and we classified studies using only information available in the abstract This might limit the ability to generalize from our findings, and certainly if ... patients, improving efficiency in drug development, possibly reducing the cost of pharmaceuticals [32], and identifying those drugs that are most likely to be clinically useful and of positive ... Decision Randomization Personal societal interest and selfinterest Accept trial VERSUS Randomization Decision Node Decline trial Expected outcomes of usual care Personal, societal interest and selfinterest...
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Tài liệu Women Sufficiently Represented in New Drug Testing, but FDA Oversight Needs Improvement doc
... continue to be underrepresented and that sex differences in responses to drugs continue to go unexamined during drug development You asked us to investigate FDA’s progress in addressing the inclusion ... Abbreviations DES FDA IND IOM NDA NME OTC PPA Page ii diethylstilbestrol Food and Drug Administration investigational new drug Institute of Medicine new drug application new molecular entity over-the-counter ... arrhythmias in women more often than in men.1 Because of potential sex differences in the safety and efficacy of new drugs, it is important to include women and men in all stages of drug development and...
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Presentation introduction on new drug development Prof. JanHasker G. Jonkman
... 20120404 13/94 INTRODUCTION ON NEW DRUG DEVELOPMENT (INT-S.) CLINICAL PHARMACOLOGY (2) JHGJ/gh 20120404 14/94 INTRODUCTION ON NEW DRUG DEVELOPMENT (INT-S.) INTRODUCTION ON NEW DRUG DEVELOPMENT TABLE ... 34/94 INTRODUCTION ON NEW DRUG DEVELOPMENT (INT-S.) NEW DRUG: PATENT LIFE (3) JHGJ/gh 20120404 35/94 INTRODUCTION ON NEW DRUG DEVELOPMENT (INT-S.) INTRODUCTION ON NEW DRUG DEVELOPMENT TABLE OF ... 20/94 INTRODUCTION ON NEW DRUG DEVELOPMENT (INT-S.) JHGJ/gh 20120404 21/94 INTRODUCTION ON NEW DRUG DEVELOPMENT (INT-S.) DEVELOPMENT OF A NEW DRUG (2) • Synthesis of the molecule • Studies in animals...
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Tài liệu Lipases and Phospholipases in Drug Development pptx
... 81 Mg2+-independent Neutral Sphingomyelinases 84 Alkaline Sphingomyelinase from the Intestinal Tract 85 Bacterial Sphingomyelinase-phospholipase C 85 Sphingomyelinase Mechanism 85 Binding of Magnesium ... Alonso Introduction and Scope Sphingomyelinases 80 Types of Sphingomyelinases 80 Acid Sphingomyelinase (aSMase) 80 Secretory Sphingomyelinase (sSMase) 81 Neutral, Mg2+-dependent Sphingomyelinases ... Ions 85 Binding of Substrate 85 Mechanism of Catalysis 86 Sphingomyelinase Assay 88 Sphingomyelinase Inhibitors 89 Sphingomyelinase–Membrane Interactions 89 Lipid Effects on Sphingomyelinase Activity...
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Patents and New Product Development in the Pharmaceutical and Biotechnology Industries
... R&D for New Drug Introductions in the 1990s,” forthcoming in Pharmco-Economics, 2002; For earlier studies of new drug introductions in the 1970s and 1980s, see “Returns to R&D on New Drug Introductions ... costs and returns in the pharmaceutical and biotechnology industries The final section examines recent policy developments and issues surrounding patent lifetime and generic competition in this industry ... Costs, Times and Risks,” 29 Drug Information Journal (1995): 375-384; Kenneth I Kaitin and Joseph A DiMasi, “Measuring the Pace of New Drug Development in the User Fee Era,” 34 Drug Information...
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philips sarah d. women's social activism in the new ukraine. development and the politics of differentiation. bloomington, 2008
... organizing in Ukraine We examine the history of women’s organizing in Soviet and post-Soviet Ukraine, and I invite readers along to a “training” seminar on women and leadership as an example of international ... differentiation Examining emerging social programs and welfare reforms is like tracking a moving target, since reforms are a work in progress and policies keep shifting with the changing political landscape ... marginalisation of women in contemporary Ukraine Honing in on differentiating processes reveals that this marginalization and disintegration is anything but natural and inevitable On the other hand, differentiation...
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Research Issues in Systems Analysis and Design, Databases and Software Development doc
... business In the second case, the information systems development was a new activity in the organization, and the tools and the way of working were introduced and implemented at the beginning In ... professionals in the industry with understanding of the capabilities and features of new ideas and concepts in information systems development, databases, and forthcoming technologies Keeping with ... analysis and design, and software engineering The primary mission of ADR is to be instrumental in the improvement and development of theory and practice related to information technology and management...
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Research Issues in Systems Analysis and Design, Databases and Software Development phần 1 ppsx
... Finland Hilkka Merisalo-Rantanen, Helsinki School of Economics, Finland Tuure Tuunanen, The University of Auckland, New Zealand Chapter II Understanding Agile Software, Extreme Programming, and ... business, to stay in it and to be the best in the business The system is tailored to the business, not to the company.” The key driver of the development work is the continuously changing and increasingly ... of research in extreme programming and agile modeling This chapter also examines research in agile software development It first presents the details of agility, XP, and AM, including a literature...
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Research Issues in Systems Analysis and Design, Databases and Software Development phần 2 pot
... business In the second case, the information systems development was a new activity in the organization, and the tools and the way of working were introduced and implemented at the beginning In ... Howard, D (2003) Swimming around the waterfall: Introducing and using agile development in a data centric, traditional software engineering company In Proceedings of 5th International Conference ... practical software engineering experiments In Proceedings of the Third International Conference on Extreme Programming and Agile Processes in Software Engineering, Alghero, Sardinia, Italy Baskerville,...
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Research Issues in Systems Analysis and Design, Databases and Software Development phần 3 docx
... structuring one’s thinking and actions) Accordingly, method has two essential functions in ISD: (a) the function that purports certain effects on human thinking (such as augmenting, facilitating, and ... hermeneutic—that is, interpretative—processes (Introna & Whitley, 1997) This has to with mutual understanding, and augmenting and structuring their way of thinking about IS and ISD Methods are just instruments, ... this interaction they have another role and posses certain intellects and even aim to convey certain thinking about IS and ISD As such, methods have their own reasoning mechanism or understanding...
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Research Issues in Systems Analysis and Design, Databases and Software Development phần 4 pdf
... advance in our thinking about the effect of method in these interplays rather than reducing its meaning to certain aspects and attributes To show how to advance in thinking, we suggest looking beyond ... within another domain by analogical reasoning Reuse is a major underlying motivation for the emergence of the domain engineering discipline Domain engineering supports the notion of a domain, ... studies in information systems MIS Quarterly, 23(1), 67-93 Linell, P., & Thunqvist, D P (2003) Moving in and out of framings: Activity contexts in talks with young unemployed people within a training...
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Research Issues in Systems Analysis and Design, Databases and Software Development phần 5 ppsx
... to the integration of domain models and viewpoints in an academic and educational context rather than proposing ORM and ORC as new modeling tools in an industrial setting Introduction and Background ... constraints specified in the domain model is determined, and (c) the links among the entities in the domain model are matched by corresponding links in the application model In case such corresponding ... Springer Verlag Eckstein, S., Ahlbrecht, P., & Neumann, K (2001) Increasing reusability in information systems development by applying generic methods In Advanced information systems engineering...
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Research Issues in Systems Analysis and Design, Databases and Software Development phần 6 pdf
... assembly into new and more suitable development methodologies Reuse and Method Engineering Providing support to development methodologies and especially in the field of situational method engineering ... generalized domain modeling method to model active domains in view of an ongoing attempt to achieve integrated domain ontologies underlying the many viewpoints in conceptual modeling In this chapter, ... consider software-based information system development from the reuse perspective As our interest is in method engineering and in software-based information systems, in the following, we discuss proposals...
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Research Issues in Systems Analysis and Design, Databases and Software Development phần 7 ppt
... the explicit modeling of stakeholders’ perspectives within their social interactions The perspective modeling and analyzing methodology focuses on representing and handling the interactions among ... about method engineering as well as what method engineers in current situational method-engineering proposals (to perform their work, which consists of building and deploying adequate development ... contexts including previous and next criteria Examples are shown in Figure Exploiting reuse-frame refinement relationships may also be interesting with regard to forbidden criteria Indeed, enlarging...
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Research Issues in Systems Analysis and Design, Databases and Software Development phần 8 ppsx
... providing and handling external data and information that will be accessed by the stakeholders Examples are to use consistent checking and version-control mechanisms to maintain the product data integrity, ... solutions include providing suitable trainings based on their perspectives and the job requirements, assisting the critical stakeholder to review the relevant information during certain conflicting ... conflicting perspectives as means to enhancing brainstorming and innovation Third, strategies can be derived to manage the conflicts through influencing stakeholders’ information access and comprehension...
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Research Issues in Systems Analysis and Design, Databases and Software Development phần 9 pptx
... al., in press; Recker et al., 2005, 2006) THING PROPERTY In General In Particular Hereditary Emergent Intrinsic Nonbinding Mutual Binding Mutual Attributes CLASS KIND Cluster Things including ... theoretical domain within philosophy dealing with identifying and understanding elements of the real world (Bunge, 2003) Today, however, Copyright © 2007, IGI Global Copying or distributing in print or ... purposes During the initial stages, intuitive business-process models are used for scoping the project, and capturing and discussing business requirements and processimprovement initiatives with...
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Research Issues in Systems Analysis and Design, Databases and Software Development phần 10 doc
... Communication and Hi-Tech Service Line His research interests include agile information systems development, the foundation and modeling of business services, and method engineering He is involved in consultancy ... modeling and development processes During the last years his major research area has been domain engineering Arnon has also gained extensive experience in developing software systems in industry and ... and others Her current research focuses on developing and applying intelligent and learning technologies to business and management Copyright © 2007, IGI Global Copying or distributing in print...
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báo cáo khoa học: " Sexual and injection-related risks in Puerto Ricanborn injection drug users living in New York City: A mixed-methods analysis" doc
... access to SEP in their new setting Previous research showed that PR IDU bring cultural norms of syringe sharing with them to NYC since most PR IDU in NYC started injecting drugs in Puerto Rico ... continue to inform continued individual and collective risk behaviors among this population in NYC This habitus migration may help explain IDU continued injection and sexual risk in spite of increased ... migrating; and this was associated with higher levels of syringe sharing in NYC [4] Other IDU migration studies have also discussed the interactions between old and new drug injection settings...
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báo cáo khoa học: " Overdose prevention for injection drug users: Lessons learned from naloxone training and distribution programs in New York City" pdf
... naloxone by drug users is a new and innovative approach to reducing opiate-related mortality Currently, in several cities in the United States (US), drug users are being trained in naloxone administration ... tolerance and supply, control your high, injection techniques, aware of risks of mixing drugs, and minimize using alone), and (c) signs of an opiate overdose The naloxone training included information ... health issue and naloxone is increasingly seen as a new and innovative approach to reducing opiate-related mortality b) Extant prescription drug laws In most states, and until recently in New York,...
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Ethical issues in embryo interventions and cloning
... interventions and cloning trates on practical issues, within the context of licensing clinics for testing speciWc inherited conditions and restricting access through guidelines that limit which ... threatened by cloning In the words of the CCNE report, ‘reproductive cloning would inaugurate a new mode of Wliation, an individual born by cloning would be both a descendant and a twin of an adult’ ... associated with a possibly diminished sense of individuality and personal autonomy, belong to the same analysis Ethical issues in embryo interventions and cloning Perhaps feminist psychoanalytical...
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