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Báo cáo khoa học: An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist docx
... mutation of Arg46 had the dualeffect of (a) decreasing agonist affinity and (b) promoting the agonist-induced active conformation due to the loss of astabilizing constraint on the ground state of the ... with the corresponding sequence of the V1aR [10]. The role of the N-terminus has beenaddressed recently by alanine-scanning mutagenesis of the N-terminus of the V1aR; this revealed that a ... transmembrane domains traversing the lipid bilayer. The enlarged circle shows the amino acid sequence of the distal N-terminus of the V1aR and indicates the position of Arg46 that was subjected...
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Báo cáo khoa học: Mutual effects of proton and sodium chloride on oxygenation of liganded human hemoglobin Oxygen affinities of the a and b subunits potx
... 2005 The Authors Journal Compilation ª 2005 FEBS 6109 The time course and the yield of the geminate phaseare both sensitive to the immediate environment of the heme, and to the dynamics of structural ... [16]. Also, the efficiency of O2escape from the protein matrix afterphotodissociation, d, is calculated as the ratio of the quantum yield of BR, c, to that of the primary quan-tum yield of photodissociation, ... FEBS 6113 the different conformational forms of HbA is a keyfactor in the complete description of the sigmoidal be-havior of HbA oxygenation.Taking advantage of the photosensitivity of the heme...
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Economic Impact of the Abolition of the Milk Quota Regime – Regional Analysis of the Milk Production in the EU – doc
... Impact of the Abolition of the Milk Quota Regime – Regional Analysis of the Milk Production in the EU" (AGRI-2007-0444). The project aimed at a thorough policy impact analysis of the EU ... through either the transfer of an entire farm, the leasing or purchase of quota, or the allocation of quota from a national reserve. The transfer of milk quota may take place via a variety of administrative ... average, with +35.5% in the EU-10 and +13.8 in the EU-15. This excess supply makes the net trade position of the EU-27 stronger towards the Rest of the World. Within the EU there is a quite heterogeneous...
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Báo cáo khoa học: Phosphorylation of the arginine/serine dipeptide-rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization pptx
... copies of the N protein, respectively. (C) The RNA binding efficiency of N protein is represented as a percentage of bound RNA (i.e. the percentage of bound RNA = 100%)percentage of free probe). The ... phosphorylation.Effect of RS motif phosphorylation onoligomerization of the N proteinTo better understand the effect of RS motif phosphor-ylation on the biological function of the N protein, weFig. 3. The translation ... that of the full-length N protein (data not shown). Taken together,these data suggest that the RS-rich region of the SARS-CoV N protein is possibly phosphorylated by SRPK1.Phosphorylation of...
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Báo cáo khoa học: H NMR study of the molecular structure and magnetic properties of the active site for the cyanomet complex of O2-avid hemoglobin from the trematode Paramphistomum epiclitum pdf
... the projection of the tilt of the z axis on the x¢,y¢ plane (defined direction of tilt of z and the x¢ axis), and j % a + c defines the location of the rhombic (x, y) axes. The orientation of the ... at position E7 as the source of the H-bond to ligand on the basis of apartial sequence, which had indicated a Tyr on the distalE-helix. The similarity in the 1HNMRspectraofthethree globin ... ligand.Comparison of the strengths of dipolar interactions insolution with the alternate crystal structures of methemo-globin establish that the solution structure of wild-type Hbmore closely resembles the...
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Báo cáo khoa học: Structure of the exceptionally large nonrepetitive carbohydrate backbone of the lipopolysaccharide of Pectinatus frisingensis strain VTT E-82164 doc
... and showed, in particular, the configuration of ManNAc to beD.From the combined the data on the structures of the isolated oligosaccharides, the overall structure of the P. frisingensis LPS carbohydrate ... with 7a (Table 1) because of the b-effect of the acetylation. Acetylation of 7b was confirmed byESI MS data, which gave the expected mass of 3221.4 Da. The spectra of oligosaccharide 6 were ... 3-O-methyl-6-deoxytalose, as setting the L-isomer instead of the D-isomer resulted in the disappearance of the contactbetween protons U6 and P4.To determine the absolute configurations of the mono-saccharides,...
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Báo cáo khoa học: Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1 doc
... FAD/NADPH domain(% 16-fold) (29). However, the domain mixture still recon-stituted only % 2% of the activity of the full length CPR. InthecaseofNR1,thekcatfor the full length enzyme is low(1.3 s)1) ... enzymes, the potentials for the FAD/NADPHdomains are rather more negative than those for the FMNdomain, reflecting the direction of electron transfer fromNADPH through FAD, then FMN and on to the ... BM3 [28]. Aggregation of the NR1FAD/NADPH domain was much less extensive in the absence of cofactor reduction.Stopped-flow kinetic studiesReduction of the FAD/NADPH domain of NR1 wasinvestigated...
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Báo cáo khoa học: Structure of the O-polysaccharide fromProteus myxofaciens Classification of the bacterium into a newProteusO-serogroup pptx
... LPS)[5,6]. The serological specificity of the bacteria is definedby the structure of the O-specific polysaccharide chain(O-antigen) of the lipopolysaccharide. On the basis of the O-antigens, the strains ... the Dconfiguration (the b effect on C3 of L-GlcAwouldbeclosetozero[27]).On the basis of the data obtained, it was concluded that the repeating unit of the O-polysaccharide of P. myxofac-iens has the following ... 2.01–2.10.These data together suggest that the tetrasacchariderepeating unit of the polysaccharide consists of two residues of GlcNAc and one residue each of GalNAc, GlcA andAlaLys. The 1Hand13C...
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Báo cáo khoa học: Expression and characterization of soluble forms of the extracellular domains of the b, c and e subunits of the human muscle acetylcholine receptor pot
... amounts of the ECDs of the non-a sub-units of human muscle AChR for use as starting material for the determin-ation of the 3D structure of the receptor ECDs and for the characterization of the ... datafrom electron images of the AChR found in largeamounts in the electric organ of the marine ray,Torpedo californica [3]. The acquisition of the crystallo-graphic structure of the mollusc acetylcholine-bindingprotein ... domain [3]. The N-terminal ECD of each of the two a subunits con-tains the major part of the binding site for the cho-linergic ligands. The two sites are nonequivalent, onebeing formed at the interface...
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Báo cáo khoa học: Role of the N- and C-terminal regions of the PufX protein in the structural organization of the photosynthetic core complex of Rhodobacter sphaeroides pptx
... demonstrated the role of PufX in the orientation of the RC inside the LH1Fig. 4. Isolation of the PMCs on a sucrose gradient. The final detergentextracts from the ICM were loaded on the top of a 10–40% ... PufXD2)7neither affects the photo-synthetic capability of the bacteria nor the efficiency of exchange of the ubiq uinol molecules between th e RC and the bc1, a s judged from the reduction kinetics of ... residues of the LH1 apolypeptide in the organization of the LH1–RC complex[12]. In the present work, we have investigated the possible involvement of the N-terminus and of the C-terminus of PufX...
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Review of the Literature Regarding Critical Information Needs of the American Public
... in the U.S. devoted to education, but there is no substantiation of this figure, and most of the blogs discuss are professional or academic blogs. There is an extended discussion of nonprofit ... that the traditional methodological approaches, and their traditional points of focus, lack relevance today. However, the complexity of the changes taking place and the shifting nature of the ... outlining the historical context of health and media studies, the authors describe major individual-level theoretical frameworks applicable in the area: social cognitive theory, the theory of reasoned...
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Báo cáo sinh học: " Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 protein" docx
... http://www.virologyj.com/content/4/1/123Page 9 of 14(page number not for citation purposes)Proposed models of the C-terminus of TMFigure 5Proposed models of the C-terminus of TM. Proposed models of LLP domains in the context of TM ... could have the effect of stabi-lizing the Env trimers and/or the resulting transmembranepore that could then be formed by the LLP-1 and -2domains. The location of the LLP-3 domain on the innerleaflet ... A blue shift of the emission maxima (Figure 3J) further corroboratesthat the peptides are entering the hydrophobic environ-ment of the lipid membrane from the aqueous solution. The manner in...
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Báo cáo hóa học: " Viroporin potential of the lentivirus lytic peptide (LLP) domains of the HIV-1 gp41 protein" docx
... http://www.virologyj.com/content/4/1/123Page 9 of 14(page number not for citation purposes)Proposed models of the C-terminus of TMFigure 5Proposed models of the C-terminus of TM. Proposed models of LLP domains in the context of TM ... that could then be formed by the LLP-1 and -2domains. The location of the LLP-3 domain on the innerleaflet of the cell membrane could also serve to nonspecif-ically destabilize the lipid bilayer ... association with the inner leaflet of the lipid bilayer. On the other hand, the LLP domains maypossess different activities in the different cell types that itinfects, or there may be some as of yet...
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Báo cáo hóa học: " The genome and proteome of the Kluyvera bacteriophage Kvp1 – another member of the T7-like Autographivirinae" docx
... [14]. The sequences of the amino termini of these proteins areidentical, but during translation a rare ribosomal slippageoccurs permitting the elongation of the protein product. The features of ... A). The masses of the proteins are indicated in the adjacent lanes. The tentative identification based on in silico analysis of the properties of the gene products (Gp) are indi-cated on the ... one of the most common types of bacteriophages with 26–29 defined or tentative speciesaccording to the VIII report of the International Commit-tee on the Taxonomy of Viruses [3,4]. Most of the...
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