pga mce6 gd dota conjugatein an animal tumor model

nanotechnology for cancer therapy, 2007, p.810

Ngày tải lên : 04/06/2014, 14:30

... Polymeric nanoparticles are also mutable for enhancement of retention at the local tumor site and to combine anti -tumor agents with antiangiogenesis strategies.24–26 In addition to delivery of anti -tumor ... of anti -tumor therapy Given the wide variety of nanovectors and nanoplatforms, Nanotechnology for Cancer Therapy cannot possibly cover each nanoscale application that has potential for use in anti -tumor ... as an adjuvant for human vaccines.21 Semiconductor nanocrystals (quantum dots) are another example of inorganic nanoparticles Quantum dots have exceptional characteristics for in vivo imaging and...

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INHIBITION OF APE1’S DNA REPAIR ACTIVITY AS A TARGET IN CANCER: IDENTIFICATION OF NOVEL SMALL MOLECULES THAT HAVE TRANSLATIONAL POTENTIAL FOR MOLECULARLY TARGETED CANCER THERAPY

Ngày tải lên : 24/08/2014, 13:10

... your family and for always treating me like a daughter and a sister Lastly and most importantly, I want to acknowledge my mum Ranjana Bapat and my late father, Ajit Bapat Your love and support ... and in India, for being so encouraging and for always believing in me To my parents-in-law, Capt Prafull Bhate and Dr Jyotsna Bhate and my brother and sister-in-law, Anmol and Rama Bhate: thank ... be thankful for your friendship and support To my friends, Vinita Deshpande, Prithi Rao and Tanisha Joshi: your love and friendship has been such a huge help during this time I want to thank my...

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Báo cáo sinh học: " Encapsulation of docetaxel in oily core polyester nanocapsule intended for breast cancer therapy" pptx

Ngày tải lên : 18/06/2014, 22:20

... cytotoxic, and antimitotic agent used in the treatment of various types of cancers, including metastatic breast, ovarian, prostate, advanced non-small-cell lung, head/neck, and advanced gastric cancers ... oily core polyester nanocapsule intended for breast cancer therapy Ibrahima Youm1, Xiao Y Yang1, James B Murowchick2, and Bi-Botti C Youan*1 Laboratory of Future Nanomedicines and Theoretical Chronopharmaceutics, ... system, but also can extravagate and accumulate into the tumor tissue This is likely due to the reliance of these nanoparticles on passive accumulation through enhanced permeability and retention,...

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báo cáo hóa học:" PTTG: an important target gene for ovarian cancer therapy" doc

Ngày tải lên : 20/06/2014, 07:20

... non-transgenic animals Transgenic animals showed enlarged ovaries, and presence of large number of corpus lutea compared to non-transgenic animals The size of the ovaries in μm2 from transgenic and non-transgenic ... Ovarian Research 2008, 1:6 Figure Histopathological analysis of the ovaries from transgenic and non-transgenic animals Histopathological analysis of the ovaries from transgenic and non-transgenic ... transgenic uterus Both wild-type and transgenic uteri were PCNA positive; PCNA staining in transgenic uteri of transgenic animals was much darker and homogeneous compared to non-transgenic animals,...

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báo cáo khoa học: " Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy" ppsx

Ngày tải lên : 11/08/2014, 00:22

... not shown the anti-cancer properties of nanocurcumin, using human pancreatic cancer cells as a model system, and directly comparing its efficacy to free curcumin The choice of the cancer type was ... utilized void nanoparticles against a panel of eight human pancreatic cancer cell lines (MiaPaca2, Su86.86, BxPC3, Capan1, Panc1, E3LZ10.7, PL5 and PL8) These cells were exposed to void nanoparticles ... normal and tumor cells: role of glutathione and bcl-2 Mol Cancer Ther 2004, 3:1101-1108 Jiang MC, Yang-Yen HF, Yen JJ, Lin JK: Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer...

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báo cáo khoa học: "Free Rhodium (II) citrate and rhodium (II) citrate magnetic carriers as potential strategies for breast cancer therapy" docx

Ngày tải lên : 11/08/2014, 00:23

... biological activities of anionic gamma-Fe2O3 nanoparticles on human melanoma cells J Nanosci Nanotechnol 2008, 8:2385-2391 46 Sahu SK, Mallick SK, Santra S, Maiti TK, Ghosh SK, Pramanik P: In vitro evaluation ... 4T1 and MCF-7) after 48 hours of treatment Cells were stained with annexin V-FITC (fluorescein-5-isothiocyanate) and PI (propidium iodide) and analyzed by flow cytometry The percentage of annexin ... treatment time and cell line, an analysis of variance (ANOVA) with general linear model procedure followed by post hoc Tukey or Dunnet’s test was used Data were presented as mean value ± SEM...

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Delivery of proapoptotic biomolecules and drugs using amphiphilic block copolymer nanoparticles for anti cancer therapy

Ngày tải lên : 30/09/2015, 05:59

... (1) blank nanoparticles, (2) paclitaxel-loaded nanoparticles, (3 and 6) Herceptin at 200 and 2000 nM, (4 and 7) blank nanoparticle/Herceptin complexes at 200 and 2000 nM Herceptin and (5 and 8) ... of humanized antibodies and also the production of fully human antibodies using transgenic animals or phage display technologies [87] For example, Herceptin is a recombinant monoclonal antibody ... biology and computational technologies can provide the alternate means to conceptualize and analyze the entire regulation and signaling networks of different normal and cancer cells The understanding...

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báo cáo hóa học:" Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences" doc

Ngày tải lên : 18/06/2014, 15:20

... both in ovarian cancer cell lines and in a subcutaneous nude mice model for ovarian cancer The results showed high killing potential in ovarian cancer cell lines and a significant tumor growth ... using the animal models for ovarian cancer Treatment of heterotopic subcutaneous tumors The ability of the DTA-H19 to promote cancer cell killing and inhibit tumor growth in-vivo was analyzed ... in an ovarian carcinoma animal model We have previously shown that these constructs are able to selectively kill tumor cell lines and inhibit tumor growth in vitro and in vivo [[28,24,23] and...

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Báo cáo hóa học: " Development of targeted therapy for bladder cancer mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences" potx

Ngày tải lên : 18/06/2014, 16:20

... targeted therapy animal models All surgical procedures and the care given to the animals were approved by the local committee for animal welfare Animals were kept in the Hebrew University’s animal facility ... bladder cancer animal models We used the double promoter construct, H19-DTA-P4DTA assessing its tumor growth inhibition activity, by DTA expression in vivo using heterotopic and orthotopic animal models ... bladder cancer Expression of IGF2-P4 and H19 transcripts in heterotopic subcutaneous tumors In order to develop a model for heterotopic bladder tumors, T24P or HT-1376 human bladder cancer cells...

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Improvement of different vaccine delivery systems for cancer therapy pptx

Ngày tải lên : 06/03/2014, 02:21

... dendritic cell tumor antigen capture and delivery to lymph nodes Cancer Res 2009, 69:3180-3187 115 Zhang H, Yee D, Wang C: Quantum Dots for cancer diagnosis and therapy: biological and clinical ... an MG7-Ag analog epitope polypeptide and CpG ODN from a biological nano-emulsion, a gastric cancer antigen MG7 and a CpG sequence motif containing oligonucleotides serving as an immune adjuvant; ... melanocyte/melanoma differentiation antigens, such as tyrosinase, MART1 and gp100, prostatespecific antigen (PSA) and Idiotype (Id) antibodies Both tumor- specific shared and unique antigens are...

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Báo cáo khoa học: Hyaluronan–CD44 interactions as potential targets for cancer therapy pptx

Ngày tải lên : 28/03/2014, 23:20

... as an antagonist to HA–CD44v signaling inhibit malignant properties in cancer cells (S Misra et al., unpublished results) These studies and 1434 co-implantation models combining tumor cells and ... aberrant vasculature in solid tumors, and retention (known as the enhanced permeability and retention effect) of ligand-coated vectors around the receptors of tumor cells, can increase the chances ... HA and CD44 appear to be vitally important from embryogenesis to morphogenesis, in inﬂammation and in cancer, which accompanies the overexpression of CD44 and its splice variants and the aberrant...

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recombinant antibodies for cancer therapy, methods and protocols

Ngày tải lên : 11/04/2014, 10:25

... Application of Recombinant Antibodies 49 156 Baselga, J., Norton, L., Albanell, J., Kim, Y M., and Mendelsohn, J (1998) Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity ... “humanized” anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo Transplantation 57, 1537–1543 Cole, M S., Anasetti, C., and Tso, J Y (1997) Human IgG2 variants of chimeric antiCD3 ... Recombinant Antibodies for Cancer Therapy: Methods and Protocols Edited by: M Welschof and J Krauss © Humana Press Inc., Totowa, NJ Kipriyanov Fig Domain organization of an IgG molecule Antigen-binding...

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nanocarriers as an emerging platform for cancer therapy

Ngày tải lên : 28/05/2014, 15:07

... in cancerchemotherapy — Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs Cancer Res 46, 6387–6392 (1986) Yuan, F et al Vascular-permeability in a human tumor ... P World Cancer Report (World Health Organization Press, Geneva, 2003) Cancer Facts & Figures 2007 (American Cancer Society, Atlanta, 2007) Duncan, R Polymer conjugates as anticancer nanomedicines ... the nanocarrier conjugates, polymeric nanoparticles, lipid-based carriers such as liposomes and micelles, dendrimers, carbon nanotubes, and gold nanoparticles, including nanoshells and nanocages...

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Báo cáo sinh học: "Targeting TNF-α for cancer therapy" potx

Ngày tải lên : 06/08/2014, 19:21

... HL-60 human leukemia cell xenograft tumors in vivo, and human MDA-MB-435 breast cancer cells [13] Fan and colleagues [14] are the first to identify a peptide that targets human gastric cancer In ... apoptosis, angiogenesis, and wound healing Angiopoietins (Ang1, Ang2) Endothelial cell adhesion, spreading, focal contact formation, and migration Angiopoietin-related growth factors For example, ANGPTL3, ... M21 human melanoma xenograft model The AAVP vector targets gene products to tumor vasculature by using an alpha-v integrin ligand (termed RGD-4C) motif There was a statistically significant reduction...

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báo cáo khoa học: "Clinical relevance of "withdrawal therapy" as a form of hormonal manipulation for breast cancer" doc

Ngày tải lên : 09/08/2014, 02:21

... analysis, drafted, revised and finalised the manuscript KLC and JFR revised and approved of the contents of the manuscript All authors read and approved the final manuscript Conflict of interests ... long-term tamoxifen therapy In an in-vivo study [12], athymic mice were transplanted with ER positive tumor cells and then exposed to tamoxifen or placebo The tumors regressed initially over ... Howell A, Dodwell DJ, Anderson H, Redford J: Response after withdrawal of tamoxifen and progestogens in advanced breast cancer Annals Of Oncology: Official Journal Of The European Society For Medical...

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Báo cáo khoa học: "The "Win-Win" initiative: a global, scientifically based approach to resource sparing treatment for systemic breast cancer therapy" pdf

Ngày tải lên : 09/08/2014, 04:21

... certain solid cancers, e.g non small cell lung cancer, breast, pancreas and bladder cancers deserves further investigation The explanation for these responses caused by low doses (of 250 mg and 180 ... infusion and cisplatin for advanced non-small cell lung cancer Anticancer Drugs 2005, 16:1129-1134 Lassarat S, Jootar S: Ongoing challenges of a global international patient assistance program Ann ... cancer: Antitumor activity and correlation with vascular endothelial growth factor levels Ann Oncol 2002, 13:73-80 Garber JE, Richardson A, Harris LN, Miron A, Silver D, Golshan M: New adjuvant...

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