performance of regression based statistical learning methods for predicting compounds of specific pharmacokinetic or toxicological property
Machine learning approach in pharmacokinetics and toxicity prediction
... Table 1.2 Performance of regression- based statistical learning methods for predicting compounds of specific pharmacokinetic or toxicological property .10 Table 2.1 Methods for selecting ... explored in earlier studies xii List of Tables Table 1.1 Performance of classification -based statistical learning methods for predicting compounds of specific pharmacokinetic or toxicological property ... CHAPTER 1: INTRODUCTION Table 1.2 Performance of regression- based statistical learning methods for predicting compounds of specific pharmacokinetic or toxicological property CON, TOP, chemical, GEO,...
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Polystyrene (PS) waste plastic conversion into aviation /kerosene category of fuel by using fractional column distillation process
... of Energy and Environment (IJEE), Volume 3, Issue 6, 2012, pp.871-880 polyethylene and most of them is in the form of containers and packaging materials The extent of conversion of plastics or ... used for fractional fuel production process One step for PS waste plastic to liquefaction and another step for aviation or kerosene grade fuel collection 316 grade stainless steel reactor was ... grade stainless steel reactor was used for this experiment and waste plastic was use for the experiment only 750 gm Experiment was performed without any kind of catalyst and experiment was perfumed...
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ANALYSIS OF NAMES OF ORGANIC CHEMICAL COMPOUNDS BY USING PARSER COMBINATORS AND THE GENERATIVE LEXICON THEORY doc
... which are used to form simple words, complex words, or bigger grammatical units, so-called multi-word expressions or well formed sentences [2] Further, the system must solve problems of lexical ambiguity ... appear in the compounds etc); • Incorrect Names: names that not correspond to theoretically possible chemical compounds THEORETICAL BACKGROUND 2.1 Principles of Organic Chemistry The organic chemistry ... structural formula In this case, the system checks whether the proposed name is correct or not - if it is not, the system just informs the user that he has not correctly named the input structural formula,...
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assessing damage of flood by using alos data in thua thien - hue province - vietnam
... distribution of landuse/cover types to correct DEM For example, in the areas with dense forest distribution of 20m of high trees, the spectrum of light to detector of the satellite is leaves of tree, ... DEM correction is reduced to 20m for each different area based on map of landuse/cover Other areas of study PI063-8 area have lowly error in DEM development because of sparse landcovers In order ... very short In this study, calculation of flooded time is based on information from the People Commutee of Thua Thien - Hue Province 4.4 Damage level Assessment of damage level of flood needs based...
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Optimization of Cost by Using 7 QC Tools docx
... Cost of machine is Rs18 lakh If we consider for years 180000/5 = Rs3.6lakh 180000-36000=RS 144000 in years For year = 30,000/year For month =30,000/12=Rs 2500/month For day = 2500/26=Rs 96/day For ... Result: Valid cause for the problem Step 5:- counter measure: Short term: • Instruction was given to all the operators & the officials about the valid cause of the size for getting over size ... standards and so on Prevention costs involve cost when organizations undertake measures to prevent poor quality of products or performance Example of prevention cost would include the costs associated...
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A computational study of chiral separation of tryptophan by using cyclodextrin
... responsible for the complexation and the discrimination (e.g the van der Waals forces or Coulomb forces)? • Which site of cyclodextrin (primary rim or secondary rim) is primarily responsible for binding ... enables cyclodextrins to form inclusion complexes with a wide range of organic, inorganic, and biological molecules in aqueous solution [27] The driving forces for the complex formation are thought ... MC methods need evaluation of force Moreover, MC can perform physically unnatural motions, e.g., a jump from one position to the other or insertion/deletion of a new molecule In its simplest form,...
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Tài liệu Báo cáo khoa học: Transcriptional upregulation of inflammatory cytokines in human intestinal epithelial cells following Vibrio cholerae infection pptx
... active form of CREB was observed at h of LPS treatment Such facts suggest an optimal association of transcription factors at the site of transcription of IL-1a and IL-6 by LPS The activation of transcription ... MOI for different times (0, 5, 10, 15, 30, 60, 120 and 180 min), (C) LPS at lgÆmL)1 for 0, and h, (D) CT at 4.5 ngÆmL)1 for 0, 1, and h, and (E) CT at ngÆmL)1 for 0, 1, and h The problem of equal ... anti-inflammatory cytokine TGF-b and the absence of expression of another major anti-inflammatory cytokine, IL-10, following V cholerae infection in Int407 cells, account for a predominant proinflammatory...
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Báo cáo Y học: Purification and characterization of novel chondroitin ABC and AC lyases from Bacteroides stercoris HJ-15, a human intestinal anaerobic bacterium pptx
... measured by a Bradford assay based on a bovine serum albumin standard curve [20] Characterization of chondroitin lyases SDS/PAGE was performed for the determination of molecular mass according to Laemmli’s ... was calculated from the change of absorbance per minute using an extinction coefficient of 3800 M)1 for products (1 U ¼ lmol of uronic acid containing product formed per min) [19] The specific ... 17.13.17–17.13.32 Wiley Interscience, New York 20 Bradford, M.M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding Anal...
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Báo cáo y học: " Prediction of viral microRNA precursors based on human microRNA precursor sequence and structural features" pot
... Support Vector Machine Support Vector Machine is a supervised machine learning method for generating functions for training data and is based on statistical and optimizing theory In the Support ... based on machine learning which performs better than recently reported methods for ab-initio prediction of microRNA hairpins The algorithm is fast and efficient and can scale for genome-scale ... negative set for training Processing of Datasets Both the positive and negative sets were tagged and encoded into the native format for SVM with corresponding values for each of the 512 vectors (see...
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Báo cáo sinh học: " Effects of the number of markers per haplotype and clustering of haplotypes on the accuracy of QTL mapping and prediction of genomic breeding values" pot
... counts and sum of off-diagonal values of the clustered haplotypes were used instead of the values for the haplotype before clustering; 3) for each clustered haplotype, the summed off-diagonals ... size of the QTL effect for the paternal (maternal) haplotype of animal i at locus j (of nloc putative QTL loci) of animal i, and ei is a random residual for animal i Gibbs sampling was used for ... considered for limitIBD of 0.55 and all four window sizes More replicates were considered only for limitIBD of 0.55, to enable more precise assessment of the differences in the prediction of the...
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Báo cáo sinh học: " Impacts of both reference population size and inclusion of a residual polygenic effect on the accuracy of genomic prediction" potx
... is the number of fitted SNP, z ij is a genotype indicator (-1 or for the two homozygotes and for the heterozygote) of marker j of bull i, uj is the random regression coefficient for marker j, ... http://www.gsejournal.org/content/43/1/19 Page of Table Genomic and phenotypic data§ used for routine genomic evaluation and for the validation study in January 2010 for German Holstein bulls Year of birth Data for ... residual polygenic effect for the reference bulls For all scenarios, regressions of conventional EBV or DRP on DGV or RPG were unity for the reference bulls, and the regression intercepts were...
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The transference of meaning through class of words denoting parts of the human body in english and vietnames
... Metonymical forms fỏmforms A part of the body for symbols A part for the whole A part for related characteristics A part for another part concerned A part for things cover it A means for product ... metaphor b: metonymy c: narrowing and broadening of meaning a1: Metaphor based on the similarity of form a2: Metaphor based on the similarity of position a3: Metaphor based on the similarity of ... this The whole for a part The tool to measure for its length A container for things contained A material for product made of material A thing for materials make thing A container for amount contained...
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Tài liệu Báo cáo khoa học: Investigation and prediction of the severity of p53 mutants using parameters from structural calculations pptx
... by the average activity of mutants in the central domain of 26% for WAF1 and 34% for MDM2, 71% for NOXA and 61% for p53R2, and around 45% for the other four promoters For some specific mutants, ... To evaluate the performance of the algorithm, test sets were created We used five-sixths of the data for training and the remaining one-sixth for evaluation This was performed for all six combinations ... slightly worse for both methods (MCC values of 0.16 for CUPSAT and 0.23 and 0.18 for the respective PREDMUT energy parameters) Interpretation of mutant severity From the prediction algorithm, each...
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Tài liệu Báo cáo khoa học: Allosteric modulation of myristate and Mn(III)heme binding to human serum albumin Optical and NMR spectroscopy characterization pptx
... changes in affinity of FA1 for myristate) This brings the value of HSA affinity for Mn(III)heme, with myristate bound to FAx, in the range of HSA affinity for Fe(III)heme [32] Furthermore, modeling indicates ... modulation of FA1 (K HM ⁄ KH ¼ 5.4 · 10)2 vs 5.0 · 10)3) The estimate of KM also differs by about one order of magnitude, but the difference is smaller for the estimate of K MM , i.e FA1 affinity for ... Mn(III)heme–HSA adduct in the presence of myristate are similar to those of the B conformational state of HSA, suggesting that myristate binding to one or more modulatory sites possibly drives the N...
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Tài liệu Báo cáo khoa học: "Evaluating the Accuracy of an Unlexicalized Statistical Parser on the PARC DepBank" docx
... compare the performance of our system on ccomp to theirs for comp, ignoring subord form King et al report individual results for selected features and relations from an evaluation of the complete ... 57.5 68.1 91.6 71.4 43.2 80.5 adegree 89.2 92.3 coord form num 92.2 number type 86.3 precoord form 100.0 pron form 92.1 71.1 prt form 60.7 subord form 72.4 85.7 89.8 92.7 16.7 91.9 58.7 48.1 79.9 ... the subordinator as a subtype of ccomp recording essentially identical information in a single relation So evaluation scores based on aggregated counts of correct decisions will be doubled for a...
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Tài liệu Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking pdf
... conformations necessary for receptor activation and for internalization A similar situation has been described for other G protein-coupled receptors [41] However, no recycling was observed for ... support a role for the extracellular domain in the stabilization of an inactive form of the unliganded receptor [29] Indeed, only cleavage in the E3 domain of the receptor, followed by receptor ... recovery of cell surface receptors was the result of receptor recycling For the b1 mutant receptor, there was a marked constitutive internalization of the receptor Indeed approximately 45% of the...
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Báo cáo " Assessment of the influence of interpolation techniques on the accuracy of digital elevation model " potx
... various regions of Laos and France The author has concluded that for a high density of sample points, all of the interpolation techniques perform similarly; and for a low density of sample points, ... Kriging: a method of interpolation for geographical information systems, International Journal of Geographic Information Systems (1990) 313 [8] M Peralvo, Influence of DEM interpolation methods in drainage ... square error) of the interpolated DEM is calculated by using the following formula: RMSE = N N ∑∆ i , (3) i =1 where N is the number of control points For automated execution of the workflow,...
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Báo cáo khoa học: Limited mutagenesis increases the stability of human carboxypeptidase U (TAFIa) and demonstrates the importance of CPU stability over proCPU concentration in down-regulating fibrinolysis doc
... annealing at 45 °C for 45 s, and elongation at 72 °C for min, followed by 72 °C for A second type of random mutagenesis was performed using the Genemorph PCR mutagenesis kit (Stratagene) according to ... for improved thermostability of CPU activity in the supernatant of mammalian cells in an HTS format The best clones selected were more thoroughly analyzed using an HPLC -based activity assay for ... reported half-lives at 37 °C from to 15 min, hence the U in its name stands for unstable [10,11] The inherent and irreversible decay of CPU’s activity is believed to be of major importance for...
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