parting of the ways transcript
Tài liệu Báo cáo khoa học: Topology, tinkering and evolution of the human transcription factor network doc
Ngày tải lên :
19/02/2014, 07:20
... and phylogeny. How-
ever, the nature of the connections between these
factors needs to be understood at the level of the pro-
tein domain. The global properties of the HTFN
topology are partially ... property of the
bHLH domains. Therefore, this seems to be a topo-
logical constrain derived from the evolution of this
family.
Evolution based on domain reusing might explain
the abundance of certain ... TFIIE-a, TFIIE-b
F 57 42% Zn finger domains. It contains the 90% of the
members of nuclear receptor
superfamily (they are Zn fingers
also) of the HTFN.
14-3-3 zeta, STAT1a, STAT1b, dCREB, ATF-1,
FTF,...
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Báo cáo khoa học: Interaction of the general transcription factor TnrA with the PII-like protein GlnK and glutamine synthetase in Bacillus subtilis potx
Ngày tải lên :
06/03/2014, 00:21
... more than 50% of the
GlnK–TnrA interaction in the presence of 2 mm ATP.
On the other hand, 2-oxoglutarate did not influence
the GlnK–TnrA interaction, either alone, in the
absence of divalent metals, ... was shown to depress the transcriptional activ-
ity of TnrA [9,10,18].
Taken together, the results from this investigation
provide indications of the physiological role of the
GlnK–TnrA interaction, ... resolve the inhibitory
effect of ATP on the GlnK–TnrA interaction in the
absence of divalent cations more clearly, ATP was
titrated to the binding assays in the absence or pres-
ence of 2-oxolguatarate....
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
Ngày tải lên :
16/02/2014, 09:20
... whether these cytokines are
produced by CD4
+
CD25
+
Foxp3
+
T
reg
or whether
they induce the production of these cytokines from
another population of cells [20].
To date, our knowledge about the ... important in the development of a number of these cell types.
They were found within the zebrafish genome, using a synteny approach in
the case of t-bet and foxp3. Multiple alignments of zebrafish ... domains
important in the functioning of these transcription
factors. T-bet (also known as Tbox-21) belongs to the
T-box family of genes, consisting of over 20 members
characterized in mammals [35]. They contain...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
Ngày tải lên :
16/02/2014, 09:20
... increase in apoptosis [73]. The authors of this study
ascribe the regulation of outgrowth of limb buds and
patterning of the digits to the chicken AP-2.
The role of AP-2a was further studied in zebrafish.
It ... because of the severe skeletal defects in growth
and the development of face and limbs [17–19]. Don-
ner et al. tried to link the expression of AP-2a in these
tissues to upstream signaling pathways. ... further analyze their interactions with AP-2 and the
functional role of these in chondrocytes.
Furthermore, it is speculated that in melanoma,
where AP-2a acts as a tumor suppressor, the loss of
AP-2a...
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Tài liệu Báo cáo khoa học: Arabidopsis thaliana BTB⁄ POZ-MATH proteins interact with members of the ERF⁄AP2 transcription factor family ppt
Ngày tải lên :
18/02/2014, 06:20
... in the central cylinder of the root, but not in the lower parts of the hypocotyl (a). Rosette leaves were
stained in the vascular tissue of the leaf blade, whereas the petiole and older parts of ... this has the potential to predict possible pro-
tein binding to the BPMs. It will also be of importance
to define the functional impact of the BPM family on
the activity of ERF ⁄ AP2 transcription ... staining within the vascular tissue at the end
of the leaf blade, whereas the basal parts close to the
petiole remained almost unstained. We observed clear
GUS expression in the primary root of 7-day-old...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
Ngày tải lên :
18/02/2014, 16:20
... interruption of the geometry
of the recognition helix for either Antp or the TTF-1
HD, the anomalous amide exchange pattern and the
NOE connectivity data of the C-terminal portion of
helix III ... conflict with the
global interpretation of the data. With the exclusion of
the N-terminal octapeptidyl and C-terminal nonapept-
idyl fragments of Glu17, Leu34 and Lys46, the average
of the {
1
H}–
15
N ... Lorentzian model of J(x) calculated over a
very wide range of correlation times, s. Most of the
experimental points accumulate rather close to the
upper intercept of the theoretical curve and the fitting
(solid)...
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Tài liệu Báo cáo khóa học: Trichostatin A reduces hormone-induced transcription of the MMTV promoter and has pleiotropic effects on its chromatin structure pptx
Ngày tải lên :
19/02/2014, 12:20
... and the cleavage
of DNA by alkali [31]. The method allows easy detection of
DNA–protein interactions via the N7 position of guanines
in the major groove and via the N3 position of adenines in
the ... coupled with the topology
changes resulting from the loss of 1.5 superhelical turns
of the DNA over the whole construct, suggest that the
chromatin is indeed more relaxed in the absence of
hormone. ... in
hormone-induced transcription ( 50% of full induction
when added early, compare lanes 3, 4 and 11, 12). Neither of
these effects depended on the TSA concentration over the
range used in these experiments,...
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Tài liệu Báo cáo khoa học: Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation ppt
Ngày tải lên :
19/02/2014, 16:20
... connected to the DEC1 E-boxes
(Fig. 2), while deletion of the Orange domain ( DEC1DOr-
ange) had no effect on the suppressive activity, indicating
the importance of t he bHLH region of DEC1.
The HXXXXXXXR ... conclude that the basic region, p artic-
ularly the conserved A rg65, but not His57, is essential for
the suppressive activity of DEC1.
Determination of the binding domain of DEC1 to BMAL1
The interaction ... that the C-terminal region, including the PAS-B
domain of BMAL1, is required for the binding to DEC1,
Fig. 4. Identification of the domain of D EC1
that interacts with BMAL 1. Interactions of
various...
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Tài liệu Báo cáo khoa học: Effect of deletion of the DNase I hypersensitive sites on the transcription of chicken Ig-b gene and on the maintenance of active chromatin state in the Ig-b locus docx
Ngày tải lên :
19/02/2014, 16:20
... acetylation of H3 and H4
histones, and the remaining DHSs in the deleted cells
were examined to determine the roles of these DHSs
on the transcription of Ig-b gene and on the mainten-
ance of the active ... Thus,
there again has been no description either of the
region involved in DNase I general sensitivity or
of the region for the formation of DHSs, although
chromatin opening activity of the LCR ... )13 kb in the Na channel gene and
the other at +13 kb downstream of the GH gene, have
Fig. 6. H3 and H4 acetylation of the Ig- b locus in the region II dele-
tion cells. The acetylation of wild...
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Tài liệu Báo cáo khoa học: The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes doc
Ngày tải lên :
19/02/2014, 17:20
... factors as the mutation
of the CRE site within the COX-2 promoter or the
expression of a dominant negative mutant of CREB
reduces inducibility of the COX-2 promoter [9,12–14].
The transcription ... observed across
the different studies as well as the similarity of the
recognition sites of the NFAT and Ets factors led us to
investigate the potential involvement of the epithelial
specific ... converts
arachidonic acid into the prostaglandin H2. This prod-
uct is the critical point of the synthetic pathway of
numerous members of the prostaglandin family. COX
exists as two major isoforms derived from...
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Tài liệu Báo cáo khoa học: Mg2+-modulated KMnO4 reactivity of thymines in the open transcription complex reflects variation in the negative electrostatic potential along the separated DNA strands ppt
Ngày tải lên :
19/02/2014, 18:20
... T)11
and T+2. Therefore, the measured contribution of these
forms to the integrated intensity of these two bases was
used in the calculation of the contribution of individual
bases to the integrated ... and elements of the b subunit
that make up the back wall of the RNAP active-site
channel, until it passes near the active site [11]. The
very low reactivity of the thymines close to the cata-
lytic ... charges of
both DNA phosphates and the carboxylic groups of
three aspartates of the NADFDGD motif involved in
the binding of catalytic Mg
2+
ions [23,42]. Chelation
of these ions to the carboxylic...
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Tài liệu Báo cáo khoa học: Characterization of the promoter for the mouse a3 integrin gene Involvement of the Ets-family of transcription factors in the promoter activity doc
Ngày tải lên :
21/02/2014, 03:20
... upstream of
the major transcription start site. The presence of a CCAAT
box and the absence of a TATA box seem to be one of the
characteristics of the mouse integrin a3 gene.
We identified two transcription ... (where A/C is the transcription start site). The
role of the sequence containing CCT is unknown but it
might play a role in the initiation of transcription.
The active promoter region of the mouse ... upstream of the SacI) sites (Fig. 1).
Sequence analysis of the 5Â-anking region and
determination of transcription start sites of mouse
integrin a3 subunit gene
The nucleotide sequence of the 0.5...
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Tài liệu Báo cáo Y học: Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins doc
Ngày tải lên :
22/02/2014, 07:20
... clarify the distinct roles of Sp1 and Sp3 at
different phases of the cell cycle.
The transcriptional cofactor p300 is coprecipitated in
complexes with Sp1 [38]. The activation of the promoter of
thegeneforp21
Waf1/Cip1
by ... Characterization of the promoter of the mouse Dnmt1 gene. (A)
Transcriptional activity of the mouse Dnmt1promoterinNIH3T3
cells. The top diagram shows the mouse Dnmt1geneandthelower
diagram shows the variously ... revealed the activation of the
promoter of the Dnmt1 gene in the presence of Sp3. The
transcriptional coactivator p300 interacted with Sp3 in
vivo and in vitro. Our results indicate that expression of
the...
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Báo cáo khoa học: Differential recognition of heat shock elements by members of the heat shock transcription factor family ppt
Ngày tải lên :
07/03/2014, 00:20
... promoters. These results show that
the configuration of nGAAn units in the promoter is
important in determining which hHSF members are
involved in the regulation of the gene.
Footprint analysis of the ... without
changing the magnitude of the heat shock response
(cp3). The mutational analysis of the CRYGA and
CRYGC HSEs suggests that the nucleotide sequences
and configuration of nGAAn-like units ... as judged from the amount and
mobility of the complex (Fig. 1B). Notably, the
amount of complex formed with hHSF4 and HSEgap
or HSEstep was more than 70% that of hHSF4–
HSE3P. Therefore, like...
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