oxidative stress in diabetes mellitus
Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... in brain in anoxia as observed by in- crease in NOx concentration in this study support the earlier findings of NO involvement in pathophysiol-ogy of hypobaric hypoxia in brain (42-43). In this ... arginine at the site of synthesis. Arginine is a semi essential amino acid and in CNS, its availability depends upon: (a) uptake from the circu-lating arginine and (b) recycling of citrulline...
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Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc
... oxidative stress. Our findings show that pilocarpine induces SE,which can produce alterations in superoxide dismutaseand catalase activities in different areas, thereby pro-tecting the brain ... [2,19,20], immediatelyafter pilocarpine administration, animals persistentlyshow behavioral changes, including initial akinesia,ataxic lurching, peripheral cholinergic signs (miosis,piloerection, ... Interstrain differences in cognitive functions in rats in relation to status epilepticus. Behav Brain Res112, 77–83.3 Treiman DM (1955) Electroclinical features of statusepilepticus. J Clin...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... neuron. The turning point upon whichthe cell looses the ability to buffer the incoming calciumresulting in an abrupt, sustained and irreversibleincrease in [Ca2+]c, probably coincides with ... functions, in addition tohaving supporting functions for oxidative defences [79],involving the thioredoxin system [40]. Aconitase actsalso as an iron-responsive element binding protein, iso-citrate ... by proteins resi-ding in both the inner and outer mitochondrialmembrane, that is activated by mitochondrial Ca2+overloading and other factors including oxidative stress [88,89]. In neurons...
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Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf
... indicating the presence of two catalyticallyindependent domains, the N-terminal domain, display-ing ALDH activity, and the C-terminal domain, con-taining an iron-binding domain, which is involved ... against oxidative stress damage, have not been reported. In vivo effects on glucose-fermenting enzymesand fluxes under oxidative stress Recently, we reported that amebas incubated for30 min in ... bindclose to the Fe–S clusters, blocking the access of ROS. In this regard, a preliminary docking analysis withcoenzymes in the 3D model of EhPFOR suggested thatthe CoA-binding site was, indeed,...
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Báo cáo khoa học: Fasting-induced oxidative stress in very long chain acyl-CoA dehydrogenase-deficient mice pdf
... mice. Fasting induced a significant increase in bothgenotypes; however, this was more evident in theVLCAD KO mice (Fig. 3A). Interestingly, the MCTdiet also induced AOX gene expression in WT mice.After ... observed in human VLCADD [5]. In fact, in both mice and humans, clinical symptoms becomemainly evident as a consequence of triggers suchas fasting, resulting in the accumulation of long-chainacylcarnitines, ... quantitation of microgram quantities of proteinutilizing the principle of protein-dye binding. AnalBiochem 72, 248–254.S. Tucci et al. Oxidative stress in VLCAD KO miceFEBS Journal 277 (2010)...
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Báo cáo khoa học: A nonribosomal peptide synthetase (Pes1) confers protection against oxidative stress in Aspergillus fumigatus ppt
... toapplied ROS. Interestingly, upregulation of pes1expression was not observed following H2O2-induced oxidative stress in cultures of A. fumigatus 293.1 grown in either Sabouraud or 5% FBS in MEM ... Infect Dis21, 161–172.4 Denning DW (1996) Therapeutic outcome in invasiveaspergillosis. Clin Infect Dis 23, 608–615.5 Denning DW (1998) Invasive aspergillosis. Clin InfectDis 26, 781–805.6 ... this strain in subsequent gene-disruption experi-ments. In order to find whether pes1 was expressed duringfungal infection in G. mellonella, A. fumigatusATCC 26933 conidia were injected into larvae...
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Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
... several LOX inhibitors, including aesculetin (anonselective LOX inhibitor), MK886 (an inhibitor of the5-LOX-activating protein), zileuton (a 5-LOX inhibitor),baicalein (a 12/15-LOX inhibitor), ... apoptosis. In fact, ROS-induced oxidative stress and cell death play important roles in the efficacy of manyantineoplastic agents [13,14].To investigate whether oxidative stress is involved in the ... National Cancer Institute. Using a reverse-phase pro-tein microarray assay, we determined molecular changes in 77 protein biomarkers in an oncrasin-sensitive lungcancer cell line after treatment...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... brain Aβ amyloidosis model.Previously, we have shown that a full dose ofindomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidative stress ... inflammation when combined with indomethacin. In summary, our findings support the hypothesis that oxi-dative stress and inflammation represent important butdistinct therapeutic targets in AD-like amyloidosis. ... burden in the hippocampus of these mice [16].However, recent studies indicate that a subset of NSAIDs,including indomethacin, also possesses a direct, COX-independent Aβ-lowering capacity in cell...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... global inhibitionof src-family tyrosine kinases or inhibition of phosphati-dylinositol-3 kinase (PI3K) attenuates ROS production.These findings suggest that these kinases are involved in upstream ... has been investi-gated with the use of specific protein kinase inhibitorsrevealing that protein kinase C (PKC) [37-39], p21-acti-vated kinase-1 (PAK1) [40], mitogen-activated proteinkinase (MAPK) ... Peroxynitrite-induced alterations in synapto-somal membrane proteins: insight into oxidative stress in Alzheimer's disease. J Neurochem 1999, 72:310-317.87. Bonfoco E, Krainc D, Ankarcrona...
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Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... origin, wasobtained from ATCC (Manassas, USA) and cultured Ham’sF-12 media (Gibco) containing 2 mM L-glutaminesupplemented with 0.01 mg/ml bovine pituitary extract(Gibco, USA), 0.005 mg/ml insulin ... study,PM2.5 induced more MDA formation than PM10suggesting that PM2.5 induced more oxidative stress thanPM10. In the single strand breakage assay using pBR322DNA, the ratio of changed form II/total ... protein in the PM2.5 - and PM10 -treated rat lung epithelial cell was determined by WesternBlotting. The lower shows the ratio of Nrf2/actin usingcalculatging by densitometor. In the...
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Báo cáo lâm nghiệp: "Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings" pot
... CO2by PEPC increased in re-sponse to O3 in both groups of seedlings (Figs. 5E–5H) dur-ing the growing season. The level of activity decreased in the neoformed flush of the episodic seedlings when ... seedling, cut into 2 ì 2 mm pieces andincubated in 5 mL of 100 mM phosphate buffer (pH 7.5) containing40 mM KNO3and 1.5% 1-propanol. Each sample was vortexed for2 min to help tissue in ltration ... by immersingthe tubes for 5 min in boiling water. The colorimetric determinationof NO2−was done by mixing 0.25 mL of incubation medium with0.25 mL 0.02% N-(1-Naphtyl) ethylenediamine and...
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Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
... production, includinghypoxic conditions and stimulation by transforming growthfactor, CD40 ligand, interleukin 1, or interleukin 6 [10]. Oxi-dative stress also promotes angiogenesis [13]. The linkbetween ... previously demonstrated a sustained major decrease in oxidative stress in response to treatment with dihydropyrid-ine-type calcium-channel blockers [17]. The data reportedherein confirm these results ... suggestthat nifedipine can ameliorate endothelium injury in SScand that VEGF signalling may by impaired in this diseasewithout implication of the sVEGFR-1.Endothelium injury is critical in SSc and...
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