our place in nature

the mit encyclopedia of the cognitive sciences

Ngày tải lên : 11/04/2014, 10:36

... role in disputes in the philosophy of mind that concern intentionality, including those over individualism, narrow content, and the role of Twin Earth arguments in thinking about intentionality In ... are the activity of the mind during sleep,” and associated talk of DREAMING as involving various mental acts, such as remembering, imagining, judging, thinking, and reasoning Malcolm argued that ... is that of a type or kind of thing that exists in the world itself, rather than a kind or grouping that exists because of our ways of perceiving, thinking about, or interacting with the world Paradigms...

1.1K
1.6K
0

Tài liệu Báo cáo khoa học: Molecular basis of glyphosate resistance – different approaches through protein engineering doc

Ngày tải lên : 14/02/2014, 14:20

... FAD-containing ﬂavoprotein of 430 amino acids GOX was overexpressed in E coli, where activity in cell lysates reached 7.15 nmolÆmin)1Æmg)1 protein [42] With oxygen as cosubstrate, the recombinant ... protein monomer GO catalyzes the dioxygen-dependent oxidative deamination of primary and secondary amines (sarcosine, N-ethylglycine, and glycine) and d-amino acids (d-alanine and dproline), ... for glycine Melting temperatures were determined by following protein and ﬂuorescence changes during temperature ramp experiments Glycine Glyphosate kcat,app (s)1) Wild-type Single-point variants...

14
794
0

Tài liệu Báo cáo khoa học: EGF receptor in relation to tumor development: molecular basis of responsiveness of cancer cells to EGFR-targeting tyrosine kinase inhibitors docx

Ngày tải lên : 16/02/2014, 09:20

... mitogen-activated protein kinases (MAPKs) in mammals, is activated by the EGFR tyrosine kinase and plays an essential role in cell proliferation In contrast, EGFR signaling inhibits the activation ... down-regulated in response to gefitinib only in NSCLC cell lines that are growth-inhibited by gefitinib Thus, activated Akt has been indicated as a molecular determinant of a response to EGFR-targeting drugs ... gefitinib and erlotinib ineffective inhibitors of EGFR kinase activity, blocks gefitinb-induced up-regulation of Bim and apoptosis [38] These experiments point to an important role for the induction...

11
611
0

Tài liệu Báo cáo khoa học: Basis of recognition between the NarJ chaperone and the N-terminus of the NarG subunit from Escherichia coli nitrate reductase pdf

Ngày tải lên : 16/02/2014, 14:20

... Surprisingly, the binding isotherm was biphasic, with the best ﬁt obtained with a two binding site model, comprising a ﬁrst site with binding stoichiometry (n) of 0.3 ± 0.2 and a binding constant ... ferredoxin-type fold, which undergoes only minor conformational changes upon binding the twin-arginine signal peptide of NapA [18] In this case, biogenesis of the NapA protein is assisted by NapF in ... hydrogen bonds Interestingly, this biphasic behaviour disappeared by increasing the pH, suggesting a protonation event At pH 8, the binding isotherm generated a sigmoidal binding curve that reached...

10
685
0

Tài liệu Towards a framework for the study of the neural correlates of aesthetic preference pdf

Ngày tải lên : 19/02/2014, 17:20

... decreases with decreasing preference Activity in left cingulate gyrus and occipital gyri increases with increasing preference Event-related fMRI 6s No interstimuli int Indicate (0–4) degree of ... It remains to be studied whether extending the degree of ugliness of the images in the sample, including really unpleasant stimuli, would elicit activity in lateral orbitofrontal cortex in an ... visual processing of the basic features of artworks and other aesthetic stimuli takes place in occipital brain regions, like any other kind of stimuli However, features processed in intermediate...

19
526
0

Tài liệu The Basis of Early Christian Theism ppt

Ngày tải lên : 21/02/2014, 08:20

... him, the statement of Zeller, in view of the many conflicting opinions, seems satisfactory: "In everything that he states concerning the Divinity the leading point of view is the idea of the ... and Understanding "Intellectual apprehension is first in the order of nature; but in our case, and in relation to ourselves, Sensation is first, and of Sensation and Understanding the essence ... as their part in the development of the theistic argument, the mere undefined feeling and growing conviction of a permanent behind the changing, a "one" behind the "many." We find the natural...

32
339
0

Molecular Basis of Pulmonary Disease Insights from Rare Lung Disorders pdf

Ngày tải lên : 05/03/2014, 23:20

... University of Cincinnati Medical Center, Cincinnati, OH, USA Ralph J Panos, MD Department of Internal Medicine, University of Cincinnati School of Medicine and Cincinnati VA Medical Center, Cincinnati, ... Department of Internal Medicine, University of Cincinnati School of Medicine and Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA Editors Francis X McCormack University of Cincinnati ... Department of Internal Medicine, University of Cincinnati School of Medicine, Cincinnati, OH Enid R Neptune, MD, Department of Internal Medicine, John Hopkins University School of Medicine, Baltimore,...

443
248
0

GENOMIC DISORDERS The Genomic Basis of Disease doc

Ngày tải lên : 05/03/2014, 23:20

... insight in the identity of the genetic defect causing CMT1A.” By now it was spring 1991, we were desperate and terribly disappointed, while running into another problem Christine was organizing ... recombination junctions found in an assortment of recombination events The darker dashed lines represent those occurring in the LDLR gene The lighter dashed lines represent those occurring in the ... because the families were still being sampled, he initially spent a lot of effort in 10 Part I / Introduction developing protocols for isolating human DNA, and in cloning probes that recognized RFLPs...

446
291
0

Báo cáo khoa học: Protein–protein interactions and selection: generation of molecule-binding proteins on the basis of tertiary structural information potx

Ngày tải lên : 06/03/2014, 11:20

... generating small binding proteins by grafting Grafting of the motif with its neighboring sequences from ﬁbronectin into an exposed loop in lysozyme functionalized lysozyme without inactivating its ... important role in molecular recognition independently of scaffold proteins The generation of recombinant binding proteins by library approaches will supply new insights into protein–protein interactions, ... A-domains consisting of 35 amino acids occur in strings of multiple domains in several cell surface receptors, and are connected via several amino acid linkers Each A A-domain in the multimer binds...

9
505
0

Báo cáo khoa học: Molecular basis of perinatal hypophosphatasia with tissue-nonspeciﬁc alkaline phosphatase bearing a conservative replacement of valine by alanine at position 406 Structural importance of the crown domain potx

Ngày tải lên : 07/03/2014, 05:20

... obtained from Qiagen (Hilden, Germany); antipain, chymostatin, elastatinal, leupeptin and pepstatin A were obtained from Protein Research Foundation (Osaka, Japan); and hygromycin B and (p-amidinophenyl) ... protease-inhibitor cocktail (antipain, aprotinin, chymostatin, elastatinal, leupeptin, pepstatin A) was added to cell lysates and media (10 lg of each protease inhibitor per mL) The lysates were incubated ... at position 406 in the crown domain results in a remarkable decrease in the catalytic efﬁciency of TNSALP In this respect, it is worth pointing out that residues in the crown domain are closely...

11
500
0

Báo cáo khoa học: "Clustering Hungarian Verbs on the Basis of Complementation Patterns" pot

Ngày tải lên : 08/03/2014, 03:20

... alterna- indul j¨ n o elindul megy kimegy elmegy acc - ins ins/com ins/com ins/com ins/com ins/com ins/com abl source source source source source source ela source source source source source source ... is for comitative – approximately encoding the meaning ’together with’ , ins is for the instrument of the described event, source denotes a starting point in the space, cause refers to entity which ... Behaviour Proceedings of the 18th International Conference on Computational Linguistics (COLING-00), pages 747– 753, Saarbr¨ cken, Germany u Sabine Schulte im Walde and Chris Brew 2002 Inducing...

6
486
0

Báo cáo khoa học: "Shallow parsing on the basis of words only: A case study" pptx

Ngày tải lên : 08/03/2014, 07:20

... Second, there are indications that increasing the training set of language processing tasks produces much larger performance gains than varying among algorithms at ﬁxed training set sizes; moreover, ... training instances as points in a multi-dimensional feature space, and stores them as such in an instance base in memory (rather than performing some abstraction over them) Classiﬁcation in memory-based ... reasonable training set sizes However the effect clearly diminuishes with more training data, so we cannot exclude that the two curves will meet with yet more training data Combining words with...

8
657
0

Báo cáo khoa học: "Predicting Strong Associations on the Basis of Corpus Data" pdf

Ngày tải lên : 08/03/2014, 21:20

... combined into a compound Therefore we developed a third approach which discovers for every cue the words in the corpus that in combination with it lead to an existing compound Since in Dutch ... extraction In Proceedings of the Conference on Empirical Methods in Natural Language Processing (EMNLP-2002), pages 222–229 Sabine Schulte im Walde and Alissa Melinger 2005 Identifying semantic ... Dutch words in a continuous task Behaviour Research Methods, 40:198– 205 Hinrich Sch¨ tze 1998 Automatic word sense disu crimination Computational Linguistics, 24(1):97– 124 Ted Dunning 1993 Accurate...

9
434
0

Molecular basis of heredity

Ngày tải lên : 13/03/2014, 16:34

... equally-spaced, resulting in major and minor grooves 1962: Nobel Prize in Physiology and Medicine James D Watson Francis H Maurice H F Crick Wilkins What about? Rosalind Franklin RNA (A pairs with ... (compare 2’ carbons) Nitrogenous base Purines Adenine Guanine Pyrimidines Cytosine Thymine (DNA) Uracil (RNA) Phosphate group attached to 5’ carbon Nucleotides are linked by phosphodiester bonds to form ... Helix Model of DNA Two sources of information: Base composition studies of Erwin Chargaff • indicated double-stranded DNA consists of ~50% purines (A,G) and ~50% pyrimidines (T, C) • amount of...

21
341
0

Molecular basis of heredity - Bio Cơ sở phân tử của di truyền - sinh học

Ngày tải lên : 13/03/2014, 17:04

... equally-spaced, resulting in major and minor grooves 1962: Nobel Prize in Physiology and Medicine James D Watson Francis H Crick Maurice H F Wilkins What about? Rosalind Franklin RNA (A pairs with ... (compare 2’ carbons) Nitrogenous base Purines Adenine Guanine Pyrimidines Cytosine Thymine (DNA) Uracil (RNA) Phosphate group attached to 5’ carbon Nucleotides are linked by phosphodiester bonds to form ... Helix Model of DNA Two sources of information: Base composition studies of Erwin Chargaff • indicated double-stranded DNA consists of ~50% purines (A,G) and ~50% pyrimidines (T, C) • amount of...

21
511
2

Báo cáo khoa học: Molecular basis of toxicity of Clostridium perfringens epsilon toxin ppt

Ngày tải lên : 14/03/2014, 22:20

... cells [54] In intravenously injected mice, pre-injection of prototoxin inhibited preferential accumulation and lethal activity of radiolabelled toxin in the brain, indicating that the toxin speciﬁcally ... N-terminal domains of the above proteins than between their C-terminal domains The N-terminal domains are expected to be important for substrate or receptor binding In aerolysin, the N-terminal ... aerolysin It has been suggested that this domain performs a similar function in e-toxin [60] and PS [62] However, none of the residues involved in sugar-binding in aerolysin are present in etoxin...

13
482
0

Báo cáo khoa học: Molecular basis of cytokine signalling – theme and variations docx

Ngày tải lên : 15/03/2014, 09:20

... homodimeric nature resulting in four binding interfaces for a single Noggin molecule BMP, for instance in a muscle pouch, the induced bone is resorbed at later stages when transplanted in a functional ... IL-4Ra, contains a large cytosolic domain with binding motifs for Janus kinase (JAK1), the intracellular signalling protein STAT6, the insulin-receptor-substrate 2, and others Again there exist ... can only initiate the intracellular signal The division of labour is indicated by the cytosolic domains The trigger, cc, contains only a binding site for the tyrosine kinase Janus kinase (JAK3),...

13
378
0

MORAL PRINCIPLES AND MEDICAL PRACTICE, THE BASIS OF MEDICAL JURISPRUDENC potx

Ngày tải lên : 15/03/2014, 13:20

... good; while injustice, disobedience, and ingratitude are essentially evil Our reason informs us of this difference; and our reason is nothing else than our very nature as intelligent beings capable ... sire Every one is only at the beginning of an endless existence, of which he is to determine the nature by his own free acts In this infinite destiny lies the infinite superiority of man over the ... and in all her channels of education And since we Jesuits are among her leading educators and writers, we have maintained that thesis in thousands of printed volumes, as firmly as I am maintaining...

115
310
0

Báo cáo khoa học: Molecular basis of the unusual catalytic preference for GDP/GTP in Entamoeba histolytica 3-phosphoglycerate kinase doc

Ngày tải lên : 16/03/2014, 01:20

... model with GDP (red) obtained using MOE software (B) Close up of the purine ring binding site in the C-terminal domain Lines indicate hydrogen bonds interactions Lettering in red corresponds to ... compensating decrements in entropy and enthalpy of binding may be involved in yielding a relatively invariable Kd value Although this compensation has been invoked in protein research [37], it remains ... Val341 (patch C) The corresponding reported amino acid residues involved in adenine binding in the other crystallized proteins, as well as in the EhPGK identiﬁed in the predicted model, were totally...

11
449
0

Báo cáo Y học: The expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis doc

Ngày tải lên : 17/03/2014, 17:20

... arginine, but contains no cysteine Protamine, which is replaced for hitstone via transit proteins during spermiogenesis, is rich in both arginine and cysteine The cysteine sulfhydryls in protamine ... the testes, the seminiferous tubules were minced using scissors and incubated in NaCl/Pi containing 0.25% type I collagenase (Wako, Osaka, Japan) at 32.5 °C for 15 The seminiferous tubules were ... processes in the male genital tract, especially in the epididymis Disulﬁde bond formation in protamine, a counter part of histone in sperm nuclei, is required for packaging the DNA into the small...

9
494
0