origins transdisciplinarity and theory of science perspectives
Organ Transplantation doc
... Physician, Division of Pulmonary Medicine, Children’s Hospital of Philadelphia; Medical Director, Lung and Heart/Lung Transplant Programs, and Assistant Professor of Pediatrics, University of Pennsylvania ... PhD Professor and Chief, Division of Transplantation, Department of Surgery, University of Wisconsin, Madison, WI, USA Kiran K Khush, MD, MAS Division of Cardiovascular Medicine, Department of Medicine, ... Division of Transplantation, Department of Surgery, and Clinical Director, Transplant Center, Massachusetts General Hospital, and Professor of Surgery, Harvard Medical School, Boston, MA, USA Mandeep...
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ABC of heart failure History and epidemiology - part 1 potx
... patients, and coronary heart disease and diabetes in Indo-Asians Some of these racial differences may be related to the higher prevalence of hypertension and diabetes in black people and coronary ... Netherlands, and Scotland) and in the United States have doubled in the past 10-15 years Furthermore, heart failure accounts for over 1% of the total healthcare expenditure in the United Kingdom, and ... expenditure and improved long term survival The pictures of William Withering and of the foxglove are reproduced with permission from the Fine Art Photographic Library The box of definitions of heart...
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ABC of heart failure History and epidemiology - part 3 doc
... department of cardiology, Guy’s and St Thomas’s Hospital, London The ABC of heart failure is edited by C R Gibbs, M K Davies, and G Y H Lip CRG is research fellow and GYHL is consultant cardiologist and ... (furosemide) and bumetanide—have a powerful diuretic action, increasing the excretion of sodium and water via their action on the ascending limb of the loop of Henle They have a rapid onset of action ... Loop of Henle Cortical collecting duct Medullary collecting duct Diagram of nephron showing sites of action of different diuretic classes: 1=loop (eg frusemide); 2=thiazide (eg bendrofluazide); and...
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ABC of heart failure History and epidemiology - part 4 ppt
... emergency, and effective management requires an assessment of the underlying cause, improvement of the haemodynamic status, relief of pulmonary congestion, and improved tissue oxygenation Clinical and ... of cardiology at Guy’s and St Thomas’s Hospital, London The ABC of heart failure is edited by C R Gibbs, M K Davies, and G Y H Lip CRG is research fellow and GYHL is consultant cardiologist and ... care and general practice, University of Birmingham The ABC of heart failure is edited by C R Gibbs, M K Davies, and G Y H Lip CRG is research fellow and GYHL is consultant cardiologist and reader...
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SURGICAL OPTIONS FOR THE TREATMENT OF HEART FAILURE - PART 1 potx
... improves, and that early to mid-term survival is adequate in the context of expectations for this category of ]iatient Our group's demonstration of good long-term survival and of maintenance of improved ... University of Ottawa, Ottawa Heart Institute, Ottawa, Canada Patrick M McCarthy Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, U.S.A Toiy Mussivand ... book is a timely and useful contribution to the overall knowledge of the management of the heart failure patient and provides a useful and worthwhile read for every cardiac surgeon of the day Wilbert...
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SURGICAL OPTIONS FOR THE TREATMENT OF HEART FAILURE - PART 2 pdf
... animal models of heart failure Abnormal intracellular Ca"^^ handling is one of the major causes of both systolic and dia.stolic d\ stunction.''' ^^ ITic mechanisms of this abnormal Ca"* handling are ... RL, Anderson JL Predictive value of immunofluorescence and electron microscopic evaluation of endomyocardial biopsies in the diagnosis and prognosis of myocarditis and idiopathic dilated cardiomyopathy ... the release of vasopressin leading to vasoconstriction, retention of sodium, increase of body fluid and formation of edema.'•* • " Angiotensin II can increase catecholamine synthesis and produce...
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SURGICAL OPTIONS FOR THE TREATMENT OF HEART FAILURE - PART 3 doc
... impaimient of systolic function, and prolonged duration of dysfanction are at the greatest risk of having in'eversible ventricular dysfunction and an inexorable process The influence of these tliree ... complete excision of the subvalvular apparatus.''" " * •fhe issues of depression of ejection fraction from elimination of the low-pressure decompression into the left atrium and of interference ... thefrequencyand size of left ventricular aneurysms has decreased.'' The widespread use of both thrombolytic agents and postinfarction angioplasty result in greater preservation of the patency of the...
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SURGICAL OPTIONS FOR THE TREATMENT OF HEART FAILURE - PART 4 pot
... entire circumference of tlie base of the aiiemysin at tlie junction of scar and noirnal myocardiuriL The degi^ee of tigblening of this suture will detenmne the final size of the remaining opening ... include the presence of right coronary stenosis (> 75%) and the fiinction of posterior basal left ventncle and negative coefficients include the presence of angina and the number of bypass grafts."''" ... cardiac and hemodynamic parameters, the substrate for arrhythmias, and the systemic cardiovascular and neuroendocrine integration,' lixpec:ted quaiily of life and survival Expected quality of He and...
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SURGICAL OPTIONS FOR THE TREATMENT OF HEART FAILURE - PART 5 pot
... Assessment of clinical stability bv histor\', particularly for evidence of congestion, examination of posliual vital signs and jugular venous pressure and laboratiin nn)nitonng of electrolytes, renal and ... nature of candidacy (From Stevenson, LW Selection and management of a potential candidate for cardiac transplantation In: Cooper DKC, Miller LW and Patterson GA (Eds) The transplantation and replacement ... evidence of other organ damage such as proteinuria and nephropathv, peripheral neuiopathy Selection and Management of Potential Candidate for Cardiac Transplantation 79 retinopathy and small-vessel...
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SURGICAL OPTIONS FOR THE TREATMENT OF HEART FAILURE - PART 6 potx
... with siir\'ival rates of 33% and 30% and years, respectively Tables VII and VIII present tlie results of the multivariate logistic regression analyses for nsk factors for - and 5-year mortality ... itninimosuppression in the population An increasing number of patients are being treated willi tacrolimus or mycophcnolatc mofetil, and more than 75% of patients arc still on corticosteroids at years ... tlie number of heart-lung trasnplantations reported to the registrv' from 1982 to 1997 and the average donor age over this period The number of heart-lung transplantations peaked in 1989 and has...
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SURGICAL OPTIONS FOR THE TREATMENT OF HEART FAILURE - PART 7 docx
... is capable of generating 65 ml of stroke volume and flow outputs of up to Lpm It does so by generating negative and positive pressures to fill and empty the VAD It operates in one of three modes ... early, pnor to the development of significant and often irreversible endorgan dysfunction Timing of device insertion in these patients is often very difficult Criteria and scoring systems have been ... Helou and Robert L Kormos Introduction Mechanical cardiac assistance had its origins as an offshoot from the development of cardiopulmonary bypass Early efforts in the design and development of...
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SURGICAL OPTIONS FOR THE TREATMENT OF HEART FAILURE - PART 8 pdf
... Framischelli and R C.-J Chiu amounts to trial and error Cardiomyoplasty, however, has reaped the rewards of completing a Phase and II clinical trial through a maturation of technique and a renewed ... selection and prompted flirther study into the mechanisms and optimization of stimulation protocols for DCMP '['he Phase II trial was set out to determine the efficacy and safety of the pr(x;edure and ... Another problem faced is one of patient crossover and the refusal of randomization After all, once the patient has been mentally prepared for the procedure and then is randomized to medical treatment,...
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SURGICAL OPTIONS FOR THE TREATMENT OF HEART FAILURE - PART 9 doc
... smaller L V size and less inofropic requirement While Boiling's work offers one possible mechanism of improvement seen with PLV, fiirther study is required to better understand the effect of volume ... cultural analysis of flora of sentinel pigs is carried out to look for bacteria and parasites For viruses, co-culture of both sentinel pig tissues and tissues from primate recipients of porcine xenografts, ... for the presence of viral DNA, RNA and antibodies A potential long term strategy is to map the loci of the integration of PERV sequences m both Imutran's pigs and other pig lines and then define...
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SURGICAL OPTIONS FOR THE TREATMENT OF HEART FAILURE - PART 10 pot
... ISBN 0-7923-0725-9 E Andries and R Stroobandt (eds.): Hemodynamics in Daily Practice 1991 J Morganroth and E.N Moore (eds.): Use and Approval of Antihyperrensive Agenrs and Surrogate Endpoints ... field of circulaton support, it is in its very early stages of investigation, and results and underlying mechanisms are not cnlirelv clear The Next Generation of Devices The next generation of mechanical ... technologies National Heart Lung, and Blood Institute, National Institutes of Health, U S Department of Health and Human Services, 1994 Guy IS F'volution and the current status of the total artificial...
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Báo cáo y học: " Isolated left ventricular non-compaction as an unusual cause of heart failure: a case report" pdf
... prognosis and treatment may differ significantly The purpose of this case report is to highlight the diagnosis of IVNC and briefly review our current understanding of the condition The presence of marked ... (Fig 2) Intravenous injection of ultrasound contrast agent confirmed an area of non-compacted myocardium subtending a thinner walled area of compaction and a diagnosis of IVNC was made (Fig 3) Discussion ... result of intrauterine arrest of left ventricular myocardial compaction, although the trigger for this phenomenon is not yet known Both familial and sporadic forms of IVNC have been described and...
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Báo cáo y học: "Different effect of exercise on left ventricular diastolic time and interventricular dyssynchrony in heart failure patients with and without left bundle branch block"
... Furthermore, the shortening of diastolic time is an often overlooked mechanism of cardiac dysfunction The duration of diastole is a principal determinant of myocardial perfusion and of the blood volume ... For comparison of the individually observed and predicted time values and for comparison of within-group changes a repeated measures analysis of variance was used If analysis of variance showed ... Duration of left ventricular systole and diastole (method of calculation) The absolute duration of left ventricular systole was defined as the time interval between the onset of the R-wave and the...
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Management of chronic heart failure pptx
... standard of care Standards of care are determined on the basis of all clinical data available for an individual case and are subject to change as scientific knowledge and technology advance and ... Diagnosis and investigations Patients often present with symptoms of fatigue and/ or shortness of breath and/ or ankle swelling These patients are frequently obese, they often smoke and they may ... PROVED Prospective Randomized study Of Ventricular failure and the Efficacy of Digoxin trial QoL quality of life RADIANCE Randomized Assessment of Digoxin on Inhibitors of the AngiotensinConverting...
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báo cáo hóa học:" Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure" pot
... participated in design and coordination of the study, data collection, and critically revised the manuscript HS conceived of the study, participated in design, interpretation of data, and critically ... after 24 hours of continuous infusion (day 1) Blood samples were centrifuged, plasma aliquoted, and frozen at -70°C until the time of testing Plasma levels of Troponin I (TnI) and myoglobin (Myo) ... elsewhere [14] The concentration of each biomarker was assayed using commercially available assay kits according to manufacturer protocol and using standard curves and software The kits for NTproBNP...
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Báo cáo hóa học: "Hybrid approach of ventricular assist device and autologous bone marrow stem cells implantation in end-stage ischemic heart failure enhances myocardial reperfusion" doc
... Collection and assembly of data AK Data analysis and interpretation, collection and assembly of data CP Conception and design, data analysis and interpretation SW Conception and design, data analysis and ... analysis and interpretation, manuscript writing PA Conception and design, data analysis and interpretation, manuscript writing HA Data analysis and interpretation GK Collection and assembly of data ... a reduced number of functionally competent cells [17] Therefore, formation of myocytes and coronary vasculature cannot counteract the chronic loss of functional cells and Page of vascular structures...
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Báo cáo sinh học: "Increase of plasma IL-9 and decrease of plasma IL-5, IL-7, and IFN-g in patients with chronic heart failure" potx
... increase of IL-9 and decrease of IL-5, IL-7, and IFN-g plasma levels, in both ICM and NIDCM CHF patients vs controls and the inverse correlation of IL-5 and IL-9 plasma levels with duration of disease ... levels and duration of disease was found in NYHA III-IV ICM patients only (n = 18) IL-7, IL-9 and IFN-g are part of signaling cascades that contribute to the development and/ or progression of chronic ... performed on ICM and NIDCM CHF patients (Table 1) and on control plasma The first group of factors was composed of MIP-1 b, VEGF, MCP-1, IL-9, and IL-8, (Figure 1A-E); the levels of these cytokines...
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