optimal surgical approach and extent of resection of the thymus in patients with myasthenia gravis

Báo cáo y học: "Relationship between anti-dsDNA, anti-nucleosome and anti-alpha-actinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study" pdf

Ngày tải lên : 09/08/2014, 14:22

... Figure DNA and α-actinin Baseline binding data for binding to nucleosomes, double-stranded DNA and α-actinin On each graph, absorbance ratios of the 30 normal controls and the 16 patients with lupus ... albumin of at least 30 g/L, and either normal serum creatinine if the baseline creatinine was less than 260 μmol/L or a 50% decrease in creatinine if the baseline value was at least 260 μmol/L Patients ... between anti-α-actinin levels and serum albumin or urine PCR in these patients and no particular clinical or demographic feature distinguished them from the other 13 patients An example of this pattern...

9
442
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Báo cáo y học: "Filter survival time and requirement of blood products in patients with severe sepsis receiving drotrecogin alfa (activated) and requiring renal replacement therapy" pptx

Ngày tải lên : 13/08/2014, 11:23

... 0.7) There was no difference in the values of the filter pressure parameters during DrotAA therapy and in the 96 hours postDrotAA The influence of clotting parameters on FST was also examined There ... sepsis-induced coagulopathy There is minimal data on how to manage anticoagulation in patients on RRT during the infusion DrotAA therapy and in clinical practice the choice of RRT modalities and ... critically revising the manuscript, were involved in the design, analysis, drafting of the manuscript and gave final approval of the version to be published All authors read and approved the final manuscript...

6
215
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Báo cáo khoa học: "Differentiating the impact of anatomic and non-anatomic liver resection on early recurrence in patients with Hepatocellular Carcinoma" pps

Ngày tải lên : 09/08/2014, 03:21

... groups in terms of tumor staging Vascular invasion (T3) occurred in patients in the anatomic group (32.1%) and patients in the non-anatomic group (28%) Nodal involvement occurred in patients in the ... defined as the complete removal of at least Couinaud's segment containing the tumor together with the related portal vein and the corresponding hepatic territory The appropriate segment margins ... between the two groups with only a single poorly differentiated tumor in each group (3.5% of the anatomic group and 4% of the non-anatomic) Two patients in the anatomic group presented with fibrolamellar...

7
275
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Báo cáo y học: " An integrated approach to diagnosis and management of severe haemoptysis in patients admitted to the intensive care unit: a case series from a referral centre" ppsx

Ngày tải lên : 12/08/2014, 15:20

... discharge, when the procedure was completed Using a strategy including a routine assessment of the amount of bleeding with a standardized scale, and promoting BAE over surgery, the outcomes of patients ... describe the characteristics of the patients managed using one of the three main initial therapeutic options (conservative measures, BAE or surgery) and to help better define the role of BAE, according ... no information was provided on patients in whom the procedure was not completed [21] In our series, bleeding was controlled in 112/131 patients (85%) within the first month and in 116/131 patients...

9
461
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Báo cáo y học: "Identification of target antigens of antiendothelial cell and anti-vascular smooth muscle cell antibodies in patients with giant cell arteritis: a proteomic approach" potx

Ngày tải lên : 12/08/2014, 17:22

... result is in agreement with the pathophysiology of GCA and the ongoing inflammatory process in the arterial wall The combined use of 2-DE and immunoblotting offers an interesting approach to the identification ... pool of patients (top) and the pool of HCs (bottom) (C) Proteome of human umbilical vein endothelial cells showing the localisation of vinculin spots displayed in (A) binding partners, including ... a-actin [39] Changes in the relative content of vinculin and a-actin have been reported in the human aortic intima of patients with atherosclerosis [40] Because vascular remodelling may occur in...

15
269
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Prevalence and Its Predictors of Extrapulmonary Involvement in Patients with Pulmonary Tuberculosis pdf

Ngày tải lên : 15/03/2014, 03:20

... one organ involved, all of them were counted independently; � patients with intestinal TB diagnosed based , on typical colonosopic findings and the other patients with TB laryngitis without AFB ... (28) In addition, the lower risk of EPTB in the elderly does not support immunity as a determinant of the spread of tuberculous bacilli to other organs because of the higher incidence of TB in the ... (Table 4) The fitness of the final model was good in terms Table Sites and methods of diagnois of extrapulmonary involvement in 40 patients Involved organ* Miliary involvement Lymph node Intestine...

5
380
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Báo cáo khoa học: Regulation of the muscle-speciﬁc AMP-activated protein kinase a2b2c3 complexes by AMP and implications of the mutations in the c3-subunit for the AMP dependence of the enzyme docx

Ngày tải lên : 30/03/2014, 08:20

... In order to study the effect of the mutations within AMPK c3 on the activity of the enzyme, we introduced several missense mutations into the c3 gene (Fig 2), and investigated the effect of these ... activator of the kinase, AMP, whereas the two pairs of CBS domains both bind one molecule of AMP [20] In terms of the structure of AMPK, the b-subunit has been reported to act as a scaffold for binding ... reaction, the AMPK trimers were incubated with increasing concentrations of AMPKK, and the amount of upstream kinase corresponding to the highest possible level of Thr172 phosphorylation was used in the...

10
553
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báo cáo hóa học:" Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma" pot

Ngày tải lên : 18/06/2014, 15:20

... safety and feasibility of combining vaccination with MVA expressing 5T4 and highdose IL-2 in patients with metastatic RCC The trial was Page of 11 (page number not for citation purposes) Journal of ... supporting the combination of MVA-5T4 vaccine and IL2 for patients with metastatic RCC The treatment regimen was associated with induction of 5T4-specific humoral and cellular immunity Twelve patients ... immunotherapy in RCC Hence, we sought to determine if vaccination with MVA-5T4 could improve the therapeutic responses observed with standard high-dose IL-2 in patients with metastatic RCC In order...

11
499
0

Báo cáo sinh học: "Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke" pot

Ngày tải lên : 18/06/2014, 19:20

... total of 129 patients were finally included in the study This research was carried out in accordance with the Declaration of Helsinki of the World Medical Association (2000) and approved by the ... NIHSS on admission and infarct volume treated with tPA [6], which is in line with the results of the present manuscript, where a greater decrease in neuroserpin serum levels within the first 24 hours ... of the neuroserpin ELISA used in the study MRY, MM, helped to acquired, analyzed and interpreted the clinical data and made critical revision of the manuscript All authors read and approved the...

7
541
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báo cáo hóa học:" Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke" pdf

Ngày tải lên : 20/06/2014, 03:20

... total of 129 patients were finally included in the study This research was carried out in accordance with the Declaration of Helsinki of the World Medical Association (2000) and approved by the ... NIHSS on admission and infarct volume treated with tPA [6], which is in line with the results of the present manuscript, where a greater decrease in neuroserpin serum levels within the first 24 hours ... of the neuroserpin ELISA used in the study MRY, MM, helped to acquired, analyzed and interpreted the clinical data and made critical revision of the manuscript All authors read and approved the...

7
404
0

$báo cáo hóa học:" Improvement in quality of life measures in patients with refractory hepatitis C, responding to re-treatment with Pegylated interferon alpha -2b and ribavirin" docx$

báo cáo hóa học:" Improvement in quality of life measures in patients with refractory hepatitis C, responding to re-treatment with Pegylated interferon alpha -2b and ribavirin" docx

Ngày tải lên : 20/06/2014, 15:20

... treatment The scores of the vitality domain were lowest in the responders at the end of treatment Compared to the baseline the responders sustained a significant decrease in the domain score of vitality, ... differently in terms of the HRQOL domain scores when re-treated with a combination of interferon alpha-2b and ribavirin Compared to the baseline, the responders sustained a significant decrease in the ... on the lower dose of interferon were similar to those on the higher dose arm at all the time points During the course of treatment, the pattern of change in the HRQOL scores of responders and...

8
288
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báo cáo hóa học: " Responsiveness of EORTC QLQ-C30, QLQ-CR38 and FACT-C quality of life questionnaires in patients with colorectal cancer" pptx

Ngày tải lên : 20/06/2014, 15:20

... therapeutic intervention [13,14] In a clinical trial, the knowledge of instrument’s responsiveness helps in the selection of measures, in setting the correct sample size and assists in prioritising the ... samples of different sizes Interpretation of the results of the course of QoL scores and their responsiveness for patients receiving chemotherapy was performed independently of the chemotherapy ... status In our study, the QLQ-CR38 and the FACT-C questionnaires provided little clinically relevant information during chemotherapy or radiotherapy Four of the 12 scores of the Uwer et al Health and...

10
716
1

Báo cáo y học: "Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren''''s syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate" pptx

Ngày tải lên : 09/08/2014, 01:23

... Notably, in salivary gland of SS, ductal IL-18 expression was observed both in the presence and in the absence of IL-18-producing cells in the periductal inflammatory foci and was also found in the ... only within the inflammatory infiltrates showing focal organization, we analyzed the anatomical relationship between the presence of IL-18 within the focus, the main lymphocytic subsets, and the ... in which the mRNA expression of several cytokines (including IL-18) in minor salivary gland biopsies from patients with SS was evaluated Thus, so far there are no definite reports regarding the...

10
668
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Báo cáo y học: "Anti-Sa antibodies and antibodies against cyclic citrullinated peptide are not equivalent as predictors of severe outcomes in patients with recent-onset polyarthritis" pdf

Ngày tải lên : 09/08/2014, 06:22

... were the single serological marker independently predictive of poor outcomes and, together with the presence of joint erosions at inclusion and with increasing age, characterized a subgroup of patients ... drafting the manuscript AJF participated in the performance and the coordination of the study, and helped to draft the manuscript PL participated in the performance and the coordination of the study, ... frequency in these patients: RF in four, anti-Sa in two, and anti-CCP in one At each of the follow-up visits, more than two-thirds of the patients (namely 101 of 156 and 101 of 149 at 18 and 30...

12
683
0

Báo cáo y học: "Magnetic resonance imaging changes of sacroiliac joints in patients with recent-onset inflammatory back pain: inter-reader reliability and prevalence of abnormalities" potx

Ngày tải lên : 09/08/2014, 07:20

... on the inter-observer agreement with respect to the inflammatory and structural findings Readers agreed on the presence of inflammation at any site in 85% of the cases in the right SI joint, and ... this finding indicates that MRI might be a useful tool in the assessment of patients with early inflammatory back pain It is the amount of variation in the outcome of interest (inflammation and/ or ... for inflammation of the joint capsule of the left SI joint, which was present in only three patients Table summarizes the concordant findings of both readers with respect to inflammation and...

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400
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Báo cáo y học: "The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis" doc

Ngày tải lên : 09/08/2014, 10:23

... blocking IL-1β but not IL-1α In RA patients, IL-1β is overexpressed in inflamed synovial tissue, in particular in the lining layer and in sublining cells [9], and it is elevated in draining lymph ... following parameters In the haematoxylin/eosin stained slides the amount of cells infiltrating the synovial lining and the joint cavity was scored from to Proteoglycan depletion was scored in the ... GB and PvR conducted the clinical study as investigators and contributed to the writing of the manuscript LJ, WvdB and HG performed the preclinical studies and contributed to the writing of the...

9
385
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Báo cáo y học: "Physical function, disease activity, and health-related quality-of-life outcomes after 3 years of adalimumab treatment in patients with ankylosing spondylitis" potx

Ngày tải lên : 09/08/2014, 14:22

... peripheral joints, and entheses [1] Symptoms of AS include pain, joint stiffness, and the loss of spinal mobility These clinical symptoms and the subsequent disease progression result in substantial ... The remaining HRQOL outcomes, including the remaining SF-36 subscale scores and the ASQOL, extend and further support these findings This study demonstrates that long-term treatment with adalimumab ... activity This index uses six 10-cm horizontal VASs to measure the severity of fatigue, spinal and peripheral joint pain, localized tenderness, and morning stiffness in patients with AS The final BASDAI...

12
595
0

Báo cáo y học: "Positive anti-citrullinated protein antibody status and small joint arthritis are consistent predictors of chronic disease in patients with very early arthritis: results from the NOR-VEAC cohort" pot

Ngày tải lên : 09/08/2014, 14:22

... therapy, and thus had a chronic inflammatory joint condition without being diagnosed with RA None of the outcomes were seen in 238 patients The distribution of diagnoses during follow-up in these ... patients in the RA group and 17 (16%) patients in the DMARD prescription group presented with monoarthritis The knee joint was the most frequently involved single joint (39.1%), followed by the ... characteristics of the 384 patients with early arthritis included in the present analyses are reported in Table The duration of joint swelling at inclusion was very short (median 31 days), and 14.3%...

8
328
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Báo cáo y học: " Phase IIb randomized trial of adjunct immunotherapy in patients with first-diagnosed tuberculosis, relapsed and multi-drug-resistant (MDR) TB" doc

Ngày tải lên : 11/08/2014, 08:21

... DB and ASB Page of participated in editing of the manuscript and statistical analysis of data VJ provided samples of V5 and preparations of the placebo and provided guidelines for conduct of the ... [35] Studying V5 as post-exposure vaccine can contribute to better understanding of the immunopathogenesis of TB resulting in the design of effective vaccines and accelerate evaluation of their efficacy ... confirmed in a larger cohort of patients in independent clinical settings [14,15] Conversion of sputum smear from positive to negative is a main indicator of the efficacy of anti-TB intervention...

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285
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Báo cáo y học: " Prevalence of metabolic syndrome in patients with schizophrenia, and metabolic changes after 3 months of treatment with antipsychotics results from a German observational study" doc

Ngày tải lên : 11/08/2014, 16:20

... circumference the properties of the respective substance and the patients individual risk factors The prevalence of MetS in the FAS of 42.8% (AHA/ NHLB definition) at baseline was comparable to the findings ... supported the conduct of the study and contributed to the data analysis, interpretation of data and writing of this report AM contributed to the data analysis, interpretation of data, and writing of ... how important the actual monitoring of vital signs and blood values is in patients with schizophrenia, as seemingly, a large proportion of these patients were neither aware of their somatic health...

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425
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