... administration of You-Gui-Wan, a classical prescription of TCM containing AP, was shown to protect mice against hydrocoticoid-induced inhibition of IFN-γ, IL-2, IL-4 and IL-10 transcription [24] In addition, ... addition, vitamin B12, folinic acid and biotin identified in AP may also contribute to stimulated hematopoiesis [25] All of these results are consistent with the present findings that AP is a tonic ... surprising that CY administration resulted in a decrease in the proliferating cell number in both the gastric and duodenal tissues Indeed the decrease in cell proliferation in gastric tissue was...
... the civil society, aiming at identifying the possible contribution at Community level of promoting healthy diets and physical activity III.2 The Commission calls on all interested organisations ... stronger integration aiming at promoting healthy diets and physical activity into health services? V.6 Addressing the obesogenic environment V.6.1 Physical activity can be integrated into daily routine ... which the Commission invites contributions include: – How can the availability and comparability of data on obesity be improved, in particular with a view to determining the precise geographical...
... ANGPTLs in obesity and related metabolic diseases T Kadomatsu et al characterized by a coiled-coil domain in the N-terminus and a fibrinogen-like domain in the C-terminus Angiopoietins have a signal ... endothelial cells may be a mediator linking smoking to cardiovascular disease in an autocrine or paracrine manner Blocking ANGPTL2 signaling may also be beneficial also in preventing and treating ... blocking ANGPTL2 signaling through suppressing its expression, neutralizing secreted ANGPTL2 or blocking Lifestyle changes (inactivity, overnutrition, etc) Induction Fig Schematic diagram showing...
... obesity results in a hypogonadal state that disrupts the endocrine milieu, which is critical for maintaining erectile function Obesity is a chronic disease and is associated with an increased risk ... Inthis minireview, we discuss the link between obesity and ED by focusing on the potential pathophysiological links including obesity-related androgen deficiency and obesity-induced endothelial ... obesity in the USA is attributed directly to increased food intake (i. e increased calorie consumption) In addition to increased food intake, defective biochemical pathways involved in energy expenditure...
... mitochondria inthis dysfunction is not fully elucidated We have shown that, in isolated rat liver mitochondria oxidizing succinate, palmitoylCoA inhibited the ANT and induced working-condition-dependent ... ATP-monitoring kit (BioOrbit, Turku, Finland) ATP concentrations in the medium and the mitochondrial matrix were determined from yeast hexokinase kinetics as described [16] As hexokinase kinetics ... were determined in medium containing creatine and creatine phosphate, this medium was used in all experiments with mitochondria AMP concentration was determined spectrophotometrically using a standard...
... composition of high lipid diet calculated by National Institute of Nutrition was represented in the Table Table Composition of high lipid diet Composition Carbohydrate Lipid Casein Cholesterol Vitamin ... extract fractions by specific reactions Compound Compounds Flavonoid Catechin Phenolic Tannin Other Polyphenol Glycoside Alkaloid Specific reaction Shinoda H2SO4 Vanilin/HCl Vanilin/H2SO4 Lead ... Obese mice treated with metformin (500mg/kg) and drinking water ad libitum + Lot 6: Obese mice fed normal diet and drink water (no treatment) and drinking water ad libitum The results obtained...
... prepare traditional remedies for treatment of in and infectious diseases and digestive, but its anti-obesity effect is not studied yet [7] Inthis report the antiobesity effect of Docynia indica (W.) ... countries The fact that the obesity explosion significantly increases the risk of developing various livethreatening diseases, including type II diabetes, hypertension, coronary heart diseases ... composition of HFD calculated by National Institute of Nutrition was represented in the Table Table Composition of high lipid diet Composition % Carbohydrate 30 Lipid 35 Casein 25 Cholesterol Vitamin...
... deterioration in water quality, in spite of industrialization Regional differences in water quality induced by rainfall patterns provide for observation of areas of China with similar levels of industrialization, ... have gained increasing clout in administrative decisions nationally, incentive icts with local administrators who rely primarily on local industries for tax revenue have limited the effectiveness ... cost of improving China's water, inthis section I examine the relationship between China's surface water quality and industrial dumping, and the relationship between industrial dumping and the...
... eating ß Eliminating advertising of unhealthy foods in schools and within a certain distance from schools ß Establishing media literacy and nutrition curricula ß Monitoring the media ß Litigation ... grassroots communities in identifying the problem and solutions 19 Developing Strategies for Preventing Obesity In addition to guiding principles, the following tactical approaches can inform strategy ... government and private-sector policies regulating marketing practices Strategies to shape public opinion: ß Bring attention to marketing practices aimed at undermining parental authority ß Identify “best...
... been isolated from tropical plants including thaumatin, monellin, mabinlin, and brazzein One problem in using these compounds in large-scale industrial production is obtaining enough plant material ... under intensive investigation The possibility that particular nutrients in the bloodstream influence food intake is also being investigated, as is the difference in the impact on satiety of solid ... oceans, where soils, and the foods grown in them, are low in iodine In 1924, iodized salt (salt containing added sodium iodide) was first introduced in Michigan, leading to a decrease in the prevalence...
... Berkel TJ (1996) Apolipoprotein E effectively inhibits lipoprotein lipase-mediated lipolysis of chylomicron-like triglyceride-rich lipid emulsions in vitro and in vivo J Biol Chem 271, 14791–14799 ... 9841–9853 46 Weisgraber KH, Innerarity TL & Mahley RW (1982) Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine–arginine interchange at a single site J Biol Chem ... of animal experiments to the absolute minimum To this date there is no in vitro system to mimic satisfactorily the lipid and lipoprotein transport system and the in vivo mechanisms leading to...
... and neck It is intended to inform commissioning and provision of cancer services by people from both clinical and non-clinical communities; it is not clinical guidance and does not include the ... difficult to achieve the necessary level of expertise in all the disciplines involved in a single hospital MDT management involves more than establishment of joint or multidisciplinary clinics; ... for Clinical Excellence Improving Outcomes in Haematological Cancers Available on the NICE website Indications inthis list are derived from guidelines published by the British...
... inflammation were omitted by injecting DEP into the peritoneum Six hours later, the expression of inducible nitric oxide synthase (iNOS) mRNA increased in the liver Injection of DEP did not induce ... ME, Kelishadi R, Amirkhani MA, Ziaoddini H, Dashti M, Aminaee T, et al Double burden of nutritional disorders in young Iranian children: findings of a nationwide screening survey Public Health ... exposure to air pollutants are accompanied by systemic low-grade inflammation, oxidative stress as well as alterations in insulin/insulin-like growth factor and insulin resistance, which contribute...
... expression in differentiating 3T3-L1 cells increases linearly with time in differentiation, 5722 whereas the inhibition of lipid accumulation in differentiated cells by biotin deprivation decreased ... stronger with increasing body mass index [60,61] These findings again raise the interesting possibility that, although hyperplastic types of obesity may be more extreme in individuals expressing other ... mouse agouti locus in chromosome that results in a number of dominant pleiotropic effects, including a yellow coat color, obesity, an insulin-resistant type II diabetic condition, and an increased...
... the expression of multiple proteins regulating insulin sensitivity, including the insulin-dependent glucose transporter GLUT4 and the insulin-sensitizing hormone, adiponectin [13] Indeed, two ... thermogenesis and the b-oxidation of lipids [27,28] The gene silencing activity of RIP140 involves an association with additional corepressors, including the NADH-dependent C-terminal-binding proteins ... subsequent to its expression in white preadipocytes Indeed, the disrup5732 tion of the Rb gene in white preadipocytes facilitates their differentiation into brown adipocytes, in part by enhancing PGC-1a...
... tissue circulation J M Rutkowski et al Fig Interactions between expanding adipose tissue and the endothelium via adipokines Adipokines induce a reduction in nitric oxide (NO) hindering vasodilation, ... Failures in intestinal lymphatic transport most likely result in cyclic worsening of these in ammatory conditions: lymphatic immune function is compromised, leading to increased in ammation and increased ... adiponectin-normal mice Adipose tissue circulation Lesions in the adiponectin null mice had impaired vascularization and displayed increased intratumoral necrosis However, similar to tumors grown in...
... nicotine significantly suppressed inflammation in adipose tissue, an important site in mediating obesityinduced inflammation in genetically obese (db/db) and diet-induced obese (DIO) mice This ... systemic inflammation in life threatening conditions such as sepsis Cholinergic signaling to the spleen also plays an important role in modulating leukocyte migration during inflammation Endothelial ... activity In general, cytokines can be divided into those with predominantly pro-inflammatory actions and those with anti-inflammatory actions Pro-inflammatory cytokines include TNFa, interleukin...
... rehabilitation program in obese patients with LBP The main limitation of this study is the small sample size resulting in limited strength of the clinical and statistical findings Our analysis ... details Bioengineering Department, Politecnico di Milano, Italy 2Laboratorio di Ricerca in Biomeccanica e Riabilitazione, Ospedale San Giuseppe, Istituto Auxologico Italiano, Via Cadorna 90, I- 28824, ... I- 28824, Piancavallo (VB), Italy 3IRCCS “San Raffaele Pisana” Tosinvest Sanità, Roma, Italy 4Italian Scientific Spine Institute (ISICO), Via Bellarmino 13/1, Milan, Italy Authors’ contributions All...
... participated in data collection and analysis, and manuscript writing; FM participated in data analysis, statistical analysis and manuscript writing; FZ participated in the definition of criteria selection ... 2Bioengineering Department, Politecnico di Milano, Italy 3ISICO (Italian Scientific Spine Institute), Via Roberto Bellarmino 13/1, 20141 Milan, Italy Authors’ contributions LV designed the study, participated ... the spine can represent a non-invasive clinically useful technique for functional investigation in various spinal conditions and evaluation of effectiveness in rehabilitation Author details Orthopaedic...
... nicotine significantly suppressed inflammation in adipose tissue, an important site in mediating obesityinduced inflammation in genetically obese (db/db) and diet-induced obese (DIO) mice This ... systemic inflammation in life threatening conditions such as sepsis Cholinergic signaling to the spleen also plays an important role in modulating leukocyte migration during inflammation Endothelial ... activity In general, cytokines can be divided into those with predominantly pro-inflammatory actions and those with anti-inflammatory actions Pro-inflammatory cytokines include TNFa, interleukin...