novel perspectives on cardiac pacemaker regulation role of the coupled function of sarcolemmal and intracellular pr
Báo cáo khoa học: " The role of NH4Cl and cysteine proteases in Human Papillomavirus type 16 infection" ppsx
... infection, we performed infections of 293 cells in the presence of protease inhibitors at non-toxic concentrations [see Additional file 1] and compared them to the loss of infection in the presence ... edge, the first description of the role of cysteine proteases on a non-enveloped virion Results Cysteine protease inhibitors inhibit HPV16 infection To determine the role of cysteine proteases on ... infection is reduced in the presence of cysteine protease inhibitors Infection of 293 cells alone, with HPV 16 DsRed reporter-virions (mock control, Infected), or in the presence of: 20 mM of lysosome...
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Tài liệu Báo cáo khoa học: Regulation of DNA fragmentation: the role of caspases and phosphorylation doc
... They induce the permeabilization of the mitochondrial membrane with the release of cytochrome c and the formation of the apoptosome [38] The major pro-apoptotic protein Bax exists mainly in the ... pro-apoptotic Bcl-2 proteins such as Bax [107] Inhibition of PP1 by OA enhances the phosphorylation of p53 at Ser15 and Ser37, decreases the expression of bcl-2 and increases the expression of ... Phosphorylation of caspases switches the cellular apoptotic signal on and off Caspase activation is under the direct control of kinases and phosphatases, and the indirect control of phosphorylation through...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
... against the epitope peptide tagged to these proteins Nonetheless, the effective expression of these proteins in the transfected cells further demonstrates the specificity of RhoA effects Moreover, the ... corresponding endogenous proteins The protein band intensity of Ca-RhoA, Ca-Cdc42 and Ca-Rac is largely dependent on the transfection efficiency and/ or the efficiency of their immunodetection with ... mechanisms of the Cyr61/CCN1 gene (Eur J Biochem 270) 3413 Fig Induction of the Cyr61/CCN1 promoter upon stimulation by S1P and mapping of the responsive elements in the Cyr61/CCN1 promoter sequence...
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Báo cáo khoa học: A novel gene, fad49, plays a crucial role in the immediate early stage of adipocyte differentiation via involvement in mitotic clonal expansion docx
... Schematic representation of the mouse fad49 gene structure The thirteen exons of the fad49 gene on chromosome 11 are represented by vertical bars in the top part of the figure The size of each exon is ... EBPd expression remain to be elucidated In this regard, further studies of the molecular function of fad49 should provide new insights into the regulation of C ⁄ EBPb and C ⁄ EBPd expression early ... was found These results suggest that the PX and SH3 domains of FAD49 play a role in the localization of FAD49 Expression profiles of fad49 in differentiating and non-differentiating cells and tissue...
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Báo cáo khoa học: 2-Oxo acid dehydrogenase complexes in redox regulation Role of the lipoate residues and thioredoxin pot
... residues of the complex mediate the regulation of its first component by the last product of the overall reaction, NADH Reduction of the lipoate residues of the complexes in the forward direction, ... 1–5), the steady-state ratio of the complex-bound lipoate/dihydrolipoate is a function of (a) concentrations of the reaction substrates and products, (b) kinetic properties of the component enzymes, ... respond to the state of the mitochondrial NAD+ and NADH pool The E1 activity is regulated both upon accumulation of NADH and decrease of NAD+ The E1 inactivation at low NAD+ concentration prevents...
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Transformation of defects into fatigue cracks; the role of kt and defect scale on fatigue life of non pristine components
... believed that none currently exists For these reasons, a further study was made of the fatigue initiation and propagation behaviour of cracks initiating from scratches in the surface of clad mm 2024-T351 ... notches and cycles to propagate it up to the complete specimen failure Because of the lack of information on early crack propagation at crack depths
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báo cáo hóa học:" Impact of recent life events on the health related quality of life of adolescents and youths: the role of gender and life events typologies in a follow-up study" potx
... comparisons, the strongest associations were seen between undesirable events and HRQoL on the Psychological Well-being and School Environment dimensions and the Overall score in boys, and on the ... than the general EU population The Spanish version of the questionnaire has demonstrated acceptable validity and reliability [33,34] In this study, only responses from adolescents and youths on the ... from the adult respondent and included the highest family level of education according to the International Standard Classification of Education (ISCED) Categories were: low (a maximum of lower...
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Báo cáo hóa học: " The Role of Intrinsic and Surface States on the Emission Properties of Colloidal CdSe and CdSe/ZnS Quantum Dots Giovanni Morello Æ Marco Anni Æ Pantaleo Davide Cozzoli " potx
... By considering only thermal population effects in the range of 15–60 K, we have imposed and solved a set of rate equations The solutions gave us the expressions for the intensities I1, I2 and ... from the relative weights of each process, the longest component being more and more important by detecting wavelengths from the blue to the red side of the whole emission spectrum Moreover, the ... relaxation times, contribute to the PL of these quantum dots We have fitted the PL spectra to a superposition of three lorentzian curves (see inset of Fig 1A), obtaining the energetic separations among...
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Functional role of p16INK4A and n myc downstream regulated gene 1 (NDRG1) up regulation in cervical carcinoma
... pathway, the over-expression of p16 is functionally sequestered and cell cycle progression is unaffected (38) The upregulation of p16 is in stark contradiction to its role as a tumour suppressor, and ... confined to the surface of the cervix CIN and CIN reveal a greater proportion of the thickness of the epithelium composed of dysplastic cells Most CIN and CIN will spontaneously regress Section ... influences and represses the transcription of the human p16 gene (96, 110) This resulted in the hypothesis that p16 expression peaks at the G1/S transition of the cell cycle after Rb phosphorylation...
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Role of calpain and cofilin in apoptosis regulation
... activation of caspase-9 The release of the apoptogenic factor is dependent on the integration of the pro- and anti-apoptotic signals at the surface of mitochondria Utilising mitochondria proteomic, ... (ced-4) and (ced-3) (Horvitz, 2001) Gain -of- function of ced-9 gene in C.elegans prevented the death of the 131 cells, suggesting a protective role of the protein (Hengartner et al., 1992) On the contrary, ... classified based on their activity on the apoptotic pathway, and this correlates to the presence of protein-protein interaction domain on the prodomain of the enzymes Caspases –2, -8, -9, and –10 are...
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This chapter studies the role of bank and nonbank fi nancial intermediaries in the provision of longterm fi nance. In particular, based on data from different fi nancial institutions, it reports on the extent to which fi nancial institutions hold longterm
... Convention on Laundering, Search, Seizure and Confiscation of the Proceeds of Crime (1990) and the revised Council of Europe Convention on Laundering, Search, Seizure and Confiscation of the Proceeds of ... standard to both conviction and confiscation See figure 2.1 in section 2.6.5 for an explanation of the standards of proof Generally, unless enhanced confiscation provisions apply, confiscation ... gathering of evidence, the implementation of provisional measures, and the eventual confiscation of the proceeds and instrumentalities of corruption And when the assets are confiscated, cooperation...
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Tài liệu Colchero, J. et al. “Friction on an Atomic Scale”Handbook of Micro and Nano Tribology P6 Handbook of Micro/Nanotribology. Ed. Bharat ppt
... orthogonal scan lines and the corresponding paths reconstructed from the measured motion of the tip In the images shown, the axes of the crystal, of the motion of the tip, and of the cantilever were ... Two-dimensional images, on the other hand, show the variation of the friction on different spots on the sample Most conveniently, two-dimensional images with the data corresponding to the back -and- forth ... three springs, one in each direction of space The force acting on the tip causes a deflection of these springs To determine the force and the exact behavior of the microscope, their spring constants...
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Tài liệu Báo cáo khoa học: Role of transcription factor activator protein 1 (AP1) in epidermal growth factor-mediated protection against apoptosis induced by a DNA-damaging agent doc
... phosphorylation of Bcl-2 family members, the transcriptional upregulation of Bcl-XL, and its translational upregulation [19,21] We showed that among Bcl-2 family members, only the level of Bcl-XL ... implicated in the regulation of apoptosis and cell proliferation [27] Members of the Jun family, JunB and c-Jun, are suggested to play roles in triggering apoptosis and promoting proliferation of erythroid ... regulated the level of the Bcl-XL protein at the transcriptional level Next we determined the effect of ADR on the expression of Bcl-XL (Fig 3C) Cells were treated with EGF for 48 h, and then exposed...
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... in the stabilization of the closed conformation of the protein This hypothesis can be tested by assessing the extent of the conformational change occurring upon addition of UDPNAG to a mutant protein ... sequences and is part of the loop region that forms a lid on the active site upon the formation of the closed protein conformation (Fig 1) Hence, it is plausible that UDPNAG plays a direct role and/ or ... assists in the assembly of the proper interactions in the active site by stabilizing the closed conformation of the protein In the closed conformation, R120 moves from an ÔoutsideÕ position into...
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Tài liệu Báo cáo khoa học: Role of cleavage and shedding in human thyrotropin receptor function and trafficking pdf
... reaction is sequential and leads to the processive digestion of the specific extracellular region of the TSHR The enzyme involved in the maturation of the TSHR shares similarities with the ADAM ... lacks the E5 region highly conserved in gonadotropin and TSH receptors (approximately 85% of homology with the corresponding part of the LH receptor) This conserved region is present in the b1 and ... internalization probably through a conformational change transmitted to the b-subunit of the receptor Deletion of the ectodomain, or addition of TSH, relieves constrained conformations and increases...
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THE FUNDAMENTAL ROLE OF SCIENCE AND TECHNOLOGYIN INTERNATIONAL DEVELOPMENT pptx
... organizations offered their observations concerning the direction the study was taking These responses were considered in preparing the present report, and some of the observations that were provided ... on the interim report and on other observations during the course of the study Chapter discusses the five problem areas selected for special attention The conclusions and recommendations of the ... including the Centers for Disease Control and Prevention, the Department of Agriculture, the Environmental Protection Agency, and the Department of Energy, have expanded the international dimensions of...
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Assessing and Managing Rapid Credit Growth and the Role of Supervisory and Prudential Policies docx
... breakdown of aggregated credit data according to the borrower, the purpose and use of the loans, their sectoral composition and concentration, the currency denomination, and the maturity and other conditions ... currency crisis The macroeconomic and microeconomic implications of rapid credit growth are interrelated On the one hand, in a situation of continued macroeconomic deterioration (inflation and/ or external ... menu of possible measures and consider their pros and cons, negative consequences and limitations in dealing with the problem, and the circumstances under which they could be used These options...
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The Role of Small and Large Businesses in Economic Development doc
... another, and the sharing of pools of workers But negative spillovers are important as well They include constraints on the supply of labor and other inputs, upward pressure on wages and rents, congestion ... succeed only at great cost A recent study of new-firm locations and expansions in Georgia suggests that, on net, the location of a new large (300+ employees) firm often retards the growth of the ... many of the largest firms operate in industries in which only a few firms operate or dominate the market For the most part, these firms not compete with one another on the basis of price, but rather...
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Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
... under ATP consumption The fatty acid is then transferred onto the acyl carrier protein DptF The C domain of DptA is predicted to catalyse the condensation reaction between the fatty acid and tryptophan ... LC-MS approach is that the back reaction was too fast or the amount of product was below the detection limit Summarizing, the present study focuses on the biochemical characterization of DptE and ... incorporation of the fatty acid moiety into nonribosomal peptides, condensation of the fatty acid with the N-terminal tryptophan of the nonribosomally synthesized peptide is necessary Here, we report the...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25