... profile of roflumilast Discussion PDE4 inhibitors have demonstrated an anti-inflammatory effect in animal models and patientswithCOPD [6,7] In two previous 12-month studies, in patientswith ... reduction in exacerbations with roflumilast treatment and identified a subgroup ofpatients who are most likely to benefit from treatment with roflumilast, namely those patientswith chronic bronchitis ... stated * Patients could have received more than one of these medications seen for post-bronchodilator FEV1 (see Additional file 1, Table S1) In the group ofpatientswithCOPD associated with chronic...
... clinic and then matched 73 patientswith similar degree of airflow obstruction randomly selected from our much larger population of men withCOPDPatientswith all degree of airflow severity were ... previously associated with health-related quality of life in patientswithCOPD Also, we also did not include generic questionnaires like the SF-36, in the evaluation of the QoL of these patients, as ... population of 202 COPD patients, worse symptomrelated QoL, and more anxiety and depressive symptoms in female patients compared with men However, all of these authors did not match for degree of airflow...
... utilization in COPDpatients compared with non -COPD patients also determine elevated health care costs within the COPD patient group Even though our patients are from an extended age range with an older ... stable patients) As a part of another study on HRQoL in COPD [13,14], in a subset of 177 patients, data were collected on HRQoL as well as measures of sleep quality As control subjects, patients without ... appears that managing care ofCOPDwith concomitant cardiovascular disease should be one of the major foci for intervention in patientswithCOPD † Chi-square test The presence of mild liver disease...
... dyspnea in COPDpatients It has been reported that BNP can be used to differentiate heart failure from respiratory diseases, including COPD, in patientswith dyspnea [23] Furthermore, COPDpatients ... subjects withCOPD in Japan, generalization of these results to women withCOPD may be uncertain Conclusion Both static hyperinflation and airflow limitation contributed greatly to dyspnea in COPDpatients ... and airflow limitation or static hyperinflation in COPD Methods A total of 167 consecutive patientswith stable COPD defined as a FEV1/FVC of less than 0.7 for all measurements made during the...
... will perform a selective review of the psychotropic medications often prescribed to patientswith bipolar disorder, with an emphasis on their use in patientswith medical comorbidity Currently, ... patientswith uncontrolled cancer pain associated with cognitive impairment or anxiety [83] Conclusions The treatment of bipolar disorder is complicated in patientswith medical comorbidity Patients ... treatment with valproate as compared to antidepressants, lithium or gabapentin in patientswith HCV [55] These findings suggest that valproate can be used for some patientswith HCV without adversely...
... than in people with Alzheimer’s disease MANAGEMENT ofpatientswith dementia Dementia with Lewy bodies Characteristic features of dementia with Lewy bodies (DLB) are fluctuation of awareness ... limited number of behavioural problems in patientswith mild to moderate dementia.97,98,101-105 1++ 1+ One small study of augmentation of perphenazine in patientswith moderate dementia, with either ... decline in people with dementia with Lewy bodies In a trial examining the value of rivastigmine in patientswith Alzheimer’s disease and hypertension, the group ofpatientswith hypertension...
... 1994; Moffatt et al 1994; Simon et al 1994) Strength of evidence IAssessment ofPatientswith Leg Ulcers The management ofpatientswith venous leg ulcers Assessment 2.1 Assessment ofPatientswith ... also fall with age Strength of evidence II 10 The management ofpatientswith venous leg ulcers Assessment 2.2 Management ofPatientswith Venous Leg Ulcers The records show that patientswith venous ... photocopy of each form before sending it 24 The management ofpatientswith venous leg ulcers Appendix 2: Audit Form The management ofpatientswith venous leg ulcers Notes 25 26 The management of patients...
... respectively All other reagents used in the experiments were of analytical grade and of the highest purity Patients The sample consisted ofpatientswith different cholesterol levels and ages ranging from ... performed by the technique of Biggs [33], consisting of the in vitro macroscopic visualization of aggregates at intervals of 15–50 s by the addition of ADP to PRP Determination of lipid peroxidation ... nucleotide hydrolysis Platelets comprise one of the components of the thrombus microenvironment and of the process of thromboregulation It is known that the rate of platelet nucleotide hydrolysis is...
... half of those attending are children under the age of 14 years The majority ofpatients are fully conscious (see Table 1), without a history of loss of consciousness or amnesia or other signs of ... department 4.1PRINCIPLES OF ADVANCED TRAUMA LIFE SUPPORT A detailed review of all aspects of care ofpatientswith a head injury before arrival and in the ED is not within the scope of this guideline ... for patientswith minor head injury Entry criteria were loss of consciousness or post-traumatic amnesia following a head injury, in patientswith a GCS of 13-15 The study excluded all patients with...
... stroke patients and their families and liaised with services with the aim of improving aspects of participation and quality of life for patientswith stroke and/or their carers The backgrounds of ... between 20 and 57% of patients. 102 The extent of the loss within the visual field may vary from the loss of the entire half of the visual field, to the loss of only a portion of the affected half ... interventions made up of a number of components, are often implemented with some form of education and usually form all or part of the patient record.13 One systematic review of three randomised...
... for patientswith stage 1A lung cancer and 38-65% for patientswith stage 1B lung cancer Surgery gives the highest chance of cure for patientswith stage I and II lung cancer D 6.2.2 Patientswith ... as offering the best compromise between accuracy of staging and containment of morbidity 17 MANAGEMENT OFPATIENTSWITH LUNG CANCER 6.2.5 RESECTION IN PATIENTSWITH STAGE IIIA NSCLC A number of ... Netherlands found that 22% ofpatients diagnosed with lung cancer had coexistent COPD, 13 but no evidence was identified on when to consider a diagnosis of lung cancer in patientswithCOPD þ A chest X-ray...
... thought that most of index cases (65%) were constituted parents of home In addition, in our study the number of male patients was higher in the index cases, but the number of female patients was higher ... tuberculosis patients in contacts of index cases whose sputum smear and culture were positive [7] Chee et al detected a rate of 0.9% TB patients in investigation of 5699 close contacts of 1374 index ... 1122-7 Lutong L, Bei Z Association of prevalence of tuberculin reactions with closeness of contact among household contacts of new smearpositive pulmonary tuberculosis patients Int J Tuberc Lung Dis...
... female and male patients as well as patientswith age ≤60 years and in patientswith non-pulmonary or non-abdominal focus the haplotype was associated with poor outcome whereas in older patients and ... Secondly, an evaluation of the association of the MIF polymorphisms with the survival of severe sepsis patients was performed Methods The investigation was in compliance with the Helsinki declaration ... power: 1-β = 0.96) for Table 1: Baseline characteristics ofpatientswith severe sepsis and patientswith abdominal surgery without signs of infection or inflammation (* unpaired t test, ** Fisher's...
... expression of a chosen sample by which the expression profile of each sample of interest is adjusted: this approach enables the investigator to compare the expression profile of the samples of interest ... factors First of all, the inclusion in our multivariable analysis (with a stepwise mode of variable selection) of a marker Table 3: Multivariate survival analysis of 70 patientswith gastric cancer ... curves ofpatientswith percentile) measured 75th peripheral blood high (> levels Kaplan-Meier survival in thepercentile) transcriptional 75th Kaplan-Meier survival curves ofpatientswith high...
... responses ofpatients to therapy but not restoration of the "normal healthy" pattern of the serum profile Conclusions Here we established the high potential of MALDI-ToFbased analyses for detection of ... [A>B>C] or [A≤B>C] types of clusters, which consisted of 5% and 3% of the components for the group of all patients and patients subjected to adjuvant therapy, respectively In line with data presented ... Analysis of the group ofpatients subjected to surgery and adjuvant therapy B - Analysis of the group ofpatients subjected only to surgery Left - the q-values are plotted against the p-values of differences...
... file Variables associated with QOL in family caregivers ofpatientswith schizophrenia The table shows the variables associated with QOL in family caregivers ofpatientswith schizophrenia found ... impact of interventions aimed to improve caregivers ofpatientswith schizophrenia's QOL In summary, it seems that "informal care" is playing an important role in the care ofpatientswith schizophrenia ... consequence of their role, lack of social and working support, course of the disease, and disruptions in family life All these factors were associated with a considerable damage of QOL The feeling of...
... [10] found that anxiety was one of the problems reported with 34.4% by patientswith diabetes These results show that while planning the treatment ofpatientswith diabetes, evaluating their ... that patientswith lower level This study explored anxiety and dimensions of problemfocused and emotion-focused coping strategies -as measured by the brief COPE- in a sample ofpatientswith ... having any type of psychiatric disorder in patientswith diabetes, and Gülseren et al [10] found that depression and anxiety account for 45% of psychiatric disorders in patientswith diabetes These...
... quality of life ofpatientswith chronic disease: a review J Clin Epidemiol 1992, 45:743-760 Tang ST, McCorkle R: Use of family proxies in quality of life research for cancer patients at the end of ... (median) score of 18.5 (17)[19,20] This is a surprising finding, as this was a sample of terminally patients, most of whom died within the next few weeks and months All of the patients and caregivers ... demands of giving support to another Studies among elderly patients and those with dementia have suggested that caregivers with higher levels of burden tend to be less in agreement withpatients' ...
... developed with the intention of creating a care path with rapid pre-operative attention, increased continuity and an accelerated training programme without disturbing the flow ofpatientswith other ... previously conducted audit of hospital records ofpatientswith a hip fracture indicated that the mean length of hospital stay was 31 days (SD 14.5) [19] We estimated that 53 patients would be required ... research [17] The aim of the present study was to evaluate the effectiveness of an ICP in patientswith an acute fracture of the hip The main outcome measure was the length of hospital stay; secondary...
... rid of any residual microscopic disease As a consequence, within few months these patients return with recurrent cancer[1] In most cases, patients present themselves with multiple sites of metastatic ... presence of 37°C with 5% CO2 Page of 12 masses and/or a family history of ovarian cancer Description ofpatients who participated in the study is provided in Additional file (Table 1) Preparation of ... from ascites of cancer patients Cell lysates (25 μg) of (a) ovarian cancer cell lines (OVCA433, OVCA429, SKOV3 and 2008) and (b) tumor cells isolated from the ascites ofpatientswith advanced-stage...