non androgen regulated transcription factors as novel potential targets for prostate cancer ther
báo cáo khoa học: "Free Rhodium (II) citrate and rhodium (II) citrate magnetic carriers as potential strategies for breast cancer therapy" docx
... cytotoxicity was observed after treatment with Magh In addition, if these nanosystems were associated to target molecules for breast carcinoma cells such as folic acid, for instance, their potential for ... spectroscopy and zeta potential measurements, as well as by saturation of magnetization The infrared spectra of Magh-Rh (H cit) (Figure 2C) showed intense absorptions assigned to asymmetrical as (COO) and ... absorbances were measured at 512 nm in a Hitachi U1100 Zeta potential was obtained from electrophoretic mobility (em) measurements performed by phase analysis light scattering using ZetaSizer Nano ZS...
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Báo cáo y học: " Oxygen-regulated transcription factors and their role in pulmonary disease" pptx
... product Transcription factor* Adenylate kinase HIF-1 α1B-Adrenergic receptor HIF-1 Adrenomedullin HIF-1 Aldolase A HIF-1 Aldolase C HIF-1 Carbonic anhydrase-9 HIF-1 Ceruloplasmin Cyclooxygenase-2 ... Endothelin-1 HIF-1 Enolase-1 HIF-1 Erythropoietin GADD153 HIF-1 Not determined NF-IL6 (also known as C/EBPβ, for CCAAT-enhancerbinding protein-β) is a basic-leucine-zipper transcription factor ... involve EGR-1 Thus, in contrast to NF-IL6, hypoxia-induced EGR-1 activity promotes pulmonary vascular thrombosis Heme oxygenase-1 AP-1, HIF-1 Hexokinase-1 HIF-1 Hexokinase-2 HIF-1 Insulin-like growth...
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Báo cáo y học: "Dynamic cumulative activity of transcription factors as a mechanism of quantitative gene regulation" docx
... often display nonlinear dynamic behavior This is probably also the case for the activation of target genes as a result of the combinatorial activity of different transcription factors Nonlinear systems ... processes for a given regulator For example, MYC responds differently to different inputs from other factors and/or signals [49] Another well-known example is represented by transcription factors ... One of the reasons for the failure to observe a significant correlation between the expression of single transcription factors and their target genes might be that, in most cases of transcription...
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Báo cáo khoa học: Distribution of the extrinsic proteins as a potential marker for the evolution of photosynthetic oxygen-evolving photosystem II ppt
... caldarium Chloroplast DNA Bacillariophyceae (diatoms) Thalassiosira pseudonana Nuclear DNA Chloroplast DNA Odontella sinensis Chloroplast DNA Prasinophyceae Mesostigma viride Chloroplast DNA Euglenophyceae ... proteins Prasinophytes are considered to be the most primitive green algae [36] Thylakoid membranes of a prasinophyte, Pyraminonas parkeae, cross-reacted with anti(H-PsbP) but not with other antibodies ... gene has been transferred to the nuclear genome in this organism, as in the case of red algae On the other hand, the failure of cross-reaction with anti-(C-PsbU) suggests that C paradoxa PsbU has...
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Báo cáo khoa học: Hyaluronan–CD44 interactions as potential targets for cancer therapy pptx
... Importantly, the overproduction of HA in cancer cells, such as fibrosarcomas, breast cancer, mesotheliomas and prostate cancer, transfected with HAS1, HAS2 and HAS3 genes, triggered intracellular signaling ... highmolecular-mass isoforms CD44v4–v7 and CD44v6–v9 in various cancers [45–52], as well as the downregulation of the CD44s isoform in colon cancer, has been postulated to result in increased tumorigenicity ... vectors holds potential promise for therapeutic approaches for silencing disease-causing genes [145] There are two ways to deliver shRNA in cancer cells: using either a viral vector or a nonviral...
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Báo cáo y học: "The role of statins as potential targets for bone formation" pptx
... identification of other potential molecular targets for drug discovery as well as other therapeutic approaches to enhance bone formation, and thus produce the ideal anabolic agent for osteoporosis ... osteoblast accumulation Cultures exposed for days show further enhancement of bone formation It has been shown that statins cause a marked increase in osteoblast accumulation and new bone formation ... regulating bone formation can act by either increasing/decreasing the replication of cells of the osteoblastic lineage or modifying the differentiated function of the osteoblast It would, therefore, be...
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Báo cáo y học: " APOBEC3G-UBA2 fusion as a potential strategy for stable expression of APOBEC3G and inhibition of HIV-1 replication" pot
... [35]), was used as controls The fusion products were cloned into a mammalian gene expression plasmid pCDNA3.1 and the resulting plasmids were designated as pcDNA3.1(-)-Apo-E/Hygromycin (E) for the ... were measured with the MAGICCR5 assay as previously described [43] This assay measures viral infectivity in a single cycle of viral infection About 50% reduction of viral infectivity was observed ... To make these plasmid constructs, the APOBEC3G gene was amplified from the plasmid pcDNA3.1-HA-APOBEC3G by PCR The 5' primer used for the construction of all three plasmids was 5'-GCGCGCGCGCCTCGAGACCATGAAGCCTCACTT-3';...
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Báo cáo sinh học: " HCV entry receptors as potential targets for siRNA-based inhibition of HCV" ppt
... different studies exhibit the feasibility of targeting host cell factors involved in infection, as they are not prone to mutations, as potential targets for siRNA therapy Henry and colleagues [85], ... interference expression cassettes Mol Ther 2006, 14:485-493 doi:10.1186/1479-0556-9-15 Cite this article as: Jahan et al.: HCV entry receptors as potential targets for siRNA-based inhibition of HCV ... with 5% CO as complete medium The medium was renewed every days and cells were passaged every 4-5 days To examine the effects of siRNAs, cells were transfected with siRNAs specific for either HCV...
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BARRIER DISRUPTION IN STAT6VT TRANSGENIC MICE AS A POTENTIAL MODEL FOR ATOPIC DERMATITIS SKIN INFLAMMATION
... 54, and 57 Furthermore, TEWL was increased in STAT6VT mice during each of the application periods, whereas the reactions seen in the WT were not as pronounced Next, we assessed whether a higher ... (Patil, Singh, Sarasour, et al., 1995) The radial spread of SLS can elicit increased TEWL and decreased skin capacitance in areas adjacent to the application sites, as far as approximately 0.75cm ... temperature was given time to acclimate to the skin temperature (approximately 20 s) The change in TEWL for each mouse was compared to each individual mouse’s baseline value and the fold increase was plotted...
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báo cáo hóa học:" Can urinary exosomes act as treatment response markers in prostate cancer?" ppt
... exosomes present Prostate Cancer cell lines produce typical exosomes, positive for prostate and cancer- associated antigens Two prostate cancer cell lines were maintained in culture, as a source of ... immune-suppressive functions for cancer exosomes, assisting cancers evade immune attack [21-24] Cancer exosomes may also contribute to angiogenic processes [25], may disseminate metastatic potential in certain ... 9), there was no significant difference compared to ADT4 or to ADT12, as out of patients demonstrated a further decrease in exosome levels, whilst out of had increasing urinary exosome levels There...
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Báo cáo hóa học: "Anti-viral state segregates two molecular phenotypes of pancreatic adenocarcinoma: potential relevance for adenoviral gene therapy" pdf
... responsiveness of cancer cells to chemotherapy and promotes cancer progression Anticancer Agents Med Chem 2005, 8:790-797 41 Ko Y, Atkins M: Chemotherapies and immunotherapies for metastatic kidney cancer ... after lysis was collected for testing viral load by real time qPCR AAV infection was performed in Costar black 96 well plates with clear flat bottom (Corning, NY) Luciferase assay was performed using ... were 96°C for 15s, 60°C for for 40 cycles The viral DNA in each sample was quantified by comparing the fluorescence profiles with a set of Ad DNA standards (449B plasmid) Plasmids for constructing...
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Nutraceuticals as new treatment approaches for oral cancer – i
... curcumin as high as 15 lM together with low-frequency ultrasound on two OSCC cell lines (OSCC-4 and OSCC-25) The ultrasound-enhanced delivery of curcumin as a cytotoxic agent for OSCC was found ... separation between them was not always feasible Therefore, whenever the cell line origin was specifically mentioned as being from the oral cavity, it will be referred to as an OSCC cell line, and ... of tobacco, alcohol and other carcinogenic substances Curcumin has been considered pharmacologically safe, based on the fact that it has been consumed for centuries as a dietary spice at doses...
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Báo cáo khoa học: " Self-assessed bowel toxicity after external beam radiotherapy for prostate cancer - predictive factors on irritative symptoms, incontinence and rectal bleeding" pptx
... first eighty patients [14] This association was also found in an independent group of patients after permanent brachytherapy with I-125 as monotherapy for prostate cancer [42] Quality of life scores ... Expanded Prostate Cancer Index Composite (EPIC) in a patient group after primary (external beam radiotherapy and permanent iodine-125 brachytherapy) and postoperative radiotherapy for prostate cancer ... LP, Wentzel-Larsen T, Dahl O: Late gastrointestinal morbidity after three-dimensional conformal radiation therapy for prostate cancer fades with time in contrast to genitourinary morbidity Int...
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Báo cáo khoa học: " The median non-prostate cancer survival is more than 10 years for men up to age 80 years who are selected and receive curative radiation treatment for prostate cancer" ppt
... incidence of non- prostate cancer mortality unadjusted and adjusted for prostate cancer mortality Deaths from prostate cancer are a competing cause of mortality with non- prostate cancer deaths ... prostate cancer survival censors deaths from non- prostate cancer and men who are still alive at the end of the study period The K-M non- prostate cancer survival censors deaths from prostate cancer ... for prostate cancer are more likely to have their death attributed to prostate cancer In this study, this bias could lead to overestimation of survival from non- cancer causes in men treated for...
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Báo cáo y học: "A filter-based feature selection approach for identifying potential biomarkers for lung cancer" pot
... more useful for constructing accurate classifiers, which can provide a good basis for further screening of biomarkers selection method could be said to corroborate the given data As before, we divided ... method, biomarker identifier (BMI), has been applied to find potential biomarkers for lung cancer from microarray Table KEGG pathways and PANTHER classifications associated with top 80 genes selected ... A new ensemble-based algorithm for identifying breath gas marker candidates in liver disease using ion molecule reaction mass spectrometry Bioinformatics 2009, 25(7):941-947 Kononenko I: Estimating...
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Báo cáo y học: " Collet-Sicard syndrome as an initial presentation of prostate cancer: a case report" doc
... skull base metastasis of prostate carcinoma Nippon Hinyokika Gakkai Zasshi 2000, 91:562-564 11 Wilson H, Johnson DH: Jugular foramen syndrome as a complication of metastatic cancer of the prostate ... one other case has been reported where metastasis to the temporal bone was the first recognized symptom of the disease [12] It is important to consider the possibility of the existence of prostate ... in the CT scan, which slightly decreased the caliber of the jugular foramen and the condylar canal Therefore, fibrous dysplasia, Paget’s disease and metastasis were considered in the differential...
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báo cáo khoa học: " Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy" ppsx
... Southeast Asia [1] For centuries, turmeric has been used as a spice and coloring agent in Indian food, as well as a therapeutic agent in traditional Indian medicine Enthusiasm for curcumin as an ... compound for cancer therapy and chemoprevention, it has by no means been embraced by the cancer community as a "panacea for all ills" The single most important reason for this reticence has been ... anti -cancer agent in this emerging class of drug formulations [39] In a quest for developing stable and efficient systemic carriers for hydrophobic anti -cancer compounds, our laboratory has developed...
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Towards identifying novel modulators and targets for alzheimers disease therapy
... further detail in Chapter 1.3 Drug targets for AD therapeutics Based on the abovementioned hypotheses, various drug targets and strategies are currently being evaluated for their therapeutic potential ... role of glycogen synthase kinase - 3β inhibitors as Wnt/β-catenin signaling pathway inducers on SH-SY5Y neuroblastoma cells as a therapeutic strategy for Alzheimer’s disease 2nd PharmSci@India ... drug targets Based on this emerging trend, the overall goal of this study is to identify novel modulators and targets for AD therapy with the aim of developing novel strategies to prevent disease...
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Nanoparticles of biodegradable polymers for delivery of diagnostic therapeutic agents their potential application in brain cancer therapy
... before freeze-drying was dispersed in mL de-ionized water in a plastic cuvette, which was sonicated for 1minute The cuvette was wiped clean and placed inside the machine for measurement The laser ... supernatant was taken out for analysis Since the Gd-DTPA released much faster than paclitaxel, the release file was obtained within 48 hours The resulted released gadolinium in PBS was measured directly ... startes, not brain cells Like other cancers, effective treatments of brain cancers include surgery, radiotherapy, chemotherapy, hormone therapy, biotherapy, and immunotherapy (Oncology, 2002) Two...
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Báo cáo khoa học: The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors pdf
... adenocarcinomas, MUC5B expression was intense and cytoplasmic (Fig 5A), whereas there was no expression of TTF-1 in MUC5B-positive cells (Fig 5B) In a papillary adenocarcinoma, MUC5B was not detected ... GATA factors seems to be more general, and may affect the expression of other mucin genes, such as MUC2, MUC3 and MUC4, as their promoters also contain cis-elements for these transcription factors ... human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells J Biol...
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