no single tyrosine residue on the d6 n terminus is essential for ligand binding
Báo cáo khoa học: The equinatoxin N-terminus is transferred across planar lipid membranes and helps to stabilize the transmembrane pore pot
... has been shown that this is the only part of the molecule that undergoes major conformational changes during pore formation, and that its flexibility is essential for formation of the final pore ... especially the topology of the first five N- terminal amino acids We demonstrated that the N- terminus is positioned on the trans side of the membrane Furthermore, the amino acids at positions and are ... the ion conductive pathway, and the N- terminus helps to stabilize the final pore Results Characterization of transmembrane channels formed by EqtII, single cysteine and deletion mutants In this...
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Báo cáo khoa học: A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone pptx
... not essential for the dimerization was verified by the data shown in Fig On the other hand, the second assumption that the 35 amino acids were involved in the client binding was not true, but the ... therefore, it is still ambiguous whether the regions, especially the region responsible for dimer formation and that for client binding, exist at distinct sites of the C-terminal region, or they ... temperatures and that this phenomenon is closely related to the client -binding function of the proteins [32,38] Taken together, we assumed that formation of the complex of the region carrying the hydrophobic...
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Báo cáo khoa học: The mitochondrial protein frataxin is essential for heme biosynthesis in plants potx
... frataxin serves as a potential donor to FC for insertion of iron into the protoporphyrin ring during heme synthesis Knocking down the expression of frataxin in human cells revealed significant defects ... heme-containing proteins [25] Although the participation of frataxin in delivering iron to heme synthesis is frequently mentioned in the literature, scarce direct evidence exists on the role of this ... and the heme groups, we decided to investigate the effect of AtFH deficiency on heme content and the activity of hemeproteins in Arabidopsis plants Construction of the antisense as-AtFH line and...
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LUẬN MẪU LỚP 12 Discuss the view that tolerance is essential for peace and harmony in any community or country
... in your country University education confers many benefits on the individual It develops his intellect and broadens his outlook on life, and enables him to discriminate between the good and the ... colour of the skin can cause trouble and violence in a community, and when passions are aroused, men lose their reason and sense of proportion and indulge in the most barbaric acts Innocent lives ... small nations soon came under the dominion of a powerful country, which then developed into an Empire The Roman Empire, for example, was created mainly by conquest Even the personal ambitions of...
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A Single-Molecule Perspective on the Role of Solvent Hydrogen Bonds in Protein Folding and Chemical Reactions pptx
... critical force for bond rupture in a protein is dependent on the dissociation strength of hydrogen bonds in the system, which vary depending on the solvent conditions.[60] In this model, an increase ... subtle and non-intuitive ways.[32–35] Interestingly, in contrast to the wealth of thermodynamic data on the influence of D2O on hydrocarbon solvation and protein stability, little is known about the ... bending motion of the proton donor molecule distorting the linearity of the hydrogen bond.[16] Although the increase in bond strength is small for individual bonds, the cumulative effect on a...
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WORKING PAPER SERIES NO 1395 / NOVEMBER 2011: ON THE IMPORTANCE OF PRIOR RELATIONSHIPS IN BANK LOANS TO RETAIL CUSTOMERS pptx
... access data that has information not only on loan performance, but also on the determinants for the loan approval decision, including the quantifiable credit information on the customer Our results ... borrowers is not significantly different, i.e they are not different based on ex-ante risk The second argument is based on the institutional setting in German banking Savings banks are mandated to ... Working Paper Series No 1395 November 2011 17 The data set not only contains information on the checking accounts that loan applicants hold at the savings banks, but also on their assets and prior...
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Báo cáo khoa học:Bounds on the Tur´n density of PG(3, 2) a pot
... cannot be contained in C, therefore z ∈ A ∪ B Thus, we have found that G contains an edge with one endpoint in A ∪ B and two endpoints in C1 ; this is impossible by (1) Hence, H3 is not contained ... follows that no edge of G is monochromatic Since H3 is contained in G, it follows that H must admit a 3-coloring such that one color class is included in A, another in B and the other in C Thus, ... G doesn’t contain H3 In obtaining an upper bound on π(H3 ), we may assume that G contains a copy F of the Fano plane, the electronic journal of combinatorics 11 (2004), #N3 otherwise π(H3 )...
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Báo cáo toán học: "On the Tur´n Properties of Infinite Graphs a" pptx
... functions of sequences A, B and C Figure describes the behavior of the density function for the sequences A, B and C on one block for k = 1000 and a large value of m More precisely, it gives the ... bound, confirming that the Tur n number for Ik –free infinite graphs differs significantly a from those for finite graphs Theorem 1.4 For any k ≥ the path Tur n number satisfies a p(k) ≤ 1.2 Reformulation ... , n2 ) | ≤ n1 < n2 ≤ l, i1 < i2 for n1 ∈ N (i1 ) , n2 ∈ N (i2 ) } Note, SC (k, l) = |SD (l)| (14) ˜ For any i ∈ {1, , k}, let ri be a function defined on N such that ri (l) = | {n ∈ N | dn =...
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Single molecule studies on the role of nucleoid associated proteins in bacterial chromatin
... 103 The responses of Ler-DNA complexes to variation in KCl concentration, MgCl2 concentration, pH, and temperature 107 The impact of variation in KCl concentration, MgCl2 concentration, pH, and ... The highly abundant IHF can induce DNA bending, overcrowd the DNA sites, and promote DNA compaction, which depend on many factors including force, monovalent salt concentration, and MgCl2 concentration ... calibration on single DNA is performed, we obtain the force-extension curves of naked DNA as our control experiment By changing the bu↵er to those containing DNA -binding protein of our interest,...
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Metaphor, based on the association of similarity, is one of the two basic types of semantic transference that have been an interest for many linguistic researchers
... refers to the consideration of meaning in an incongruent way at the level of the organization of the discourse The most congruent form of joining two ideas is An investigation into the role of ... different way of construing the world Second, it can increase the information load of the nominal group by nominalizing the dynamic process and putting several epithets before the head of the nominal ... sleep Taking concession as process An investigation into the role of metaphor in description of emotion in poetic discourse 28 To express the meaning of concession in the congruent way, connectives...
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Tài liệu REPORT BY THE DIRECTOR-GENERAL ON THE UNITED NATIONS DECADE OF EDUCATION FOR SUSTAINABLE DEVELOPMENT: INTERNATIONAL IMPLEMENTATION SCHEME AND UNESCO’S CONTRIBUTION TO THE IMPLEMENTATION OF THE DECADE doc
... social and economic transformation Encouragement for future-oriented thinking and anticipation is gaining importance Old notions of quality are no longer enough … despite the different contexts there ... environmental degradation needed international attention and collaboration rather than national approaches and solutions While some attention was attached to the social and economic issues inherent ... require innovation to capture the unique conditions and infuse them into ESD programmes 172 EX/11 Annex I – page 15 Use of Information and Communication Technologies Information and communication technologies...
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Case Studies on the Effectiveness of State Financial Incentives for Renewable Energy pdf
... example, the NC Solar Center at NCSU in North Carolina, and the NY and LI Shines programs in New York, are natural conduits for this information and assist in promoting the incentive within the context ... environment The credit is allowed for tax years beginning on or after January 1, 1998 Included in the legislation is a provision for the net metering and interconnection of the photovoltaic equipment ... quick interconnection process for grid-connected systems, and complementary financial incentives (tax incentives, net metering, and low-interest financing) the effectiveness of financial-incentive...
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Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx
... continued to exhibit ERC/punctate localization and regulate transferrin binding, consistent with production and localization of a functional protein Many studies have demonstrated the importance ... glycosylation patterns on HFE intracellular trafficking, localization and function Initially this was done in the context of inhibiting cellular glycan production, with tunicamycin treatment altering HFE localization ... basis for the observed deficiency in b2M binding of the triple mutant remains unclear One possibility is that glycosylation deficiency compromises HFE folding and the misfolded protein cannot bind...
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Báo cáo khoa học: The N-terminal hybrid binding domain of RNase HI from Thermotoga maritima is important for substrate binding and Mg2+-dependent activity pot
... depression containing the active site interacts with the RNA backbone and the other depression containing the phosphate -binding pocket interacts with the DNA backbone These two depressions are ... that the conformation of the active site is not significantly changed on removal of the HBD Because the HBD is important for substrate binding, the HBD may affect the interaction between the enzyme ... The genome contains single rnhA and single rnhB genes, encoding type (TmaRNase HI; accession no AAD36370) and type (Tma-RNase HII; accession no AAD35996) RNases H, respectively Tma-RNase HI is...
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On the Control Aspects of Semiactive Suspensions for Automobile Applications doc
... suspension’s stiffness on the relationship between vibration isolation and suspension travel, using the dimensionless expressions shown in Equations (3.20) and (3.21), which are shown in detail in ... damping ratio minimizing the rms suspension travel can therefore be associated with any given suspension stiffness for the hybrid configuration and the skyhook configuration It can be noted that the ... 4], the tradeoff between resonance control and high-frequency isolation, common in passive suspensions, is eliminated [5] Notice that skyhook control focuses on the sprung mass; 10 as C sky increases,...
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Báo cáo khoa học: ATP-binding domain of heat shock protein 70 is essential for its effects on the inhibition of the release of the second mitochondria-derived activator of caspase and apoptosis in C2C12 cells potx
... interaction between HSP70 and Smac HSP70 contains three functional regions: the ATPbinding domain, the peptide -binding domain, and the EEVD motif Although the EEVD motif is considered to be involved ... H2O2-induced apoptosis in transfected C2C12 cells Furthermore, there was no direct interaction between HSP70 and Smac proteins, and the ATP -binding domain of HSP70, rather than the peptide -binding ... detected in the motichondrial fraction but not in the cytosolic fraction, consistent with its known subcellular location After exposure of cells to H2O2 for h, Smac accumulated in the cytosol and the...
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Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx
... substrate concentrations of carnitine: mm (for standard comparison with other published data), and a concentration equal to the Km for carnitine of each enzyme (for comparison between mutants) In this ... determinant between residues 19 and 28 in the N- terminal region of the enzyme Switching the N- terminal region between human and pig CPT1B affects malonyl-CoA inhibition To study the role of the N- terminal ... variation affects both the carnitine affinity and malonyl-CoA inhibition of the pig enzyme, whereas Asp17 only affects malonyl-CoA inhibition of the human enzyme (Fig and Table 2) Therefore, the...
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Báo cáo khoa học: The N-terminal cysteine pair of yeast sulfhydryl oxidase Erv1p is essential for in vivo activity and interacts with the primary redox centre doc
... This already demonstrates the importance of the N- terminal domain for dimer-formation Under nonreducing conditions all of the cysteine mutant proteins display only a small amount of monomeric form ... covalently linked under nonreducing conditions [15] While the wild-type proteins exist as a mixture of dimers and monomers under these conditions, the DN-Erv1p is found exclusively in the monomeric form ... In one conformation, this arm brings the CGC close to the redox-active centre of the other monomer, while in the second conformation the arm reaches out to the open space Thus, the CGC motif on...
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Đề tài " On the nonnegativity of L(1/2, π) for SO2n+1 " potx
... both zeta integrals take Φ of the form Φ1 Φ1 in (8) are nonnegative and the one on the right-hand side is nonzero Hence ε( , π ⊗ π, ψ) has the same sign as ωπ (−1 )n 1 and consequently, it is equal ... representations, so that it does not depend on γ The same argument as in Proposition with the exponent γ > instead of gives: 913 ON THE NONNEGATIVITY OF L( ,π) FOR SO 2n+ 1 admits a Langlands Proposition ... fonctionnelle de la fonction L e d’Artin d’une repr´sentation orthogonale, Invent Math 35 (1976), 299–316 e ¨ [FQ73] A Frohlich and J Queyrut, On the functional equation of the Artin L-function for...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008