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nitric oxide no as a transmitter substance

Báo cáo y học:

Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"

Y học thưởng thức

... Hosokawa H, Sawamura T, Kobayashi S, et al Cloning and characterization of a brain-specific amino acid transporter J Biol Chem 1997; 272: 8717-8722 50 Bommarius AS, Makryaleas K, Drauz K An enzymatic ... was earlier reported (20) Apart from NO synthesis L-arginine may also serve as a substrate for glutamate formation and may also provide increased substrate for arginase (50) No significant changes ... et al (28) as described by Sadasivudu et al (29) Estimations of NO, TBARS and TAS: NO was estimated as NOx by Griess reaction after conversion of nitrate to nitrite by nitrate reductase, as described...
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Báo cáo y học:

Báo cáo y học: "Gender-based reciprocal expression of transforming growth factor-β1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis" ppsx

Báo cáo khoa học

... from each hourly interval were thawed, and 20 μl of each sample were analyzed NO was measured as NO2 - /NO3 - by the nitrate reductase method [29] using a commercially available kit (Cayman Chemical, ... latent TGF-β1 (panel B) and active TGFβ1 (panel A) was maintained across all groups The substantial levels of latent TGF-β1 in female rats at baseline and after CYP was accompanied by only minor ... levels of active and latent/total TGF-β1 at baseline and after CYP Urine levels of active and latent/total TGF-β1 at baseline and after CYP Active and latent/total TGF-β1 values are reported as pg/mg...
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Báo cáo y học:

Báo cáo y học: "Involvement of nitric oxide (NO) in cough reflex sensitivity between non-sensitized and OVA-sensitized guinea pigs" pptx

Báo cáo khoa học

... nitric oxide synthase after sensitization and allergen challenge of Brown Norway rat lung Br J Pharmacol 1997, 121:1241-1246 27 Prado CM, Leicki-Maldonado EA, Arata V, Kasahara DI, Martins MA, ... 12 Barnes PJ: NO or no NO in asthma? Thorax 1996, 51:218-220 13 Kharitonov SA, Yates D, Robbins RA, Logan SR, Shinebourne EA, Barnes PJ: Increased nitric oxide in exhaled air of asthmatic patients ... analyzer was calibrated with Bronchoalveolar lavage (BAL) BAL was performed immediately after ENO sampling The lungs were lavaged twice through the tracheal cannula with 10 mL of saline (total:...
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Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx

Tài liệu Báo cáo Y học: Enhancement by a-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-c through the upregulation of protein kinase C in rat vascular smooth muscle cells docx

Báo cáo khoa học

... 381S Badamchian, M., Spangelo, B.L., Bao, Y., Hagiwara, Y., Hagiwara, H., Ueyama, H & Goldstein, A. L (1994) Isolation of a vitamin E analog from a green barley leaf extract that stimulates release ... participate in the TS effect, and that the inhibitory effect of a- T was mediated by a nonantioxidative reaction a- T was reported to decrease PKCa activity due to activation of protein phosphatase 2A ... highest grade commercially available Data were expressed as the mean ± standard deviation of at least three independent experiments Statistical significance was assessed by multiple-comparison test...
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Báo cáo khoa học: Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO pptx

Báo cáo khoa học: Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO pptx

Báo cáo khoa học

... only an a- amino moiety (NOHAgma) interacted with iNOSoxy with an affinity (Kd  250 lm) much lower than that found for BuNOHG, and the NOHA analogue bearing only an a- carboxylate moiety (NOHGPA) ... N-aryl-N¢-hydroxyguanidines that lead to kcat values of formation of NO as high as 83 and 69% that obtained for NOHA (Table 2) As in the case of the N-hydroxyguanidines, the kcat values of NO formation from ... experiments are shown in Table NOHA was found to bind to iNOS with a Kapp value slightly lower than that of l-Arg (18 ± lm, Table 1) Homo-L-Arg and homo-NOHA, the l-Arg and NOHA analogues bearing one...
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Báo cáo khoa học: A pathway through interferon-c is the main pathway for induction of nitric oxide upon stimulation with bacterial lipopolysaccharide in mouse peritoneal cells pot

Báo cáo khoa học: A pathway through interferon-c is the main pathway for induction of nitric oxide upon stimulation with bacterial lipopolysaccharide in mouse peritoneal cells pot

Báo cáo khoa học

... regulatory factors Clin Diagn Lab Immunol 9, 530–543 26 Funatogawa, K., Matsuura, M., Nakano, M., Kiso, M & Hasegawa, A (1998) Relationship of structure and biological activity of monosaccharide ... H2SO4 and the absorbance was measured at 450 nm Quantification of each cytokine (in ngÆmL)1 for IFN-c and in pgÆmL)1 for IL-12p70) was performed based on the standard curve in each assay Preparation ... from the American Type Culture Collection (Manassas, VA, USA) and maintained in our laboratory, was also used For cell culture, RPMI-1640 (Dainippon Pharmaceutical Co Ltd, Osaka, Japan) supplemented...
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Báo cáo khoa học: In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS–HSP90 heterocomplex pot

Báo cáo khoa học: In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS–HSP90 heterocomplex pot

Báo cáo khoa học

... immunoblotting analysis was performed as described above The immunoreactive material was detected and quantified as described above Assay of NOS activity NOS activity was assayed by detecting the ... The Authors Journal compilation ª 2008 FEBS 2503 In vivo degradation of NOS and HSP90 by calpain M Averna et al Table Levels of native and 15 kDa calpastatin species in brain and aorta of NMS and ... aorta, the inhibitor was predominantly inactivated As both the inactivation and fragmentation of calpastatin are known to be produced by active calpain [32], these observations further indicate...
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Báo cáo khoa học: Neuropeptide S as a novel arousal promoting peptide transmitter pdf

Báo cáo khoa học: Neuropeptide S as a novel arousal promoting peptide transmitter pdf

Báo cáo khoa học

... sensory nucleus and the lateral parabrachial nucleus of the brainstem A small number of scattered NPS-positive cells were found in other brain areas, such as amygdala and hypothalamus The NPS-producing ... produce a transient increase in intracellular free Ca2+, indicating that NPS might be an excitatory transmitter in vivo by elevating intracellular Ca2+ A radiolabled analog of NPS (125I-labeled ... profound increase in locomotion, measured as the total distance traveled over one hour It is well known that animals naturally show increased exploratory activity when they are exposed to a novel environment...
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báo cáo hóa học:

báo cáo hóa học: " Signaling pathways mediating a selective induction of nitric oxide synthase II by tumor necrosis factor alpha in nerve growth factor-responsive cells" pptx

Hóa học - Dầu khí

... NGF-treated cells showed a significant increase in AP-1 and CRE activity at 12 hr, while NF-κB activity was not affected As a result, there was also a significant increase in AP-1 and CRE activity ... rat iNOS were as follows; forward 5'-CAC GGA GAA CAG AGT TGG-3' and reverse 5'-GGA ACA CAG TAA TGG CCG ACC-3' Amplified samples were run on agarose gels and stained with ethidium bromide Images ... interleukin-1beta; iNOS, inducible nitric oxide synthase; MAPK, mitogen activated protein kinase; NF-κB, nuclear factor kappa B; NGF, nerve growth factor; NO, nitric oxide; nNOS, neuronal nitric oxide synthase;...
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Báo cáo khoa học:

Báo cáo khoa học: " Effects of L-NAME, a non-specific nitric oxide synthase inhibitor, on AlCl3-induced toxicity in the rat forebrain cortex" doc

Báo cáo khoa học

... Neuropharmacological data indicate that Abeta toxicity is mediated by an excitotoxic cascade involving blockade of astroglial glutamate uptake, sustained activation of NMDA receptors 2+ and an overt ... spatial and temporal regulation of cortical perfusion following basal forebrain activation Aluminium accumulation in the brain can alter neuronal signal transduction pathways associated with glutamate ... and contralateral) was measured by the Lowry method using bovine serum albumin (Sigma, USA) as a standard [18] Statistical analysis Results are given as means ± SD Experimental group comparisons...
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Báo cáo khoa học:

Báo cáo khoa học: " A novel b-glucan produced by Paenibacillus polymyxa JB115 induces nitric oxide production in RAW264.7 macrophages" docx

Báo cáo khoa học

... up-regulation of nitric oxide and tumor necrosis factor-alpha from peritoneal macrophages J Ethnopharmacol 2004, 95, 69-76 Kim YM, Bombeck CA, Billiar TR Nitric oxide as a bifunctional regulator of apoptosis ... conducted to examine the potential use of the novel β-glucan purified from P polymyxa JB115 as an immunostimulant or as an adjuvant of some animal vaccines β-glucan-induced nitric oxide production ... YJ Macrophage activation by polysaccharide fraction isolated from Salicornia herbacea J Ethnopharmacol 2006, 103, 372-378 12 Li J, Li DF, Xing JJ, Cheng ZB, Lai CH Effects of beta-glucan extracted...
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Báo cáo y học:

Báo cáo y học: "Effect of allergen-specific immunotherapy with purified Alt a1 on AMP responsiveness, exhaled nitric oxide and exhaled breath condensate pH: a randomized double blind study" ppsx

Báo cáo khoa học

... that of the glycerinated saline Data analysis An intention-to-treat approach was followed in the analysis of efficacy data All patients with a baseline and at least one postrandomization measurement ... Prieto has served as consultant to GSK, Novartis and Stallergenes, and has received grant founding from GSK and Novartis; R Palacios and D Aldana are employees of Diater Laboratorios SA; A Ferrer, ... moderate or serious severity Specific immunotherapy Alternaria alternata extract and nAlt a1 were produced by Diater (Madrid, Spain) Raw material containing spores and mycelia of Alternaria Alternata...
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Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolateral medulla pps

Heme oxygenase-1 plays a pro-life role in experimental brain stem death via nitric oxide synthase I/protein kinase G signaling at rostral ventrolateral medulla pps

Báo cáo khoa học

... 2-way ANOVA with repeated measures was used, as appropriate, to assess group means This was followed by the Scheffé multiple-range test for post hoc assessment of individual means P < 0.05 was ... oxygenase: contrasts to nitric oxide synthase Proc Natl Acad Sci USA 2001, 98:10996-11002 42 Kaur C, Sivakumar V, Ang LS, Sundaresan A: Hypoxic damage to the periventricular white matter in neonatal ... therapeutic applications Physiol Rev 2006, 86:583-650 37 Satoh T, Baba M, Nakatsuka D, Ishikawa Y, Aburatani H, Furuta K, Ishikawa T, Hatanaka H, Suzuki M, Watanabe Y: Role of heme oxygenase-1 protein...
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Báo cáo y học:

Báo cáo y học: " Protein kinase A-dependent Neuronal Nitric Oxide Synthase Activation Mediates the Enhancement of Baroreflex Response by Adrenomedullin in the Nucleus Tractus Solitarii of Rats" pps

Báo cáo khoa học

... pentobarbital sodium (50 mg/kg) and placed on a heating pad The trachea was intubated to facilitate ventilation, and the femoral artery was cannulated for monitoring systemic arterial pressure (SAP) ... proteins: RAMPing up adrenomedullin signaling Mol Endocrinol 2007, 21:783-796 Kuwasako K, Kitamura K, Ito K, Uemura T, Yanagita Y, Kato J, Sakata T, Eto T: The seven amino acids of human RAMP2 and RAMP3 ... light and electron microscopy Brain Res 2000, 853:245-268 Takahashi H, Watanabe TX, Nishimura M, Nakanishi T, Sakamoto M, Yoshimura M, Komiyama Y, Masuda M, Murakami T: Centrally induced vasopressor...
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Báo cáo y học:

Báo cáo y học: " Diagnosing asthma in general practice with portable exhaled nitric oxide measurement – results of a prospective diagnostic study" ppsx

Báo cáo khoa học

... obstruction was classified as asthma when FEV1was  12% as compared to baseline and at least 200 ml and lung volumes returned to predicted normal range An incomplete bronchodilator response was stated ... 12% and > 200ml but norm value not reached Δ FEV1 > 12% and > 200ml and norm value reached Overlap between asthma and COPD Asthma Yes No No OAD Figure tive airway disease) Diagnostic decision making ... small risk of inducing severe bronchospasm [7] A promising non-invasive and easily available method for diagnosing asthma seems to be the measurement of fractional exhaled nitric oxide (FENO),...
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Báo cáo y học:

Báo cáo y học: " ''''Diagnosing Asthma in General Practice with Portable Exhaled Nitric Oxide Measurement – Results of a " pps

Báo cáo khoa học

... moderate to severe BHR positive bronchodilator reversibility (n = 58)§ *prevalence of asthma = 46.9%, prevalence of 'no asthma' = 53.1% § prevalence of asthma = 36,3%, prevalence of 'no asthma' ... Schermer T, Gindner L, Laux G, Szecsenyi J, Meyer FJ: Diagnosing asthma in general practice with portable exhaled nitric oxide measurement – results of a prospective diagnostic study Respir Res ... Nair A, Lipworth BJ: Portable exhaled nitric oxide measurement: Comparison with the "gold standard" technique Chest 2007, 131:410-414 Publish with Bio Med Central and every scientist can read...
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Báo cáo y học:

Báo cáo y học: "Inhaled nitric oxide in acute respiratory distress syndrome with and without septic shock requiring norepinephrine administration: a dose–response study" ppt

Báo cáo khoa học

... discontinuation of NO 150 ppm, hemodynamic and respiratory paramaters were measured at the same ventilator settings as in phase Statistical analysis Cardiorespiratory parameters at control were compared between ... fracture Measurements Systolic and diastolic arterial pressures (SAP and DAP), and systolic and diastolic pulmonary arterial pressures (SPAP and DPAP) were simultaneously measured using the arterial ... DPAP, pulmonary capillary wedge pressure (PWP), right atrial pressure (RAP), VT, Paw and gas flow were recorded at a paper speed of 50 mm/s Mean arterial pressure (MAP) was calculated as 1/3 SAP...
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Báo cáo y học:

Báo cáo y học: " Nitric oxide: a pro-inflammatory mediator in lung disease?" potx

Báo cáo khoa học

... JA, Hamada K, Mehta S, Scott JA, Jiao A, Yandava CN, Kobzik L, Wolyniec WW, Fabian AJ, Venugopal CS, Grasemann H, Huang PL, Drazen JM: Contribution of nitric oxide synthases 1, 2, and to airway ... in association with human airway inflammatory diseases such as asthma, does not seem to occur in mouse models of asthma [43] Therefore the importance of granule proteins, such as heme peroxidases, ... [abstract] Am J Respir Crit Care Med 2000, 161 :A5 42 44 Honda K, Kobayashi H, Hataishi R, Hirano S, Fukuyama N, Nakazawa H, Tomita T: Inhaled nitric oxide reduces tyrosine nitration after lipopolysaccharide...
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Báo cáo khoa học:

Báo cáo khoa học: " Nitric oxide inhibition rapidly increases blood pressure with no change in outcome in cardiogenic shock: the TRIUMPH trial" pptx

Báo cáo khoa học

... Critical Care Vol 11 No Salem and Mebazaa no difference in secondary outcomes such as resolution or duration of the CS, New York Heart Association functional class and 6-month mortality There was, ... CS with early acute MI primary angioplasty remains the gold standard Percutaneous left-ventricle-assisting devices may serve as a bridge to recovery or final treatment, namely transplantation Competing ... patients with cardiogenic shock: looking for the reasons JAMA 2007, 297:1711-1713 Dzavik V, Cotter G, Reynolds HR, Alexander JH, Ramanathan K, Stebbins AL, Hathaway D, Farkouh ME, Ohman EM, Baran...
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Báo cáo y học:

Báo cáo y học: "Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration: a prospective, controlled animal experiment" docx

Báo cáo khoa học

... Medical School, an Associated Physician at Massachusetts General Hospital, and an employee of Novartis Pharmaceuticals Novartis Pharmaceuticals was otherwise not involved in this research and ... tilation-induced activation of apoptosis signal-regulated kinase (ASK1), nuclear factor-κB-inducing kinase (NIK), c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways [12,25,32] ... lungs were lavaged and lung tissue was prepared for pathological examination or measurement of EBD extravasation, MPO activity, and kinase activation Oxygen was fed into the inspiratory port of...
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