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Tài liệu Báo cáo khóa học: Quantitative analysis, using MALDI-TOF mass spectrometry, of the N-terminal hydrolysis and cyclization reactions of the activation 2 process of onconase pdf

Tài liệu Báo cáo khóa học: Quantitative analysis, using MALDI-TOF mass spectrometry, of the N-terminal hydrolysis and cyclization reactions of the activation 2 process of onconase pdf

Ngày tải lên : 19/02/2014, 12:20
... evaluating the influence of Table 2. Thermodynamic parameters of the thermal denaturaturation of the different onconase (ONC) variants at 25 C and pH 2.0. (C Gdm/HCl ) ẵ 13 , midpoint of guanidinium ... hydrogen bonded to the e-amino group of the Lys9 side-chain, which simultaneously interacts with the main phosphate of the substrate [32]. The closer positioning of the N-terminus to the main protein ... immunogenicity. Acknowledgements The authors thank Professor Ron Raines for the generous gift of the genes encoding onconase and the variant. We are also indebted to Dr Francesc Canals for his help in the mass spectra...
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Tài liệu Euphorion Being Studies of the Antique and the Mediaeval in the Renaissance - Vol. II pot

Tài liệu Euphorion Being Studies of the Antique and the Mediaeval in the Renaissance - Vol. II pot

Ngày tải lên : 21/02/2014, 21:20
... a hierarchy attending to the business of factory or counting-house under the orders of the father of the family, and to the economy of the house-under the superintendence of the mother; a manner ... mythical meaning had been lost in the several centuries of Christianity, was very decayed and obscure; and the fact of the blood on the lance being that of a murdered kinsman of Peredur, and of the ... land of bliss. And there is in the very sensuousness and love of beauty -of these men a vagueness and melancholy, a constant: sense of the fleeting and of the eternal, as in that passage, translated...
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Báo cáo Y học: Identification of residues critical for activity of the wound-induced leucine aminopeptidase (LAP-A) of tomato pptx

Báo cáo Y học: Identification of residues critical for activity of the wound-induced leucine aminopeptidase (LAP-A) of tomato pptx

Ngày tải lên : 08/03/2014, 23:20
... caused changes in the conformation of the tomato L AP-A enzyme did not reveal any correlation with the n ature of t he residue in the mutant His 6 –LAP-A enzyme. X-ray structures of the unliganded ... important for LAP catalysis and coordination of the two zinc io ns in the a ctive site. The i mpact of the mutations on the tomato LAP enzyme must be viewed in the context o f these data. The most ... (Lys342), and the N-terminal amine of the P1 residue of the peptide substrate. A water molecule that bridges Zn1 and Zn2 is the sixth ligand. In addition to the zinc-bridging water molecule and the...
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Structure of the S15,S6,S18-rRNA Complex:Assembly of the 30S Ribosome Central Domain

Structure of the S15,S6,S18-rRNA Complex:Assembly of the 30S Ribosome Central Domain

Ngày tải lên : 13/03/2014, 19:08
... birefringence studies, and the conformation of the bound junction is clearly seen in the structure of the Tth T4 RNP (Fig. 2C) and in the structure of the 30S subunit (1). Biochemical studies of the S15-rRNA ... helix 23a, and to the folded RNA backbone (Figs. 2C and 5). The S6 binding site for S18 is a concave surface made of one strand of the ␤ sheet, the loop between ␤2 and ␤3, and the extended COOH-terminal coil. ... in the loop region be- tween helices ␣1 and ␣2 and in the COOH- terminal end of helix ␣3 interact with the RNA backbone of the lower three-helix junction and with adjacent nucleotides in the...
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Báo cáo khoa học: The propeptide of cruzipain ) a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F ppt

Báo cáo khoa học: The propeptide of cruzipain ) a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F ppt

Ngày tải lên : 16/03/2014, 11:20
... loop in the primed side of the binding site groove. Although the prodomains of cathepsins F and W share the same degree of similarity to the prodo- main of cruzipain, the similarity of the mature ... in the micromolar range. The potency of PCZ as an inhibitor of cruzipain and brucipain decreased moderately at the more acidic pH value of 5 (Table 1), but remained in the subnano- molar range. ... tag at the N-terminus. This type of N-terminal tag was previ- ously used for the expression of the propeptide of human cathepsin K, and it did not interfere with the inhibitory activity of the protein...
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Báo cáo Y học: Amino acids 3–13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor pdf

Báo cáo Y học: Amino acids 3–13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor pdf

Ngày tải lên : 17/03/2014, 10:20
... Rotterdam, the Netherlands The N-terminal domain (NTD) and the ligand-binding domain (LBD) of the androgen receptor (AR) exhibit a ligand–dependent interaction (N/C interaction). Amino acids 3–36 in the ... detection of androgen receptor N/C interaction The ligand-dependent interaction between AR NTD and AR LBD, N/C interaction, was studied in yeast and mammalian in vivo protein interaction systems, and ... K., Trapman, J. & Brinkmann, A.O. (1998) Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator...
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Báo cáo khoa học: Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1 doc

Báo cáo khoa học: Determination of the redox potentials and electron transfer properties of the FAD- and FMN-binding domains of the human oxidoreductase NR1 doc

Ngày tải lên : 23/03/2014, 21:20
... transfer electrons from the FAD/NADPH domain to the FMN domain, and (b) the thermodynamic properties of the FMN domain in CPR and nitric oxide synthase. Despite overall structural resemblance of ... to CPR and NOS, the rate of hydride transfer in NR1 (% 1s )1 )is substantially less than the rates in CPR (% 200 s )1 [24]); and NOS (% 200 s )1 for the first hydride transfer reaction in the FAD-FMN ... a role in the metabolic activation of bioreductive drugs. The lack of a membrane anchor in NR1 suggests that reduction of the P450 enzymes attached to the endoplasmic reticulum is an unlikely...
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Báo cáo khoa học: Internalization of the human CRF receptor 1 is independent of classical phosphorylation sites and of b-arrestin 1 recruitment potx

Báo cáo khoa học: Internalization of the human CRF receptor 1 is independent of classical phosphorylation sites and of b-arrestin 1 recruitment potx

Ngày tải lên : 30/03/2014, 15:20
... stimulation with agonist (Fig. 1). The change is characterized by shrinkage of the cells and detachment from the surface of the culture dish. A similar change in the shape of the cell following agonist ... with the Substance P receptor [25]. Detachment of the cells from the surface of the culture dish could r eflect disassembly of the actin cytoskeleton in the me mbrane regions as a consequence of ... for several GPCRs [29]. The function of b-arrestin is to uncouple the receptor f rom the G-protein, thereby mediating recepto r desensitization, and furthermore to couple the receptor to the endocytic...
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Báo cáo khoa học: Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein pot

Báo cáo khoa học: Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein pot

Ngày tải lên : 31/03/2014, 01:20
... (JASCO). Fig. 3. Alignment of the sequences of the second Kunitz-modules of the human and fugu WFIKKN proteins (wfikkn_hu_2; wfikkn_fugu_2) with the second Kunitz-domains of the human and the two fugu WFIKKNRP ... [8–10]). Thermal unfolding of the protein was monitored at 203 nm at a heating rate of 60 Cặh )1 . Effect of the recombinant protein on the activity of proteases The activity of the proteases on synthetic ... of the second Kunitz–type protease inhibitor module of human WFIKKN. The solid line indicates the spectrum of the recombinant protein, the dotted line indicates the CDPro-predicted spectrum of...
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The Education Of The Negro Prior To 1861 - A History of the Education of the Colored People of the United States from the Beginning of Slavery to the Civil War pdf

The Education Of The Negro Prior To 1861 - A History of the Education of the Colored People of the United States from the Beginning of Slavery to the Civil War pdf

Ngày tải lên : 31/03/2014, 18:20
... if the circumstances of the Negroes were changed, they would equal, if not excel, the rest of the human family "in majesty of intellect, elegance of manners, purity of morals, and ardor of ... colonists, to the mutual aid resulting from the proximity of the communities, and to the coöperation of the Canadians. The previous experience of most of these adventurers as sojourners in the free ... Christian teachers of the Negro race, and the prevention of the immigration of workers from the Northern States rendered the blacks helpless and dependent upon a few benevolent white ministers of the...
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Báo cáo hóa học: " Comparison of the self-administered and interviewer-administered modes of the child-OIDP" ppt

Báo cáo hóa học: " Comparison of the self-administered and interviewer-administered modes of the child-OIDP" ppt

Ngày tải lên : 18/06/2014, 22:20
... participated in the study design and led the writing of the manuscript, EB carried out the data analysis and participated in writing the manuscript, KOB participated in the study design and critically reviewed ... from most other studies on Child-OIDP and some of the asso- ciations between the Child-OIDP and proxy measures were not significant. While the low value of alpha is affected by the nature of the Child-OIDP ... critically reviewed the manuscript, AS conceived of the study and critically reviewed the manuscript, CO participated in the study design, carried out the data collection and partici- pated in writing the manuscript....
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báo cáo hóa học:" The occurrence of osteoarthritis at a minimum of ten years after reconstruction of the anterior cruciate ligament" pdf

báo cáo hóa học:" The occurrence of osteoarthritis at a minimum of ten years after reconstruction of the anterior cruciate ligament" pdf

Ngày tải lên : 20/06/2014, 01:20
... necessity for repeated operations, may increase the risk of developing OA. Another factor of pos- sible importance might be the required tension of the graft and the post-operative rehabilitation ... meniscal tears and degenerative changes. Dis- ruption of the ACL often leads to significant disability which can lead to changes in lifestyle. Although both operative and non-operative treatments ... in 55% of the patients A (1–2 mm), in 29 % of the patients B (3–5 mm) and in 16% of the patients C (6–10 mm) stability. Looking at the osteoarthritis rate of the operated knee, 55 % of the patients...
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báo cáo hóa học:" Revision hip replacement for recurrent Hydatid disease of the pelvis: a case report and review of the literature" doc

báo cáo hóa học:" Revision hip replacement for recurrent Hydatid disease of the pelvis: a case report and review of the literature" doc

Ngày tải lên : 20/06/2014, 04:20
... along the lateral side of rectus femoris and the other one deep to gluteus medius on 25/10/99. The operation was covered with Praziquental and Albenda- zole and she was discharge d home on Albendazole. ... disease of the pelvis: a case report and review of the literature. Journal of Orthopaedic Surgery and Research 2010 5:17. Submit your next manuscript to BioMed Central and take full advantage of: ... thus ending up in remote organs. Due to their physiologic role as capillary filters and their vast capillary volume, the liver and lung are most often affected. The brain, the muscle s or the bones...
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báo cáo hóa học:" Repositioning and stabilization of the radial styloid process in comminuted fractures of the distal radius using a single approach: the radio-volar double plating technique" pot

báo cáo hóa học:" Repositioning and stabilization of the radial styloid process in comminuted fractures of the distal radius using a single approach: the radio-volar double plating technique" pot

Ngày tải lên : 20/06/2014, 04:20
... drafting of the manuscript. GK participated in the design of the study and coordination and helped to draft the manuscript. All authors read and approved the final manuscript. Competing interests There ... release of the distal osseous insertion of the brachioradialis tendon [4]. This permits better manipulation of the fracture fragments because the brachioradialis tendon is known to be an important deforming ... postoperatively and at 24 months for both groups 7.5°(± 3.5/range 0-12). Preoperative loss of radial length was 6.3 mm (± 3.7/range 2-12) and was equal postopera- tively and at 2 4 months...
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